Biological treatment options for eosinophilic asthma, with consideration of markers of eosinophilic inflammation as predictors of treatment efficacy by Aleksandra Niemiec, Olga Branicka, Barbara Rymarczyk, Radosław Gawlik

“…These limitations prompted the development of targeted biological drugs that inhibit the mediators involved in T helper 2-inflammation, which is linked to the pathogenesis of asthma, such as interleukin 4, 5, 9, 13 and immunoglobulin E. …”
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Single-cell transcriptomics in thyroid eye disease by Sofia Ahsanuddin, Albert Y. Wu

“…In the past 4 years, vision researchers have harnessed high-throughput single-cell RNA sequencing to elucidate the diversity of cell types and molecular mechanisms driving the pathogenesis of TED at single-cell resolution. Such studies have provided unprecedented insight regarding novel biomarkers and therapeutic targets in TED. …”
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A General Mathematical Method for Investigating the Thymic Microenvironment, Thymocyte Development, and Immunopathogenesis by Guanyu Wang, Gerhard R. F. Krueger

“…The process is profoundlyaffected by the thymic microenvironment, the dysregulation of whichmay be the pathogenesis or the etiology of some diseases. On thebasis of a general conceptual framework, we have designed the firstbiophysical model to describe thymocyte development. …”
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Tracing the Spectrum of Inborn Errors of Immunity from Past to Present by Safa Barış, Talal A. Chatila

“…In this special issue of the Turkish Journal of Immunology, we will survey some recent advances in the field of IEI with a focus on disease pathogenesis and outcomes.…”
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Complicated Community-Acquired Staphylococcus Endocarditis and Multiple Lung Abscesses: Case Report and Review of Literature by Musa A. Garbati, Imad M. Tleyjeh, Abdullah A. Abba

“…Conclusion. We discuss the pathogenesis of this patient's presentation highlight the need for assessment and proper evaluation of patients with unexplained bacteremia.…”
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Protein Phosphatase 2A: Role in T Cells and Diseases by Suyasha Roy, Lalit Batra

“…PP2A fosters Th17 cell differentiation which contributes to the pathogenesis of systemic lupus erythematosus (SLE) by enhancing the transactivation of the Il17 gene. …”
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Virus Infection-Induced Bronchial Asthma Exacerbation by Mutsuo Yamaya

“…Here, I review the literature on the pathogenesis of the viral infection-induced exacerbation of asthma and on the modulation of viral infection-induced airway inflammation.…”
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The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models by Adam B. Glick

“…The mouse skin carcinogenesis model has been a useful tool to dissect the function of this pathway in cancer pathogenesis, with transgenic and null mice as well as small molecule inhibitors to alter the function of the TGFβ1 pathway and assess the effects on cancer development. …”
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Canonical and noncanonical autophagy: involvement in Parkinson’s disease by Maria Sakurai, Tomoki Kuwahara

“…In this review, we will summarize and discuss the contributions of canonical and noncanonical autophagy to cellular functions, with a special focus on the pathogenesis of PD.…”
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Exercise as a Mean to Control Low-Grade Systemic Inflammation by Neha Mathur, Bente Klarlund Pedersen

“…It has now become clear that low-grade chronic inflammation is a key player in the pathogenesis of most CNCDs. Given that regular exercise offers protection against all causes of mortality, primarily by protection against atherosclerosis and insulin resistance, we suggest that exercise may exert some of its beneficial health effects by inducing anti-inflammatory actions. …”
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Crosstalk between ferroptosis and autophagy: broaden horizons of cancer therapy by Xingyu Liu, Halahati Tuerxun, Yixin Zhao, Yawen Li, Shuhui Wen, Xi Li, Yuguang Zhao

“…Numerous studies have demonstrated that both ferroptosis and autophagy play important roles in cancer pathogenesis and cancer therapy. We also found that there are intricate connections between ferroptosis and autophagy. …”
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The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion by Marina G. Smirnova, John P. Birchall, Jeffrey P. Pearson

“…Inflammation in the middle ear mucosa, which can be provoked by different primary factors such as bacterial and viral infection, local allergic reactions and reflux, is the crucial event in the pathogenesis of otitis media with effusion (OME). Unresolved acute inflammatory responses or defective immunoregulation of middle inflammation can promote chronic inflammatory processes and stimulate the chronic condition of OME. …”
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ASSOCIATION BETWEEN PR PROTEINS WITH RIBONUCLEASE ACTIVITY AND PLANT RESISTANCE AGAINST PATHOGENIC FUNGI by E. A. Filipenko, A. V. Kochetov, Y. Kanayama, V. I. Malinovsky, V. K. Shumny

“…Pathogenesis-related (PR) proteins participate in complex plant defense response to pathogens. …”
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Post-COVID-19 Dermatomyositis: A Delayed Reaction That Evades Early Detection by Nur Ili Syazwani MD HADIS, Siti Suhaila MOHD YUSOFF, Rosediani MUHAMAD, Fatin Hanani CHE JUHA

“…Viral infections may cause autoimmunity and trigger the pathogenesis of myositis. We present the case of a man with a long history of myalgia and muscle weakness, who was initially diagnosed with post-COVID-19 myalgia and subsequently developed progressive muscle weakness. …”
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Recurrent Focal Segmental Glomerulosclerosis: A Discrete Clinical Entity by Elena Torban, Martin Bitzan, Paul Goodyer

“…Capitalizing on recent studies in which patients have been screened for slit diaphragm gene mutations, this review focuses on the natural history and pathogenesis of R-FSGS.…”
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Portal Vein Thrombosis by Ronny Cohen, Thierry Mallet, Michael Gale, Remigiusz Soltys, Pablo Loarte

“…Imaging revealed the presence of multiple nonocclusive thrombi involving the right portal vein, the splenic vein, and the left renal vein, as well as complete occlusion of the left portal vein and the superior mesenteric vein. We discuss pathogenesis, clinical presentation, and management of both acute and chronic thrombosis. …”
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Nanosystems for modulation of immune responses in periodontal therapy: a mini-review by Anirudh B. Acharya, Usha Hegde, Swetha Acharya

“…The current understanding of the pathogenesis of periodontitis has unraveled the importance of the inflammatory and immune reactions to combat periodontitis whose etiology is an overlap of microbial, genetic, and environmental factors in a susceptible host. …”
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Pathophysiology of Vascular Remodeling in Hypertension by Nicolás F. Renna, Natalia de las Heras, Roberto M. Miatello

“…We terminate by considering the potential role of remodeling in the pathogenesis of endorgan damage and in the perpetuation of hypertension.…”
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Persistent and extended COVID, post-COVID-19. New reflections in 2024 by Alfredo Darío Espinosa Brito

“…There is no solid evidence of its detailed pathogenesis, nor tests that confirm or rule out its diagnosis. …”
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Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease by Kyeong-Ah Kwak, Seung-Pyo Lee, Jin-Young Yang, Young-Seok Park

“…Many unsuccessful attempts have been made to develop new small molecules or antibodies to intervene in the disease’s pathogenesis. Stem cell-based therapies cast a new hope for AD treatment as a replacement or regeneration strategy. …”
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