A machine learning model and identification of immune infiltration for chronic obstructive pulmonary disease based on disulfidptosis-related genes by Sijun Li, Qingdong Zhu, Aichun Huang, Yanqun Lan, Xiaoying Wei, Huawei He, Xiayan Meng, Weiwen Li, Yanrong Lin, Shixiong Yang

“…Disulfidptosis-related genes (DRGs) may be involved in the pathogenesis of COPD. From the perspective of predictive, preventive, and personalized medicine (PPPM), clarifying the role of disulfidptosis in the development of COPD could provide a opportunity for primary prediction, targeted prevention, and personalized treatment of the disease. …”
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Astrocyte-Derived Interleukin 11 Modulates Astrocyte–Microglia Crosstalk via Nuclear Factor-κB Signaling Pathway in Sepsis-Associated Encephalopathy by Dandan Zhu, Peng Wang, Xiyue Chen, Kaituo Wang, Yunsong Wu, Min Zhang, Jianhua Qin

“…In this study, we aim to investigate the molecular basis of the astrocyte–microglia crosstalk underlying SAE pathogenesis and also to explore the new therapeutic strategies targeting this crosstalk in this devastating disease. …”
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Osteoarthritis-like changes in rat temporomandibular joint induced by unilateral anterior large overjet treatment by Xinru Xie, Rui Chao, Yi Mao, Tianhao Wan, Yexin Wang, Yan Zhu, Weifeng Xu, Xuzhuo Chen, Yong Wang, Zhigui Ma, Shanyong Zhang

“…However, the current understanding of TMJOA pathogenesis is limited and necessitates further research. …”
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Primary multiple cancer in practice of urological oncologist by M. D. Ter-Ovanesov, D. M. Yagudaev, A. A. Gritskevich, E. V. Anikanova, K. I. Medvedev

“…Two tumors are usually observed among patients with PMMs (in 84–100 % of patients), three tumors occur in 9.9–16.0 % of these patients, four in 1.62 %, and five or more occur in only 0.095 %.Currently, the pathogenesis of this condition has not yet been fully studied. …”
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Therapeutic potential of monomethyl fumarate and aluminum ion combination in alleviating inflammation and oxidative stress in psoriasis by Hang Han, Guojiang Zhang, Yuanyuan Yang, Chenxi Li, Xiandeng Li, Ling Zhong, Zan Chen, Jianxia Xiong, Tao Cai, Lingjuan Zhang, Xiao Zhang, Qinjian Zhao

“…Psoriasis is a chronic inflammatory skin condition characterized by erythematous plaques with white scales. Its pathogenesis is closely linked to oxidative stress and an imbalance in Th1/Th2 immune responses. …”
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Gut mycobiome alterations and network interactions with the bacteriome in patients with atherosclerotic cardiovascular disease by Guangming Su, Ping Huang, Dan Liu, Guorui Xing, Ruochun Guo, Shenghui Li, Shao Fan, Lin Cheng, Qiulong Yan, Wei Yang

“…These findings underscore the importance of the gut mycobiome in the pathogenesis of ACVD and offer new avenues for developing preventive and therapeutic strategies targeting the gut fungal community. …”
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Preparation and evaluation of Brucella T4SS recombinant proteins in serodiagnosis of human brucellosis based on TMT-based proteomics technology by Qi Wu, Chen Sun, Liping Guo, Yujia Xie, Jinpeng Zhang, Jinpeng Zhang, Dehui Yin, Dehui Yin

“…VirB proteins, components of the Type IV secretion system (T4SS) in Brucella, play a pivotal role in bacterial virulence and pathogenesis but have been understudied for their diagnostic potential.MethodsTandem Mass Tag (TMT) proteomics technology was utilized to identify highly expressed VirB proteins from wild-type Brucella strains. …”
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Exploring Systemic Autoimmunity in Thyroid Disease Subjects by Thushani Siriwardhane, Karthik Krishna, Vinodh Ranganathan, Vasanth Jayaraman, Tianhao Wang, Kang Bei, John J. Rajasekaran, Hari Krishnamurthy

“…Individuals with one autoimmune disease are at risk of developing a second autoimmune disease, but the pathogenesis or the sequential occurrence of multiple autoimmune diseases has not been established yet. …”
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Implications of cytokine genes polymorphisms in Jordanian patients with obsessive compulsive disorder by Ahmad M. Khalil, Manal W. Khrais, Khaled M. Al-Qaoud, Mohamad Y. Al Ta’any

“…There is substantial evidence that immune system and genetic changes are involved in OCD pathogenesis. Only a few studies have been encountered in the literature in this field. …”
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Does Adiponectin Act as an Antiangiogenic Factor in B-Cell Chronic Lymphocytic Leukemia? by Stefano Molica, Giovanna Digiesi, Angelo Vacca, Rosanna Mirabelli, Katia Todoerti, Caterina Battaglia, Fortunato Morabito, Antonino Neri, Domenico Ribatti

“…Angiogenesis is involved in the pathogenesis of B-cell chronic lymphocytic leukemia (CLL), and high microvascular density has been found in CLL to be associated with a poor prognosis. …”
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AcfA Regulates the Virulence and Cell Envelope Stress Response of <i>Vibrio parahaemolyticus</i> by Huan Liu, Huayu Lei, Juanjuan Cao, Zhaobang Xie, Yile Shi, Yanni Zhao

“…These findings suggest that AcfA may play a role in the overall success of pathogenesis and the cell envelope stress response of <i>V. parahaemolyticus</i>.…”
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HACE1 protects against myocardial ischemia–reperfusion injury via inhibition of mitochondrial fission in mice by Bang-Xia Liu, Juan Zheng, Zhan-Wei Tang, Lei Gao, Meng Wang, Ying Sun, Chen Chen, Heng-Chen Yao

“…However, little is known about the role of HACE1 in the pathogenesis of myocardial I/RI. Methods Male C57BL6 mice with HACE1 knockout (KO) were subjected to 30 min of ischemia via ligation of the left anterior descending artery, followed by 0, 2, 6, or 24 h of reperfusion. …”
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Lack of Association of C677T Methylenetetrahydrofolate Reductase Polymorphism with Breast Cancer Risk in Mali by Brehima Diakite, Yaya Kassogue, Mamoudou Maiga, Guimogo Dolo, Oumar Kassogue, Jane L. Holl, Brian Joyce, Jun Wang, Kadidiatou Cisse, Fousseyni Diarra, Mamadou L. Keita, Cheick B. Traore, Bakarou Kamate, Sidi B. Sissoko, Bourama Coulibaly, Adama S. Sissoko, Drissa Traore, Fatoumata M. Sidibe, Sekou Bah, Ibrahim Teguete, Madani Ly, Sellama Nadifi, Hind Dehbi, Kyeezu Kim, Robert Murphy, Lifang Hou

“…We therefore hypothesized that such mutations could also play an important role in the occurrence and pathogenesis of breast cancer in a Malian population. …”
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The burden of group A Streptococcus (GAS) infections: The challenge continues in the twenty-first century by Aswin Thacharodi, Saqib Hassan, Avadh Vithlani, Tawfeeq Ahmed, Sanjana Kavish, Nicole-Mae Geli Blacknell, Ali Alqahtani, Arivalagan Pugazhendhi

“…This review thus provides insights into the most recent research on the pathogenesis, virulence, resistance, and host interaction mechanisms of GAS, as well as novel management options to assist scientific communities in combating GAS infections.…”
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Circulating T Cells Exhibit Different TIM3/Galectin-9 Expression in Patients with Obesity and Obesity-Related Diabetes by Lili Sun, Shengyi Zou, Sisi Ding, Xuan Du, Yu Shen, Cuiping Liu, Bimin Shi, Xueguang Zhang

“…Our results suggested that TIM3 and galectin-9 may be potential biomarkers related to the pathogenesis of obesity-related T2DM.…”
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Sex differences of molecular mechanisms of insulin sensitivity in young and adult C57BL/6J mice by T. V. Yakovleva, A. Yu. Kazantseva, E. N.  Makarova, N. M. Bazhan

“…Reduced insulin sensitivity plays an important role in the pathogenesis of type II diabetes. There are sex differences in the development of metabolic disorders. …”
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The Association between Deoxyribonucleic Acid Hypermethylation in Intron VII and Human Leukocyte Antigen-C∗07 Expression in Patients with Endometriosis by Wenrong Zhao, Lei Lei, Rui Chen, Yanmin Zhang, Linlin Chang, Jingxin Cheng

“…There is an increasing amount of evidence that suggests that epigenetic aberrations, including deoxyribonucleic acid (DNA) methylation, play a definite role in the pathogenesis of endometriosis. This study aimed to explore the noninvasive or minimally invasive biomarkers of this disease. …”
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Relationship between triglyceride levels and different snoring states: a systematic review and meta-analysis by Fei-Fei Hou, Bei-Bei Wang, Ye Chen, Qiong Wang, Qiong Wu, Li-Na Yan

“…Some recent studies have shown that snoring is also closely related to elevated TG levels. The specific pathogenesis of elevated TG levels in snoring patients is still unclear. …”
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Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD by Katarzyna Neubauer, Malgorzata Matusiewicz, Iwona Bednarz-Misa, Sabina Gorska, Andrzej Gamian, Malgorzata Krzystek-Korpacka

“…Despite the acknowledged contribution of eosinophils to the disease pathogenesis, available data on cytokines closely related to the peripheral eosinophils in inflammatory bowel disease (IBD) are scattered. …”
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Identification of biomarkers for chronic lymphocytic leukemia risk: a proteome-wide Mendelian randomization study by Changyu Jin, Zehong Lu, Yuzhan Chen, Huijie Hu, Miao Zhou, Yanli Zhang, Guifang Ouyang, Tongyu Li, Lixia Sheng

“…Conclusion This study identifies nine plasma proteins linked to CLL risk, with PPIE offering new insights into the disease's pathogenesis. Further research is needed to validate these findings and explore their potential as therapeutic targets.…”
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