Different Pathological Roles of Toll-Like Receptor 9 on Mucosal B Cells and Dendritic Cells in Murine IgA Nephropathy by Tadahiro Kajiyama, Yusuke Suzuki, Masao Kihara, Hitoshi Suzuki, Satoshi Horikoshi, Yasuhiko Tomino

“…Although pathogenesis of IgA nephropathy (IgAN) is still obscure, pathological contribution of mucosal immunity including production of nephritogenic IgA and IgA immune complex (IC) has been discussed. …”
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Mechanisms of Herbal Nephroprotection in diabetes mellitus by Dorin Dragoș, Maria Mirabela Manea, Delia Timofte, Dorin Ionescu

“…Despite the multilayered complexity of the mechanisms involved in the pathogenesis of DN, the conventional treatment is limited to just a few drug classes fraught with the risk of adverse events, including the progression of renal dysfunction. …”
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Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells by Samanta Melgar-Rodríguez, Emilio A. Cafferata, Nicolás I. Díaz, Miguel A. Peña, Luis González-Osuna, Carolina Rojas, Alfredo Sierra-Cristancho, Angélica M. Cárdenas, Jaime Díaz-Zúñiga, Rolando Vernal

“…In the present review, we revise and discuss the pathogenic characteristics of NKT cells in these diseases and their role in the pathogenesis of periodontitis; particularly, we analyze the potential regulatory role of the IL-10-producing NKT10 cells.…”
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Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking by Xiao Zhang, Xi Zhu, Wenbo Gu, Xusheng Li, Tenyao Niu, Pengcheng Mao, Haifeng Yuan

“…Abstracts: Objective: This study investigated the effects of plasticizers (phthalates) on the pathogenesis of osteoporosis (OP) and the associated molecular mechanisms, especially the interaction of plasticizers with key pathways. …”
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Bioinformatics Analysis of Genes and Mechanisms in Postherpetic Neuralgia by Yong Qiu, Meng-Lei Hao, Xu-Tao Cheng, Zhen Hua

“…As a result, the life quality of patients was seriously reduced. However, the pathogenesis of PHN has not been fully elucidated, and current treatments remain inadequate. …”
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Colon Cancer Genetic and Epigenetic Changes, Etiopathogenesis, Risk Factors, Treatment: Literature Review by Gabrielė Ūbaitė, Aurelija Remeikaitė, Justas Žilinskas

“…To review the latest scientific developments and novel factors on the epidemiology, etiology, pathoge­nesis of colon cancer, focusing on the influence of genetics and epigenetics, risk factors, and the advancement of prevention and treatment methods. …”
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Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy by Yuyang Wang, Hailing Zhao, Qian Wang, Xuefeng Zhou, Xiaoguang Lu, Tongtong Liu, Yongli Zhan, Ping Li

“…Diabetic kidney disease (DKD), a leading cause of end-stage renal disease (ESRD), has become a serious public health problem worldwide and lacks effective therapies due to its complex pathogenesis. Recent studies suggested defective autophagy involved in the pathogenesis and progression of DKD. …”
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Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. by Lance D Eckerle, Michelle M Becker, Rebecca A Halpin, Kelvin Li, Eli Venter, Xiaotao Lu, Sana Scherbakova, Rachel L Graham, Ralph S Baric, Timothy B Stockwell, David J Spiro, Mark R Denison

“…Most RNA viruses lack the mechanisms to recognize and correct mutations that arise during genome replication, resulting in quasispecies diversity that is required for pathogenesis and adaptation. However, it is not known how viruses encoding large viral RNA genomes such as the Coronaviridae (26 to 32 kb) balance the requirements for genome stability and quasispecies diversity. …”
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Correlations of inflammatory processes caused by cerebral stroke with the outcome of the disease by A. Vaitkus, J. Valinčiūtė, S. Gylytė

“…Inflammation plays a central role in the pathogenesis of stroke, so understanding inflammatory processes can greatly improve stroke treatment options. …”
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Expression of TGF-β in malignant transformation of oral lichen planus - A systematic review by Harinisubasri M, Priyadharsini Nataraj, Dineshkumar Thayalan, Divya Bose, Rameshkumar Annasamy, Rajkumar K

“…Results: All the articles included in this study included TGF-β and its related protein expression in both its pathogenesis and cancer growth.This help to bring in newer and targeted treated options. …”
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Assessment of Interleukin-1β in Saliva of Smoker and Non-smoker Patients with Chronic Periodontitis. by Solav Abdul-Qadir Mustafa, Haween T. Nanakaly, Hozan Wrya Azeez

“… Background and objectives: Smoking is considered a significant risk factor in periodontitis. The pathogenesis of periodontal disease may be affected by alterations of the inflammatory response by smoke. …”
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Gene Expression Signatures of Smoking and Acute Myocardial Infarction: A Blood Transcriptome Analysis by Fang-Fang Liu, Yi-Xuan Yan, Hong-Feng Zhang, Ke Li

“…These identified genes are likely to play critical roles in the pathogenesis of AMI. Given the accessibility of peripheral blood samples, the expression levels of these genes could potentially serve as biomarkers for assessing cardiovascular health, particularly in individuals with a history of long-term exposure to cigarette smoke.…”
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Multiple Hepatic Abscesses Following Yersinia Enterocolitica Septicemia by Franco Colizza, Serge LePage, Jean-François LaJoie, Raymond Duperval, André Marcoux, Jacques Mongeau, Denis Bergeron

“…General considerations regarding the manifestations and pathogenesis of Y enterocolitica are discussed, with a review of the literature.…”
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Inflammatory Bowel Disease, the Oral Contraceptive Pill and Pregnancy by Robert N Allan

“…This paper summarizes our current knowledge of the role of the oral contraceptive pill in the pathogenesis of inflammatory bowel disease (IBO), followed by a review of fertility in women and men. …”
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IL-7 is a Key Driver Cytokine in Spondyloarthritis? by Rafaela Silva Guimarães Gonçalves, Angela Luzia Branco Pinto Duarte

“…The rationale for a type 17 signature in the pathogenesis of spondyloarthritis (SpA) has been increasing and being ratified in studies recently. …”
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SPONTANEOUS MISCARRIAGE: STATE STUDY QUESTIONS by E. I. Borovkova, I. V. Martynova

“…Presented modern classification, The etiology and pathogenesis of complications, diagnostic criteria and differential diagnosis, and treatment standards and opportunities for prevention.…”
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Prevalence of Gastroesophageal Reflux in Infants with Recurrent Brief Apneic Episodes by Shahid Sheikh, Thomas C Stephen, Barbara Sisson

“…It is suggested that in some infants, gastroesophageal reflux (GER) might be a factor in the pathogenesis of apnea, although its role as a cause of apnea is still controversial.…”
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Cutaneous and Gastrointestinal Symptoms in Two Patients with Systemic Mastocytosis Successfully Treated with Omalizumab by Sofie Lieberoth, Simon Francis Thomsen

“…The pathogenesis of mastocytosis is not well defined and thus treatment remains challenging and remains on a palliative basis. …”
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TNF-α Dysregulation in Asthma: Relationship to Ongoing Corticosteroid Therapy by Susan Waserman, Jerry Dolovich, Mary Conway, Jean S Marshall

“…BACKGROUND: Tumour necrosis factor-alpha (TNF-α) is a major proinflammatory cytokine that is thought to be important in the pathogenesis of asthma. However, alterations in systemic regulation of this cytokine in asthma have not been examined in the context of corticosteroid therapy.…”
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Development of a latency model for HIV-1 subtype C and the impact of long terminal repeat element genetic variation on latency reversal by Shreyal Maikoo, Robert-Jan Palstra, Krista L. Dong, Tokameh Mahmoudi, Thumbi Ndung'u, Paradise Madlala

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