A Case Report of X-Linked Hyperimmunoglobulin M Syndrome with Lipoma Arborescens of Knees by Qiuting Dong, Jinxia Zhao, Zhongqiang Yao, Xiangyuan Liu, Huiying He

“…Lipoma arborescens (LA) is a rare benign tumor, of which the pathogenesis mechanism has not been clearly understood. …”
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Cell Death and Ageing – A Question of Cell Type by Pidder Jansen-Dürr

“…While there are data suggesting that apoptotic cell death plays a key role for ageing in vitro and in the pathogenesis of various age-associated diseases, this is not reflected in the current literature on in vitro senescence. …”
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Antivascular Endothelial Growth Factor Agents for Neovascular Age-Related Macular Degeneration by Ilias Zampros, Anna Praidou, Periklis Brazitikos, Panagiotis Ekonomidis, Sofia Androudi

“…Vascular endothelial growth factor (VEGF) is considered as a critical molecule in the pathogenesis of choroidal neovascularization (CNV), which characterizes the neovascular AMD. …”
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In vitro interleukin 4 and interferon-gamma production by mononuclear cells from atopic dermatitis patients by Serge Well, Friedhelm Diel

“…In order to elucidate further the possible role of specific cytokines in the pathogenesis of atopic dermatitis (AD) the in vitro production of interleukin 4 (IL-4) and interferon-gamma (IFN-γ) in patients with severe atopic dermatitis (n = 4) was compared with that in a group of non-atopic healthy controls. …”
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αSynuclein and Mitochondrial Dysfunction: A Pathogenic Partnership in Parkinson’s Disease? by David Protter, Charmaine Lang, Antony A. Cooper

“…The protein αSynuclein is a central component in PD pathogenesis yet its cellular targets and mechanism of toxicity remains unknown. …”
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Epigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases by Andrea Stoccoro

“…Epigenetic mechanisms, including DNA methylation, histone tail modifications, and the activity of non-coding RNAs, are strongly implicated in the pathogenesis of neurodegenerative diseases. While it is known that epigenetic mechanisms play a crucial role in sexual differentiation and that distinct epigenetic patterns characterize females and males, sex-specific epigenetic patterns have been largely overlooked in studies aiming to identify epigenetic alterations associated with neurodegenerative diseases. …”
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Bladder Cancer and Cancer Stem Cells: Basic Science and Implications for Therapy by Richard T. Bryan

“…We therefore urgently require detailed molecular insights into the pathogenesis of muscle-invasive bladder cancer so that the disease can be more adequately and appropriately treated at presentation, so that progression from stages Ta/T1 can be abrogated, and so that the risk of recurrence following treatment can be minimised. …”
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Diverse Presentation of Breath Holding Spells: Two Case Reports with Literature Review by Geetanjali Rathore, Paul Larsen, Cristina Fernandez, Manish Parakh

“…Pallid breath holding spells result from exaggerated, vagally-mediated cardiac inhibition, whereas the more common, cyanotic breathholding spells are of more complex pathogenesis which is not completely understood. A detailed and accurate history is the mainstay of diagnosis. …”
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A Case of Essential Thrombocythemia and IgA Nephropathy with Literature Review of the Concurrence by Shoja Rahimian, Timothy Johnson, Ronald Herb

“…Improved management of such cases depends on the recognition of the combined occurrence of ET and glomerular diseases and uncovering the shared pathogenesis between platelets and glomeruli.…”
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Mapping transcriptomic profiles of seminal vesiculitis and experimental verification by Chenkui Miao, Shaobo Zhang, Jiajin Wu, Meiling Bao, Zengjun Wang, Bianjiang Liu

“…Objective: Seminal vesiculitis is a prevalent infectious disease in the genitourinary system, but its intrinsic pathogenesis and molecular features remain unclear. Methods: In this study, we utilized a next-generation sequencing technology to demonstrate transcriptomic landscapes of clinical specimens from seminal vesiculitis patients. …”
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MiRNAs as major players in brain health and disease: current knowledge and future perspectives by Sarika V. Kapplingattu, Sujata Bhattacharya, Yogita K. Adlakha

“…Several reports show downregulation of miR-135 in glioblastoma, indicating its tumor suppressor role in the pathogenesis of brain tumors. In this review, by performing in silico analysis of molecular targets of miR-135, we reveal the significant pathways and processes modulated by miR-135. …”
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Lentiviral-Mediated shRNA Silencing of PDE4D Gene Inhibits Platelet-Derived Growth Factor-Induced Proliferation and Migration of Rat Aortic Smooth Muscle Cells by Lin Liu, Xiaowei Xu, Jiejie Li, Xia Li, Wenli Sheng

“…Proliferation and migration of vascular smooth muscle cells (VSMCs) play a critical role in the pathogenesis of atherosclerosis. In this study, infection of VSMCs with lentivrius particles carrying shRNA direct against PDE4D significantly inhibited platelet-derived growth factor-induced VSMC proliferation and migration, and the inhibitory effects were not associated with global intracellular cAMP level. …”
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Dystrophic Epidermolysis Bullosa in Pregnancy: A Case Report of the Autosomal Dominant Subtype and Review of the Literature by Nicole Colgrove, Rayan Elkattah, Howard Herrell

“…Epidermolysis bullosa (EB) is a group of inherited blistering skin diseases that vary widely in their pathogenesis and severity. There are three main categories of EB: simplex, junctional, and dystrophic. …”
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Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza Viruses by Jennifer Juno, Keith R. Fowke, Yoav Keynan

“…Following the 2009 H1N1 pandemic and ongoing sporadic avian-to-human transmission of H5N1 viruses, an emphasis has been placed on better understanding the determinants and pathogenesis of severe influenza infections. Much of the current literature has focused on viral genetics and its impact on host immunity as well as novel risk factors for severe infection (particularly within the H1N1 pandemic). …”
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Chronic Myelomonocytic Leukemia following Multicentric Castleman Disease by Feng Li, Xiaomei Zhang, Yanting Guo, Yuandong Zhu, Yicun Wu, Yun Ling

“…The coexistence of MCD with chronic myelomonocytic leukemia (CMML) has been rarely reported. Although the pathogenesis remains unclear, this association probably reflects an incidental and fortuitous finding rather than the alteration of a common pluripotent stem cell precursor. …”
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Newer Perspectives of Mechanisms for Euglycemic Diabetic Ketoacidosis by Xiaofang Yu, Saifei Zhang, Long Zhang

“…The main purpose of this work is to have a better understanding of the situation and update our knowledge with a focus on the pathogenesis of EDKA.…”
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Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis by Qinghua Fang, Chun Zhou, Kutty Selva Nandakumar

“…Hence, comprehensive knowledge on pathogenesis is a prerequisite for prevention and development of targeted clinical treatment for RA patients that can restore the immune balance improving clinical therapy.…”
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Currently important pathogenic Listeria species affecting animals and birds (review) by P. N. Shastin

“…Infection with Listeria monocytogenes causes an invasive disease in animals and humans, which is transmitted via the fecal-oral route from an animal to a human, from a mother to a fetus. The pathogenesis of Listeria infection has been well studied. …”
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microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome by Qian Ge, Sonia Brichard, Xu Yi, QiFu Li

“…It is well known that obesity-induced chronic inflammation plays a fundamental role in the pathogenesis of MS. White adipose tissue (AT) is the primary site for the initiation and exacerbation of obesity-associated inflammation. …”
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Psoriasis: Unraveling Disease Mechanisms and Advancing Pharmacological and Nanotechnological Treatments by Miao M, Yan J, Sun Y, Liu J, Guo S

“…Miao Miao,1 Jiong Yan,2 Yujin Sun,3 Jia Liu,2 Shun Guo2 1Outpatient Department, Disease Prevention and Control Center of Tongshan District, Xuzhou, People’s Republic of China; 2Dermatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 3Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of ChinaCorrespondence: Jia Liu; Shun Guo, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, Qinhuai District, Nanjing, Jiangsu Province, 210029, People’s Republic of China, Email aliceyoyo1986@163.com; 260873@njucm.edu.cnAbstract: Research into the pathogenesis of inflammatory skin diseases, including dermatitis and psoriasis, has yielded significant advancements in the last decades. …”
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