Identification of early prediction biomarkers of severity in patients with severe fever with thrombocytopenia syndrome based on plasma proteomics by Qian Zhang, Qian Zhang, Zhengyi Jiang, Nan Jiang, Luchen Shi, Jiaying Zhao, Jie Zhao, Jie Zhao, Ke Ouyang, Ke Ouyang, Huaying Huang, Huaying Huang, Yaqin Zhang, Yan Dai, Nannan Hu, Ping Shi, Yaping Han, Ke Jin, Jun Li

“…A prediction model was developed at the early stage to accurately predict severe conditions with the area under the curve of 0.931 (95% CI, 0.885, 0.963).ConclusionThe proteomic signatures identified in this study provide insights into the potential pathogenesis of SFTS. The predictive models have substantial clinical implications for the early identification of SFTS patients who may progress to severe conditions.…”
Get full text

Elevations in D-dimer levels in patients with Plasmodium infections: a systematic review and meta-analysis by Suriyan Sukati, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Ching-Ping Tseng, Aongart Mahittikorn, Nsoh Godwin Anabire, Polrat Wilairatana, Kinley Wangdi, Hideyuki J Majima, Apiporn Thinkhamrop Suwannatrai, Wiyada Kwanhian Klangbud, Wanida Mala, Rujikorn Rattanatham, Manas Kotepui

“…Further research should also explore the role of D-dimer in the pathogenesis of Plasmodium infections to deepen our understanding of their clinical significance.…”
Get full text

The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in e... by Biao Peng, Mu-Yun Yan, Yun-Rong Chen, Fei Sun, Xu-Dong Xiang, Da Liu

“…Neutrophil extracellular traps (NETs) play a critical role in the pathogenesis of severe asthma. This study aims to detect if MBD2 can reduce NETs formation and the potential mechanism in severe asthma.Methods A severe asthma model was established in C57BL/6 wild-type mice exposure to house dust mite (HDM), ovalbumin (OVA), and lipopolysaccharide (LPS). …”
Get full text

Immunohistochemical Expression of p53 Gene and Clinicopathological Assessment of Low-grade Serous Ovarian Cancer and High-grade Serous Ovarian Cancer: A Cohort Study by Geeta Bazard, Minakshi Vashist, Sunita Singh, Gulshan Rohilla, Nidhi Paliwal

“…Conclusion: The significant difference in p53 IHC expression between LGSOC and HGSOC highlighted the role of p53 mutation in pathogenesis of HGSOC. However, by understanding genetic predisposition of ovarian tumour preventive steps as well as planning of early treatment can reduce the mortality rate.…”
Get full text

Understanding the role of nerves in head and neck cancers - a review by Krzysztof Rutkowski, Michał Gola, Michał Gola, Janusz Godlewski, Janusz Godlewski, Anna Starzyńska, Anna Starzyńska, Giulia Marvaso, Giulia Marvaso, Federico Mastroleo, Federico Mastroleo, Maria Giulia Vincini, Maria Giulia Vincini, Alice Porazzi, Mattia Zaffaroni, Barbara Alicja Jereczek-Fossa, Barbara Alicja Jereczek-Fossa

“…Carcinogenesis is a complex, multidimensional molecular process leading to cancer development, and in recent years, the role of nerves in the pathogenesis of various malignancies has been increasingly recognized. …”
Get full text

AIP56, an AB toxin secreted by Photobacterium damselae subsp. piscicida, has tropism for myeloid cells by Inês Lua Freitas, Inês Lua Freitas, Inês Lua Freitas, Maria Fátima Macedo, Maria Fátima Macedo, Liliana Oliveira, Liliana Oliveira, Pedro Oliveira, Ana do Vale, Ana do Vale, Nuno M.S. dos Santos, Nuno M.S. dos Santos

“…This points to an evolutionary conservation of its receptor(s) and mechanism of action across species, raising the possibility that AIP56-like and -related toxins may also play a role in pathogenesis. These findings are relevant for both pathogenicity and biomedical contexts.…”
Get full text

Emergence of Carbapenem-Resistant <i>bla</i>_POM-1 Harboring <i>Pseudomonas otitidis</i> Isolated from River Water in Ghana by Frederick Ofosu Appiah, Samiratu Mahazu, Isaac Prah, Taira Kawamura, Yusuke Ota, Yohei Nishikawa, Mitsunori Yoshida, Masato Suzuki, Yoshihiko Hoshino, Toshihiko Suzuki, Tomoko Ishino, Anthony Ablordey, Ryoichi Saito

Get full text

Features of pancreatic parenchyma fibrosis in the comorbid course of chronic pancreatitis and chronic obstructive pulmonary disease by I.V. Dudka, O.S. Khukhlina, T.V. Dudka, O.Y. Hryniuk, V.O. Pavliuk

“…In patients with a comorbid course of CP and COPD, a correlational interdependence was established between the indicators of the state of the protein components of the connective tissue of the extracellular matrix of the pancreas (PBOP) and hyperamylasemia (r=0.32, p<0.05), the intensity of endotoxicosis (r=0, 37, p<0.05), the level of glycemia (r=0.45, p<0.05), and the inverse relationship between the content of elastase-1 in feces (r=-0.33, p<0.05 ), insulinemia (r=-0.46, p<0.05), which indicates the interdependence of these changes and their role in the pathogenesis of the progression of chronic pancreatitis. …”
Get full text

Immunoregulatory programs in anti‐N‐methyl‐D‐aspartate receptor encephalitis identified by single‐cell multi‐omics analysis by Xinhui Li, Yicong Xu, Weixing Zhang, Zihao Chen, Dongjie Peng, Wenxu Ren, Zhongjie Tang, Huilu Li, Jin Xu, Yaqing Shu

“…These findings provide deeper insights into the molecular mechanism driving the pathogenesis of anti‐NMDARE and offer promising targets for future therapeutic intervention. …”
Get full text

Mendelian randomization and multiomics comprehensively reveal the causal relationship and potential mechanism between atrial fibrillation and gastric cancer by Zhao Sicheng, Zhao Sicheng, Zhang Jingcheng, Zhang Jingcheng, Zhang Shuo, Zhang Shuo, Lou Jiaheng, Lou Jiaheng, Cai Yan, Cai Yan, Bai Xing, Bai Xing, Jiang Tao, Jiang Tao, Jiang Tao, Zhang Guangji, Zhang Guangji, Zhang Guangji

“…Finally, prognosis analysis and gene mutation analysis using TCGA-STAD data indicate an adverse prognosis associated with the key gene set in GC.ConclusionThis study provides new insights into the association between AF and GC and offers novel clues for understanding its impact on the pathogenesis and therapeutic strategies of GC.…”
Get full text

The control effect and induced disease resistance mechanism of Bacillus tequilensis on wheat powdery mildew by Qiuyan Bi, Fen Lu, Jie Wu, Xiangyu Liu, Xiuying Han, Jianjiang Zhao

“…The expression levels of actin-7-like, lipoxygenase, linoleic acid 9S-lipoxygenase 6-like, pathogenesis-related protein PR-1-like, superoxide dismutase, phenylalanine ammonia lyase and polyphenol oxidase were significantly increased. …”
Get full text

Molecular and pharmacological heterogeneity of ETV6::RUNX1 acute lymphoblastic leukemia by Zhenhua Li, Huanbin Zhao, Wenjian Yang, Maud Maillard, Satoshi Yoshimura, Yu-Chih Hsiao, Xin Huang, Yoshihiro Gocho, Lauren Rowland, Anthony Brown, Landon Choi, Kristine R. Crews, Charles G. Mullighan, Samuel W. Brady, Cheng Cheng, Ti-Cheng Chang, Gang Wu, Mignon L. Loh, Allen Eng Juh Yeoh, Federico Antillon-Klussmann, Sima Jeha, Hiroto Inaba, Jiyang Yu, Ching-Hon Pui, Seth E. Karol, William E. Evans, Jun J. Yang

“…Our results point to molecular heterogeneity within ETV6::RUNX1 ALL linked to divergent drug responses, providing insights into the pathogenesis and therapeutic vulnerability of this common pediatric ALL subtype.…”
Get full text

The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

“…Results: Combining the results of network pharmacology with other bioinformatics databases suggests that myrrh’s active components exert anti-cancer effects by regulating genes involved in breast cancer pathogenesis, particularly PTGS2, EGFR, ESR2, MMP2, and JUN. …”
Get full text

Anti-sperm Antibody Positivity in Men with Varicocele: A Systematic Review and Meta-Analysis by Marco Falcone, Kadir Bocu, Hakan Keskin, Jesus Fernando Solorzano Vazquez, Ravi Banthia, Tara Mahendran, Muslim Dogan Deger, Vinod Kv, Preto Mirko, Ahmed M. Harraz, Ramadan Saleh, Rupin Shah, Ashok Agarwal

“…Purpose: Despite the significant role of varicocele in the pathogenesis of male infertility, its association with anti-sperm antibodies (ASA) remains controversial. …”

The PD-1 with PD-L1 Axis Is Pertinent with the Immune Modulation of Atrial Fibrillation by Regulating T Cell Excitation and Promoting the Secretion of Inflammatory Factors by Guodong Chang, Yingwei Chen, Zichang Liu, Yong Wang, Wenkun Ge, Yongan Kang, Shuling Guo

“…PD-1/PD-L1 signaling pathway may play an immunomodulatory role in the pathogenesis of atrial fibrillation by promoting increased secretion of inflammatory factors through regulating T cell activation.…”
Get full text

Functional Analysis of Durum Wheat GASA1 Protein as a Biotechnological Alternative Against Plant Fungal Pathogens and a Positive Regulator of Biotic Stress Defense by Mohamed Taieb Bouteraa, Walid Ben Romdhane, Alina Wiszniewska, Narjes Baazaoui, Mohammad Y. Alfaifi, Anis Ben Hsouna, Miroslava Kačániová, Stefania Garzoli, Rania Ben Saad

“…This resistance was correlated with the upregulation of pathogenesis-related genes (<i>AtPDF1.2a</i>, <i>AtERF1</i>, <i>AtVSP2</i>, <i>AtMYC2</i>, <i>AtPR1</i>, <i>AtACS6</i>, <i>AtETR1</i>, and <i>AtLOX2</i>) in the transgenic lines. …”
Get full text

Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data by Zhou J, Jiao S, Huang J, Dai T, Xu Y, Xia D, Feng Z, Chen J, Li Z, Hu L, Meng Q

“…Diverse programmed cell death (PCD) pathways are closely linked to the pathogenesis of OA, but few studies have explored the relationship between PCD-related genes and synovitis.Methods: The transcriptome expression profiles of OA synovial samples were obtained from the Gene Expression Omnibus (GEO) database. …”
Get full text

Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice by Yihong Yang, Guanghua Xiong, Huangqi Shi, Yulin Peng, Jinghong Liu, Yaxuan Jiang, Min Lu, Hongbo Liu, Yong Liu

“…However, the hepatoprotective effect of sinensetin in HIRI pathogenesis have not been fully explored.MethodsWe constructed the HIRI model in mice, with blood and liver samples collected at 6 and 24 h after reperfusion to evaluate liver injury. …”
Get full text

Exploring the relationship between sepsis and Golgi apparatus dysfunction: bioinformatics insights and diagnostic marker discovery by Wanli Ma, Xinyi Liu, Ran Yu, Jiannan Song, Lina Hou, Ying Guo, Hongwei Wu, Dandan Feng, Qi Zhou, Haibo Li

“…Validation with an independent dataset confirmed the differential expression patterns of B3GNT5, C1GALT1C1, and GALNT14, reinforcing their potential as robust diagnostic biomarkers for sepsis.ConclusionThis study elucidates the link between sepsis and the Golgi apparatus, introduces novel biomarkers for sepsis diagnosis, and offers valuable insights for future research on its pathogenesis and treatment strategies.…”
Get full text

Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats by Hong Yang, Cheng Zhang, Woonghee Kim, Mengnan Shi, Metin Kiliclioglu, Cemil Bayram, Ismail Bolar, Özlem Özdemir Tozlu, Cem Baba, Nursena Yuksel, Serkan Yildirim, Shazia Iqbal, Jihad Sebhaoui, Ahmet Hacımuftuoglu, Matthias Uhlen, Jan Boren, Hasan Turkez, Adil Mardinoglu

“…Excessive consumption of sucrose, in the form of sugar-sweetened beverages, has been implicated in the pathogenesis of metabolic dysfunction‐associated fatty liver disease (MAFLD) and other related metabolic syndromes. …”
Get full text