Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus? by Joshua Juwono, Ryan D. Martinus

“…The focus of this review is to summarise the known relationships between the expression of heat shock protein 60 (Hsp60) and its association with the pathogenesis of Type 1 and Type 2 diabetes mellitus. …”
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Current status of cytokine-induced killer cells and combination regimens in breast cancer by Yuancong Jiang, Jie Qiu, Nanwei Ye, Yingchun Xu

“…Breast cancer remains a significant health challenge worldwide, with substantial efforts aimed at understanding its pathogenesis, biological characteristics, and clinical triggers. …”
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Continuous Dual Resetting of the Immune Repertoire as a Basic Principle of the Immune System Function by Silvana Balzar

“…Understanding the pathogenesis of ICIC is essential for their successful therapy and prevention. …”
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Olfm4 Is Highly Expressed in HCC Patients and as a Biomarker and Therapeutic Target for HCC by Yulong Wei, Qingzhu Song, Fenglan Zhang, Tian Yuan

“…Conventional therapies against liver cancer are inadequate, and the pathogenesis of HCC remains unclear. Thus, not only are more effective therapies to treat HCC required but also identification of the key genes involved in its pathogenesis is important for developing such therapies. …”
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Role of Leukotrienes on Protozoan and Helminth Infections by Alexandre P. Rogerio, Fernanda F. Anibal

“…LTs play a role in the control of helminth and protozoan infections by modulating the immune system and/or through direct cytotoxicity to parasites; however, LTs may also be associated with pathogenesis, such as in cerebral malaria and schistosomal granuloma. …”
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Silencing hepatic PCSK9 via novel chimeric AAV8 mitigates the progression of atherosclerosis by inhibiting inflammation in ApoE−/− mice by Xiaocui Chen, Minghui Sun, Xiang Ma, Yitong Ma, Bangdang Chen

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Allergic Rhinoconjunctivitis: the Role of Histamine by M. Andersson, L. Greiff, C. Svensson

“…Allergic rhinoconjunctivitis is the most common atopic condition encountered in clinical practice. Analysis of the pathogenesis of this condition permits identification of optimal therapeutic targets. …”
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The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease by Rachel E. Nisbet, Roy L. Sutliff, C. Michael Hart

“…Existing treatment strategies for pulmonary hypertension, the most common manifestation of pulmonary vascular disease, are limited by an incomplete understanding of the underlying disease pathogenesis and lack of efficacy indicating an urgent need for new approaches to treat this disorder. …”
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Focus on Basal Cell Carcinoma by Venura Samarasinghe, Vishal Madan, John T. Lear

“…This paper focuses on the pathogenesis and management of BCC.…”
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Diabetes in HFE Hemochromatosis by James C. Barton, Ronald T. Acton

“…Later observations revealed that the pathogenesis of diabetes in HFE hemochromatosis is multifactorial and its clinical manifestations are heterogeneous. …”
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Epigenetics: The New Frontier in the Landscape of Asthma by Bharti Chogtu, Dipanjan Bhattacharjee, Rahul Magazine

“…This is despite the prevalence of varied therapeutic options to counter the pathogenesis of asthma. Asthma, as a disease per se, is a very complex one. …”
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Clinical presentation, diagnosis and treatment of intrahepatic cholestasis of pregnancy by Yu. B. Uspenskaya, A. A. Sheptulin

“…To present the modern concept of etiology and pathogenesis of the intrahepatic cholestasis of pregnancy (ICP) and the modern diagnostic and treatment approaches to gastroenterologists. …”
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Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson’s Disease by Jason R. Richardson, Muhammad M. Hossain

“…Although there are many hypotheses regarding the mechanism of PD progression, neuroinflammation may be a major contributor to PD pathogenesis. Indeed, activated microglia and subsequent neuroinflammation have been consistently associated with the pathogenesis of PD. …”
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Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder? by Ihor V. Yosypiv

“…Because increasing numbers of children with CAKUT are surviving to adulthood, better understanding of the molecular pathogenesis of CAKUT, development of new strategies aiming at prevention of CAKUT, preservation of renal function, and avoidance of associated cardiovascular morbidity are needed. …”
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Local Bone Marrow Renin-Angiotensin System and Atherosclerosis by Yavuz Beyazit, Tugrul Purnak, Gulay Sain Guven, Ibrahim C. Haznedaroglu

“…The aim of this paper is to review the function of local BM RAS in the pathogenesis of atherosclerosis.…”
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Immunopathogenesis of spondyloarthropathies – Concept of major histocompatibility locus-I-opathy by Amlan Kusum Datta, Uddalak Chakraborty, Swati Kumar, Atanu Chandra

“…Historically, most of the research into the pathogenesis of SpA and other types of chronic arthritis have conventionally focused on the adaptive immune system. …”
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The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy by Qi Feng, Dongwei Liu, Yanfang Lu, Zhangsuo Liu

“…Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of DN. Except for traditional functions, abnormally regulated RAS has been proved to be involved in the inflammatory process of DN. …”
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Liver Damage in Type 1 Diabetes Mellitus by A. O. Bueverov, A. V. Zilov

“…An up-to-date review of the prevalence, pathogenesis, diagnosis and management of hepatological complications of type 1 diabetes mellitus (T1D).Key points. …”
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Association of p53 with Neurodegeneration in Parkinson’s Disease by Qiang Luo, Wei Sun, Yi-Fan Wang, Ji Li, Da-Wei Li

“…Recent studies have revealed that p53 levels and activity are substantially increased in affected neurons in cellular and animal models of Parkinson’s disease (PD) as well as in the brains of PD patients. p53 activation in response to neurodegenerative stress is closely associated with the degeneration of dopaminergic neurons accompanied by mitochondrial dysfunction, reactive oxygen species (ROS) production, abnormal protein aggregation, and impairment of autophagy, and these pathogenic events have been implicated in the pathogenesis of PD. Pathogenic p53 integrates diverse cellular stresses and activate these downstream events to induce the degeneration of dopaminergic neurons; thus, it plays a crucial role in the pathogenesis of PD and appears to be a potential target for the treatment of the disease. …”
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Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus by Muhammad U. Sohail, Asmaa Althani, Haseeb Anwar, Roberto Rizzi, Hany E. Marei

“…This article aims to summarize the role of the gut microbiome in the pathogenesis of diabetes. Additionally, we summarize gut microbial dysbiosis in preclinical and clinical diabetes cases reported in literature in the recent years.…”
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