Dietary Glycaemic Index and Type 2 Diabetes Mellitus: Potential Modulation of Gut Microbiota by Hanusha Durganaudu, Thubasni Kunasegaran, Amutha Ramadas

“…As a conclusion, we have pointed out several key research directions that may have helpful impact on diet interventions with modulation of gut microbiota on the pathogenesis and therapeutic implications in T2DM.…”
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Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent by Mitsuharu Hattori

“…However, in recent decades, its role in the adult brain has become increasingly important, and it is now clear that diminished Reelin function is involved in the pathogenesis and progression of neuropsychiatric and neurodegenerative disorders, including schizophrenia and Alzheimer’s disease (AD). …”
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Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases by Claire J. Wiggins, Susan Y. Chon

“…By illuminating connections between medication side effects and disease pathogenesis, our goal is to increase awareness of the cutaneous side effects of Notch inhibitor treatment.…”
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Role and Function of Regulatory T Cell in Chronic Rhinosinusitis with Nasal Polyposis by Chenyang Lei, Juan Jiang, Yanyan Zhang, Gaoyun Xiong

“…Chronic rhinosinusitis with nasal polyps (CRSwNP) is a subtype of chronic rhinosinusitis characterized by high edema in the stroma, albumin deposition, and formation of pseudocysts. The pathogenesis of CRSwNP is not yet fully understood. Regulatory T (Treg) cells are a subset of CD4+ T cells that play a suppressive immunoregulatory role in the process of CRSwNP. …”
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Consensus Meeting of European Society of Neurogastroenterology and Motility on Functional Dyspepsia (2020): Have We Dotted All the I’s? by A. A. Sheptulin, O. A. Storonova, D. E. Rumyantseva

“…Expert votes at the consensus meeting generally confirmed the main statements of the Rome Criteria Revision IV on the definition of functional dyspepsia, its aetiology and pathogenesis, diagnosis and treatment, as well as those of the Kyoto Consensus covering the possible association of dyspeptic complaints with H. pylori infection. …”
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Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis by Da-Long Dong, Guang-Zhen Jin

“…Although there is no definitive evidence to date confirming that chondrocyte hypertrophy is the direct cause of OA, substantial experimental data indicate that it plays an important role in the disease’s pathogenesis. In this review, we first explore the mechanisms underlying chondrocyte hypertrophy in OA and offer new insights. …”
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Tezepelumab for asthma with current or previous smoking habit: Case series by Yoshiro Kai, MD, PhD, Kentaro Suzuki, MD, Ryosuke Kataoka, MD

“…Tezepelumab effectively treated severe asthma in a current smoker and a former smoker, suggesting that thymic stromal lymphopoietin is involved in the pathogenesis of severe asthma in these patients. Tezepelumab may additionally be used for severe asthma in current and former smokers.…”
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Challenges and updates in the management of eosinophilic esophagitis by Tsvetelina Velikova

“…The growing knowledge on the pathogenesis of EE has allowed further progression of encouraging targeted biologic therapies. …”
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Pigeon Fever in Florida Horses by Sally DeNotta, Amanda House

“…It is important to note that birds are not involved in the transmission or pathogenesis of this condition. In Florida, the largest number of pigeon fever cases are typically reported in the dry months of fall and winter. …”
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Cardiac Calcified Amorphous Tumor of the Mitral Valve Presenting as Transient Ischemic Attack by Mohammad Abbasi Teshnizi, Atefeh Ghorbanzadeh, Nahid Zirak, Babak Manafi, Aliasghar Moeinipour

“…Thus, the incidence, pathogenesis, and best approach to the treatment are not certain. …”
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Amiloride-Sensitive Sodium Channels and Pulmonary Edema by Mike Althaus, Wolfgang G. Clauss, Martin Fronius

“…This paper describes how sodium channels contribute to alveolar fluid clearance under physiological conditions and how deregulation of sodium channel activity might contribute to the pathogenesis of lung diseases associated with pulmonary edema. …”
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Pycnodysostosis with Special Emphasis on Dentofacial Characteristics by Aisha Khoja, Mubassar Fida, Attiya Shaikh

“…The aim of this case report is to give an insight into the etiology, pathogenesis, and differential diagnosis of this disorder and to prepare the dentists and maxillofacial surgeons to overcome the challenges in treating these patients.…”
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Repigmentation of Tenacious Vitiligo on Apremilast by Sara B. Huff, Lorie D. Gottwald

“…Treatment options are limited and are difficult given the fact that the pathogenesis of the disease is not well elucidated. We present the case of a 52-year-old woman with vitiligo for over 2 decades. …”
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Intraosseous Lipomatous Meningioma by Lauren Kim, Christopher Huang, Adrienne L. Morey, Mark J. Winder

“…Lipomatous meningiomas are very uncommon subtype of meningiomas, with ongoing discussions as to their true pathogenesis. To our knowledge this case represents the first reported case of a lipomatous meningioma with predominant intraosseous extension.…”
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Non-communicable Chronic Diseases and the COVID-19 Pandemic by Miguel Ángel Serra Valdés

“…The repercussion of the pathogenesis of this disease in chronic diseases is analyzed. …”
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Polyarteritis Nodosa Presenting as Digital Gangrene and Breast Lesion following Exposure to Silicone Breast Implants by Yamen Homsi, John Andrew Carlson, Samer Homsi

“…Although the relationship between silicone implants and connective tissue diseases has been investigated in the literature, no prior reports were found documenting PAN after silicone mammoplasty. While the pathogenesis of idiopathic PAN is not known yet, responsiveness to immunosuppressive therapy may suggest an immunologic mechanism. …”
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Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma by Owen Ngalamika, Sody Munsaka

“…This narrative review is focused on discussing cells of the innate and adaptive immune systems in KSHV infection and KS pathogenesis, including how these cells can be useful in the control of KSHV infection and treatment of KS.…”
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Optic neuritis and multiple sclerosis association by L. Matukynaitė, G. Repšytė, R. Liutkevičienė, R. Balnytė

“…The close relation between these two conditions in etiology and pathogenesis is a key to finding the earliest and the most accurate diagnostic possibilities, which is linked to a better understanding of the ongoing mechanisms. …”
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Current Pharmacologic Approaches for Prevention and Treatment of Bronchopulmonary Dysplasia by Kristen Tropea, Helen Christou

“…Continued improved understanding of BPD pathogenesis leads to opportunities for newer preventive approaches. …”
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Food allergens and oral immunotherapy as indicators of eosinophilic oesophagitis by Andrzej Kuźmiński, Justyna Przybyszewska, Zbigniew Bartuzi

“…Unfortunately, our knowledge of EoE is full of gaps and requires numerous studies to fill in the missing elements of the pathogenesis and clinic of the described disease.…”
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