Wnt signaling as a translational target in rheumatoid and psoriatic arthritis by Gloria Riitano, Francesca Spinelli, Valeria Manganelli, Daniela Caissutti, Antonella Capozzi, Cristina Garufi, Tina Garofalo, Roberta Misasi, Maurizio Sorice, Fabrizio Conti, Agostina Longo, Cristiano Alessandri

“…Recent evidence described the involvement of the Wnt pathway in the pathogenesis of these diseases. Thus, we aimed to analyze some components of Wnt signaling, i.e. …”
Get full text

Interleukin-1 Gene Variability and Plasma Levels in Czech Patients with Chronic Periodontitis and Diabetes Mellitus by Petra Borilova Linhartova, Hana Poskerova, Marie Tomandlova, Jirina Bartova, Katerina Kankova, Antonin Fassmann, Lydie Izakovicova Holla

“…Haplotype analysis suggests that variability in IL-1 gene cluster may be one of the factors in the CP and T1DM pathogenesis, although single variants of these polymorphisms are not substantial for protein production.…”
Get full text

Leucine-rich alpha-2-glycoprotein 1 deficiency suppresses ischemia–reperfusion injury-induced renal fibrosis by Naohito Okami, Hiromichi Wakui, Kengo Azushima, Tomohito Miyazawa, Eisuke Kubo, Shunichiro Tsukamoto, Mari Sotozawa, Shinya Taguchi, Shingo Urate, Kohei Ishiga, Sho Kinguchi, Tomohiko Kanaoka, Kouichi Tamura

“…These findings indicate that LRG1 is involved in the pathogenesis of the transition from AKI to CKD and may be a potential therapeutic target.…”
Get full text

Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support by Tae Higuchi, Tomomi Ide, Takeo Fujino, Takeshi Tohyama, Yuta Nagatomi, Tomoyuki Nezu, Masataka Ikeda, Toru Hashimoto, Shouji Matsushima, Keisuke Shinohara, Masaaki Nishihara, Takeshi Iyonaga, Tomohiko Akahoshi, Tomoki Ushijima, Akira Shiose, Shintaro Kinugawa, Hiroyuki Tsutsui, Kohtaro Abe

“…Abstract Intensive care unit-acquired weakness (ICU-AW) is recognized as newly-acquired bilateral muscle weakness, which is a complication of critical illness in the ICU; however, there are no reports on the pathogenesis and early predictors of ICU-AW specifically associated with cardiogenic shock (CS). …”
Get full text

Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis by Heliang Liu, Jingjing Ma, Tian Jiang, Enhong Li, Xiaokun Zhao, Ying Wang, Jie Cui, Xiaohui Hao, Lingli Guo

“…A decrease in serum sRAGE and its association with inflammatory response might suggest a role for sRAGE in the pathogenesis of silicosis.…”
Get full text

Liraglutide and GLP-1(9–37) alleviated hepatic ischemia-reperfusion injury by inhibiting ferroptosis via GSK3β/Nrf2 pathway and SMAD159/Hepcidin/FTH pathway by Chenqi Lu, Cong Xu, Shanglin Li, Haiqiang Ni, Jun Yang

“…Ferroptosis plays a pivotal role in the pathogenesis of ischemia-reperfusion injury (IRI). Liraglutide, as a GLP-1 receptor (GLP-1R) agonist, has exhibited extensive biological effects beyond its hypoglycemic action. …”
Get full text

Genomic Alterations in Primary Gastric Adenocarcinomas Correlate with Clinicopathological Characteristics and Survival by Marjan M. Weiss, Ernst J. Kuipers, Cindy Postma, Antoine M. Snijders, Daniel Pinkel, Stefan G. M. Meuwissen, Donna Albertson, Gerrit A. Meijer

“…Background & aims: Pathogenesis of gastric cancer is driven by an accumulation of genetic changes that to a large extent occur at the chromosomal level. …”
Get full text

Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD by Pritha Majumder, Biswanath Chatterjee, Khadiza Akter, Asmar Ahsan, Su Jie Tan, Chi-Chen Huang, Jen-Fei Chu, Che-Kun James Shen

“…The misregulation of this switch could contribute to the pathogenesis of FMRP-related neurodisorders including the autism spectrum disorder (ASD). …”
Get full text

Group 2 Innate Lymphoid Cells Participate in Renal Fibrosis in Diabetic Kidney Disease Partly via TGF-β1 Signal Pathway by Cuiping Liu, Ludan Qin, Jingya Ding, Luping Zhou, Chenlin Gao, Ting Zhang, Man Guo, Wei Huang, Zongzhe Jiang, Yang Long, Yong Xu

“…To explore the role of group 2 innate lymphoid cells (ILC2s) in the pathogenesis of renal fibrosis in diabetic kidney disease (DKD). …”
Get full text

Heightened expression of type I interferon signaling genes in CD4+ T cells from acutely HIV-1–infected women is associated with lower viral loads by Elina El-Badry, Luxiao Chen, Khader Ghneim, Ziyi Li, Kelsie Brooks, Jake Rhodes, Rafick Sekaly, William Kilembe, Susan Allen, Susan Allen, Susan Allen, Hao Wu, Eric Hunter, Eric Hunter

“…Sex differences play a role in the pathogenesis of a number of viral diseases. In HIV-1, several studies have reported that chronically infected women have significantly lower plasma viremia than men, although the exact mechanism by which this occurs has yet to be identified. …”
Get full text

Safety and Intranasal Retention of a Broad-Spectrum Anti-SARS-CoV-2 Monoclonal Antibody SA55 Nasal Spray in Healthy Volunteers: A Phase I Clinical Trial by Chaoying Hu, Yibo Zhou, Xing Meng, Jianhua Li, Jinxia Chen, Zhifang Ying, Xiaoliang Sunney Xie, Yaling Hu, Yunlong Cao, Ronghua Jin

Get full text

A Pooling Genome-Wide Association Study Identifies Susceptibility Loci and Signaling Pathways of Immune Thrombocytopenia in Chinese Han Population by Yanmei Xu, Jing Li, Wentao Yang, Xiaoli Tang, Bo Huang, Jing Liu, Jin Lin, Jing Zhang, Weiming Yang, Shuqi Li, Fan Sun, Libin Deng, Xiaozhong Wang

“…In conclusion, our results revealed four novel loci and three pathways related to ITP and provided new clues to explore the pathogenesis of ITP.…”
Get full text

Mitochondrial Fusion Proteins and Human Diseases by Michela Ranieri, Simona Brajkovic, Giulietta Riboldi, Dario Ronchi, Federica Rizzo, Nereo Bresolin, Stefania Corti, Giacomo P. Comi

“…While these disorders can still be considered rare, defective mitochondrial dynamics seem to play a significant role in the molecular and cellular pathogenesis of more common neurodegenerative diseases, for example, Alzheimer’s and Parkinson’s diseases. …”
Get full text

Relationship between CCL25/CCR9 Levels in Follicular Fluid and High Ovarian Response in Patients with Polycystic Ovary Syndrome by Yongxin Hao, Qianqian Yin, Fangfang Hu, Xiaoyan Liu, Yaru Yang, Fang Sun, Xiaonan Yan

“…The CCL25/CCR9 levels in FF are positively correlated with the clinical indicators of HOR, suggesting that CCL25/CCR9 may play a role in the pathogenesis of HOR in patients with PCOS.…”
Get full text

Clinical features of cystic neutrophil granulomatous mastitis in 62 cases by Mengjie Wang, Dongxiao Zhang, Na Fu, Min Liu, Hongkai Zhang, Shuo Feng, Yifei Zeng, Wenjie Zhao, Jianchun Cui, Khattak Mazher Mansoor

“…Despite its rarity, understanding its pathogenesis and clinical features is crucial for accurate diagnosis and effective management. …”
Get full text

Gambaran Jumlah Eosinofil Darah Tepi Penderita Asma Bronkial di Bangsal Paru RSUP Dr. M. Djamil Padang by Demas Nico M Manurung, Ellyza Nasrul, Irvan Medison

“…One of cells which is known to play a major role in asthma pathogenesis is eosinophil. Eosinophil release a variety of mediators such as Major Basic Protein, Eosinophil Cationic Protein, Eosinophil Peroxidase, Leukotriene C4, and Platelet Activating Factor that will damage airway epithelium and cause inflammation. …”
Get full text

Exome Sequencing Identified a Recessive RDH12 Mutation in a Family with Severe Early-Onset Retinitis Pigmentosa by Bo Gong, Bo Wei, Lulin Huang, Jilong Hao, Xiulan Li, Yin Yang, Yu Zhou, Fang Hao, Zhihua Cui, Dingding Zhang, Le Wang, Houbin Zhang

“…Our results emphasize the importance of c.437T<A (p.V146D) substitution in RDH12 and provide further support for the causative role of this mutation in the pathogenesis and clinical diagnosis of RP.…”
Get full text

PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women by H. Gbelcová, P. Bakeš, P. Priščáková, V. Šišovský, I. Hojsíková, Ľ. Straka, M. Konečný, J. Markus, C. W. D’Acunto, T. Ruml, D. Böhmer, Ľ. Danihel, V. Repiská

“…Loss of PTEN function has been implicated in the pathogenesis of a number of different tumors, particularly endometrial carcinoma (ECa). …”
Get full text

Expression of Wnt signaling proteins LEF1, β-catenin, GSK3β, DVL1, and N-myc varies across retinoblastoma subtypes and pRb phosphorylation status by Leon Marković, Anja Bukovac, Ana Maria Varošanec, Antonia Jakovčević, Davor Tomas, Zdenko Sonicki, Borna Puljko, Fran Dumančić, Reno Hrašćan, Nives Pećina-Šlaus

“…The findings highlight the meaningful role of the Wnt signaling pathway in retinoblastoma pathogenesis, providing insights into potential therapeutic targets. …”
Get full text

Exploring lipidome mediated inflammatory pathways in acute pancreatitis using mendelian randomization by Wenbin Liu, Song Yang, Yuhan Li, Dava Tenzing, Ruizi Shi, Yang Jiang, Hao Deng, Enqiang Mao, Ying Chen, Yihui Wang

“…These findings elucidate the complex interplay between lipid metabolites, inflammation, and AP pathogenesis, potentially informing novel therapeutic strategies. …”
Get full text