Audio-vestibular dysfunction in rheumatoid arthritis associated secondary Sjogren syndrome, and its correlation to serum level of anticardiolipin and muscarinic type 3 receptors an... by Doaa Waseem Nada, Heba Ahmed Almokadem, Rania Elsaied Elkholy, Amani Mohamed El-Gharib, Marwa Ahmed Abdelwahab, Nema Ali Soliman, Alaa Mohamed Alsalawy

“…Hence, to ascertain if individuals with Rheumatoid arthritis (RA) associated secondary Sjogren syndrome (sSS) had subclinical audio-vestibular impairment as well as to investigate whether serum anticardiolipin and muscarinic receptors type 3 antibodies had a role in its pathogenesis, this cross-sectional study was conducted on 50 RA patients with secondary Sjogren syndrome manifestations and 50 RA patients without such manifestations were included, along with 50 apparently healthy volunteers who were aged, and sex-matched as controls. …”
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Research progress of Traditional Chinese Medicine nursing techniques for cough symptoms of lung cancer patients (中医护理技术改善肺癌患者咳嗽症状的研究进展) by HOU Yanli (侯燕丽), ZHANG Ying (张英), LIN Haiqing (林海青), CHEN Mengna (陈梦娜), CHEN Yang (陈扬)

“…This paper summarized the etiology and pathogenesis, operating procedure and effective evaluation of Tradition Chinese Medicine nursing technology in the treatment of cough symptoms of lung cancer patients. …”
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Antioxidant and Anti-Inflammatory Potential of Cymbopogon nardus Ethanol Extract on 3T3-L1 Cells by Rohmawaty E, Wiraswati HL, Zahra TA, Amalina SN, Ramadhanti J, Rosdianto AM, Laelalugina A, Nasution GTD, Kamisah Y

“…However, there is limited scientific evidence of its cellular effects. Given that the pathogenesis of many diseases involves oxidative stress and inflammation, this study aimed to evaluate the potential antioxidant and anti-inflammatory effects of the plant extracts in 3T3-L1 cells.Methods: Phytochemical screening of C. nardus extracts was performed to identify bioactive compounds. …”
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Specific plasma metabolite profile in intestinal Behçet’s syndrome by Cheng-cheng Hou, Hua-fang Bao, Chun-hui She, Hua-yu Chen, Guan-xing Pan, Hua-ning Chen, Hong-bing Rui

“…The potential pathways involved in the pathogenesis of IBS include linoleic acid metabolism; GABAergic synapse; biosynthesis of unsaturated fatty acids; valine, leucine and isoleucine biosynthesis; ovarian steroidogenesis; and others. …”
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Definition of clinical immunology around the globe by José C. Crispín, José C. Crispín, José C. Crispín, Tineke Cantaert, Tineke Cantaert, Alberto Pinzon-Charry, Alberto Pinzon-Charry, Alberto Pinzon-Charry, Domenico Mavilio, Domenico Mavilio, Domenico Mavilio, Ahmed Seri, Ahmed Seri, Pierre Miossec, Pierre Miossec

“…Immune cells and immune mediators are now known to participate in the pathogenesis of a wide variety of diseases and therapies based on the modulation of immune function are increasingly used. …”
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Efficacy of a new treatment algorithm for capsulitis of the fingers in rock climbers by Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Christoph Lutter, Christoph Lutter, Hans-Christoph Lang, Mario Perl, Othmar Moser, Michael Simon

“…A better understanding of the underlying pathogenesis is essential in order to better assess long-term progress.…”
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Complex immunohistochemical and molecular study on 5 cases of ovarian juvenile granulosa cell tumors reveals a consistent alteration in the PI3K/AKT/mTOR signaling pathway by Adam Šafanda, Nikola Hájková, Michaela Kendall Bártů, Marián Švajdler, Radoslav Matěj, Jitka Hausnerová, Tomáš Zima, Pavel Dundr, Kristýna Němejcová

“…Conclusion The results of our study further support the hypothesis that the pathogenesis of JGCT may be driven by activation of the PIK3/AKT/mTOR pathway. …”
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Impaired Iron–Sulfur Cluster Synthesis Induces Mitochondrial PARthanatos in Diabetic Cardiomyopathy by Mengyi Wang, Shiwu Zhang, Jinwei Tian, Fan Yang, He Chen, Shuzhi Bai, Jiaxin Kang, Kemiao Pang, Jiayi Huang, Mingjie Dong, Shiyun Dong, Zhen Tian, Shaohong Fang, Huitao Fan, Fanghao Lu, Bo Yu, Shuijie Li, Weihua Zhang

“…It is hypothesized that impaired iron–sulfur (Fe–S) cluster synthesis plays a crucial role in the pathogenesis of DCM. Reduced S‐sulfhydration of cysteine desulfurase (NFS1) is a novel mechanism that contributes to mitochondrial dysfunction and PARthanatos in DCM. …”
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The Gut Microbiota and Its Relevance to Peripheral Lymphocyte Subpopulations and Cytokines in Patients with Rheumatoid Arthritis by Yuan Li, Sheng-Xiao Zhang, Xu-Fang Yin, Ming-Xing Zhang, Jun Qiao, Xiao-Hong Xin, Min-Jing Chang, Chong Gao, Ya-Feng Li, Xiao-Feng Li

“…Abnormal bacteria communities are associated with the altered levels of lymphocyte subpopulation and cytokines, which might be one of the pathogenesis of RA.…”
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Type B thymomas in patients with myasthenia gravis display a distinctive pattern of αβ TCR and IL-7 receptor α expression on CD4+CD8+ thymocytes by Tianlai Wang, Boyu Wang, Xiaowu Fan, Yixin Cai, Lequn Li, Shengling Fu

“…However, due to the heterogeneity of thymoma and the intricate pathogenesis of MG, it remains unclear why some patients with thymoma develop MG and others do not. …”
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Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a M... by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo del Valle-Mondragón, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Elizabeth Carreón-Torres, Alicia Sánchez-Mendoza, María Esther Rubio-Ruíz

“…Recently, nonclassical RAS components have been implicated in the pathogenesis of hypertension and myocardial dysfunction; however, their cardiac functions are still controversial. …”
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CENPN contributes to pancreatic carcinoma progression through the MDM2-mediated p53 signaling pathway by Ming Xu, Jie Tang, Qiong Sun, Jing Meng, Guoyu Chen, Yunli Chang, Yao Yao, Jieru Ji, Hao Luo, Lingling Chen, Minxue Lu, Weiwei Shi

“…Conclusions The findings of our study substantiate that CENPN is associated with the pathogenesis of PAAD. Consequently, CENPN appears to be a promising candidate for targeted precision therapy in clinical applications.…”
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Whole-Genome Expression Analysis and Signal Pathway Screening of Synovium-Derived Mesenchymal Stromal Cells in Rheumatoid Arthritis by Jingyi Hou, Yi Ouyang, Haiquan Deng, Zhong Chen, Bin Song, Zhongyu Xie, Peng Wang, Jinteng Li, Weiping Li, Rui Yang

“…Synovium-derived mesenchymal stromal cells (SMSCs) may play an important role in the pathogenesis of rheumatoid arthritis (RA) and show promise for therapeutic applications in RA. …”
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Autophagy inhibitor 3-methyladenine mitigates the severity of colitis in aged mice by inhibiting autophagy by Ailing Liu, Hongying Wang, Hong Lv, Hong Yang, Yue Li, Jiaming Qian

“…Aim: This study investigates the role of autophagy in the pathogenesis of UC in young and elderly patients, and explores the therapeutic potential and mechanisms of autophagy modulators in aged mice with dextran sulfate sodium (DSS)-induced colitis. …”
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Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States by Hao Deng, Mengmeng Sun, Zhentong Zhao, Kun Fan, Zizhang Zhao, Yifan Chi, Wei Sheng

“…Given the pivotal role of inflammatory mediators in the pathogenesis of aortic calcification, inflammation has attracted interest as a peripheral biomarker for early mortality prediction in patients with aortic calcification. …”
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Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT... by Huizhen Xing, Xinwei Bai, Xiaoying Pei, Yuqi Zhang, Xueying Zhang, Shujun Chen, Dan Li, Bin Lv, Xiaoying Wang, Xiaoli Wu

“…Abstract Oxidative stress and inflammatory dysregulation play crucial roles in pathogenesis of acute lung injury (ALI), and their cyclic synergy drives excessive inflammatory responses and further exacerbates ALI. …”
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Gut Microbiota as Mediator and Moderator Between Hepatitis B Virus and Hepatocellular Carcinoma: A Prospective Study by Bingren Hu, Yi Yang, Jiangqiao Yao, Ganglian Lin, Qikuan He, Zhiyuan Bo, Zhewei Zhang, Anlvna Li, Yi Wang, Gang Chen, Yunfeng Shan

“…Conclusions Gut microbes are important factors between HBV and HCC through its potential mediating and moderating effects, which can be used as valuable biomarkers for the pathogenesis of HBV‐related HCC.…”
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Unveiling the role of melatonin‐related gene CSNK1D in osteoclastogenesis and its implications for osteoporosis treatment by Jiewen Zhang, Shaobo Wu, Fangze Xing, Ning Kong, Yiwei Zhao, Xudong Duan, Yiyang Li, Kunzheng Wang, Run Tian, Pei Yang

“…Osteoclast (OC) activity and circadian rhythm play a role in the pathogenesis of OP. Melatonin is a circadian regulator that affects bone metabolism, but its molecular mechanism has not been studied in detail. …”
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Diagnostics and treatment of pancreatic exocrine insufficiency: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…To present the modern concept on the causes and pathogenesis of pancreatic exocrine insufficiency (PEI) as well as the new diagnostic and therapeutic approaches at this syndrome to general practitioners. …”
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Association of HLA-B Gene Polymorphisms with Type 2 Diabetes in Pashtun Ethnic Population of Khyber Pakhtunkhwa, Pakistan by Asif Jan, Muhammad Saeed, Muhammad Hussain Afridi, Fazli Khuda, Muhammad Shabbir, Hamayun Khan, Sajid Ali, Muhammad Hassan, Samiullah, Rani Akbar, Zakiullah

“…Polymorphism in HLA class II genes has been reported to play an important role in the pathogenesis of type 1 diabetes (T1D). It also showed association with T2D in different ethnic populations. …”
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