NSAIDs and Triptans – a (not) New Treatment Option for Migraine by B. Kakta, Rasa Mameniškienė

“…Migraine is one of the leading causes of years lived with disability, and it also causes significant negative economic impact, as most as the affected population is of working age. Pathogenesis of migraine includes neurogenic inflammation, which, in turn, causes peripheral sensitization of trigeminal nerve mechanoreceptors. …”
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The trend of Epstein-Barr virus DNA loads and CD8+ T lymphocyte numbers can predict the prognosis of pediatric liver transplant recipients with PTLD by Wang Kedi, Xu Dongjiang, Gao Yan, Ma Kaihui, Zhao Wen

“…Epstein-Barr virus (EBV) can cause lymphoproliferative disorders (PTLD) in immunodeficiency individuals. The pathogenesis of EBV infection depends on its effective recognition and elimination. …”
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Multicentric Castleman’s Disease, Associated with Idiopathic Thrombocytopenic Purpura by Ruchi Sood, Harris C. Taylor, Hamed Daw

“…We present the third known association between MCD and previous immune thrombocytopenia in the absence of HIV and HHV-8 infection and review its association with other autoimmune disorders and attendant implications for pathogenesis. Finally, we summarize the current approach to therapy.…”
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Isolation of Klebsiella Pneumoniae from an Hepatic Inflammatory Pseudotumour by Dickran K Malatjalian, John Morris, Audley Bodurtha

“…lnflammatory pseudotumours of the liver are rare, solid mass lesions (often mistaken for malignancy) and although inflammatory in nature, are obscure in etiology and pathogenesis. An hepatic inflammatory pseudotumour is presented in which cultures obtained from the lesion intraoperatively grew Klebsiella pneumoniae. …”
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Cannabinoids and the endocannabinoid system in liver diseases by Anna Parfieniuk-Kowerda, Diana Martonik, Aleksandra Andrzejuk, Aleksander Tarasik, Robert Flisiak

“…In end-stage liver disease, the endocannabinoid system plays an important role in the pathogenesis of encephalopathy and vascular effects, such as portal hypertension, splanchnic vasodilatation and cirrhotic cardiomyopathy. …”
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Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular Pathologies by Afifah Zahirah Abd Rami, Adila A. Hamid, Nur Najmi Mohamad Anuar, Amilia Aminuddin, Azizah Ugusman

“…However, dysfunctional PVAT produces more proinflammatory adipocytokines such as leptin, resistin, interleukin- (IL-) 6, IL-1β, and tumor necrosis factor-alpha, thus inducing an inflammatory response that contributes to the pathogenesis of vascular diseases. In this review, current knowledge on the role of PVAT inflammation in the development of vascular pathologies such as atherosclerosis and hypertension was discussed.…”
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Adiponectin in Cardiovascular Inflammation and Obesity by Tamar R. Aprahamian, Flora Sam

“…Therefore, adipose tissue may have a more important role than previously thought in the pathogenesis of several disease types. This review explores the recently described role of adiponectin as an immunomodulatory factor and how it intersects with the inflammation associated with both cardiovascular and autoimmune pathologies.…”
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Concurrent Hairy Cell Leukemia and Metastatic Merkel Cell Carcinoma by Ajay Prakash, Alhossain A. Khalafallah

“…This is the first reported case of these two rare malignancies occurring concurrently at initial presentation and may represent a role of immunosuppression in the pathogenesis of MCC.…”
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Pneumococcal Endometritis with Peritonitis: Case Report and Review of the Literature by KI Ostrowska, C Rotstein, JH Thornley, LA Mandell

“…The patient responded to removal of the tampon and administration of broad spectrum antibiotics. The pathogenesis of pneumococcal endometritis and peritonitis and the potential significance of a tampon in situ are discussed.…”
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Ribosomal Alteration-Derived Signals for Cytokine Induction in Mucosal and Systemic Inflammation: Noncanonical Pathways by Ribosomal Inactivation by Yuseok Moon

“…In the present study, ribosomal inactivation-related modulation of cytokine production was reviewed in leukocyte and epithelial pathogenesis models to characterize mechanistic evidence of ribosome-derived cytokine induction and its implications for potent therapeutic targets of mucosal and systemic inflammatory illness, particularly those triggered by organellar dysfunctions.…”
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Hepatitis B and Hepatitis C Viral Infections in Patients with Chronic Lymphocytic Leukemia by Gerald Y Minuk, Betty Lerner, Spencer B Gibson, James B Johnston, Julia Uhanova, Anton Andonov, Jun Wu

“…BACKGROUND: Whether chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections contribute to the pathogenesis and/or course of chronic lymphocytic leukemia is unclear.…”
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Persistent Peril: Confronting Recurrent Chest Abscess from Nontuberculous Mycobacteria by P Prem Ananth, R Anand, S Raghul Raj, N Nagarajan, M Thoupikka

“…It also underscores the importance of considering environmental exposure in the pathogenesis of NTM infections and highlights the need for a multidisciplinary approach to effectively manage such complex cases.…”
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Intrasurgical Imaging of Subinternal Limiting Membrane Blood Diffusion in Terson Syndrome by Lorenzo Iuliano, Giovanni Fogliato, Marco Codenotti

“…We highlight some remarkable in vivo anatomical findings that may give a contribution to the debate about its pathogenesis. Here we hypothesize that the subretinal space might be unlikely to be a primary source of intraocular hemorrhage, and we support the two generally accepted theories about blood diffusion from the retinal vasculature or from the perivascular spaces.…”
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Single monoclonal spike characterized as double monoclonal gammopathy in a patient with multiple myeloma: A rare finding by Rajni Saijpaul, Vatsala Khurana, Rashmi Verma, Smita Kaushik

“…Double monoclonal gammopathies need to be identified to increase diagnostic accuracy and reliability, and to get a better understanding of the disease pathogenesis and progression.…”
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Increased Growth Differentiation Factor 15 Levels Are Associated with HIV-Associated Neurocognitive Impairment: A Pilot Study by Ali Boustani, Mary K. Ford, Jacqueline R. Kulbe, Anna E. Laird, Leeann Shu, Matthew Spencer, Bryant Avalos, Kyle C. Walter, Ronald J. Ellis, Jerel Adam Fields

“…<b>Conclusions</b>: The findings indicate that GDF15 may play a role in the pathogenesis of HIV-associated NCI, possibly through neuroinflammatory mechanisms. …”
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Neuregulin1 ameliorates metabolic dysfunction-associated fatty liver disease via the ERK/SIRT1 signaling pathways by Chengan Xu, Shouhao Wang, Di Meng, Mingshan Wang, Rong Yan, Yining Dai

“…Conclusion NRG1 might play a protective role in the pathogenesis of MAFLD by activating the downstream ERK1/2 through ErbB2-ErbB3, which promotes the expression of SIRT1 and autophagy markers. …”
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12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis by Nathalie Deckx, Inez Wens, Amber H. Nuyts, Niel Hens, Benedicte Y. De Winter, Gudrun Koppen, Herman Goossens, Pierre Van Damme, Zwi N. Berneman, Bert O. Eijnde, Nathalie Cools

“…However, the effect of exercise on the underlying disease pathogenesis remains elusive. Since recent evidence supports a crucial role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of a 12-week combined exercise program in MS patients on the number and function of DC. …”
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Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases by Emi Haga, Naoya Inoue, Yoshinori Iwatani, Yuya Arakawa, Emi Morita, Hidemi Hashimoto, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe

“…Then, histone H3 acetylation levels were evaluated in AITD patients to clarify the association with the pathogenesis of AITD. Although we could not find a common pattern of circadian variance, we observed daily variation in histone H3 acetylation levels, and their coefficient of variances (CVs) were approximately 48.3%. …”
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Role of Cathepsin S in Periodontal Inflammation and Infection by S. Memmert, A. Damanaki, A. V. B. Nogueira, S. Eick, M. Nokhbehsaim, A. K. Papadopoulou, A. Till, B. Rath, S. Jepsen, W. Götz, C. Piperi, E. K. Basdra, J. A. Cirelli, A. Jäger, J. Deschner

“…The objective of this study was to investigate whether cathepsin S is involved in the pathogenesis of periodontal diseases. Human periodontal fibroblasts were cultured under inflammatory and infectious conditions elicited by interleukin-1β and Fusobacterium nucleatum, respectively. …”
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Evidence and perspectives on miRNA, circRNA, and lncRNA in myocardial ischemia-reperfusion injury: a bibliometric study by Xiaowen Bo, Qiuyu Li, Siyuan Chen, Tian Zhou, Ning Yin, Wenpeng Song, Donghui Zhao, Jinghua Liu, Qian Fan

“…Abstract Objective miRNA, circRNA, and lncRNA play crucial roles in the pathogenesis and progression of myocardial ischemia-reperfusion injury (MI/RI). …”
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