Advances in Murine Models of Diabetic Nephropathy by Li-li Kong, Hao Wu, Wen-peng Cui, Wen-hua Zhou, Ping Luo, Jing Sun, Hang Yuan, Li-ning Miao

“…Diabetic nephropathy (DN) is one of the microvascular complications of both type 1 and type 2 diabetes, which is also associated with a poor life expectancy of diabetic patients. However, the pathogenesis of DN is still unclear. Thus, it is of great use to establish appropriate animal models of DN for doing research on pathogenesis and developing novel therapeutic strategies. …”
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Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity by Doaa Salah Hegab, Mohamed Attia Saad Attia

“…Dysregulation of Tregs may be one of the factors that can break tolerance to melanocyte self-antigens and contribute to vitiligo pathogenesis. Methods. In order to sustain the role of Tregs in pathogenesis and disease activity of vitiligo, surface markers for CD4+CD25+ and FoxP3+ peripheral Tregs were evaluated by flow cytometry in 80 Egyptian patients with nonsegmental vitiligo in addition to 60 healthy control subjects and correlated with clinical findings. …”
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Neurobiological Mechanism of Acupuncture for Relieving Visceral Pain of Gastrointestinal Origin by Fang Zhang, Luyi Wu, Jimeng Zhao, Tingting Lv, Zhihai Hu, Zhijun Weng, Shuoshuo Wang, Huangan Wu, Huirong Liu

“…In recent years, research has examined the pathogenesis of GI visceral pain and its influencing factors and has explored the neural transduction pathways of this disease.…”
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The possible effects of chili peppers on ADHD in relation to the gut microbiota by Yinyue Li, Jing Feng, GuangYao Ding, Lin Deng, Ying He, Qiongqiong Zhang, Jianhui Wang, Xia Chen

“…Although the etiology and pathogenesis of ADHD are not fully understood, existing studies have shown that it may be related to genetic factors, environmental factors, abnormal brain development, and psychosocial factors. …”
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Peripheral Expression of IL-6, TNF-α and TGF-β1 in Alzheimer's Disease Patients by Gamze Güven, Pınar Köseoğlu, Ebba Lohmann, Bedia Samancı, Erdi Şahin, Başar Bilgiç, Haşmet Ayhan Hanağası, Hakan Gürvit, Nihan Erginel-Ünaltuna

“…Peripheral levels of various inflammatory cytokines are altered during AD pathogenesis. This study aimed to examine the role of peripheral inflammation in AD pathogenesis by measuring serum levels and gene expression of specific inflammatory cytokines in AD patients. …”
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Microvascular dysfunction in a murine model of Alzheimer’s disease using intravital microscopy by Danielle Sidsworth, Noah Tregobov, Noah Tregobov, Colin Jamieson, Jennifer Reutens-Hernandez, Joshua Yoon, Geoffrey W. Payne, Geoffrey W. Payne, Stephanie L. Sellers, Stephanie L. Sellers, Stephanie L. Sellers, Stephanie L. Sellers

“…Early theories of AD sought to identify a single unifying explanation underlying AD pathogenesis; however, evolving evidence suggests it is a multifactorial, systemic disease, involving multiple systems. …”
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Host genetics and gut microbiota influence lipid metabolism and inflammation: potential implications for ALS pathophysiology in SOD1G93A mice by Elena Niccolai, Leandro Di Gloria, Maria Chiara Trolese, Paola Fabbrizio, Simone Baldi, Giulia Nannini, Cassandra Margotta, Claudia Nastasi, Matteo Ramazzotti, Gianluca Bartolucci, Caterina Bendotti, Giovanni Nardo, Amedeo Amedei

“…Further elucidating the mechanisms underlying these interactions could offer novel insights into ALS pathogenesis and potential therapeutic targets.…”
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Flt3/Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis by Jing-Wei Mao, Yu-Shuang Huang, Hai-Ying Tang, Jian Bi, Yan-Fei Liu, Ying-De Wang

“…Flt3/Flt3L participates in the process of regulating DCS and T-regs in the pathogenesis of UC, at least, in the acute stage of this disease.…”
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Sustained High Levels of Both Total and High Molecular Weight Adiponectin in Plasma during the Convalescent Phase of Haemorrhagic Fever with Renal Syndrome Are Associated with Dise... by Kang Tang, Chunmei Zhang, Yusi Zhang, Yun Zhang, Ran Zhuang, Boquan Jin, Ying Ma

“…These results may provide insights into understanding the roles of total and HMW APN in the pathogenesis of HFRS.…”
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Role of Neutrophil Extracellular Traps in Hypertension and Their Impact on Target Organs by Fei Yu, Jianshu Chen, Xiaowei Zhang, Zhengke Ma, Jingtao Wang, Qiang Wu

“…The process involving the formation of neutrophil extracellular traps (NETs) is called NETosis are involved in the pathogenesis and progression of CVDs, including coronary artery disease, acute myocardial infarction, peripheral arterial disease, heart failure, and atrial fibrillation. …”
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TPX2 Serves as a Cancer Susceptibility Gene and Is Closely Associated with the Poor Prognosis of Endometrial Cancer by Jun Wang, Hua Zheng, Hui He, Shuying Meng, Yatian Han, Zhe Su, Hanbing Yan, Yanan Zhang

“…Copy number variation (CNV) was also evaluated for its association with the pathogenesis of EC. Gene set enrichment analysis (GSEA) was conducted to enrich significant pathways driven by the hub genes. …”
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Rheumatic Diseases and Obesity: Adipocytokines as Potential Comorbidity Biomarkers for Cardiovascular Diseases by Rossana Scrivo, Massimiliano Vasile, Ulf Müller-Ladner, Elena Neumann, Guido Valesini

“…Inflammation has been recognized as a common trait in the pathogenesis of multifactorial diseases including obesity, where a low-grade inflammation has been established and may be responsible for the cardiovascular risk related to the disease. …”
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Virulence and Antimicrobial-Resistant Gene Profiles of Salmonella spp. Isolates from Chicken Carcasses Markets in Ibague City, Colombia by Kelly Johanna Lozano-Villegas, Iang Schroniltgen Rondón-Barragán

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Ocular Surface Temperature in Age-Related Macular Degeneration by Andrea Sodi, Sara Matteoli, Giovanni Giacomelli, Lucia Finocchio, Andrea Corvi, Ugo Menchini

“…Considering the possible relationship between ocular blood flow and OST, these findings might support the central role of ischemia in the pathogenesis of AMD.…”
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FROM ONCOLOGIST TO SURGEON - GENETICS IN COLORECTAL METASTASIS FOR SURGEONS by Marília Polo Mingueti e SILVA, Jorge SABBAGA, Henry Luiz NAJMAN, Carlos David Carvalho NASCIMENTO, Ricardo Lemos COTTA-PEREIRA, João Eduardo Leal NICOLUZZI, Maria Ignez BRAGHIROLI

“…Sporadic disease is characterized by the absence of a family history and accounts for approximately 70% of all colorectal cancers, being more common over 50 years of age, with dietary and environmental factors implicated in its pathogenesis. Sporadic disease is characterized by the absence of a family history and accounts for approximately 70% of all colorectal cancers, being more common over 50 years of age, with dietary and environmental factors implicated in its pathogenesis. …”
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The Hyperactivation of JAK-STAT Signaling Connects Inborn Errors of Immunity and Autoimmune Diseases by JIANG Yi, AN Yunfei, ZHAO Xiaodong

“…Meanwhile, we hope to make IEI a good model to study the pathogenesis of autoimmune diseases and to provide new ideas and directions for the clinical treatment of autoimmune diseases.…”
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Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque by Tingfu Du, Shuaiyao Lu, Qinfang Jiang, Yun Li, Kaili Ma

“…In addition to providing potential T2DM biomarkers, this quantitative proteomic study may also shed insights regarding the molecular pathogenesis of T2DM.…”
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Downregulation of HBx Restrains Proliferation, Migration, and Invasion of HepG2 Cells by Chaoqun Huang, Wei Liu, Xiaochuan Zhao, Libin Zhao, Fuxiang Wang

“…HBx and XB130 may be potential targets for liver cancer pathogenesis.…”
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Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases by Juan Shi, Shuhong Chi, Jing Xue, Jiali Yang, Feng Li, Xiaoming Liu

“…Under a physiological condition, it is tightly controlled at different layers and arrays, and a dysregulated activation of this signaling has been implicated into the pathogenesis of various human disorders, including autoimmune diseases. …”
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Antioxidant Properties of Albumin and Diseases Related to Obstetrics and Gynecology by Kazushi Watanabe, Hiroyuki Kinoshita, Tomohito Okamoto, Kazumasa Sugiura, Shingo Kawashima, Tetsuro Kimura

“…In particular, we focused on preeclampsia, in which oxidative stress is closely involved in the pathogenesis, and renal dysfunction leads to increased albumin excretion into the urine, resulting in hypoalbuminemia. …”
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