Variable Presentation of the CYBB Mutation in One Family, Approach to Management, and a Review of the Literature by Tatyana Gavrilova, Ari Zelig, Diana H. Lee

“…While generally spared from infectious complications, heterozygous carriers of the abnormal genes implicated in CGD pathogenesis can still present with autoimmune disorders. …”
Get full text

Chemokines and Neurodegeneration in the Early Stage of Experimental Ischemic Stroke by Pawel Wolinski, Andrzej Glabinski

“…Recently inflammation has been implicated in pathogenesis of neurodegeneration and neurodegenerative diseases. …”
Get full text

Biology of Inflammation in Crohn's Disease: Mechanisms of Action of Anti-TNF-αAlpha Therapy by Stephan R Targan

“…Understanding how TNF-αmodulates mucosal Th1 function may lead to the definition of a key feature of Crohn’s disease pathogenesis.…”
Get full text

Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases: Towards Future Therapeutic Application by Dorit Trudler, Dorit Farfara, Dan Frenkel

“…While TLR signaling was linked to neurogenesis, it was also found to be involved in the pathogenesis of neurodegenerative diseases. This paper will focus on TLR signaling in glial cells in neurodegenerative diseases such as Alzheimer's disease, prion diseases, amyotrophic lateral sclerosis, and Parkinson's disease. …”
Get full text

Studies on the Interleukin-10 Gene in Animal Models of Colitis by Hugh J Freeman

“…Interestingly, in IL-10 gene-deficient mice raised in germ-free conditions, the intestinal inflammatory changes normally observed in conventional nongerm-free conditions are not detected, suggesting a role for luminal bacteria in the pathogenesis of the inflammatory process.…”
Get full text

Immunopeptidomics for autoimmunity: unlocking the chamber of immune secrets by Sanya Arshad, Benjamin Cameron, Alok V. Joglekar

“…Abstract T cells mediate pathogenesis of several autoimmune disorders by recognizing self-epitopes presented on Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA) complex. …”
Get full text

Perinatal Cerebellar Injury in Human and Animal Models by Valerie Biran, Catherine Verney, Donna M. Ferriero

“…Most cerebellar lesions are cerebellar hemorrhage and infarction usually leading to cerebellar abnormalities and/or atrophy, but the exact pathogenesis of lesions of the cerebellum is unknown. …”
Get full text

Insulin Autoimmune Syndrome: A Systematic Review by MingXu Lin, YuHua Chen, Jie Ning

“…This review provides a comprehensive analysis of the epidemiology, pathogenesis, clinical manifestations, diagnosis and identification, and monitoring and treatment management of IAS.…”
Get full text

Unique Cytokine Signature in the Plasma of Patients with Fibromyalgia by Jamie Sturgill, Elizabeth McGee, Victoria Menzies

“…Fibromyalgia (FMS) is a chronic pain syndrome with a complex but poorly understood pathogenesis affecting approximately 10 million adults in the United States. …”
Get full text

Cyclooxygenase Inhibition in Sepsis: Is There Life after Death? by David M. Aronoff

“…The prostaglandins participate in the pathogenesis of hemodynamic collapse, organ failure, and overwhelming inflammation that characterize severe sepsis and shock. …”
Get full text

Dilating Vascular Diseases: Pathophysiology and Clinical Aspects by Ertan Yetkin, Selcuk Ozturk

“…Although there are some similarities in terms of pathogenesis, they are distinct from atherosclerotic disease of the vessels. …”
Get full text

Role of Adaptive Immunity in Alcoholic Liver Disease by Emanuele Albano

“…Stimulation of innate immunity is increasingly recognized to play an important role in the pathogenesis of alcoholic liver disease (ALD), while the contribution of adaptive immunity has received less attention. …”
Get full text

Novel serum biomarkers for early diagnosis of gestational diabetes mellitus—a review by Michał Kunicki, Natalia Rzewuska, Paulina Sopońska, Agata Pawłosek, Iwona Sowińska, Anna Kloska

“…Undiagnosed or poorly managed GDM is associated with both short- and long-term complications in the fetus and mother. The pathogenesis of GDM is complex and has not yet been fully elucidated. …”
Get full text

PPAR Regulation of Inflammatory Signaling in CNS Diseases by John J. Bright, Saravanan Kanakasabai, Wanida Chearwae, Sharmistha Chakraborty

“…The activation of NF-𝜅B and Jak-Stat signaling pathways and secretion of inflammatory cytokines are critical in the pathogenesis of CNS diseases. Interestingly, PPAR agonists mitigate CNS disease by modulating inflammatory signaling network in immune cells. …”
Get full text

Role of Matrix Metalloproteinases in Angiogenesis and Its Implications in Asthma by Khuloud Bajbouj, Rakhee K. Ramakrishnan, Qutayba Hamid

“…MMPs have been implicated in the pathogenesis of asthma by interacting with both the airway inflammatory cells and the resident structural cells. …”
Get full text

Targeting Polymorphonuclear Leukocytes in Acute Myocardial Infarction by Clara Di Filippo, Francesco Rossi, Michele D'Amico

“…The present review would support the relatively new discovered role that the polymorphonuclear leukocytes (PMNs) have in the pathogenesis of the AMI, through a brief analysis of past and ongoing research. …”
Get full text

Which Are the Cells of Origin in Merkel Cell Carcinoma? by Thomas Tilling, Ingrid Moll

“…Studies on MCC and MCPyV as well as other risk factors have significantly increased our knowledge of MCC pathogenesis, but the cells of origin, which could be important targets in future therapies, are still unknown. …”
Get full text

Testing for Gluten-Related Disorders in Clinical Practice: The Role of Serology in Managing the Spectrum of Gluten Sensitivity by David Armstrong, Andrew C Don-Wauchope, Elena F Verdu

“…However, our understanding of the pathogenesis and spectrum of gluten sensitivity has improved, and gluten-sensitive irritable bowel syndrome patients are increasingly being recognized. …”
Get full text

Pathogenetic aspects and modern possibilities of therapy of vulvovaginal candidiasis by Margarita R. Rakhmatulina, Elena V. Lipova, Viktoria A. Nyanenko

“…The literature review presents modern aspects of the etiology and pathogenesis of vulvovaginal candidiasis, highlights issues of immunological resistance and the significance of polymorphic and pathological gene loci, the functioning of which leads to insufficient activation of the immune system in the disease. …”
Get full text

Vasospasm in Cerebral Inflammation by Michael Eisenhut

“…Another key factor in the pathogenesis of cerebral arterial vasospasm may be the reduced bioavailability of the vasodilator nitric oxide. …”
Get full text