Tezepelumab for asthma with current or previous smoking habit: Case series by Yoshiro Kai, MD, PhD, Kentaro Suzuki, MD, Ryosuke Kataoka, MD

“…Tezepelumab effectively treated severe asthma in a current smoker and a former smoker, suggesting that thymic stromal lymphopoietin is involved in the pathogenesis of severe asthma in these patients. Tezepelumab may additionally be used for severe asthma in current and former smokers.…”
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Pigeon Fever in Florida Horses by Sally DeNotta, Amanda House

“…It is important to note that birds are not involved in the transmission or pathogenesis of this condition. In Florida, the largest number of pigeon fever cases are typically reported in the dry months of fall and winter. …”
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Cardiac Calcified Amorphous Tumor of the Mitral Valve Presenting as Transient Ischemic Attack by Mohammad Abbasi Teshnizi, Atefeh Ghorbanzadeh, Nahid Zirak, Babak Manafi, Aliasghar Moeinipour

“…Thus, the incidence, pathogenesis, and best approach to the treatment are not certain. …”
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Amiloride-Sensitive Sodium Channels and Pulmonary Edema by Mike Althaus, Wolfgang G. Clauss, Martin Fronius

“…This paper describes how sodium channels contribute to alveolar fluid clearance under physiological conditions and how deregulation of sodium channel activity might contribute to the pathogenesis of lung diseases associated with pulmonary edema. …”
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Pycnodysostosis with Special Emphasis on Dentofacial Characteristics by Aisha Khoja, Mubassar Fida, Attiya Shaikh

“…The aim of this case report is to give an insight into the etiology, pathogenesis, and differential diagnosis of this disorder and to prepare the dentists and maxillofacial surgeons to overcome the challenges in treating these patients.…”
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Repigmentation of Tenacious Vitiligo on Apremilast by Sara B. Huff, Lorie D. Gottwald

“…Treatment options are limited and are difficult given the fact that the pathogenesis of the disease is not well elucidated. We present the case of a 52-year-old woman with vitiligo for over 2 decades. …”
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Intraosseous Lipomatous Meningioma by Lauren Kim, Christopher Huang, Adrienne L. Morey, Mark J. Winder

“…Lipomatous meningiomas are very uncommon subtype of meningiomas, with ongoing discussions as to their true pathogenesis. To our knowledge this case represents the first reported case of a lipomatous meningioma with predominant intraosseous extension.…”
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Non-communicable Chronic Diseases and the COVID-19 Pandemic by Miguel Ángel Serra Valdés

“…The repercussion of the pathogenesis of this disease in chronic diseases is analyzed. …”
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Polyarteritis Nodosa Presenting as Digital Gangrene and Breast Lesion following Exposure to Silicone Breast Implants by Yamen Homsi, John Andrew Carlson, Samer Homsi

“…Although the relationship between silicone implants and connective tissue diseases has been investigated in the literature, no prior reports were found documenting PAN after silicone mammoplasty. While the pathogenesis of idiopathic PAN is not known yet, responsiveness to immunosuppressive therapy may suggest an immunologic mechanism. …”
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Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma by Owen Ngalamika, Sody Munsaka

“…This narrative review is focused on discussing cells of the innate and adaptive immune systems in KSHV infection and KS pathogenesis, including how these cells can be useful in the control of KSHV infection and treatment of KS.…”
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Optic neuritis and multiple sclerosis association by L. Matukynaitė, G. Repšytė, R. Liutkevičienė, R. Balnytė

“…The close relation between these two conditions in etiology and pathogenesis is a key to finding the earliest and the most accurate diagnostic possibilities, which is linked to a better understanding of the ongoing mechanisms. …”
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Current Pharmacologic Approaches for Prevention and Treatment of Bronchopulmonary Dysplasia by Kristen Tropea, Helen Christou

“…Continued improved understanding of BPD pathogenesis leads to opportunities for newer preventive approaches. …”
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Food allergens and oral immunotherapy as indicators of eosinophilic oesophagitis by Andrzej Kuźmiński, Justyna Przybyszewska, Zbigniew Bartuzi

“…Unfortunately, our knowledge of EoE is full of gaps and requires numerous studies to fill in the missing elements of the pathogenesis and clinic of the described disease.…”
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Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation by Chang Xia, Xiaoquan Rao, Jixin Zhong

“…There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.…”
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The Role of Small Extracellular Vesicles and MicroRNAs in the Diagnosis and Treatment of Allergic Rhinitis and Nasal Polyps by Yiting Liu, Jichao Sha, Cuida Meng, Dongdong Zhu

“…Although very detailed and in-depth studies on the pathogenesis and pathophysiology of allergic rhinitis and nasal polyps have been conducted, few studies have assessed the regulatory effects of exosomes and microRNAs on allergic rhinitis and nasal polyps. …”
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Where Are We Heading with Noninvasive Clinical Vascular Physiology? Why and How Should We Assess Endothelial Function? by Elizabeth A. Ellins, Julian P. J. Halcox

“…The first investigations in humans involved invasive pharmacological vascular function testing, which have been used to gain a detailed understanding of the mechanisms involved in the pathogenesis of endothelial dysfunction and atherosclerosis as well as novel targets for intervention. …”
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Bilateral De Quervain Syndrome after Aromatase Inhibitor Administration: A Case Report and Review of the Literature by Konstantinos Papadimitriou, Panteleimon Kountourakis, Emmanouil Morakis, Vassilios Vassiliou, Vasileios Barbounis, Alexandros Ardavanis

“…Unfortunately, musculoskeletal symptoms are often presented in patients treated with aromatase inhibitors (AIs), and, although the pathogenesis is unknown, postulated mechanisms have been described. …”
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The Role of the Aceullular Pertussis Vaccine and the Comeback of 'Pertussis Pete'? by John M Conly, B Lynn Johnston

“…Given the recognition of the importance of pertussis as a cause of prolonged cough in adults and the advent of the new acellular pertussis vaccines, it is timely to review current concepts of the pathogenesis of pertussis, its epidemiology in adults and the utility of the anticipated impact of the acellular vaccine.…”
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MRI Texture Analysis in Multiple Sclerosis by Yunyan Zhang

“…Accurate identification and quantification of pathological changes may facilitate a better understanding of disease pathogenesis and progression and help identify novel therapies for MS patients. …”
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Circulating MicroRNAs in Patients with Psoriasis Treated with Anti-IL-23: A Cohort Study by Federico Diotallevi, Giulia Matacchione, Anna Campanati, Elena Marinelli Busilacchi, Nadia Viola, Ilaria Pace, Beatrice Fontana, Roberta Roncarati, Massimiliano Bonafè, Manuela Ferracin, Jacopo Sabbatinelli, Fabiola Olivieri

“…Objectives This study aimed to investigate changes in circulating miRNAs in psoriasis patients undergoing risankizumab therapy, an anti-IL-23 monoclonal antibody, to understand its impact on disease pathogenesis and treatment response. Methods Plasma samples from 12 psoriasis patients were collected before (T0) and after 1 year (T1) of risankizumab treatment and analyzed using small RNA sequencing. …”
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