Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation by Gaia Favero, Lorenzo Franceschetti, Francesca Bonomini, Luigi Fabrizio Rodella, Rita Rezzani

“…The exact aetiology leading to the development of inflammation is not known, but a combination of genetic, epigenetic, and environmental factors seems to play an important role in the pathogenesis of many inflammation-related clinical conditions. …”
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Complement activated granulocytes can cause autologous tissue destruction in man by E. Löhde, H. Raude, M. Lück, E. Kraas, W. Lierse

“…Activation of polymorphonuclear granulocytes (PMNs) by C5a is thought to be important in the pathogenesis of multiple organ failure during sepsis and after trauma. …”
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Busting the Breast Cancer with AstraZeneca’s Gefitinib by S. Chemmalar, A. R. Intan Shameha, Che Azurahanim Che Abdullah, Nor Asma Ab Razak, Loqman Mohamad Yusof, Mokrish Ajat, Kim Wei Chan, Md Zuki Abu Bakar Zakaria

“…Epidermal growth factor receptors (EGFRs) and their respective ligands have been blamed for the pathogenesis and resistance to treatment in specific breast cancer cases. …”
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Endocan expression and correlation with other endothelial determinants in developing a score for early identification of diabetic peripheral neuropathy by Prajna Parimita Jena, Rachita Nanda, Amritava Ghosh, Suprava Patel, Seema Shah, Eli Mohapatra

“…Despite the multifactorial background of the pathogenesis of this disease, the mechanism underlying peripheral neuropathy is still unclear. …”
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Protective Role of Platelets in Myocardial Infarction and Ischemia/Reperfusion Injury by Kornela Hałucha, Alina Rak-Pasikowska, Iwona Bil-Lula

“…Thrombotic occlusion of the coronary artery is a key component in the pathogenesis of myocardial ischemia and myocardial infarction (MI). …”
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NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics by Yuzhou Liu, Ying Wang, Ping Yan, Ning Cui, Kejin Xu, Da Liu, Yuan Tian, Lingling Cao

“…Thus, understanding OA’s pathogenesis and devising effective therapies is crucial. …”
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Inflammatory Bowel Disease: Progress Towards a Gene by David A van Heel, Jack Satsangi, Alisoun H Carey, Derek P Jewell

“…The pathogenesis of ulcerative colitis (UC) and Crohn’s disease (CD) is still unknown, but the importance of genetic susceptibility has been clearly shown by epidemiological data from family and twin studies. …”
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The Role of MicroRNAs in Diabetic Nephropathy by Hao Wu, Lili Kong, Shanshan Zhou, Wenpeng Cui, Feng Xu, Manyu Luo, Xiangqi Li, Yi Tan, Lining Miao

“…Diabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major cause of end-stage renal disease. However, the pathogenesis of this disease is not fully understood. …”
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High-fat diet and neuroinflammation: The role of mitochondria by Mingxue Song, Yao Bai, Fuyong Song

“…As the key organelles responsible for energy metabolism in the cell, mitochondria are believed to involved in the pathogenesis of a variety of neurological disorders. …”
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Evaluation of T memory cells in knee osteoarthritis patients by Rehab S. Mohamed, Alaa M. Hashim, Abdelhafeez M. Moshrif, Ali Sobhy

“…Therefore, this study aims to assess the role of T memory cells in the pathogenesis of knee OA. Patients and methods This case–control study was carried out on 30 symptomatic patients with radiographic evidence of knee OA, who were attending Al-Azhar University Hospital, Assuit and 30 healthy volunteers. …”
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Cough in non-cystic fibrosis bronchiectasis by Ahmad Kantar, Woo-Jung Song, Andrew Bush, Grigorios Chatziparasidis

“…In NCFBE, mucus hyperviscosity contributes to impaired mucus clearance and determines disease pathogenesis; therefore, it may be a therapeutic target. …”
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A Review of the Aetiopathogenesis and Clinical and Histopathological Features of Oral Mucosal Melanoma by Liviu Feller, Razia A. G. Khammissa, Johan Lemmer

“…The aetiology is unknown, the pathogenesis is poorly understood, and the 5-year survival rate rarely exceeds 30%. …”
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Deep learning-based prediction of autoimmune diseases by Donghong Yang, Xin Peng, Senlin Zheng, Shenglan Peng

“…T cells, as a core component of the immune system, play a critical role in the human immune system and have a significant impact on the pathogenesis of autoimmune diseases. Several studies have demonstrated that T-cell receptors (TCRs) may be involved in the pathogenesis of various autoimmune diseases, which provides strong theoretical support and new therapeutic targets for the prediction and treatment of autoimmune diseases. …”
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The Role of Cyclooxygenase in Multiplication and Reactivation of HSV-1 in Vestibular Ganglion Neurons by Yuehong Liu, Shufeng Li, Zhengmin Wang

“…Reactivation of latent herpes simplex type 1 (HSV-1) and nerve inflammation have been shown to be involved in vertigo-related vestibular pathogenesis. Treatments of such diseases have been less than perfect. …”
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Treatment of irritable bowel syndrome: the past, present and future by V. T. Ivashkin, Ye. A. Poluektova, O. S. Lyashenko, D. V. Reykhart

“…To present data on foreign and Russian clinical studies devoted to improvement of irritable bowel syndrome (IBS) treatment according to the new data on disease pathogenesis.Summary. Spasmolytics, laxatives or antidiarrheal agents are traditionally applied for treatment of IBS patients according to leading symptom. …”
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Unraveling the microbial mysteries: gut microbiota’s role in ulcerative colitis by Keyu Ren, Chunming Yong, Yanchun Jin, Shanwei Rong, Kuijin Xue, Bin Cao, Hongyun Wei

“…Additionally, the role of extra-intestinal microbiota in UC pathogenesis is explored, which has been less studied but is gaining attention. …”
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CONDITIONS OF SKIN AND INTESTINE MICROBIOTES IN PATIENTS WITH PSORIASIS by Ya.O. Yemchenko, K.E. Ishcheikin, I.P. Kaidashev, G.Yu. Morokhovets

“…Thus, the human microbiota plays a key role in various aspects of the disease, from its pathogenesis to response to treatment.…”
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Effect of Interleukin and Hepcidin in Anemia of Chronic Diseases by Maha F. Yacoub, Hala Fouad Ferwiz, Fadwa Said

“…These findings offer an insight into the role played by both cytokine and peptide in the pathogenesis of ACD and thus provide a rationale for future use of novel drugs inhibiting their effects on iron metabolism.…”
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Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia by Jing Wang, Terry W. Wright, Francis Gigliotti

“…These features highlight the importance of developing a better understanding of the pathogenesis of this disease, and the need to search for new therapeutic strategies to improve the outcome of Pcp patients. …”
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Mutational signature analysis predicts bacterial hypermutation and multidrug resistance by Kalen M. Hall, Leonard G. Williams, Richard D. Smith, Erin A. Kuang, Robert K. Ernst, Christine M. Bojanowski, William C. Wimley, Lisa A. Morici, Zachary F. Pursell

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