The value of biomarkers in the diagnosis and prognostic analysis of IgA nephropathy by Lu Min, Li Gui-sen

“…Immunoglobulin A nephropathy （IgAN） is the most common primary glomerulonephritis worldwide and the main cause of chronic kidney disease and renal failure worldwide. Its etiology and pathogenesis are still unknown， and the most reliable method for clinical diagnosis of this disease is kidney biopsy. …”
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Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases: Towards Future Therapeutic Application by Dorit Trudler, Dorit Farfara, Dan Frenkel

“…While TLR signaling was linked to neurogenesis, it was also found to be involved in the pathogenesis of neurodegenerative diseases. This paper will focus on TLR signaling in glial cells in neurodegenerative diseases such as Alzheimer's disease, prion diseases, amyotrophic lateral sclerosis, and Parkinson's disease. …”
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Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research by Zheng Yixian, Wang Hai, Liu Xiuying, Yan Jichun

“…Moreover, the pivotal roles of epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs, in the pathogenesis of MG are gradually being unveiled. This review comprehensively summarizes the latest advances in MG genetic research, focusing on the discovery and validation of susceptibility genes, genetic heterogeneity and subtype-specific genetic factors, gene–environment interactions, epigenetic mechanisms, and progress in genetics-based diagnostic and prognostic biomarkers.…”
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Studies on the Interleukin-10 Gene in Animal Models of Colitis by Hugh J Freeman

“…Interestingly, in IL-10 gene-deficient mice raised in germ-free conditions, the intestinal inflammatory changes normally observed in conventional nongerm-free conditions are not detected, suggesting a role for luminal bacteria in the pathogenesis of the inflammatory process.…”
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Immunopeptidomics for autoimmunity: unlocking the chamber of immune secrets by Sanya Arshad, Benjamin Cameron, Alok V. Joglekar

“…Abstract T cells mediate pathogenesis of several autoimmune disorders by recognizing self-epitopes presented on Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA) complex. …”
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Perinatal Cerebellar Injury in Human and Animal Models by Valerie Biran, Catherine Verney, Donna M. Ferriero

“…Most cerebellar lesions are cerebellar hemorrhage and infarction usually leading to cerebellar abnormalities and/or atrophy, but the exact pathogenesis of lesions of the cerebellum is unknown. …”
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Insulin Autoimmune Syndrome: A Systematic Review by MingXu Lin, YuHua Chen, Jie Ning

“…This review provides a comprehensive analysis of the epidemiology, pathogenesis, clinical manifestations, diagnosis and identification, and monitoring and treatment management of IAS.…”
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Unique Cytokine Signature in the Plasma of Patients with Fibromyalgia by Jamie Sturgill, Elizabeth McGee, Victoria Menzies

“…Fibromyalgia (FMS) is a chronic pain syndrome with a complex but poorly understood pathogenesis affecting approximately 10 million adults in the United States. …”
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Cyclooxygenase Inhibition in Sepsis: Is There Life after Death? by David M. Aronoff

“…The prostaglandins participate in the pathogenesis of hemodynamic collapse, organ failure, and overwhelming inflammation that characterize severe sepsis and shock. …”
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Dilating Vascular Diseases: Pathophysiology and Clinical Aspects by Ertan Yetkin, Selcuk Ozturk

“…Although there are some similarities in terms of pathogenesis, they are distinct from atherosclerotic disease of the vessels. …”
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Role of Adaptive Immunity in Alcoholic Liver Disease by Emanuele Albano

“…Stimulation of innate immunity is increasingly recognized to play an important role in the pathogenesis of alcoholic liver disease (ALD), while the contribution of adaptive immunity has received less attention. …”
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Novel serum biomarkers for early diagnosis of gestational diabetes mellitus—a review by Michał Kunicki, Natalia Rzewuska, Paulina Sopońska, Agata Pawłosek, Iwona Sowińska, Anna Kloska

“…Undiagnosed or poorly managed GDM is associated with both short- and long-term complications in the fetus and mother. The pathogenesis of GDM is complex and has not yet been fully elucidated. …”
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PPAR Regulation of Inflammatory Signaling in CNS Diseases by John J. Bright, Saravanan Kanakasabai, Wanida Chearwae, Sharmistha Chakraborty

“…The activation of NF-𝜅B and Jak-Stat signaling pathways and secretion of inflammatory cytokines are critical in the pathogenesis of CNS diseases. Interestingly, PPAR agonists mitigate CNS disease by modulating inflammatory signaling network in immune cells. …”
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Role of Matrix Metalloproteinases in Angiogenesis and Its Implications in Asthma by Khuloud Bajbouj, Rakhee K. Ramakrishnan, Qutayba Hamid

“…MMPs have been implicated in the pathogenesis of asthma by interacting with both the airway inflammatory cells and the resident structural cells. …”
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Targeting Polymorphonuclear Leukocytes in Acute Myocardial Infarction by Clara Di Filippo, Francesco Rossi, Michele D'Amico

“…The present review would support the relatively new discovered role that the polymorphonuclear leukocytes (PMNs) have in the pathogenesis of the AMI, through a brief analysis of past and ongoing research. …”
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Which Are the Cells of Origin in Merkel Cell Carcinoma? by Thomas Tilling, Ingrid Moll

“…Studies on MCC and MCPyV as well as other risk factors have significantly increased our knowledge of MCC pathogenesis, but the cells of origin, which could be important targets in future therapies, are still unknown. …”
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Testing for Gluten-Related Disorders in Clinical Practice: The Role of Serology in Managing the Spectrum of Gluten Sensitivity by David Armstrong, Andrew C Don-Wauchope, Elena F Verdu

“…However, our understanding of the pathogenesis and spectrum of gluten sensitivity has improved, and gluten-sensitive irritable bowel syndrome patients are increasingly being recognized. …”
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Pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasis by Margarita R. Rakhmatulina, Elena V. Lipova, Viktoria A. Nyanenko

“…The literature review presents modern aspects of the etiology and pathogenesis of vulvovaginal candidiasis, highlights issues of immunological resistance and the significance of polymorphic and pathological gene loci, the functioning of which leads to insufficient activation of the immune system in the disease. …”
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Vasospasm in Cerebral Inflammation by Michael Eisenhut

“…Another key factor in the pathogenesis of cerebral arterial vasospasm may be the reduced bioavailability of the vasodilator nitric oxide. …”
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Mixed Large Cell Neuroendocrine Carcinoma of the Ovary: Report of a Rare Case by Ilias Galanis, Georgios Floros, Maria Sotiria Bompoula, Christophoros Theodoropoulos

“…LCNC (large cell neuroendocrine carcinomas) of the ovary is a rare aggressive tumor entity of the genital tract. Its pathogenesis, origin, and prognosis have not been fully elucidated, since there are a limited number of cases reported in literature. …”
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