Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in pelvic organ prolapse by Qian Wang, Zuoxi He, Lisha Ding, Yuqing Liu, Xiaoli Zhang, Tao Wang, Xiaoyu Niu

“…The circRNA-miRNA-mRNA network of two DEcircRNAs comprised nine mRNAs, which indicated that hsa_circ_0067962 and hsa_circ_0057051 may be involved in the pathogenesis of POP by regulating these nine mRNAs.…”
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Novel introductions of human-origin H3N2 influenza viruses in swine, Chile by Belen Monserrat Agüero, Naomi Ariyama, Felipe Berrios, Nikita Enciso, Barbara Quezada, Rafael A. Medina, Rafael A. Medina, Victor Neira, Victor Neira

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CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation by Yan-Yan Xue, Zhe-Sheng Zhang, Rong-Rong Lin, Hui-Fen Huang, Ke-Qing Zhu, Dian-Fu Chen, Zhi-Ying Wu, Qing-Qing Tao

“…However, the precise mechanisms by which CD2AP is linked to AD pathogenesis remain unclear. Methods The spatiotemporal expression pattern of CD2AP was determined. …”
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Mesenchymal Stromal Cells from Osteoarthritic Synovium Are a Distinct Population Compared to Their Bone-Marrow Counterparts regarding Surface Marker Distribution and Immunomodulati... by Sebastien Hagmann, Claudia Rimmele, Florin Bucur, Thomas Dreher, Felix Zeifang, Babak Moradi, Tobias Gotterbarm

“…The participation of an inflammatory joint milieu has been described in osteoarthritis (OA) pathogenesis. Mesenchymal stromal cells (MSCs) play an important role in modulating inflammatory processes. …”
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A Proteomic Study Based on Home Quarantine Model Identifies NQO1 and Inflammation Pathways Involved in Adenoid Hypertrophy by Chen P, Hou S, Pang X, Li L, Wei W

“…Penghui Chen,1– 3,* Shule Hou,1– 3,* Xiuhong Pang,4 Lei Li,1– 3 Wei Wei1– 3 1Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 4Department of Otolaryngology-Head and Neck Surgery, the Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Wei; Lei Li, Department of Otolaryngology-Head & Neck Surgery, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai, 200082, People’s Republic of China, Tel +86-21-25078893, Fax +86-21-65152394, Email weiwei8319@xinhuamed.com.cn; xyyh2711@126.comBackground: Adenoid hypertrophy is a common disorder of childhood, and has an unclear pathogenesis. At the beginning of the COVID-19 pandemic, there was a significant reduction in the incidence of adenoid hypertrophy in children under long-term home quarantine, providing a rare research model to explore the pathogenesis and treatment targets of adenoidal hypertrophy in children.Methodology: Before and during the home quarantine period, adenoids that underwent surgery were detected using label-free proteomics. …”
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A20 as a Potential Therapeutic Target for COVID‐19 by Yongyao Wu, Lilan He, Rong Li, Jiuxuan Li, Qing Zhao, Bin Shao

“…Precise regulation of A20 to induce antiviral activity and an anti‐inflammatory response could mediate the pathogenesis of COVID‐19 and could become an effective treatment.…”
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Inflammasome in Intestinal Inflammation and Cancer by Tiago Nunes, Heitor S. de Souza

“…In this review, we discuss the molecular structure, the mechanisms behind the inflammasome activation, and its possible role in the pathogenesis of inflammatory bowel diseases and intestinal cancer. …”
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A Rare Combination of Ovarian and Uterine Leiomyomas with Goblet Cell Carcinoid of the Appendix by Abdulrahman F. Al-Shaikh, Abdulla Darwish, Veena Nagaraj, Abeer Alsada

“…In this paper, the pathogenesis and differential diagnosis of both types of tumors are discussed.…”
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Genetics of Childhood Obesity by Jianhua Zhao, Struan F. A. Grant

“…Besides environmental factors, genetic factors are known to play an important role in the pathogenesis of obesity. Genome-wide association studies (GWAS) have revealed strongly associated genomic variants associated with most common disorders; indeed there is general consensus on these findings from generally positive replication outcomes by independent groups. …”
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PRIMARY MENINGOENCEPHALITIS CAUSED BY NAEGLERIA FOWLERI: A MINI REVIEW by Hassan Bin-Asif et al

“…FLA other than N. fowleri such as Acanthamoeba and Balamuthia species are also harmful because they are vectors of many bacterial pathogens including Vibrio, Pseudomonas, Legionella, Enterobacter and Mycobacterium species which help them to feed and colonize in environments, thus contributing to their pathogenesis and transferability to their hosts. Pakistan, being an underdeveloped country, faces long-term shortfalls of electricity resulting in serious water scarcity leading to public dependence on stored water resources, which are breeding hubs for FLA. …”
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The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases by Simon J. Conway, Thomas Doetschman, Mohamad Azhar

“…Information about hierarchal connections between periostin and TGFβ and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.…”
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Chemokines and Chemokine Receptors in Multiple Sclerosis by Wenjing Cheng, Guangjie Chen

“…Each helper T cell subset expresses different chemokine receptors so as to exert their different functions in the pathogenesis of MS. Recently published results have shown that the levels of some chemokines and chemokine receptors are increased in blood and cerebrospinal fluid of MS patients. …”
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Extramedullary Hematopoiesis: An Unusual Finding in Subdural Hematomas by Rong Li, Vishnu V. B. Reddy, Cheryl Ann Palmer

“…A brief review of published information on extramedullary hematopoiesis in subdural hematoma and the mechanisms of pathogenesis are also discussed. While extramedullary hematopoiesis is seen anecdotally by neuropathologists in chronic subdural hematomas, only a few cases are documented in the literature. …”
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Pulmonary Embolism as the First Manifestation of Multiple Myeloma by N. Vallianou, V. Lazarou, J. Tzangarakis, R. Barounis, E. Sioula

“…Multiple myeloma is considered a hypercoagulable state due to several mechanisms such as the increased IL-6 and immunoglobulins production, the defective fibrinolytic mechanism, and the acquired resistance to activated protein C that are involved in the pathogenesis and clinical futures of the disease. We describe a case of a female patient who presented to the hospital with pulmonary embolism as the first manifestation of the hypercoagulability of multiple myeloma.…”
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Postinfectious Irritable Bowel Syndrome: Polemic and Open Issues by A. A. Sheptulin, M. A. Vize-Khripunova

“…An analysis of polemic and open topics in epidemiology, pathogenesis, clinic, diagnosis and treatment of postinfectious irritable bowel syndrome (IBS).Key points. …”
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Oxi-Inflamm-Aging: a New Theory with Practical Implications by Ángel Julio Romero Cabrera, Leocadia Amores Hernández

“…The present article describes the foundations of this theory, the current research studies that support it, and its link with the pathogenesis of some age-related diseases. It is concluded that the adoption of a healthy lifestyle from an early age can contribute to a successful aging. …”
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Targeting the chemokines in acute graft-versus-host disease by Ziwei Xu, Huafang Wang

“…In this review, we aim to elucidate the role of chemokines in the pathogenesis of acute GVHD and further understand their potential as diagnostic biomarkers. …”
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A case of xanthogranulomatous epididymitis complicated by florid testicular cystic ectasia by Gregory Apap Bologna, David Pisani, Cressida Gauci, Steven Camilleri, Simon Bugeja

“…Xanthogranulomatous inflammation (XGI) is a rare, benign inflammatory condition of unclear pathogenesis, characterised by infiltration and subsequent destruction of normal tissue by lipid-laden macrophages together with lymphocytes and plasma cells. …”
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Sarcopenia, a Neurogenic Syndrome? by Ping Kwan

“…As a result, it is vital to investigate deeper into the mechanism underlying the pathogenesis of sarcopenia in order to develop more effective therapeutic interventions and to inscribe a more uniform characterization. …”
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Pathogenicity of Virulent Species of Group C Streptococci in Human by Marta Kłos, Jadwiga Wójkowska-Mach

“…In this paper, the virulence factors have also been mentioned and an interesting link has been made between GCS and the pathogenesis of rheumatic diseases among the native people of India and Aboriginal populations.…”
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