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461
A Quarter Century of Liver Transplantation: Learning from Livers
Published 1989-01-01“…Recurrence of the primary disease in the liver following transplantation has furthered understanding of the pathogenesis of hepatitis and the cell biology of hepatobiliary tumours. …”
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462
PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration
Published 2025-02-01“…In the IDD rat model, PDE4 inhibitor roflumilast, ferroptosis inhibitor Fer-1, or Nrf2 activator dimethyl fumarate (DMF) delayed IDD pathogenesis. While administration of ferroptosis inducer elastin enhanced IDD pathogenesis. …”
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463
Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future Perspectives
Published 2019-01-01“…Despite recent advances in decoding the pathophysiology of IBD, many questions regarding disease pathogenesis remain. Genome-wide association studies (GWAS) and knockout mouse models have significantly advanced our understanding of genetic susceptibility loci and inflammatory pathways involved in IBD pathogenesis. …”
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464
Wpływ czynników środowiskowych na powstawanie chorób układu krążenia – wybrane problemy
Published 2009-06-01“…Schetler (70) divided the factors favoring diseases of circulation system into two groups: risk factors (which have admitted participations in pathogenesis of heart and vascular diseases) and environmental factors which significance in pathogenesis of heart diseases still increases. …”
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465
Activation of TLR4-Mediated NF𝜅B Signaling in Hemorrhagic Brain in Rats
Published 2009-01-01“…Inflammation and immunity play a crucial role in the pathogenesis of Intracerebral hemorrhage (ICH). Toll-like receptor 4- (TLR4-) mediated nuclear factor kappa-B (NF𝜅B) signaling plays critical roles in the activation and regulation of inflammatory responses in injured brain. …”
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466
Coexistence of giant cell arteritis and subacute thyroiditis: A case report and literature review
Published 2025-02-01“…Giant cell arteritis and subacute thyroiditis are often regarded as clinically distinct diseases with differing pathogenesis. We report a rare case of coexisting giant cell arteritis and subacute thyroiditis that were both successfully managed using glucocorticoid therapy. …”
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467
Diabetic Kidney Disease: Pathophysiology and Therapeutic Targets
Published 2015-01-01“…Over the past two decades, there has been significant clarification of the various pathways implicated in the pathogenesis of DKD. Nonetheless, very little has changed in the way clinicians manage patients with this disorder. …”
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468
Cytokines in inflammatory bowel disease
Published 1997-01-01“…Over the past decade, much has been learned regarding the role of various cytokines in the pathogenesis of inflammatory bowel disease. Several cytokine ‘knockout’ models in mice have been shown to develop colitis, while alterations in the production of various cytokines has been documented in human Crohn's disease and ulcerative colitis. …”
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469
Avian Bornaviral Ganglioneuritis: Current Debates and Unanswered Questions
Published 2020-01-01“…Research regarding the pathogenesis and treatment for this disease is ongoing, with implications for understanding other emerging human and nonhuman diseases, as well as the health and ecology of wildlife. …”
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470
General and Specific Genetic Polymorphism of Cytokines-Related Gene in AITD
Published 2017-01-01“…These two diseases exhibit similar pathogenesis but opposite trends in the clinical manifestations. …”
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471
In silico study about β-amyloid’s role in Alzheimer’s disease and glaucoma and prediction of its interactions with glaucoma related proteins
Published 2023-08-01“…This study is an attempt to evaluate the chances of β-amyloid’s role in pathogenesis of retinal neurodegenerative disorder called glaucoma, in silico. …”
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472
Pathogenic Process-Associated Transcriptome Analysis of Stemphylium lycopersici from Tomato
Published 2022-01-01“…Additionally, some genes involved in signal regulation or encoding hemicellulose- and cellulose-degrading enzymes and extracellular proteases were commonly upregulated during pathogenesis. Overall, we present some putative key genes and processes that may be crucial for S. lycopersici pathogenesis. …”
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473
A Relationship between Epithelial Maturation, Bronchopulmonary Dysplasia, and Chronic Obstructive Pulmonary Disease
Published 2012-01-01“…Recent evidence suggests that defective transcriptional regulation of epithelial differentiation and maturation may contribute to BPD pathogenesis as well as early onset of COPD. The transcriptional regulators CCAAT/enhancer-binding protein (C/EBP)α and C/EBPβ, SMAD family member (Smad)3, GATA binding protein (GATA)6, and NK2 homeobox (NKX)2-1 are reported to be involved in processes contributing to pathogenesis of both BPD and COPD. …”
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474
Intrathecal Immunoglobulin A Synthesis in Multiple Sclerosis: From Biological Aspects to Clinical Relevance
Published 2025-01-01“…Intrathecal immunoglobulin A (IgA) synthesis in multiple sclerosis (MS) has long earned little attention, despite a potential significance in disease pathogenesis and prognosis. The presence of IgA-positive plasma cells in MS lesions and along damaged axons suggests a role in disease pathogenesis. …”
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475
Plasma MicroRNA Expression Profiles in Psoriasis
Published 2020-01-01“…Network analysis revealed pivotal deregulated plasma miRNAs and their relevant target genes and pathways regulating psoriasis pathogenesis. Conclusions. This study analysed the expression of plasma miRNAs and their target pathways, elucidating the pathogenesis of psoriasis; these results may be used to design novel therapeutic strategies and to identify diagnostic biomarkers for psoriasis.…”
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476
Lipid-Induced Mechanisms of Metabolic Syndrome
Published 2020-01-01“…Insulin resistance (IR) is the crucial cause of the MetS pathogenesis, which develops against the background of abdominal obesity. …”
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477
Peran Kemokin dalam Patogenesis Rinitis Alergi
Published 2014-05-01“…Conclusion: Eotaxin and CCR3 are the major factor in pathogenesis of allergic rhinitis which is involve eosinophil.…”
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478
Matrix Metalloproteinase-2 Isoforms Differ within the Aortic Wall of Ascending Aortic Aneurysms Associated with Bicuspid Aortic Valve
Published 2020-01-01“…The pathogenesis of ascending thoracic aortic aneurysm (aTAA) is thought to differ between patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV), and one of the causes is different hemodynamics. …”
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479
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480
Role of Neutrophils in Psoriasis
Published 2020-01-01“…In this review, we highlight the role of neutrophils in the pathogenesis of psoriasis.…”
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