Research Progress on Animal Models of Sepsis-Related Organ Injury by YANG Jiahao, DING Chunlei, QIAN Fenghua, SUN Qi, JIANG Xusheng, CHEN Wen, SHEN Mengwen

“…Establishing corresponding animal models of organ dysfunction syndrome is an essential step in clarifying its pathogenesis, researching potential effective drugs, and evaluating the effectiveness and safety of treatment plans. …”
Get full text

S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis by Panpan Lian, Li Li, Renwei Lu, Bin Zhang, Junaid Wazir, Chaode Gu, Bojie Ma, Wenyuan Pu, Wangsen Cao, Zhiqiang Huang, Zhonglan Su, Hongwei Wang

“…Although persistent activation of signal transducer and activator of transcription 3 (STAT3) is implicated in its pathogenesis, the mechanisms underlying the sustained STAT3 activation remain poorly understood. …”
Get full text

Comparative Analysis of the Occurrence and Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Hemophilic Arthropathy and Osteoarthritis by Piotr Wojdasiewicz, Łukasz A. Poniatowski, Andrzej Kotela, Marta Skoda, Michał Pyzlak, Aleksandra Stangret, Ireneusz Kotela, Dariusz Szukiewicz

“…The involvement of CX3CL1 (fractalkine) and its receptor CX3CR1 was observed in the pathogenesis of numerous arthritis-associated diseases. …”
Get full text

Vascular involvement in idiopathic pulmonary fibrosis by Michele Mondoni, Rocco Rinaldo, Christopher J. Ryerson, Cristina Albrici, Andrea Baccelli, Claudio Tirelli, Francesca Marchetti, Jacopo Cefalo, Giulia Nalesso, Giulia Ferranti, Fausta Alfano, Giovanni Sotgiu, Marco Guazzi, Stefano Centanni

“…Background Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrosing and progressive interstitial lung disease of unknown aetiology with a pathogenesis still partly unknown. Several microvascular and macrovascular abnormalities have been demonstrated in the pathogenesis of IPF and related pulmonary hypertension (PH), a complication of the disease. …”
Get full text

Genome rearrangements in neurodevelopmental disorders of the central nervous system: origins, genomic mechanisms, functional and clinical consequences. Review article by V. Kučinskas, E. Preikšaitienė, L. Ambrozaitytė, L. Cimbalistienė, A. Utkus

“…We believe that new insights into the molecular causes and pathogenesis mechanisms of the intellectual disability may be useful in developing treatment options in the future. …”
Get full text

High-resolution manometry in diagnostics and evaluation of therapy effectiveness in patients with eosinophilic esophagitis – underestimated breakthrough or dead end? by Joanna A. Sarbinowska, Dorota Waśko-Czopnik

“…Mentioned investigations result from advances in comprehension of disease pathogenesis, in which it is suggested that development of a chronic inflammatory reaction of the esophageal wall may lead to consecutive fibrosis and motility disorders. …”
Get full text

Dynamic Roles of RNA and RNA Epigenetics in HTLV-1 Biology by Emily M. King, Amanda R. Panfil

“…Viruses, particularly retroviruses like human T-cell leukemia virus type 1 (HTLV-1), rely heavily on RNA and RNA post-transcriptional modifications to regulate the viral lifecycle, pathogenesis, and evasion of host immune responses. With the emergence of new sequencing technologies in the last decade, our ability to dissect the intricacies of RNA has flourished. …”
Get full text

The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth by Nicole S. Olgun, Sandra E. Reznik

“…As there is currently no FDA-approved therapy for infection-associated PTB, understanding the pathogenesis of preterm labor (PTL) and delivery should be given high priority. …”
Get full text

Borrelia burgdorferi Tolerance-Associated Changes in Gene Expression of Murine Macrophages by Sophia Chen, Ricki Deng, Anis Hadi, Sara Nandwana, William Ryan, John B. Presloid, R. Mark Wooten

“…Ultimately, these findings offer new insights into the pathogenesis and potential treatment strategies for Lyme disease. …”
Get full text

Kelainan Hemostasis pada Leukemia by Zelly Dia Rofinda

“…One of clinical manifestation of<br />leukemia is bleeding that is caused by several hemostasis disorders.Hemostasis disorders in leukemia such as<br />thrombocytopenia, platelet dysfunction, disseminated intravascular coagulation, coagulation protein defect, primary<br />fibrinolysis and thrombosis. Pathogenesis and pathophysiology of thus hemostasis disorders in leukemia occur with<br />different mechanism.…”
Get full text

First isolation and characterization of SARS-CoV-2 from COVID-19 patient of North East India by Aniruddha Jakharia, Biswajyoti Borkakoty, Sumi Pait, Gautam Baruah, Rahul Hazarika, Dipankar Biswas

“…Virus isolation is of paramount importance for development of vaccines, in-vitro screening of antiviral compounds, pathogenesis studies, etc., Many cell lines were studied for amplification and replication of SARS-CoV-2 and Vero cells were found to be ideal cell lines for isolation. …”
Get full text

Novel therapy: Combined BRAF and MEK inhibitors for locally advanced BRAF V600L–Positive mucosal melanoma in hypopharynx by Sivakamavalli Jeyachandran

“…A cutting-edge strategy involves the administration of combined BRAF and MEK inhibitors, targeting specific molecular pathways implicated in mucosal melanoma pathogenesis. BRAF inhibitors, such as vemurafenib and dabrafenib, block mutated BRAF activity, while MEK inhibitors, like trametinib and cobimetinib, target downstream components of the MAPK pathway. …”
Get full text

Histological and Immunohistochemical Characterization of a Case of Endometriosis in a Guinea Pig (Cavia tschudii) by Alfonso Baldi, Andrea Lanza, Francesco Menicagli, Pietro G. Signorile, Enrico P. Spugnini

“…Endometriosis is a chronic gynecological disease characterized by the ectopic proliferation of endometrial tissue outside of the uterine cavity. The pathogenesis of this disease is still obscure, and Sampson’s theory of retrograde menstruation is still the most widely accepted explanation. …”
Get full text

The role of Nrf2 transcription factors in various physiological and pathological states by Deasyka Yastani, Sri Widia A Jusman

“…Understanding Nrf2's diverse functions offers valuable insights into disease pathogenesis and potential therapeutic approaches. This review explores the pleiotropic role of Nrf2 regulation. …”
Get full text

Microbiome role in pancreatic diseases development by Yu. V. Evsyutina, V. T. Ivashkin

“…To present the modern concept on the mechanisms of pancreatic disease development and role of intestinal and oral microbiome in pancreatitis pathogenesis. Summary. Intestinal barrier dysfunction, bacterial overgrowth syndrome and endotoxinemia are features of acute pancreatitis. …”
Get full text

Importins and Exportins Regulating Allergic Immune Responses by Ankita Aggarwal, Devendra K. Agrawal

“…The classical NLS are found on many transcription factors and molecules that are involved in the pathogenesis of allergic diseases. In addition, several immune modulators, including corticosteroids and vitamin D, elicit their cellular responses by regulating the expression and activity of importin molecules. …”
Get full text

Air Pollution and Respiratory Permeability in Obstructive Sleep Apnea — A Review by Nguyen Thanh Tung, Hoang Ba Dung, Tran Phan Chung Thuy, Huynh Nguyen Xuan Thao, Hsiao-Chi Chuang

“…This review article explored the role of air pollution and airway permeability in the pathogenesis of OSA.…”
Get full text

Gingival Vitiligo: Report of a Case and Review of the Literature by Nipun Ashok, Anila Karunakaran, Prabath Singh, Jean Rodrigues, Navya Ashok, Bassel Tarakji, Azzeghaiby Saleh, Alzoghaibi Ibrahim

“…Differential diagnosis, detailed clinical history, histopathology, immunohistochemistry, and pathogenesis of this condition are discussed.…”
Get full text

Inherited glycosylphosphatidylinositol deficiency disorders: a new group of inherited metabolic disorders by Michał Patalan, Alicja Leśniak, Justyna Paprocka, Agnieszka Zubkiewicz-Kucharska, Kaja Giżewska-Kacprzak, Marta Glińska, Lidia Babiak-Choroszczak, Maria Giżewska, Robert Śmigiel

“…We present a comprehensive review of the pathogenesis, clinical symptomatology and management options in IGDs.…”
Get full text

Metabolomic Analysis of Key Regulatory Metabolites in the Urine of Flavivirus-Infected Mice by Xiaoyan Zheng, Ran Wang

“…Metabolomics is an emerging research perspective to uncover and observe the pathogenesis of certain infections. Methods. To improve the understanding of the specific metabolic changes that occur during infection with different flaviviruses, considering the principle of noninvasive sampling, this article describes our comprehensive analysis of metabolites in urine samples from the three kinds of flavivirus-infected mice using a liquid chromatography tandem mass spectrometry method to better understand their infection mechanisms. …”
Get full text