Research progress on the mechanisms of apolipoprotein E in Alzheimer’s disease by Jiayuan Li, Ting Liu, Shengxi Meng

“…Alzheimer’s disease (AD) is a degenerative disorder of the central nervous system that predominantly affects the elderly.The Apolipoprotein E (ApoE) gene is identified as the most significant genetic factor associated with AD.This article reviews current findings on the relationship between ApoE and AD, the impact of APOE gene polymorphisms on AD, the interaction between ApoE and other pathogenic factors, and the role of ApoE in AD.Additionally, it discusses the diagnosis and treatment of AD to enhance the understanding of its pathogenesis and to provide new perspectives for the prevention and management of the disease.…”
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Hypocomplementemic urticarial vasculitis syndrome: A disease with many faces by Ankit Agrawal, Sangeetha Pabolu, Shirisha Ale, Yesenia Galan

“…Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare autoimmune disease process where the exact pathogenesis is not known. It is an independent immunological condition affecting multiple organ systems. …”
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Role of sirtuin 1 (SIRT1) gene polymorphisms in pituitary adenoma development. Literature review by G. Morkūnaitė, B. Glebauskienė, R. Liutkevičienė

“…In this article, we will review the PA classification’s innovation, etiology, pathogenesis, SIRT1 polymorphisms and their significance for PA development. …”
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Toward Molecular Level of the “Salmonella-Victim” Ecology, Genetics, and Evolution by S.N. Rumyantsev

“…In this article, some key findings concerning ecology, molecular ecology, and cell level of the Salmonella infection genetics are summarized and interpreted from the viewpoint of evolutionary theory with certitude that this approach can help to decipher the undiscovered secrets of Salmonella infections epidemiology and pathogenesis, as well as the clinical course and severity, and to select ways for fighting against Salmonella.…”
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Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis by Adrianos Nezos, Clio P. Mavragani

“…We aimed to summarize the current evidence related to the contributory role of genetic factors in the pathogenesis of Sjögren’s syndrome (SS) and SS-related lymphoma. …”
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Uncommon Progression of an Extradural Spinal Meningioma by Atef Ben Nsir, Mohamed Boughamoura, Houda Mahmoudi, Mohamed Kilani, Nejib Hattab

“…In addition we discuss the pathogenesis of these tumors and the potential pitfalls in differential diagnosis and review the relevant literature concerning their treatment and outcome.…”
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Global stability of an HIV-1 model with distributed intracellular delays and a combination therapy by Shengqiang Liu, Lin Wang

“…Global stability is analyzed for a general mathematical model of HIV-1 pathogenesis proposed by Nelson and Perelson [11]. The general model include two distributed intracellular delays and a combination therapy with a reverse transcriptase inhibitor and a protease inhibitor. …”
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Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest by Julie Mondet, Kais Hussein, Pascal Mossuz

“…In this review, we present the current knowledge on alteration of circulating cytokine profiles in MPNs and their role in myelofibrosis pathogenesis. Phenotypic correlation, prognostic value of cytokines, and impact of JAK inhibitors are also discussed.…”
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Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis by Maryam Mehdipour Dalivand, Parastou Tizro, Julie Partain, Anita Aggarwal, Jack Lichy, Francisco Mot Ara, Victor E. Nava

“…These findings may stimulate further research to clarify the pathogenesis of hematologic neoplasms.…”
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Diffuse Melanosis and Ascites due to Metastatic Malignant Melanoma by Elena Sendagorta, Angel Pizarro, Marta Feito, Matias Mayor, Paloma Ramírez, Uxua Floristán, Rosa Feltes

“…We discuss briefly the current evidence on pathogenesis of melanosis arising from metastatic melanoma.…”
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Predicting, Treating and Preventing Postoperative Recurrence of Crohn’s Disease: The State of the Field by Anna M Borowiec, Richard N Fedorak

“…Unfortunately, postsurgical remission tends to be short lived; a significant number of patients experience clinical relapse and many require additional operations. The pathogenesis of this postoperative recurrence is poorly understood and, currently, there are no reliable tools to predict when and in whom the disease will recur. …”
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Correlation between the Neutrophil-to-Lymphocyte Ratio and Multiple Sclerosis: Recent Understanding and Potential Application Perspectives by Qingqing Zhou, Rui Jia, Jingxia Dang

“…Low-grade systemic inflammation has been considered to lead to pathogenesis owing to the amplification of pathogenic immune response activation. …”
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A Critical Appraisal on the Role of Varicocele in Male Infertility by Ricardo Miyaoka, Sandro C. Esteves

“…This paper reviews the most recent data available on the pathogenesis, diagnosis, and management of varicocele with regard to male infertility.…”
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Sebaceous Lymphadenoma of Parotid: Imaging, Cytological, and Histological Findings in Detail by Golsa Shekarkhar, Hossein Soleimanpour, Seyed Hamed Jafari, Fatemeh Zamani

“…Few case reports have been published in literature about their pathogenesis and accompanying malignant lesions. The cytological and imaging findings have been dealt with in some articles. …”
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Dietary Glycaemic Index and Type 2 Diabetes Mellitus: Potential Modulation of Gut Microbiota by Hanusha Durganaudu, Thubasni Kunasegaran, Amutha Ramadas

“…As a conclusion, we have pointed out several key research directions that may have helpful impact on diet interventions with modulation of gut microbiota on the pathogenesis and therapeutic implications in T2DM.…”
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Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent by Mitsuharu Hattori

“…However, in recent decades, its role in the adult brain has become increasingly important, and it is now clear that diminished Reelin function is involved in the pathogenesis and progression of neuropsychiatric and neurodegenerative disorders, including schizophrenia and Alzheimer’s disease (AD). …”
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Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases by Claire J. Wiggins, Susan Y. Chon

“…By illuminating connections between medication side effects and disease pathogenesis, our goal is to increase awareness of the cutaneous side effects of Notch inhibitor treatment.…”
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Role and Function of Regulatory T Cell in Chronic Rhinosinusitis with Nasal Polyposis by Chenyang Lei, Juan Jiang, Yanyan Zhang, Gaoyun Xiong

“…Chronic rhinosinusitis with nasal polyps (CRSwNP) is a subtype of chronic rhinosinusitis characterized by high edema in the stroma, albumin deposition, and formation of pseudocysts. The pathogenesis of CRSwNP is not yet fully understood. Regulatory T (Treg) cells are a subset of CD4+ T cells that play a suppressive immunoregulatory role in the process of CRSwNP. …”
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Consensus Meeting of European Society of Neurogastroenterology and Motility on Functional Dyspepsia (2020): Have We Dotted All the I’s? by A. A. Sheptulin, O. A. Storonova, D. E. Rumyantseva

“…Expert votes at the consensus meeting generally confirmed the main statements of the Rome Criteria Revision IV on the definition of functional dyspepsia, its aetiology and pathogenesis, diagnosis and treatment, as well as those of the Kyoto Consensus covering the possible association of dyspeptic complaints with H. pylori infection. …”
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Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis by Da-Long Dong, Guang-Zhen Jin

“…Although there is no definitive evidence to date confirming that chondrocyte hypertrophy is the direct cause of OA, substantial experimental data indicate that it plays an important role in the disease’s pathogenesis. In this review, we first explore the mechanisms underlying chondrocyte hypertrophy in OA and offer new insights. …”
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