Health, Complexity and non-communicable Diseases by Alfredo Darío Espinosa Brito

“…The presence of the chronic inflammatory state of the endothelium and the dysfunction of this organ are highlighted as a possible final common path of the pathogenesis, evolution and subsequent clinical expression of many of the so-called non-communicable diseases, true systemic syndromes. …”
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Role of Coagulation Factors in Hepatocellular Carcinoma: A Literature Review by Azeem Azam, Aleksandra Klisic, Filiz Mercantepe, Hamza Faseeh, Tolga Mercantepe, Saira Rafaqat

“…In addition, this review highlights the underlying mechanisms linking coagulation pathways to HCC pathogenesis and explores potential therapeutic targets. …”
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Inflammatory Mechanisms of Idiopathic Epiretinal Membrane Formation by Malav Joshi, Shivi Agrawal, John Byron Christoforidis

“…The pathogenesis of idiopathic epiretinal membranes (iERMs), a common pathology found in retina clinics, still eludes researchers to date. …”
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Immune Optimization as a Preventive and Therapeutic Adjunct for the Management of Renin–Angiotensin–Aldosterone System Dysfunction Diseases: A Review by Michael T. Okafor, Queenet C. Onyebuchukwu, Germaine A. Okafor, Samuel C. Niteh, Chikere A. Anusiem

“…Immune dysfunction provokes their pathogenesis and clinical symptoms. Hence, immune optimization interventions may be useful for their prevention and management. …”
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The Role of CARD9 Deficiency in Neutrophils by Ruanmei Sheng, Xiaoming Zhong, Zhiwen Yang, Xuemin Wang

“…Here, the review summarizes recent preclinical and clinical advances that have provided a novel insight into the pathogenesis of CARD9 deficiency in neutrophils.…”
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Oral lichen planus involving the palate: Case report and review of literature by Shahen Ali Ahmed, Ali Fakhree Alzubaidee

“…Women are most often affected and lichen planus is usually reported in individuals over 50 years of age The etiology of lichen planus is unknown at present and the disorder has been classified as a chronic disease of immune-mediated pathogenesis. The oral lesions are usually bilateral and involve the buccal mucosa in about 90 percent of all cases. …”
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Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies by Verónica Muñoz-Soriano, Nuria Paricio

“…Indeed, many of the existing fly PD models exhibit key features of the disease and have been instrumental to discover pathways relevant for PD pathogenesis, which could facilitate the development of therapeutic strategies.…”
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The Opportunistic Pathogen Listeria monocytogenes: Pathogenicity and Interaction with the Mucosal Immune System by Markus Schuppler, Martin J. Loessner

“…Animal models for L. monocytogenes infection have provided many insights into the mechanisms of pathogenesis, and the development of new model systems has allowed the investigation of factors that influence adaptation to the gastrointestinal environment as well as adhesion to and invasion of the intestinal mucosa. …”
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Mining the Prognostic Value of HNRNPAB and Its Function in Breast Carcinoma by Yun Cao, Wei Zhang, Yi-Ting Jin, Qiang Zou

“…Heterogeneous nuclear ribonucleoproteins (HNRNPs) are crucial members in the pathogenesis and progression of numerous cancers. However, the expression pattern and clinical significance of HNRNPs in breast carcinoma (BC) remain to be investigated. …”
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Osteoporosis Syndrome in Thalassaemia Major: An Overview by Meropi Toumba, Nicos Skordis

“…Osteoporosis in thalassaemia major (TM) represents a prominent cause of morbidity. The mechanism of pathogenesis of bone disease (BD) in TM is multifactorial and complicated. …”
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Granulomatous Osteonecrosis in Crohn’s Disease by Hugh J Freeman, David Owen, Mario Millan

“…Because prior specialized perfusion fixation pathological studies of the intestine in Crohn’s disease have shown that granulomas are located in the walls of blood vessels, a possible mechanism for the pathogenesis of osteonecrosis in Crohn’s disease is chronic microvascular ischemia of bone.…”
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Diversity in the Regulation of Autophagy and Mitophagy: Lessons from Parkinson's Disease by Charleen T. Chu

“…Further studies are needed to address whether alterations in autophagy regulation play a directly injurious role in PD pathogenesis, or if the observed changes reflect impaired, appropriate, or excessive autophagic responses to other forms of cellular injury.…”
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Whether pH-metry and investigation of esophageal motor function are necessary for diagnosis and choice of therapy for us today? by O. A. Storonova, A. S. Trukhmanov, V. T. Ivashkin

“…Assessment of physical and chemical properties of refluxate and parameters of peristalsis of the esophagus is necessary for establishment of etiology and pathogenesis of diseases that allows to prescribe specific treatment to the patient.…”
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Biomechanics in the onset and severity of spondyloarthritis: a force to be reckoned with by Mark Hwang, Priyanka Iyer, Lauren Ridley, Michael M Weisman

“…Over the past several years, mechanotransduction, the mechanism by which mechanical perturbation influences gene expression and cellular behaviour, has recently gained popularity because of emerging data from both animal models and human studies of the pathogenesis of ankylosing spondylitis (AS). In this review, we provide evidence towards an appreciation of the unsolved paradigm of how biomechanical forces may play a role in the initiation and propagation of AS.…”
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Relationship between Experimental Diet in Rats and Nonalcoholic Hepatic Disease: Review of Literature by Ayane A. Rodrigues, Raíssa S. B. Andrade, Daniel F. P. Vasconcelos

“…Both the broader recognition of the disease and the additional efforts to elucidate the NAFLD pathogenesis have led to an increase in animal models in recent years. …”
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Pediatric Multiple Sclerosis and Cognition: A Review of Clinical, Neuropsychologic, and Neuroradiologic Features by Ozgul Ekmekci

“…In this review, I discuss the main features of cognitive impairment in pediatric MS as determined by long-term follow-up studies, neuropsychiatric test batteries, and the results of neuroradiological imaging studies that investigated the pathogenesis of pediatric MS. The most commonly affected cognitive domains in adults are attention, processing speed, and visuomotor skills; language and intelligence are also affected in pediatric MS. …”
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The Role of 5-Lipoxygenase and Leukotrienes in Shock and Ischemia-Reperfusion Injury by Antonietta Rossi, Carlo Pergola, Salvatore Cuzzocrea, Lidia Sautebin

“…In particular, the 5-LO activation has been proposed to be an important regulator for pathogenesis in multicellular organisms. The role of LTs in tissue damage, associated with septic and nonseptic shock and ischemia-reperfusion, has been extensively studied by the use of 5-LO inhibitors, receptor antagonists, and mice with a targeted disruption of the 5-LO gene (5-LOKO). …”
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ISG15 promotes M5-induced hacat cell proliferation through Wnt signaling in psoriasis by Sun Xianqi, Li Yuzhen, Yu Huiwen, Lin Jiaying, Wang Chen, Liu Quanlin, Bai Bingxue

“…Psoriasis is a common chronic, recurrent, immune-mediated inflammatory skin disease, which tends to occur in cold areas. Its pathogenesis is currently unclear. This study aims to screen differentially expressed genes in the psoriasis dataset, identify the central genes, detect the expression of central genes in psoriasis lesions of patients in the cold regions and then conduct further research.…”
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Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy by Yuan-qiao Xu, Yanjiao Chen, Jia-xin Xing, Jun Yao

“…Additionally, we scrutinized the influence of EE on epigenetic modifications and autophagy, processes pivotal to ND pathogenesis. Animal models, encompassing both rodents and larger animals, offer insights into the disease-modifying effects of EE, underscoring its potential as a complementary approach to pharmacological interventions. …”
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Biological rhythms of the liver by Anatol Panasiuk, Mirosław Tarasewicz, Albert Chodowiec, Anna Łokić, Kacper Gan

“…Clock dysfunctions contribute to the pathogenesis of various disorders, including fatty liver disease, liver cirrhosis and different types of cancer. …”
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