Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection by Yung-Chun Chuang, Hong-Ru Chen, Trai-Ming Yeh

“…However, the role of MIF in the pathogenesis of DHF/DSS is not limited to immune cell recruitment. …”
Get full text

Serum Bile Acid Profiles in Latent Autoimmune Diabetes in Adults and Type 2 Diabetes Patients by Yu Zhou, Deli Ye, Xiaofen Yuan, Yonglie Zhou, Jun Xia

“…However, the contribution of BAs to the pathogenesis of latent autoimmune diabetes in adults (LADA) remains unclear. …”
Get full text

PANoptosis in intestinal epithelium: its significance in inflammatory bowel disease and a potential novel therapeutic target for natural products by Chuanxiang Zhao, Shan Lin

“…Our objective is to broaden the comprehension of innovative molecular mechanisms underlying the pathogenesis of IBD and to furnish a foundation for developing more natural drugs in the treatment of IBD, benefiting both clinical practitioners and research workers.…”
Get full text

Mediators of Inflammation and Their Effect on Resident Renal Cells: Implications in Lupus Nephritis by Susan Yung, Kwok Fan Cheung, Qing Zhang, Tak Mao Chan

“…In this review, we provide an overview of the synthesis and putative roles of IL-6, TNF-α, IFN-α, and hyaluronan in the pathogenesis of lupus nephritis focusing on their effects on human mesangial cells and proximal renal tubular epithelial cells.…”
Get full text

The Role of the Innate Immune System in Alzheimer’s Disease and Frontotemporal Lobar Degeneration: An Eye on Microglia by Elisa Ridolfi, Cinzia Barone, Elio Scarpini, Daniela Galimberti

“…While short-term microglial activity has generally a neuroprotective role, chronic activation has been implicated in the pathogenesis of neurodegenerative disorders, including AD and FTLD. …”
Get full text

Circulating Endothelial Microparticles: A Key Hallmark of Atherosclerosis Progression by Keshav Raj Paudel, Nisha Panth, Dong-Wook Kim

“…This review aims to provide updated information of EMPs in relation to atherosclerosis pathogenesis.…”
Get full text

Detection of Helicobacter suis bacteria in pigs of different age groups by F. M. Nurgaliev

“…Currently, the pathogenesis of gastric ulcer in pigs remains largely unexplored. …”
Get full text

Influence of N6-Methyladenosine Modification Gene HNRNPC on Cell Phenotype in Parkinson’s Disease by Wei Quan, Jia Li, Li Liu, Qinghui Zhang, Yidan Qin, Xiaochen Pei, Jiajun Chen

“…This study aimed to explore the N6-methyladenosine (m6A) modification genes involved in the pathogenesis of Parkinson’s disease (PD) through data analysis of the two data sets GSE120306 and GSE22491 in the GEO database and further explore its influence on cell phenotype in PD. …”
Get full text

Liver Fibrosis and Protection Mechanisms Action of Medicinal Plants Targeting Apoptosis of Hepatocytes and Hepatic Stellate Cells by Florent Duval, Jorge E. Moreno-Cuevas, Maria Teresa González-Garza, Carlos Rodríguez-Montalvo, Delia Elva Cruz-Vega

“…Treatment strategies should take into account the versatility of its pathogenesis and act on all the cell lines involved to reduce liver fibrosis. …”
Get full text

Differential Gene Expression Profile of Human Neutrophils Cultured with Plasmodium falciparum-Parasitized Erythrocytes by Mohamad Alaa Terkawi, Ryo Takano, Kentaro Kato

“…Neutrophils (PMNs) are the most abundant cellular component of our innate immune system, where they play central roles in the pathogenesis of and resistance to a broad range of diseases. …”
Get full text

Detection of exon2-MED12 mutations in uterine leiomyomas from Syrian patients by Lina Albitar, Eyad Al-Chatty, Fariz Ahmad

“…MED12 is one of the mediator complex subunits that has been implicated in uLMs pathogenesis. Somatic mutations in exon2-MED12 have been found in ~ 70% of uLMs. …”
Get full text

Molecular Detection of Virulence Factors in Salmonella serovars Isolated from Poultry and Human Samples by Kelly Johanna Lozano-Villegas, María Paula Herrera-Sánchez, Mónica Alexandra Beltrán-Martínez, Stefany Cárdenas-Moscoso, Iang Schroniltgen Rondón-Barragán

Get full text

Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications by Alessia Alunno, Mirko Manetti, Sara Caterbi, Lidia Ibba-Manneschi, Onelia Bistoni, Elena Bartoloni, Valentina Valentini, Riccardo Terenzi, Roberto Gerli

“…In recent years several studies investigated the role of T lymphocyte subpopulations in the pathogenesis of rheumatoid arthritis (RA). Pathogenic Th17 cells mediate pannus growth, osteoclastogenesis, and synovial neoangiogenesis; hence they are key players in the development of the disease. …”
Get full text

Risk Factors for Endothelial Decompensation after Penetrating Keratoplasty and Its Novel Therapeutic Strategies by Mengyuan Liu, Jing Hong

“…To review the risk factors and pathogenesis of endothelial decompensation after penetrating keratoplasty (PKP) and its novel therapeutic strategies. …”
Get full text

Editorial: Understanding biofilms: recent trends and developments by Sujogya Kumar Panda, Luis Cláudio Nascimento da Silva

Get full text

The theses for MD degree by article Editorial

“…Stepanov – Regulatory disorders in pathogenesis of irritable bowel syndrome in children.…”
Get full text

Perspective on the 65-Year Anniversary of the Discovery of Cytomegalovirus by Edward S. Mocarski

“…This volume presents research and reviews bringing forward new insights into cytomegalovirus (CMV) pathogenesis and biology; CMV is a herpesvirus that has long been recognized as being medically significant [...]…”
Get full text

Discussion: acoustic density and ocular structures rigidity in healthy individuals and patients with primary open-angle glaucoma (response to the article by Kazemi A., Zhou B., Zha... by I.N. Koshits, O.V. Svetlova, A.A. Ryabtseva, M.G. Guseva, M.B. Egemberdiev, P.P. Bakshinsky, M.V. Zaseeva

“…</p> <p> <b>Keywords: </b>scleral functions, rigidity, fluctuation, intraocular pressure, key branches in glaucoma pathogenesis, errors in measurement techniques, laws of mechanics. …”
Get full text

Research progress of hypoxia-inducible factor-1α and zinc in the mechanism of diabetic kidney disease by Wei Qin, Ping Nie, Xuejun Hui, Fei Chen, Xingbao Hu, Wenjiao Shi, Manyu Luo, Bing Li

“…This article provides references and insights for further research on the pathogenesis and progression of diabetic kidney disease.…”
Get full text

Research Progress on the Relationship between Peripheral Somatosensory Neurons and Autism Spectrum Disorder by ZHUANG Wanyu, HONG Yu, LIN Dong, HUANG Longsheng

“…However, due to the diversity of clinical manifestations of ASD, differences in different pathogenic genes and pathogenesis, and the high diversity of sensory interneurons in the spinal dorsal horn, the next step still needs to be in-depth study on the application of peripheral somatosensory neurons in ASD, and further clarify its internal mechanism.…”
Get full text