Identifying disulfidptosis-related biomarkers in epilepsy based on integrated bioinformatics and experimental analyses by Sijun Li, Lanfeng Sun, Hongmi Huang, Xing Wei, Yuling Lu, Kai Qian, Yuan Wu

“…Disulfidptosis, a proposed novel cell death mechanism, is thought to play a part in the pathogenesis of epilepsy, but the exact role is unclear. …”
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Regulation of Paneth cell-specific genes in COVID-19 patients and SARS-CoV-2-infected mice by quantification of mRNA from exfoliated cells in stool samples by Gill Diamond, Erika L. Figgins, Denny Gao, Tanya O. Robinson, Kenneth Wilson, Jon D. Gabbard, Charles D. Anderson, Lalit Batra, Chithra Sreenivasan, Jian Zheng, Uyen Do, Braden Mulcahy, Lisa K. Ryan, Nathaniel McLaughlin, Anna H. Owings, Neha Dhaliwal, Haley B. Williams, T. Grant Wichman, Michelle Galeas-Pena, Sarah C. Glover

“…It also shows the coordinate regulation of these genes as a response to infection with SARS-CoV-2, possibly through viral pathogenesis, to increase infectivity in the gut.…”
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Genetic and biochemical analysis of severe hypertriglyceridemia complicated with acute pancreatitis or with low post-heparin lipoprotein lipase mass by Takashi Suzuki, Makoto Kurano, Akari Isono, Takuya Uchino, Yohei Sayama, Honami Tomomitsu, Daiki Mayumi, Ruriko Shibayama, Toru Sekiguchi, Naoki Edo, Kiyoko Uno-Eder, Kenji Uno, Koji Morita, Toshio Ishikawa, Kazuhisa Tsukamoto

“…In summary, this study revealed a new disease-causing gene mutation in LMF1, confirmed an association between overlapping of multiple gene mutations and severe hypertriglyceridemia, and suggested that some classes of phospholipid may be involved in the pathogenesis of AP.…”
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Identification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia by Tao Liu, Yang Wang, Xi-Zhou An, Jiaqi Liu, Yuqin Wu, Yan Xiang, Yong-Jie Zhang, Lan Huang, Jia-Cheng Li, Yu-Zhuo-Pu Li, Jie Yu

“…Abstract Genetic alterations play a pivotal role in leukemic clonal transformation, significantly influencing disease pathogenesis and clinical outcomes. Here, we report a novel fusion gene and investigate its pathogenic role in acute lymphoblastic leukemia (ALL). …”
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Pseudomonas aeruginosa alkyl quinolone response is dampened by Enterococcus faecalis by Maggie M. Fink, Abigail A. Weaver, Dharmeshkumar Parmar, Jon E. Paczkowski, Lingyun Li, Maggie K. Klaers, Ella A. Junker, Elizabeth A. Jarocki, Jonathan V. Sweedler, Joshua D. Shrout

“…Here, we directly demonstrate how notorious pathogens such as P. aeruginosa might persist in polymicrobial infections under the influence of metabolites produced by other bacterial species.IMPORTANCEWhile we now appreciate that many infections are polymicrobial, we understand little of the specific actions between a given set of microbes to enable combinatorial survival and pathogenesis. The bacteria Pseudomonas aeruginosa and Enterococcus faecalis are both prevalent pathogens in wound, urinary tract, and bacteremic infections. …”
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Ovarian cancer prevention through opportunistic salpingectomy during abdominal surgeries: A cost-effectiveness modeling study. by Angela Kather, Habib Arefian, Claus Schneider, Michael Hartmann, Ingo B Runnebaum

“…<h4>Background</h4>There is indication that the fallopian tubes might be involved in ovarian cancer pathogenesis and their removal reduces cancer risk. Hence, bilateral salpingectomy during hysterectomy or sterilization, so called opportunistic salpingectomy (OS), is gaining wide acceptance as a preventive strategy. …”
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Integrated bioinformatics analysis and experimental validation of exosome-related gene signature in steroid-induced osteonecrosis of the femoral head by Renqun Mao, Wen Bi, Mengyue Yang, Lei Qin, Wenqing Li

“…The understanding of the pathogenesis of SIONFH is still limited, and the identification of efficient diagnostic biomarkers is insufficient. …”
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The fundus changes in pathological myopia by Markosyan G.A., Tarutta E.P, Tarasova N.A., Maksimova M.V.

“…<p> <i>The article presents a literature review covering formation of views and the modern aspects of the etiology and pathogenesis of pathological myopia, which is one of the main causes of visual impairment and blindness worldwide. …”
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Excessive activation of JAK-STAT signaling contributes to inflammation induced by acute Vibrio infection in shrimp by Hongliang Zuo, Xiya Yang, Youxi Wang, Bangping Hu, Zhiming Zhu, Zhixun Guo, Shaoping Weng, Jianguo He, Xiaopeng Xu

“…Therefore, this study indicates that, similar to that in mammals, the pathogenesis of infectious diseases in invertebrates is complicated by inflammatory responses triggered by dysregulated immune signaling.…”
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Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region by Giovanni Matera, Maria Teresa Loria, Cinzia Peronace, Tatiana Catanzariti, Pio Settembre, Aida Giancotti, Angelo G. Lamberti, Giorgio S. Barreca, Luisa Galati, Gessica Dodaro, Maria Mazzitelli, Alessio Strazzulla, Carlo Torti, Angela Quirino, Maria Carla Liberto, Alfredo Focà

“…Indeed, real-time PCR indicated the presence of G2/G3 genotypes of Echinococcus granulosus complex. Regarding pathogenesis, a relevant novel tool of immune depression should be deemed the reduced level of serum MCP-1. …”
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A perfusion-independent high-throughput method to isolate liver sinusoidal endothelial cells by Anna Babin-Ebell Gonçalves, Yifang Mao, Tinja Baljkas, Felix Wiedmann, Larissa Eis, Franziska Pilz, Manuel Winkler, Sina W. Kürschner-Zacharias, Marlene Hoffarth, Charlotta Funaya, Réza Shahidi, Cyrill Géraud, Chi-Chung Wu, Constanze Schmidt, Sergij Goerdt, Philipp-Sebastian Reiners-Koch, Mahak Singhal

“…Abstract Liver sinusoidal endothelial cells (LSECs) critically regulate homeostatic liver function and liver pathogenesis. However, the isolation of LSECs remains a major technological bottleneck in studying molecular mechanisms governing LSEC functions. …”
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Preliminary investigation on the establishment of a new meibomian gland obstruction model and gene expression by Ming Sun, Huanmin Cheng, Zheng Yang, Jiangqin Tang, Shengshu Sun, Zhanglin Liu, Shaozhen Zhao, Lijie Dong, Yue Huang

“…Abstract Meibomian gland dysfunction is a chronic ocular surface disease with a complex pathogenesis, whose main clinical manifestations are meibomian gland obstruction or/and lipid abnormalities. …”
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Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells by Alexia Carré, Fatoumata Samassa, Zhicheng Zhou, Javier Perez-Hernandez, Christiana Lekka, Anthony Manganaro, Masaya Oshima, Hanqing Liao, Robert Parker, Annalisa Nicastri, Barbara Brandao, Maikel L. Colli, Decio L. Eizirik, Jahnavi Aluri, Deep Patel, Marcus Göransson, Orlando Burgos Morales, Amanda Anderson, Laurie Landry, Farah Kobaisi, Raphael Scharfmann, Lorella Marselli, Piero Marchetti, Sylvaine You, Maki Nakayama, Sine R. Hadrup, Sally C. Kent, Sarah J. Richardson, Nicola Ternette, Roberto Mallone

“…Thus, the inflammatory milieu of insulitis may skew the autoimmune response toward alternative epitopes presented by HLA-B, hence recruiting T cells with a distinct repertoire that may be relevant to T1D pathogenesis.…”
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Functional status, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio as prognostic factors of one-year survival rate in elderly patients with advanced-stage non-small... by Ratna Nurhayati, Aulia Rizka, Cleopas Martin Rumende, Noorwati Sutandyo, Arif Hanafi, Edy Rizal Wahyudi, Hamzah Shatri, Anna Mira Lubis, Em Yunir, Muhammad Firdaus, Yuniar Harris Prayitno, Nadira Nibras Taqiyya

“…Aging and chronic inflammation are related to its pathogenesis. Functional status, lymphocyte-to-monocyte ratio and platelet-to-lymphocyte ratio describe a chronic inflammation and correlate to the survival of older adults with advanced-stage (IIIB-IV) NSCLC. …”
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Inflammatory and Redox Blood Gene Expression Fingerprint of Severe Obstructive Sleep Apnoea in Patients With Mild Alzheimer&rsquo;s Disease by Romero-ElKhayat L, Dakterzada F, Huerto R, Carnes-Vendrell A, Mínguez O, Pujol Sabaté M, Targa A, Barbé F, Milanesi E, Dobre M, Manda G, Cuadrado A, Piñol-Ripoll G

“…The intermittent hypoxia (IH) caused by OSA may participate in AD pathogenesis through increase in oxidative damage and inflammation. …”
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Cerebrospinal fluid β2-microglobulin promotes the tau pathology through microglia–astrocyte communication in Alzheimer's disease by Zehu Sheng, Lanyang Wang, Ming Chen, Fuxin Zhong, Shijing Wu, Shuyu Liang, Jiaqi Song, Lihua Chen, Yingxi Chen, Shiyu Chen, Weihua Yu, Yang Lü

“…However, more investigation is required to ascertain the relationship between β2M and glial activities in AD pathogenesis. Methods In this study, 211 participants from the Alzheimer’s disease Neuroimaging Initiative (ADNI) with CSF and Plasma β2M, CSF glial fibrillary acidic protein (GFAP), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), Aβ42, phosphorylated-tau (P-tau) and total tau (T-tau) were divided into four groups, stage 0, 1, 2, and suspected non-AD pathology (SNAP) based on the National Institute on Aging- Alzheimer’s Association (NIA-AA) criteria. …”
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Protective effects and possible mechanisms of mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles against kidney fibrosis in animal models: a systematic... by Yuanchen Lv, Zibo Hua, Xiaomei Lu

“…Additionally, transforming growth factor beta 1 (TGF-β1) is a significant cytokine implicated in the pathogenesis of kidney fibrosis. TUNEL-positive tubular cells represent tubular cells undergoing apoptosis. …”
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Comprehensive treatment of the macular edema in patients with retinal vein occlusion and hemostasis system disturbances by T.V. Shelkovnikova, Kh.P. Takhchidi, G.V. Vavin, N.Yu. Barkova, N.Yu. Shishlyannikova

“…<br> LA exacerbates endothelial dysfunction in the microvasculature, supports autoimmune inflammation and is involved in the pathogenesis of ME, epiretinal membrane in patients with RVO. …”
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Development and utilization of Treponema pallidum expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox... by Kristina N. Delgado, Crystal F. Vicente, Christopher M. Hennelly, Farhang Aghakhanian, Jonathan B. Parr, Kevin P. Claffey, Justin D. Radolf, Kelly L. Hawley, Melissa J. Caimano

“…The alarming increase in syphilis cases globally underscores the importance of developing novel strategies to understand the complexities of syphilis pathogenesis. In this study, we took advantage of recent advances in in vitro cultivation and genetic manipulation of syphilis spirochetes to engineer a TPA strain that constitutively expresses green fluorescent protein (GFP). …”
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Single‐cell sequencing reveals the features of adaptive immune responses in the liver of a mouse model of dengue fever by Yizhen Yuan, Qian Chen, Zhe Li, Fangzhou Cai, Dan Li, Wei Wang

“…Our study provides a better understanding of the pathogenesis of liver injury in dengue fever patients.…”
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