Autoantibodies Targeting AT1 Receptor from Patients with Acute Coronary Syndrome Upregulate Proinflammatory Cytokines Expression in Endothelial Cells Involving NF-κB Pathway by Weijuan Li, Zhi Li, Yaoqi Chen, Songhai Li, Yuanyuan Lv, Wenping Zhou, Mengyang Liao, Feng Zhu, Zihua Zhou, Xiang Cheng, Qiutang Zeng, Yuhua Liao, Yumiao Wei

“…AT1-AAs may play a great role in the pathogenesis of the acute coronary syndrome by mediating vascular inflammatory effects involved in the NF-κB pathway.…”
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Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity by Matthew C. Austin, Charanya Muralidharan, Saptarshi Roy, Justin J. Crowder, Jon D. Piganelli, Amelia K. Linnemann, Amelia K. Linnemann

“…Previously, we discovered that β-cell autophagy is impaired prior to the onset of T1D, implicating this pathway in T1D pathogenesis.AimsTo assess the role of autophagy in β-cell health and survival, and whether defects in autophagy render islets more immunogenic.MethodsWe knocked out the critical autophagy enzyme, ATG7, in the β-cells of mice (ATG7Δβ-cell) then monitored blood glucose, performed glucose tolerance tests, and evaluated bulk islet mRNA and protein. …”
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TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC by Xiao-Mei Tang, Min-Min Shi, Jia-Cheng Wang, Yi-Jin Gu, Yu-Ting Dai, Qin-Xin Yang, Jia Liu, Ling-Jie Ren, Xin-Yun Liu, Chun Yang, Fang-Fang Ma, Ji-Bing Liu, Hong Yu, Da Fu, Yun-Feng Wang

“…This study investigated the biological role of TOPBP1 in PDAC pathogenesis and evaluated its clinical relevance in guiding treatment regimens. …”
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Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation by Jiamei Fu, Xinglong Liu, Yuchuan Zhou, Shengnan Zhao, Liang Zeng, Yan Pan, Jianghong Zhang, Kevin M. Prise, Chunlin Shao, Yaping Xu

“…However, the underlying mechanisms of its pathogenesis are still inconclusive. No approved biomarker or medicine is available to prevent pulmonary toxicities in LC-ILD patients. …”
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Hei-Gu-Teng Zhuifenghuoluo Granule Modulates IL-12 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis by Kang Zheng, Zexu Chen, Wen Sun, Bin Liu, Danping Fan, Qingqing Guo, Hui Luo, Jiawen Shen, Li Li, Xiaojuan He, Shuang Kou, Xiaoya Li, Guoming Pang, Hongchuan Zhao, Cheng Lu

“…Rheumatoid arthritis (RA) is a type of chronic systemic inflammatory disease; it has a very complicated pathogenesis, and multiple pathological changes are implicated. …”
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Exploring the role of ELOVLs family in lung adenocarcinoma based on bioinformatic analysis and experimental validation by Zihan Wang, Wenjing Cui, Long Liang, Jingge Qu, Yuqiang Pei, Danyang Li, Ying Luo, Yue Zhang, Yifan Qiu, Yongchang Sun

“…The aim of our study is to explore whether there are genes related to the pathogenesis of LUAD in the ELOVLs family, and even to guide clinical medication and potential prognostic indicators. …”
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miR-10a in Peripheral Blood Mononuclear Cells Is a Biomarker for Sepsis and Has Anti-Inflammatory Function by Guoping Zheng, Guanguan Qiu, Menghua Ge, Jianbiao Meng, Geng Zhang, Jiangmei Wang, Ruoqiong Huang, Qiang Shu, Jianguo Xu

“…Levels of miR-10a could distinguish between sepsis and infection and predict 28-day mortality. miR-10a plays an anti-inflammatory role in the pathogenesis of sepsis.…”
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Evaluation of exo-long noncoding RNA MALAT1 in OSCC in comparison to dysplastic and normal: A cross-sectional study by Ramya Sekar, Selvaraj Jayaraman, VishnuPriya Veeraraghavan, Kalaiselvi Krishnamoorthy, Shubhra Chauhan Aramanai, Sathan Raj Natarajan

“…Conclusion: MALAT1 stands out as a key player in the complex landscape of OSCC pathogenesis, impacting tumorigenesis, metastasis, and treatment outcomes through multifaceted molecular mechanisms. …”
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Transarterial chemoembolization for hepatocellular carcinoma: Treatment algorithm proposed by Chinese College of Interventionalists (CCI) by Hai-Dong Zhu, Rong Liu, Zhong-Zhi Jia, Dong-Dong Xia, Bin-Yan Zhong, Wen-Zhe Fan, Jian Lu, Ming Zhao, Gao-Jun Teng

“…Experts from the Chinese College of Interventionalists proposed a treatment algorithm regarding the use of TACE for the treatment of HCC in the context of the pathogenesis and biological behavior of HCC, incidence of concurrent hepatitis virus infection or liver cirrhosis, patient characteristics, and potential adverse reactions to treatment. …”
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Mathematical modeling in autoimmune diseases: from theory to clinical application by Yaroslav Ugolkov, Yaroslav Ugolkov, Yaroslav Ugolkov, Antonina Nikitich, Antonina Nikitich, Cristina Leon, Gabriel Helmlinger, Kirill Peskov, Kirill Peskov, Kirill Peskov, Kirill Peskov, Victor Sokolov, Victor Sokolov, Alina Volkova, Alina Volkova

“…The research & development (R&D) of novel therapeutic agents for the treatment of autoimmune diseases is challenged by highly complex pathogenesis and multiple etiologies of these conditions. …”
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Inducing aggresome and stable tau aggregation in Neuro2a cells with an optogenetic tool by Shigeo Sakuragi, Tomoya Uchida, Naoki Kato, Boxiao Zhao, Toshiki Takahashi, Akito Hattori, Yoshihiro Sakata, Yoshiyuki Soeda, Akihiko Takashima, Hideaki Yoshimura, Gen Matsumoto, Hiroko Bannai

“…Understanding the mechanism by which locally developed tau pathology propagates throughout the brain is crucial for comprehending AD pathogenesis. Therefore, a novel model of tau pathology that artificially induces tau aggregation in targeted cells at specific times is essential. …”
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A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's disease by Zhongying Gong, Dan Guo, Yufeng Lin, Zhiwei Liu, Mengdi Lv, Xinxin Liu, Yang Yao, Sijia Wang, Yuan Wang, Zhiyun Wang

“…It has been reported that astrocytes play a critical role in the pathogenesis and progression of PD. Here, we aimed to identify the heterogeneity of astrocytes and investigate genes associated with astrocyte differentiation trajectories in PD. …”
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Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice by Ryan Brown, Donna M. Small, Declan F. Doherty, Leslie Holsinger, Robert Booth, Richard Williams, Rebecca J. Ingram, J. Stuart Elborn, Marcus A. Mall, Clifford C. Taggart, Sinéad Weldon

“…These results indicate the important role CatS may play in the pathogenesis and progression of mucoobstructive lung disease.…”
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Korelasi Kadar Hemoglobin dengan Kadar Nitric Oxide pada Preeklamsia dan Kehamilan Normal by Siska Helina, Ariadi , Delmi Sulastri

“…<br />Kata kunci:  hemoglobin, nitric oxide, preeklamsia, kehamilan normal</p><p> </p><p>Abstract <br />Endothelial cell activation or dysfunction becomes a major factor pathogenesis of preeclampsia. This mechanism is characterized by the decrease of Nitric Oxide (NO) level. …”
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Acetylation of proximal cysteine-lysine pairs by alcohol metabolism by Courtney D. McGinnis, Peter S. Harris, Brenton I.M. Graham, John O. Marentette, Cole R. Michel, Laura M. Saba, Richard Reisdorph, James R. Roede, Kristofer S. Fritz

“…These factors alter proteomic and epigenetic marks, including alcohol-induced protein acetylation, which is a key post-translational modification (PTM) that regulates hepatic metabolism and is associated with the pathogenesis of alcohol-associated liver disease (ALD). …”
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The clinical implication of CD45RA+ naïve T cells and CD45RO+ memory T cells in advanced pancreatic cancer: a proxy for tumor biology and outcome prediction by Junjie Hang, Junjie Huang, Siyuan Zhou, Lixia Wu, Yingwei Zhu, Lina Zhu, Hanyu Zhou, Kequn Xu, Hua Jiang, Xuguang Yang

“…Abstract Naïve and memory T cells play a pivotal role in solid tumor pathogenesis but their role in pancreatic cancer progression remains elusive. …”
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Association between vascular endothelial growth factor and atrial fibrillation: a systematic review by Nikhil Sharma, Mahalaqua Nazli Khatib, R. Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G. V. Siva Prasad, Pranchal Rajput, Rukshar Syed, Kamal Kundra, Vinamra Mittal, Muhammed Shabil, Amit Kumar, Pancham Cajla, Ganesh Bushi, Rachana Mehta, Zaid Khan, Prakasini Satapathy, Shilpa Gaidhane, Afukonyo Shidoiku Daniel, Renu Sah

“…Abstract Background Atrial fibrillation (AF) is the most prevalent form of sustained cardiac arrhythmia, with vascular endothelial growth factor (VEGF) increasingly recognized for its potential role in the pathogenesis of AF through mechanisms involving atrial remodeling, inflammation, and fibrosis. …”
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Hypocrellin A-mediated photodynamic antibacterial activity against Cutibacterium acnes: An in vitro study by Muqiu Zhang, Xinyao Liu, Xin Ran, Runyan Gao, Jitong Sun, Kaiwen Zhuang, Zimeng You, Zhi Zhang, Yuping Ran

“…Skin dysbiosis caused by Cutibacterium acnes contributes greatly to the complex pathogenesis of acne, and antimicrobial photodynamic therapy (PDT) has emerged as a promising treatment option for acne treatment. …”
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Protein Level and Infantile Diarrhea in a Postweaning Piglet Model by Jing Gao, Jie Yin, Kang Xu, Hui Han, ZeMin Liu, ChenYu Wang, TieJun Li, YuLong Yin

“…The levels and sources of dietary protein are potential sources of diarrhea, but the relationship between the pathogenesis causes of infantile diarrhea and protein intake remains poorly understood. …”
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uN2CpolyG-mediated p65 nuclear sequestration suppresses the NF-κB-NLRP3 pathway in neuronal intranuclear inclusion disease by Yu Shen, Kaiyan Jiang, Dandan Tan, Min Zhu, Yusen Qiu, Pencheng Huang, Wenquan Zou, Jianwen Deng, Zhaoxia Wang, Ying Xiong, Daojun Hong

“…Emerging clinical evidence suggests that inflammation contributes to NIID pathogenesis, yet the underlying molecular mechanisms remain elusive. …”
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