Efficient multi-omics clustering with bipartite graph subspace learning for cancer subtype prediction by Shuwei Zhu, Hao Liu, Meiji Cui

“…Due to the complex nature and highly heterogeneous of cancer, as well as different pathogenesis and clinical features among different cancer subtypes, it was crucial to identify cancer subtypes in cancer diagnosis, prognosis, and treatment. …”
Get full text

Marfan syndrome: insights from animal models by Yuanyuan Jiang, Ping Jia, Xiaoying Feng, Dingding Zhang

“…The fibrillin-1 gene (FBN1) is a major gene involved in the pathogenesis of MFS. It has been shown that the aortic pathogenesis of MFS is associated with the imbalances of the transforming growth factor-beta (TGF-β) signaling pathway. …”
Get full text

Glucose metabolism impairment in major depressive disorder by Fanhao Meng, Jing Wang, Long Wang, Wei Zou

“…These mechanical changes contribute to the pathogenesis of MDD and severely interfere with the prognosis. …”
Get full text

The theses for PhD degree by article Editorial

“…Tarasova – The role of nutritional deficiency of selenium, zinc and manganese in pathogenesis of chronic gastritis and duodenal peptic ulcer (evidence from Chuvash Republic).M.A. …”
Get full text

Abnormal ac4C modification in metabolic dysfunction associated steatotic liver cells by Xiqian Zhang, Yaxian Zheng, Jing Yang, Yan Yang, Qin He, Min Xu, Fangyi Long, Yujie Yang

“…Abstract The pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear due to the complexity of its etiology. …”
Get full text

Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension by Shanshan Wang, Yuanlong Hu, Yuqi Wang, Yueyue Song, Dan Liang, Jiufeng Yin, Yunlun Li, Wenqing Yang, Dan Zhang

“…Mining biological characteristics is crucial for exploring the pathogenesis of RH and for early diagnosis and treatment. …”
Get full text

Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation by Hermine Counil, Rummenigge Oliveira Silva, Jean‐Michel Rabanel, Charlotte Zaouter, Mohamed Haddad, Mohamed Raâfet Ben Khedher, Davide Brambilla, Tamas Fülöp, Shunmoogum A. Patten, Charles Ramassamy

“…Brain‐derived extracellular vesicles (EVs) have been demonstrated to be implicated in AD pathogenesis by facilitating the propagation of Tau, amyloid‐β and inflammatory cytokines. …”
Get full text

Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease by Tian Meng, Yazhou Zhang, Yuan Ye, Hui Li, Yongsheng He

“…Abstract Background There is growing evidence that the pathogenesis of Alzheimer's disease is closely linked to the resident innate immune cells of the central nervous system, including microglia and astrocytes. …”
Get full text

Alzheimer’s disease and infectious agents: a comprehensive review of pathogenic mechanisms and microRNA roles by Seyyed Sam Mehdi Hosseininasab, Rasoul Ebrahimi, Shirin Yaghoobpoor, Kiarash Kazemi, Yaser Khakpour, Ramtin Hajibeygi, Ashraf Mohamadkhani, Mobina Fathi, Kimia Vakili, Arian Tavasol, Zohreh Tutunchian, Tara Fazel, Mohammad Fathi, Mohammadreza Hajiesmaeili

“…There are various theories concerning the causes of AD, but the connection between viral and bacterial infections and their potential role in the pathogenesis of AD has become a fascinating area of research for the field. …”
Get full text

Identification of Potential miRNA-mRNA Regulatory Network Contributing to Parkinson’s Disease by Xi Yin, Miao Wang, Wei Wang, Tong Chen, Ge Song, Yixuan Niu, Ziying Jiang, Zhongbao Gao, Zhenfu Wang

“…Parkinson’s disease (PD) is a common neurodegenerative disease, and the mechanism underlying PD pathogenesis is not completely understood. Increasing evidence indicates that microRNAs (miRNAs) play a critical regulatory role in the pathogenesis of PD. …”
Get full text

Identification of EGR1 as a Key Diagnostic Biomarker in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Through Machine Learning and Immune Analysis by Wu X, Pan T, Fang Z, Hui T, Yu X, Liu C, Guo Z, Liu C

“…Enrichment analyses and immune infiltration assessments revealed multiple pathways involving EGR1 in the pathogenesis and progression of MASLD, showing significant correlations with various immune cells. …”
Get full text

IL-21 shapes the B cell response in a context-dependent manner by Youngjun Kim, Francesca Manara, Simon Grassmann, Kalina T. Belcheva, Kanelly Reyes, Hyunu Kim, Stephanie Downs-Canner, William T. Yewdell, Joseph C. Sun, Jayanta Chaudhuri

Get full text

Inflammation and Immune Response in COPD: Where Do We Stand? by Nikoletta Rovina, Antonia Koutsoukou, Nikolaos G. Koulouris

“…Finally, autoimmunity is another novel aspect that may play a critical role in the pathogenesis of COPD. This review is un update of the currently discussed roles of inflammatory and immune responses in the pathogenesis of COPD.…”
Get full text

Impact of Thrombopoietin Receptor Agonists on Pathophysiology of Pediatric Immune Thrombocytopenia by Paschalis Evangelidis, Konstantinos Tragiannidis, Eleni Gavriilaki, Athanasios Tragiannidis

“…In the current literature review, the data regarding the impact of TPO agonists in the pathogenesis of ITP and treatment outcomes of the patients are examined. …”
Get full text

Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Schönlein Purpura Nephritis by Yuhong Zhao, Youngki Kim, Milind Junghare, Viral Vakil, Xuesong Su, Faqian Li, Lihong Bu

“…Recent studies suggest that galactose-deficient IgA1 (Gd-IgA1) plays a role in the pathogenesis of primary IgA nephropathy (IgAN) and Henoch–Schönlein purpura nephritis (HSPN). …”
Get full text

Prevention and treatment of cerebral vasospasm following aneurysmal subarachnoid hemorrhage by Kyle McGrath, Grace Hey, Ghaidaa Ebrahim, Noah Gilberstadt, David Mahan, Brandon Lucke-Wold

“…Further investigation of the glymphatic system and its role in PHCV pathogenesis could result in novel pharmacologic targets. …”
Get full text

Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation by Zhaoshan Zhang, Jiawei Guo

“…Oxidative stress plays a pivotal role in the pathogenesis and progression of cardiovascular diseases (CVDs). …”
Get full text

Increased Mast Cell Counts and Degranulation in Microscopic Colitis by Zhikai Chi, Jing Xu, Romil Saxena

“…The increased mast cell count and degranulation are identified in MC, suggesting that mast cell activation might be involved in the pathogenesis of MC.…”
Get full text

Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and... by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, A. A. Sheptulin, T. L. Lapina, V. I. Simanenkov, K. A. Sokolov

“…In the treatment of functional gastrointestinal diseases characterized by multifactorial pathogenesis, preference should be given to multi-targeted therapy with the use of drugs that have an effect on its various links.…”
Get full text

Serum Uric Acid, Alanine Aminotransferase, Hemoglobin and Red Blood Cell Count Levels in Pseudoexfoliation Syndrome by Hüseyin Simavlı, Yasin Yücel Bucak, Mehmet Tosun, Mesut Erdurmuş

“…Purpose. The pathogenesis of pseudoexfoliation (PEX), the most common cause of secondary glaucoma, has not been clearly identified, but there is increasing evidence that points out the role of oxidative stress. …”
Get full text