The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models by Adam B. Glick

“…The mouse skin carcinogenesis model has been a useful tool to dissect the function of this pathway in cancer pathogenesis, with transgenic and null mice as well as small molecule inhibitors to alter the function of the TGFβ1 pathway and assess the effects on cancer development. …”
Get full text

Canonical and noncanonical autophagy: involvement in Parkinson’s disease by Maria Sakurai, Tomoki Kuwahara

“…In this review, we will summarize and discuss the contributions of canonical and noncanonical autophagy to cellular functions, with a special focus on the pathogenesis of PD.…”
Get full text

Exercise as a Mean to Control Low-Grade Systemic Inflammation by Neha Mathur, Bente Klarlund Pedersen

“…It has now become clear that low-grade chronic inflammation is a key player in the pathogenesis of most CNCDs. Given that regular exercise offers protection against all causes of mortality, primarily by protection against atherosclerosis and insulin resistance, we suggest that exercise may exert some of its beneficial health effects by inducing anti-inflammatory actions. …”
Get full text

The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion by Marina G. Smirnova, John P. Birchall, Jeffrey P. Pearson

“…Inflammation in the middle ear mucosa, which can be provoked by different primary factors such as bacterial and viral infection, local allergic reactions and reflux, is the crucial event in the pathogenesis of otitis media with effusion (OME). Unresolved acute inflammatory responses or defective immunoregulation of middle inflammation can promote chronic inflammatory processes and stimulate the chronic condition of OME. …”
Get full text

ASSOCIATION BETWEEN PR PROTEINS WITH RIBONUCLEASE ACTIVITY AND PLANT RESISTANCE AGAINST PATHOGENIC FUNGI by E. A. Filipenko, A. V. Kochetov, Y. Kanayama, V. I. Malinovsky, V. K. Shumny

“…Pathogenesis-related (PR) proteins participate in complex plant defense response to pathogens. …”
Get full text

Post-COVID-19 Dermatomyositis: A Delayed Reaction That Evades Early Detection by Nur Ili Syazwani MD HADIS, Siti Suhaila MOHD YUSOFF, Rosediani MUHAMAD, Fatin Hanani CHE JUHA

“…Viral infections may cause autoimmunity and trigger the pathogenesis of myositis. We present the case of a man with a long history of myalgia and muscle weakness, who was initially diagnosed with post-COVID-19 myalgia and subsequently developed progressive muscle weakness. …”
Get full text

Recurrent Focal Segmental Glomerulosclerosis: A Discrete Clinical Entity by Elena Torban, Martin Bitzan, Paul Goodyer

“…Capitalizing on recent studies in which patients have been screened for slit diaphragm gene mutations, this review focuses on the natural history and pathogenesis of R-FSGS.…”
Get full text

Portal Vein Thrombosis by Ronny Cohen, Thierry Mallet, Michael Gale, Remigiusz Soltys, Pablo Loarte

“…Imaging revealed the presence of multiple nonocclusive thrombi involving the right portal vein, the splenic vein, and the left renal vein, as well as complete occlusion of the left portal vein and the superior mesenteric vein. We discuss pathogenesis, clinical presentation, and management of both acute and chronic thrombosis. …”
Get full text

Pathophysiology of Vascular Remodeling in Hypertension by Nicolás F. Renna, Natalia de las Heras, Roberto M. Miatello

“…We terminate by considering the potential role of remodeling in the pathogenesis of endorgan damage and in the perpetuation of hypertension.…”
Get full text

Persistent and extended COVID, post-COVID-19. New reflections in 2024 by Alfredo Darío Espinosa Brito

“…There is no solid evidence of its detailed pathogenesis, nor tests that confirm or rule out its diagnosis. …”
Get full text

Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease by Kyeong-Ah Kwak, Seung-Pyo Lee, Jin-Young Yang, Young-Seok Park

“…Many unsuccessful attempts have been made to develop new small molecules or antibodies to intervene in the disease’s pathogenesis. Stem cell-based therapies cast a new hope for AD treatment as a replacement or regeneration strategy. …”
Get full text

Usefulness of the Vitreous Fluid Analysis in the Translational Research of Diabetic Retinopathy by Olga Simó-Servat, Cristina Hernández, Rafael Simó

“…In addition, their role in the pathogenesis of DR will be discussed. The usefulness of new technologies such as flow cytometry and proteomics in identifying new candidates involved in the inflammatory process that occurs in DR will be overviewed. …”
Get full text

Neuropsychiatric symptoms in Alzheimer’s disease by J. Vegytė, R. Podėnė, E. Dlugauskas, A. Vaitkevičius

“…Despite the large number of studies, the pathogenesis of the neuropsychiatric symptoms has not been studied in depth, therefore the treatments provided are not always effective. …”
Get full text

Delirium after Deep Brain Stimulation in Parkinson’s Disease by Hanyi Li, Shunchang Han, Juan Feng

“…The current article reviews the pathogenesis, epidemiology, prognosis, and treatment of delirium following deep brain stimulation in Parkinson’s disease to help clinicians better understand this common complication and to prevent, identify, and treat it as soon as possible, as well as to provide more accurate treatment for patients.…”
Get full text

Gene expression of cell surface antigens in the early phase of murine influenza pneumonia determined by a cDNA expression array technique by Shinya Sakai, Naoki Mantani, Toshiaki Kogure, Hiroshi Ochiai, Yutaka Shimada, Katsutoshi Terasawa

“…To study the gene expression pattern induced by influenza virus infection, it is useful to reveal the pathogenesis of influenza virus infection; but this has not been well examined, especially in vivo study.…”
Get full text

Occlusion of Internal Carotid Artery in Kimura's Disease by Tomonori Tamaki, Node Yoji

“…In our patient, the pathogenesis of internal carotid artery occlusion was unknown. …”
Get full text

Application of immunohistochemical markers in mycosis fungoides by SHAO Kaixin, LIU Xiangjun, TANG Zhenzhen

“…In-depth research on immunohistochemical markers helps better understand the pathogenesis of MF and provides a more accurate basis for clinical treatment, such as guiding the selection of treatment regimens and evaluating treatment effects, in addition to its indispensable role in the clinical management of MF. …”
Get full text

Bone Metastasis as the Only Metastatic Site in a Patient with Pancreatic Cancer following Distal Pancreatectomy by Muhammad Wasif Saif, Natalie Galanina, L. Ravage-Mass, Kristin Kaley, Daniel Cornfeld, Lynne Lamb, David Chhieng

“…Here, we report an interesting case of pancreatic adenocarcinoma with exclusive bone metastases and discuss briefly the possible pathogenesis.…”
Get full text

Hepatocellular Carcinoma with Prominent Intracytoplasmic Inclusions: A Report of Two Cases by Adeline R. Chelliah, Jasim M. Radhi

“…Inclusion bodies are believed to represent organized structures of proteins which contribute to their pathogenesis and share several constituents like chaperones, p62, ubiquitin, and Valosin containing protein. …”
Get full text

Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers? by M. W. Saif, B. Fallon, K. N. Syrigos

“…Recent developments in the understanding of the pathogenesis of ACC have led to multiple clinical trials involving targeted agents in the management of ACC. …”
Get full text