Helicobacter mastomyrinus infection induces autoimmune hepatitis in mice by Liqi Zhu, Yuanyuan Liang, Linghan Yang, Qihui Yang, Jun Yin, Tao Wang, Xiangming Xu, Quan Zhang

“…The role of the gut microbiome in the pathogenesis and progression of AIH is of considerable significance. …”
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A temporary cholesterol-rich diet and bacterial extracellular matrix factors favor Salmonella spp. biofilm formation in the cecum by Alonso Cruz-Cruz, Megan E. Schreeg, John S. Gunn

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Non-invasive imaging with ICOS-targeting monoclonal antibody for preclinical diagnosis of rheumatoid arthritis in a humanized mouse model by Shao Duan, Chao Li, Feng Yan, Yifei Xia, Shuaiming Shao, Weiyu Chen, Zunyu Xiao, Gongping Xu

“…Abstract Background Activated T cells play a pivotal role in rheumatoid arthritis (RA) pathogenesis, and imaging of activated T cells may provide a non-invasive tool for RA detection. …”
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A structural genomics approach to investigate Dystrophin mutations and their impact on the molecular pathways of Duchenne muscular dystrophy by Abdelbaset Mohamed Elasbali, Farah Anjum, Osama A. AlKhamees, Waleed Abu Al-Soud, Mohd Adnan, Anas Shamsi, Md. Imtaiyaz Hassan

“…These findings could inform future therapeutic strategies targeting Dystrophin mutations to address DMD pathogenesis.…”
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Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications by Haiming Wang, Zifan Liu, Junjie Shao, Lejian Lin, Min Jiang, Lin Wang, Xuechun Lu, Haomin Zhang, Yundai Chen, Ran Zhang

“…Immune and inflammation dysfunction have been indicated in the pathogenesis of ACS. The imbalance in the proatherogenic and antiatherogenic immune networks promotes the transition of plaques from a stable to unstable state and results in the occurrence of acute coronary events. …”
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Machine learning-driven identification of critical gene programs and key transcription factors in migraine by Lei Zhang, Yujie Li, Yunhao Xu, Wei Wang, Guangyu Guo

“…This study applies machine learning techniques to explore region-specific gene expression profiles and identify critical gene programs and transcription factors linked to migraine pathogenesis. Methods We utilized single-nucleus RNA sequencing (snRNA-seq) data from 43 brain regions, along with genome-wide association study (GWAS) data, to investigate susceptibility to migraine. …”
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Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review by Wen Zeng, Dong He, Yifan Xing, Junyu Liu, Nan Su, Chong Zhang, Yi Wang, Xinhui Xing

“…Ulcerative colitis (UC) is a chronic systematic inflammation disorder with increasing incidence, unknown pathogenesis, limited drug treatment, and abundant medical expenses. …”
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Simple hypertrophic tonsils have more active innate immune and inflammatory responses than hypertrophic tonsils with recurrent inflammation in children by Qun Huang, Hu Hua, Wei Li, Xi Chen, Lei Cheng

“…Abstract Background Tonsil hypertrophy has negative impact on children’s health, but its pathogenesis remains obscure despite the fact that numerous bacteriological studies have been carried out. …”
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Potential Strategies Applied by <i>Metschnikowia bicuspidata</i> to Survive the Immunity of Its Crustacean Hosts by Ji Zhang, Bingyu Li, Bingnan Zuo, Xiaodong Li

“…And yet, there is no precise study describing the pathogenesis of <i>M. bicuspidata</i>, largely hindering the development of novel control methods against its causing diseases. …”
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Toll-Like Receptor Homolog CD180 Expression Is Diminished on Natural Autoantibody-Producing B Cells of Patients with Autoimmune CNS Disorders by Zsófia Hayden, Szabina Erdő-Bonyár, Beáta Bóné, Noémi Balázs, Kornélia Bodó, Zsolt Illes, Timea Berki, Diána Simon

“…Effectiveness of anti-CD20 therapy in neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) strengthens the role of B cells in the pathogenesis. Therefore, we aimed to investigate the CD180 expression of peripheral blood B cell subsets in NMOSD and MS patients and analyze the levels of natural anti-citrate synthase (CS) IgG autoantibodies and IgG antibodies induced by bacterial infections reported to play a role in the pathogenesis of NMOSD or MS. …”
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Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances by Chong Ning, Yuhan Jiao, Jiaqi Wang, Weiwei Li, Jingqiu Zhou, Yi-Chieh Lee, Dik-Lung Ma, Chung-Hang Leung, Rugang Zhu, Hui-Min David Wang

“…The occurrence of T2DM is usually the outcome of both genetic and environmental factors and their interactions. The etiology and pathogenesis of diabetes have not been fully elucidated, and no radical therapeutic cure has been found. …”
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Association Analysis of Polymorphisms with Aspirin-Exacerbated Respiratory Disease in a Korean Population by Jin Sol Lee, Joon Seol Bae, Byung-Lae Park, Hyun Sub Cheong, Jeong-Hyun Kim, Jason Yongha Kim, Suhg Namgoong, Ji-On Kim, Choon-Sik Park, Hyoung Doo Shin

“…Findings from the present study might contribute to the genetic etiology of AERD pathogenesis.…”
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Identification and Immunological Characterization of Cuproptosis Related Genes in Preeclampsia Using Bioinformatics Analysis and Machine Learning by Tiantian Yu, Guiying Wang, Xia Xu, Jianying Yan

“…ABSTRACT Preeclampsia (PE) is a pregnancy‐specific disorder characterized by an unclearly understood pathogenesis and poses a great threat to maternal and fetal safety. …”
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DENND5B Gene Expression as a Trigger for the Development of Diabetes Mellitus–Peripheral Artery Disease: Insights from a Univariate and Multivariate Mendelian Randomization Study by Qiaoqiao Li, Fuli Cao, Xueping Gao, Yuan Xu, Bo Li, Tianyang Hu

“…Method: To identify candidate hub genes and develop insights into the pathogenesis of DM-PAD, we employed a comprehensive approach encompassing two-sample Mendelian Randomization (two-sample MR), summary data-based Mendelian randomization (SMR), and Bayesian colocalization (COLOC) methods. …”
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Pathological roles of ubiquitination and deubiquitination systems in sepsis-induced myocardial dysfunction by Zhiping Wang, Simiao Sun, Lili Huang, Xinlong Chen, Huifen Xu, Hongwei Ma, Mingbing Xiao, Linhua Wang

“…This review summarizes current findings on the roles of ubiquitination and deubiquitination in SIMD pathogenesis, highlights the key challenges in advancing this field, and proposes directions for future research. …”
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Primary dysmenorrhea: pathophysiology, improvement of diagnostic and treatment possibilities by T.V. Fartushok, N.V. Fartushok

“…Purpose: to specify some links in the pathogenesis of primary dysmenorrhea and, taking into account its multicomponent nature, to evaluate the effectiveness of the proposed treatment. …”
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Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma by Jiannan Lin, Shuwen Lu, Xiaoyu Zhao

“…The proportion of asthma patients associated with obesity is also gradually rising. However, the pathogenesis of obesity-related asthma remains incompletely understood, and conventional pharmacological treatments generally show limited efficacy. …”
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Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes by Anne-Marie L. Wegeberg, Tina Okdahl, Tina Fløyel, Christina Brock, Niels Ejskjaer, Sam Riahi, Flemming Pociot, Joachim Størling, Birgitte Brock

“…Our findings emphasize the importance of the neuroimmune regulatory system in the pathogenesis of neuropathy in type 1 diabetes.…”
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Adolescent mice exposed to TBI developed PD-like pathology in middle age by Rong Sha, Mingzhe Wu, Pengfei Wang, Ziyuan Chen, Wei Lei, Shimiao Wang, Shun Gong, Guobiao Liang, Rui Zhao, Yingqun Tao

“…However, the precise mechanism by which chronic TBI initiates PD pathogenesis is not yet fully understood. In our present study, we assessed the chronic progression and pathogenesis of PD-like behavior at different intervals in TBI mice. …”
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Augmenter of Liver Regeneration Crotonylation Assists in Mitochondria-ER Contact to Alleviate Hepatic SteatosisSummary by Xiao-lin Wang, Jia-hao He, Ping Xie, Yuan Wu, Ling-yue Dong, Wei An

“…However, the connection between dysregulated ALR crotonylation and MASLD pathogenesis remains largely unknown. Methods: Steatotic liver samples from human and Western diet (WD)-fed mice were employed for detecting Kcr levels. …”
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