Treatments for Severe Cutaneous Adverse Reactions by Yung-Tsu Cho, Chia-Yu Chu

“…In the past years, emerging studies have provided better understandings regarding the pathogenesis of these diseases. These diseases have unique presentations and distinct pathomechanisms. …”
Get full text

Interaction between 𝛼-Synuclein and Other Proteins in Neurodegenerative Disorders by Kurt A. Jellinger

“…Novel findings that have shifted our understanding in the role of pathologic proteins in the pathogenesis of Parkinson and Alzheimer diseases have confirmed correlations/overlaps between these and other neurodegenerative disorders. …”
Get full text

Novel perspectives on the pharmacological treatment of thyroid-associated ophthalmopathy by Zilin Li

“…As a result, the development of novel targeted drugs has become a research hotspot for addressing the pathogenesis of TAO. A range of novel targeted drugs, such as teprotumumab and tocilizumab, have been successfully developed and demonstrated remarkable efficacy in relieving inflammation and managing this disease. …”
Get full text

MicroRNA Dysregulation in Cystic Fibrosis by Paul J. McKiernan, Catherine M. Greene

“…Their involvement in the pathogenesis of CF lung disease stems from the fact that their expression is altered in vivo in the CF lung due to intrinsic and extrinsic factors; to date defective chloride ion conductance, endoplasmic reticulum stress, inflammation, and infection have been implicated in altering endogenous miRNA expression in this setting. …”
Get full text

A review of quorum-sensing and its role in mediating interkingdom interactions in the ocean by Megan Coolahan, Kristen E. Whalen

“…In this review, we examine how these molecules mediate communication between bacteria and marine eukaryotes; influencing processes such as development, disease pathogenesis, and microbiome regulation within marine ecosystems. …”
Get full text

The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors by Lucia D’Amico, Ilaria Roato

“…Many studies report the importance of the immune system in the pathogenesis of bone metastasis. Indeed, bone and immune system are strictly linked to each other because bone regulates the hematopoietic stem cells from which all cells of the immune system derive, and many immunoregulatory cytokines influence the fate of bone cells. …”
Get full text

Noncompaction Cardiomyopathy with Charcot-Marie-Tooth Disease by Sherif Ali Eltawansy, Andrea Bakos, John Checton

“…It is usually associated with genetic disorders and that could explain the genetic pathogenesis of the non-compaction cardiomyopathy. Our case had a history of Charcot-Marie-Tooth disease. …”
Get full text

Cholesterol Granuloma in Odontogenic Cyst: An Enigmatic Lesion by Mala Kamboj, Anju Devi, Shruti Gupta

“…It also lays stress on the fact that more cases of CG should be reported so that its nature and pathogenesis in the oral cavity become more perceivable.…”
Get full text

Peptidoglycan and Bacterial DNA Induce Inflammation and Coagulation Markers in Synergy by Marie-Claude Amoureux, Nandani Rajapakse, Lazlo Stipkovits, Susan Szathmary

“…These findings provide a new proinflammatory and procoagulant mechanism likely to play a role in sepsis pathogenesis.…”
Get full text

The Possible Role of Transplacentally-Acquired Antibodies to Infectious Agents, With Molecular Mimicry to Nervous System Sialic Acid Epitopes, as Causes of Neuromental Disorders: P... by André J. Nahmias, Susanne Beckman Nahmias, Dan Danielsson

“…Lessons from four-decade investigations of the epidemiology, immunology, pathogenesis, prevention and therapy of perinatal infectious agents, which invade directly the nervous system, have led us to propose a new indirect effect hypothesis: maternal transplacentally-acquired antibodies, to agents with epitope molecular mimicry with the developing nervous system, can cross the fetus/infant's blood–nervous system barriers to cause NMD's, clinically manifest years later.…”
Get full text

Protein carbamylation and proteomics: from artifacts to elucidation of biological functions by Youngki You, Gina Many, Ernesto S. Nakayasu

“…Lysine carbamylation is a non-enzymatic protein post-translational modification (PTM) that plays important roles in regulating enzymatic activity and the pathogenesis of diseases such as atherosclerosis, rheumatoid arthritis, and uremia. …”
Get full text

Pediatric optic neuritis: literature review by S. Bubnytė, J. Andrulionytė

“…The aim of this article is to review the symptoms, etiology, pathogenesis, diagnosis, treatment options, and prognosis of pediatric optic neuritis described in the literature. …”
Get full text

Gene Therapy for HIV Infections: Intracellular Immunization by Alain Piché

“…Current understanding of HIV molecular biology and pathogenesis has opened the way for the development of gene therapy strategies for HIV infections. …”
Get full text

Enteritis necroticans and Clostridium perfringens type C; Epidemiological and pathological findings over the past 20 years. by Stuart Johnson, Andrew M Skinner, Calob Lostutter, Trevor Duke, Horst Posthaus

“…Research into the pathogenesis of this disease has confirmed the central role of beta toxin and its target, the endothelial cell. …”
Get full text

Subsequent Development of Desmoid Tumor after a Resected Gastrointestinal Stromal Tumor by Areen Abdulelah Murshid, Hatim Q. Al-Maghraby

“…We discuss the two entities of Desmoid tumor and GIST by comparing their definitions, clinical presentations, histological features, immunohistochemistry stains, molecular pathogenesis, prognosis, and treatment. We also discuss the relationship between GIST and the subsequent development of Desmoid tumors and compare our case with case reports in literature.…”
Get full text

What is true and what is new in esophageal microbiome in 2024? by M. Jauvain, E. Bessède

“…While the microbiota in the lower tract of the intestine, namely the small and large bowel, has been the core of scientific interest over the last 20 years, the resident microbial flora of the esophagus and its potential role in the pathogenesis of esophageal diseases have been neglected. …”
Get full text

Micro-RNA Expression and Function in Lymphomas by Sukhinder K. Sandhu, Carlo M. Croce, Ramiro Garzon

“…Study of miRNA expression and function in animal models and human lymphomas has improved our knowledge of the pathogenesis of this heterogeneous disease. In this paper, we attempt to describe the expression of miRNAs and their function in lymphomas and discuss potential miRNA-based therapies in the diagnosis and treatment of lymphomas.…”
Get full text

The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure by Lili Yu, Zhiwei Feng

“…Medical systems worldwide are being faced with a growing need to understand mechanisms behind the pathogenesis of heart failure (HF) that is considered as a leading cause of morbidity and mortality around the world. …”
Get full text

Mpox Virus as a Global Public Health Emergency: A Scoping Review by Sathish Sankar, Pachamuthu Balakrishnan, Yean K. Yong, Sivadoss Raju, Vijayakumar Velu, Esaki M. Shankar, Marie Larsson

“…This comprehensive analysis describes the virus epidemiology, pathogenesis, clinical manifestations, complications including secondary bacterial infections, diagnosis, treatment and vaccination. …”
Get full text

The role of major virulence factors and pathogenicity of adherent-invasive Escherichia coli in patients with Crohn’s disease by Khalid A. Abdelhalim, Ataç Uzel, Nalan Gülşen Ünal

“…In the last two decades, the progressive implication of adherent-invasive Escherichia coli (AIEC) pathogenesis in patients with CD has been increasing. …”
Get full text