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1041
Comparative Analysis of the Occurrence and Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Hemophilic Arthropathy and Osteoarthritis
Published 2020-01-01“…The involvement of CX3CL1 (fractalkine) and its receptor CX3CR1 was observed in the pathogenesis of numerous arthritis-associated diseases. …”
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1042
Genome rearrangements in neurodevelopmental disorders of the central nervous system: origins, genomic mechanisms, functional and clinical consequences. Review article
Published 2022-03-01“…We believe that new insights into the molecular causes and pathogenesis mechanisms of the intellectual disability may be useful in developing treatment options in the future. …”
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1043
Dynamic Roles of RNA and RNA Epigenetics in HTLV-1 Biology
Published 2025-01-01“…Viruses, particularly retroviruses like human T-cell leukemia virus type 1 (HTLV-1), rely heavily on RNA and RNA post-transcriptional modifications to regulate the viral lifecycle, pathogenesis, and evasion of host immune responses. With the emergence of new sequencing technologies in the last decade, our ability to dissect the intricacies of RNA has flourished. …”
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1044
The Matrix Metalloproteases and Endothelin-1 in Infection-Associated Preterm Birth
Published 2010-01-01“…As there is currently no FDA-approved therapy for infection-associated PTB, understanding the pathogenesis of preterm labor (PTL) and delivery should be given high priority. …”
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1045
Borrelia burgdorferi Tolerance-Associated Changes in Gene Expression of Murine Macrophages
Published 2025-02-01“…Ultimately, these findings offer new insights into the pathogenesis and potential treatment strategies for Lyme disease. …”
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1046
Kelainan Hemostasis pada Leukemia
Published 2012-09-01“…One of clinical manifestation of<br />leukemia is bleeding that is caused by several hemostasis disorders.Hemostasis disorders in leukemia such as<br />thrombocytopenia, platelet dysfunction, disseminated intravascular coagulation, coagulation protein defect, primary<br />fibrinolysis and thrombosis. Pathogenesis and pathophysiology of thus hemostasis disorders in leukemia occur with<br />different mechanism.…”
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1047
First isolation and characterization of SARS-CoV-2 from COVID-19 patient of North East India
Published 2023-01-01“…Virus isolation is of paramount importance for development of vaccines, in-vitro screening of antiviral compounds, pathogenesis studies, etc., Many cell lines were studied for amplification and replication of SARS-CoV-2 and Vero cells were found to be ideal cell lines for isolation. …”
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1048
Histological and Immunohistochemical Characterization of a Case of Endometriosis in a Guinea Pig (Cavia tschudii)
Published 2017-01-01“…Endometriosis is a chronic gynecological disease characterized by the ectopic proliferation of endometrial tissue outside of the uterine cavity. The pathogenesis of this disease is still obscure, and Sampson’s theory of retrograde menstruation is still the most widely accepted explanation. …”
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1049
The role of Nrf2 transcription factors in various physiological and pathological states
Published 2024-07-01“…Understanding Nrf2's diverse functions offers valuable insights into disease pathogenesis and potential therapeutic approaches. This review explores the pleiotropic role of Nrf2 regulation. …”
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1050
Microbiome role in pancreatic diseases development
Published 2018-08-01“…To present the modern concept on the mechanisms of pancreatic disease development and role of intestinal and oral microbiome in pancreatitis pathogenesis. Summary. Intestinal barrier dysfunction, bacterial overgrowth syndrome and endotoxinemia are features of acute pancreatitis. …”
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1051
Importins and Exportins Regulating Allergic Immune Responses
Published 2014-01-01“…The classical NLS are found on many transcription factors and molecules that are involved in the pathogenesis of allergic diseases. In addition, several immune modulators, including corticosteroids and vitamin D, elicit their cellular responses by regulating the expression and activity of importin molecules. …”
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1052
Air Pollution and Respiratory Permeability in Obstructive Sleep Apnea — A Review
Published 2020-11-01“…This review article explored the role of air pollution and airway permeability in the pathogenesis of OSA.…”
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1053
Gingival Vitiligo: Report of a Case and Review of the Literature
Published 2014-01-01“…Differential diagnosis, detailed clinical history, histopathology, immunohistochemistry, and pathogenesis of this condition are discussed.…”
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1054
Inherited glycosylphosphatidylinositol deficiency disorders: a new group of inherited metabolic disorders
Published 2024-12-01“…We present a comprehensive review of the pathogenesis, clinical symptomatology and management options in IGDs.…”
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1055
Metabolomic Analysis of Key Regulatory Metabolites in the Urine of Flavivirus-Infected Mice
Published 2022-01-01“…Metabolomics is an emerging research perspective to uncover and observe the pathogenesis of certain infections. Methods. To improve the understanding of the specific metabolic changes that occur during infection with different flaviviruses, considering the principle of noninvasive sampling, this article describes our comprehensive analysis of metabolites in urine samples from the three kinds of flavivirus-infected mice using a liquid chromatography tandem mass spectrometry method to better understand their infection mechanisms. …”
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1056
Biological treatment options for eosinophilic asthma, with consideration of markers of eosinophilic inflammation as predictors of treatment efficacy
Published 2024-02-01“…These limitations prompted the development of targeted biological drugs that inhibit the mediators involved in T helper 2-inflammation, which is linked to the pathogenesis of asthma, such as interleukin 4, 5, 9, 13 and immunoglobulin E. …”
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1057
A General Mathematical Method for Investigating the Thymic Microenvironment, Thymocyte Development, and Immunopathogenesis
Published 2004-06-01“…The process is profoundlyaffected by the thymic microenvironment, the dysregulation of whichmay be the pathogenesis or the etiology of some diseases. On thebasis of a general conceptual framework, we have designed the firstbiophysical model to describe thymocyte development. …”
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1058
Complicated Community-Acquired Staphylococcus Endocarditis and Multiple Lung Abscesses: Case Report and Review of Literature
Published 2011-01-01“…Conclusion. We discuss the pathogenesis of this patient's presentation highlight the need for assessment and proper evaluation of patients with unexplained bacteremia.…”
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1059
Protein Phosphatase 2A: Role in T Cells and Diseases
Published 2023-01-01“…PP2A fosters Th17 cell differentiation which contributes to the pathogenesis of systemic lupus erythematosus (SLE) by enhancing the transactivation of the Il17 gene. …”
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1060
Virus Infection-Induced Bronchial Asthma Exacerbation
Published 2012-01-01“…Here, I review the literature on the pathogenesis of the viral infection-induced exacerbation of asthma and on the modulation of viral infection-induced airway inflammation.…”
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