Efficacy of tezepelumab in patients with severe asthma and persistent airflow obstruction by Elliot Israel, Mario Castro, Christopher S. Ambrose, Jean-Pierre Llanos, Nestor A. Molfino, Nicole L. Martin, Sandhia S. Ponnarambil, Neil Martin

“…Tezepelumab blocks thymic stromal lymphopoietin, an epithelial cytokine implicated in asthma pathogenesis. This analysis evaluated the efficacy of tezepelumab in patients with severe, uncontrolled asthma and PAO. …”
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Disorders of circadian rhythms of heart rate variability in diabetic cardiac autonomic neuropathy: mechanisms and consequences by V.A. Serhiyenko, M.I. Dolynay, V.B. Sehin, Y.V. Lazur, A.A. Serhiyenko

“…Particular attention is paid to the risk factors of diabetic CAN; insights into the mechanisms of excess mortality associated with CAN; the pathogenesis of diabetic CAN; possible pathogenic pathways binding CAN and atherosclerosis progression; genetic and epigenetic factors and CAN; DM and circadian rhythms of HRV; diabetic CAN and circadian rhythm disorders. …”
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A meta-analysis of whole blood transcriptome reveals genes associated with increased neutrophil activity and T cell suppression in sepsis by T. N. Shruthi, Anbazhagan Kolandaswamy, Prabakara Somanna

“…Hence our study was limited to transcriptome data derived solely from whole blood to understand the pathogenesis and immune regulation in sepsis. Methods We considered six publically available whole blood transcriptome gene expression omnibus (GEO) datasets and analyzed them using GEO2R. …”
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Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D by Yang Qin, Li Liu, Yanwen Zhang, Xiaowei Chen, Jiani Zhang, Sunwang Ling, Jianguang Wang, Xinyu Yang

“…Abstract Protein citrullination modification plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA), and anti-citrullinated protein antibodies (ACPAs) are extensively employed for clinical diagnosis of RA. …”
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Comparison of SNP Genotypes Related to Proliferative Vitreoretinopathy (PVR) across Slovenian and European Subpopulations by Xhevat Lumi, Mateja M. Jelen, Daša Jevšinek Skok, Emanuela Boštjančič, Metka Ravnik-Glavač, Marko Hawlina, Damjan Glavač

“…The present study investigated the distribution of genotypes within single nucleotide polymorphisms (SNPs) in genes, related to PVR pathogenesis across European subpopulations. Genotype distributions of 42 SNPs among 96 Slovenian healthy controls were investigated and compared to genotype frequencies in 503 European individuals (Ensembl database) and their subpopulations. …”
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Role of Long Non-Coding RNA GUSBP11 in Chronic Periodontitis Through Regulation of miR-185-5p: A Retrospective Cohort Study by Zhang X, Shen X

“…The purpose of this study was to explore the role of GUSBP11/miR-185-5p in chronic periodontitis (CP) and its potential mechanism, so as to provide a basis for elucidating the pathogenesis of CP.Patients and Methods: The expression trends of GUSBP11 and miR-185-5p in gingival crevicular fluid of CP patients and control group were analyzed by RT-qPCR. …”
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Glutamine-glutamate centered metabolism as the potential therapeutic target against Japanese encephalitis virus-induced encephalitis by Mengyuan Li, Hang Yuan, Xiaofei Yang, Yingfeng Lei, Jianqi Lian

“…Results Here, we have delineated a novel perspective on the pathogenesis of JE by identifying an aberrant low flux in glutamine-glutamate metabolism both in vivo and in vitro, which was critical in the establishment of JEV infection and progression of JE. …”
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Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Diseas... by Hugh Chan, Helen Paur, Anthony C. Vernon, Virginia Zabarsky, Krishna P. Datla, Martin J. Croucher, David T. Dexter

“…Importantly, evidence suggests that these drugs may also be neuroprotective against glutamate excitotoxicity, implicated in the pathogenesis of Parkinson's disease (PD). However, whether this neuroprotection also translates into functional recovery is unclear. …”
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Relationship between meteorological factors and the incidence of severe fever with thrombocytopenia syndrome: a systematic review and meta-analysis by Guangju Mo, Hongmei Zhu, Jing Li, Huaiping Zhu, Qiyong Liu

“…Future studies on the relationship between meteorological factors and the incidence of SFTS should fully consider human activities and environmental factors, and explore the pathogenesis and transmission mechanisms in greater depth, so as to provide targeted preventive measures. …”
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Median and Ulnar Neuropathy Assessment in Parkinson’s Disease regarding Symptom Severity and Asymmetry by Nilgul Yardimci, Ozlem Cemeroglu, Eda Ozturk, Gülsüm Gürlü, Esra Şahin, Saliha Bozkurt, Tugba Cengiz, Gulderen Karali, Hasim Cakirbay, Atilla İlhan

“…While increasing evidence suggests comorbidity of peripheral neuropathy (PNP) and Parkinson’s disease (PD), the pathogenesis of PNP in PD is still a debate. The aim of this article is to search the core PD symptoms such as rigidity and tremor as contributing factors to mononeuropathy development while emphasizing each individual patient’s asymmetric symptom severity. …”
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Antiparkinsonian activity of selective MAO-B inhibitors of different chemical structures by Vladimir N. Fedorov, Mikhail K. Korsakov, Anton A. Shetnev, Sergey S. Petukhov, Nikita N. Volkhin, Vladimir P. Vdovichenko, Anastasia A. Khokhlova, Salavat Sh. Suleymanov

“…Introduction: Parkinson’s disease (PD) is a chronic neurodegenerative disease of the central nervous system, the pathogenesis of which is associated with the death of dopaminergic neurons of the midbrain substantia nigra. …”
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Role of CX3CL1/CX3CR1 Signaling Axis Activity in Osteoporosis by Piotr Wojdasiewicz, Pawel Turczyn, Barbara Dobies-Krzesniak, Justyna Frasunska, Beata Tarnacka

“…Recently conducted studies revealed the participation of CX3CL1 chemokine in the pathogenesis of osteoporosis. CX3CL1 and its receptor CX3CR1 present unique properties among over 50 described chemokines. …”
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B Cell Activation, Differentiation, and Their Potential Molecular Mechanisms in Osteoarthritic Synovial Tissue by Lu P, Li Y, Yang S, Yao H, Tu B, Ning R

“…Additionally, the proportion of naive B cells decreased as disease severity progressed.Conclusion: Synovial fibroblasts in OA have been shown to promote the differentiation and activation of B cells, indicating that B cells play a significant role in the pathogenesis of synovium inflammation in OA.Keywords: osteoarthritis, B cells, inflammation, immune, transcriptome sequencing, synovium…”
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Intranasal Insulin Diminishes Postoperative Delirium and Elevated Osteocalcin and Brain Derived Neurotrophic Factor in Older Patients Undergoing Joint Replacement: A Randomized, Do... by Yang M, Zhou L, Long G, Liu X, Ouyang W, Xie C, He X

“…Mi Yang, Lei Zhou, Ge Long, Xing Liu, Wen Ouyang, Chang Xie, Xi He Department of Anesthesia, The Third Xiangya Hospital of Central South University, Changsha, People’s Republic of ChinaCorrespondence: Xi He, Email hexitougao@163.comBackground: Brain energy metabolism disorders, including glucose utilization disorders and abnormal insulin sensitivity, are linked to the pathogenesis of postoperative delirium. Intranasal insulin has shown significant benefits in improving glucose metabolism, insulin sensitivity and cognitive function. …”
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Collagen-1 and elastin expression in cervical tissue: A comparison across cervical elongation, pelvic organ prolapse, and combined conditions by Anis Widyasari, Gatut Hardianto, Etty Hari Kusumastuti, Eighty Mardiyan Kurniawati

“…HIGHLIGHTS • Pathogenesis of cervical elongation is still limited, including the histological and molecular differences between a cervical elongation and a normal cervix…”
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An integrated investigation of mitochondrial genes in COPD reveals the causal effect of NDUFS2 by regulating pulmonary macrophages by Xiaoli Zou, Qiqing Huang, Tutu Kang, Shaoran Shen, Chenxi Cao, Jianqing Wu

“…Abstract Background Despite the increasing body of evidence that mitochondrial activities implicate in chronic obstructive pulmonary disease (COPD), we are still far from a causal-logical and mechanistic understanding of the mitochondrial malfunctions in COPD pathogenesis. Results Differential expression genes (DEGs) from six publicly available bulk human lung tissue transcriptomic datasets of COPD patients were intersected with the known mitochondria-related genes from MitoCarta3.0 to obtain mitochondria-related DEGs associated with COPD (MitoDEGs). …”
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Unique Biomarker Characteristics in Gestational Diabetes Mellitus Identified by LC-MS-Based Metabolic Profiling by Xingjun Meng, Bo Zhu, Yan Liu, Lei Fang, Binbin Yin, Yanni Sun, Mengni Ma, Yuli Huang, Yuning Zhu, Yunlong Zhang

“…The rise of metabolomics has expanded the opportunity to better identify early diagnostic biomarkers and explore possible pathogenesis. Methods. We collected blood serum from 34 GDM patients and 34 normal controls for a LC-MS-based metabolomics study. …”
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Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study by Jijo Francis, Honey Sebastian, Saley Daniel, Leyon Varghese, Sareena Gilvaz, Ragitha Thenkattil Sankarankutty, Siji Susan George, Pulikkottil Raphael Varghese, Suresh Kumar Raveendran

“…Chronic inflammation plays a pivotal role in PCOS pathogenesis.The monocyte chemoattractant protein-1 (MCP-1) is an important chemotactic factor for inflammatory response ofmonocytes. …”
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Research progress in the role of β-arrestin 1 in the regulation of inflammatory response by YI Wenjing, FAN Yixuan, QIU Jiatai, FU Xiaoyan, LIU Meifang

“…The inflammatory response is closely related to the pathogenesis of various diseases, and plays an important role in the progression and outcome of diseases. …”
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Chronic abdominal pain. A multidisciplinary approach in gastroenterology and psychiatry by O.Yu. Gubska

“…Purpose: to review publications on the pathogenesis, general principles of diagnosis and treatment of CAPS as an independent nosology in the category of the gut-brain axis disorders (GBAD), as well as to draw attention to the need for a comprehensive psychosomatic approach to the management of patients with this disease. …”
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