Causal relationship between blood lipids and diabetic kidney disease：a Mendelian randomization study by Wang Hao-hao, Liu Hao-fei, Miao Shao-bo, Jia Run-ke, Ma Ji-wei

“…HDL （OR=0.879， 95%CI： 0.707-1.092， P=0.244） and LDL （OR=0.911， 95%CI： 0.698-1.191， P=0.496） had no evidence to prove their causal relationship with DKD.ConclusionTG and TC may play a role in the pathogenesis of DKD， but there is no evidence that HDL and LDL play a role in the pathogenesis of DKD.…”
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The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis by Gordon P. Flake, Alicia B. Moore, Norris Flagler, Benita Wicker, Natasha Clayton, Grace E. Kissling, Stanley J. Robboy, Darlene Dixon

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Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression by Daphne Wijnbergen, Mridul Johari, Ozan Ozisik, Peter A.C. ‘t Hoen, Friederike Ehrhart, Anaïs Baudot, Chris T. Evelo, Bjarne Udd, Marco Roos, Eleni Mina

“…Abstract Background Inclusion Body Myositis is an acquired muscle disease. Its pathogenesis is unclear due to the co-existence of inflammation, muscle degeneration and mitochondrial dysfunction. …”
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Tryptophan metabolism-related gene CYP1B1 serves as a shared biomarker for both Parkinson’s disease and insomnia by Xin-Yu Li, Wen-Kai Yu, Jing-Hao Wu, Wen-Jun He, Yu-Nan Cheng, Kai Gao, Yi-Han Wei, Yu-Sheng Li

“…Abstract Parkinson’s disease (PD) and insomnia are prevalent neurological disorders, with emerging evidence implicating tryptophan (TRP) metabolism in their pathogenesis. However, the precise mechanisms by which TRP metabolism contributes to these conditions remain insufficiently elucidated. …”
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Evaluation of IL-29 in Euthyroid Patients with Graves’ Orbitopathy: A Preliminary Study by Bogusz Falkowski, Ewelina Szczepanek-Parulska, Nadia Sawicka-Gutaj, Aleksandra Krygier, Marek Ruchala

“…Orbitopathy is the most prevalent and recognizable extrathyroidal manifestation of Graves’ disease with unrevealed pathogenesis. Interleukin 29 (IL-29) is a relatively newly discovered inflammatory cytokine. …”
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Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura by Jue Xie, Yan Liu, Lei Wang, Guoxiang Ruan, Huiming Yuan, Hong Fang, Jianyong Wu, Dawei Cui

“…Taken together, these findings suggest that TFH cells and associated molecules might play critical roles in the pathogenesis of HSP, which are possible therapeutic targets in HSP children.…”
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Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages by Diana Martínez-Saucedo, Juan de Dios Ruíz-Rosado, César Terrazas, Blanca E. Callejas, Abhay R. Satoskar, Santiago Partida-Sánchez, Luis I. Terrazas

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Copper homeostasis; A rapier between mycobacteria and macrophages by Di Hu, Zisha Yang, Jun‐ai Zhang, Ganbin Liu, Jiang Pi, Junfa Xu, Yan Wang, Yi Zhao

“…Therefore, elucidating the regulatory role of copper is pivotal for advancing our understanding of metal homeostasis in immune cell–pathogen dynamics and TB pathogenesis. Furthermore, we recommend further investigation into the role of copper in TB pathogenesis to advance tuberculosis diagnosis and treatment and gain comprehensive insights into metal homeostasis in infectious disease contexts.…”
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Urinary phthalate metabolites associated with increased prevalence of gallstone disease in U.S. adults: data from the NHANES study by Feng Jia, Yu Chang, Yuguang Li, Fangqi Li, Xinqiao Chen, Xiangliang Liu, Wei Li, Jiuwei Cui

“…These novel findings suggest phthalate exposure may contribute to lithogenic pathogenesis. Future prospective and mechanistic research is warranted.…”
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Morphological Features and In Vitro Cytopathic Effect of Acanthamoeba griffini Trophozoites Isolated from a Clinical Case by Arturo González-Robles, Lizbeth Salazar-Villatoro, Maritza Omaña-Molina, Maria Reyes-Batlle, Carmen M. Martín-Navarro, Jacob Lorenzo-Morales

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Instationary metabolic flux analysis reveals that NPC1 inhibition increases glycolysis and decreases mitochondrial metabolism in brain microvascular endothelial cells by Bilal Moiz, Matthew Walls, Viviana Alpizar Vargas, Anirudh Addepalli, Callie Weber, Andrew Li, Ganesh Sriram, Alisa Morss Clyne

“…Together, our data highlight the importance of NPC1 in BMEC metabolism and implicate brain endothelial dysfunction in NP-C pathogenesis.…”
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Identification of ubiquitination-related key biomarkers and immune infiltration in Crohn’s disease by bioinformatics analysis and machine learning by Wei Chen, Zeyan Xu, Haitao Sun, Wen Feng, Zhenhua Huang

“…Ubiquitination plays a significant role in the pathogenesis of CD. This study aimed to explore the functional roles of ubiquitination-related genes in CD. …”
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Copper homeostasis and neurodegenerative diseases by Yuanyuan Wang, Daidi Li, Kaifei Xu, Guoqing Wang, Feng Zhang

“…Emerging evidence suggests that abnormal copper metabolism or copper binding to various proteins, including ceruloplasmin and metallothionein, is involved in the pathogenesis of neurodegenerative disorders. However, the exact mechanisms underlying these processes are not known. …”
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YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints by Tuija Väänänen, Anna Koskinen, Erja-Leena Paukkeri, Mari Hämäläinen, Teemu Moilanen, Eeva Moilanen, Katriina Vuolteenaho

“…The present study introduces YKL-40 as a cartilage-derived factor associated with mediators of inflammation and cartilage destruction involved in the pathogenesis of OA.…”
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Assessing the inflammation in pediatric MOGAD: Significance of CSF HMGB1 and related biomarkers by Xin Wang, Ruibin Zhao, Jiayu Fan, Chong Liu, Li Zhang, Huafang Yang, Weiyi Wang

“…Evaluation and monitoring of biomarkers associated with its pathogenesis would provide vital information on disease progression and therapeutic assessment.MethodsWe assessed NLRP3, HMGB1, IL-6, and IL-33 levels in the cerebrospinal fluid (CSF) of pediatric patients with MOGAD at different time points and their association with the risk of disease. …”
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Serum Levels of SDF-1 and CXCR4 in Breast Cancer: Correlation with Disease Progression and Chemotherapy Response in Iraqi Women by Noor Al Rubaiey, Hazima ALabassi

“…This study aimed to investigate the role of autophagy markers, specifically SDF1 and CXCR4, in breast cancer pathogenesis among Iraqi women.A total of 90 participants, aged 25–65 years, were divided into three groups: 30 newly diagnosed breast cancer patients, 30 patients undergoing chemotherapy, and 30 healthy controls. …”
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A systematic review of circulating IP-10/CXCL10 in patients with Plasmodium infections in relation to disease severity by Manas Kotepui, Aongart Mahittikorn, Frederick Ramirez Masangkay, Kwuntida Uthaisar Kotepui

“…It provided insights into its role in malaria pathogenesis and potential as a biomarker for Plasmodium infections and disease severity. …”
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Profiling Proteins in the Hypothalamus and Hippocampus of a Rat Model of Premenstrual Syndrome Irritability by Mingqi Qiao, Peng Sun, Yang Wang, Sheng Wei, Xia Wei, Chunhong Song, Fushun Wang, Jibiao Wu

“…Our findings contribute to understanding the pathogenesis of PMS irritability and could provide a reference point for further studies.…”
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Cytokines in Liver Cirrhosis (Their Importance in Assessing Activity and Decompensation) by G. K. Mirodzhov, S. D. Pulatova

“…Aim: studying the role of pro-inflammatory and anti-inflammatory cytokines in the pathogenesis of liver cirrhosis progression.Materials and methods. …”
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The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules by Ayfer Altas, Fatih Kuzu, Dilek Arpaci, Mustafa Unal, Murat Can, Figen Barut, Furuzan Kokturk, Sevil Uygun Ilikhan, Taner Bayraktaroglu

“…IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties. …”
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