Mesenchymal Stem Cells from Patients with Rheumatoid Arthritis Display Impaired Function in Inhibiting Th17 Cells by Yue Sun, Wei Deng, Linyu Geng, Lu Zhang, Rui Liu, Weiwei Chen, Genhong Yao, Huayong Zhang, Xuebing Feng, Xiang Gao, Lingyun Sun

“…Mesenchymal stem cells (MSCs) possess multipotent and immunomodulatory properties and are suggested to be involved in the pathogenesis of immune-related diseases. This study explored the function of bone marrow MSCs from rheumatoid arthritis (RA) patients, focusing on immunomodulatory effects. …”
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Research on a traditional Chinese medicine case-based question-answering system integrating large language models and knowledge graphs by Yuchen Duan, Qingqing Zhou, Yu Li, Chi Qin, Ziyang Wang, Hongxing Kan, Hongxing Kan, Jili Hu, Jili Hu

“…A large language model (LLM) was employed to automatically extract key entities, including symptoms, pathogenesis, treatment principles, and prescriptions. …”
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Clinical Holistic Medicine (Mindful,Short-Term Psychodynamic Psychotherapy Complemented with Bodywork) in the Treatment of Experienced Mental Illness by Søren Ventegodt, Suzette Thegler, Tove Andreasen, Flemming Struve, Lars Enevoldsen, Laila Bassaine, Margrethe Torp, Joav Merrick

“…., had experienced what Aaron Antonovsky (1923–1994) called “salutogenesis”, defined as the process exactly the opposite of pathogenesis. For the treatment responders, the treatment provided lasting benefits, without the negative side effects of drugs. …”
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Correlation of Vitreous Vascular Endothelial Growth Factor and Uric Acid Concentration Using Optical Coherence Tomography in Diabetic Macular Edema by Libuse Krizova, Marta Kalousova, Ales Antonin Kubena, Oldrich Chrapek, Barbora Chrapkova, Martin Sin, Tomas Zima

“…Second, apart from VEGF, the role of UA in the pathogenesis and progression of DR should be considered.…”
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Effect of metformin on the neuronal morphology of frontal cortex and hippocampal regions in lipopolysaccharide induced neuroinflammation in male Wistar rats by Vandana Blossom, Sheetal D. Ullal, Rajalakshmi Rai, Amit Massand, Chettiar Ganesh Kumar, Teresa Joy, Melisha Michael D souza, B.V. Murlimanju

“…Background: Neuroinflammation in the frontal cortex and hippocampus is the key contributor in the pathogenesis of neurodegenerative diseases. Lipopolysaccharide (LPS) is a bacterial endotoxin (E-coli phenol extract) used to induce the neuroinflammation in animal models. …”
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TACSTD2 in gelatinous drop-like corneal dystrophy: variant functional analysis and expression in the cornea after limbal stem cell transplantation by Liubov O. Skorodumova, Ekaterina N. Grafskaia, Daria D. Kharlampieva, Dmitry I. Maltsev, Tatiana V. Petrova, Alexandra V. Kanygina, Elena V. Fedoseeva, Pavel V. Makarov, Boris E. Malyugin

“…However, despite LSCT, amyloid deposition recurs in some patients. The pathogenesis of recurrence is poorly studied. We present the case of a patient with GDLD. …”
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Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients by Yanhua Zheng, Zemin Huang, Xianhua Chen, Yi Tian, Jun Tang, Yi Zhang, Xiaomin Zhang, Jijun Zhou, Qing Mao, Bing Ni, Qinghong Wang, Yuzhang Wu

“…These findings not only improve our understanding of hepatitis pathogenesis but also can aid in future development of appropriate therapeutic strategies to control viral hepatitis.…”
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The clinical characteristics and implications of acute kidney injury during induction therapy for acute promyelocytic leukemia by Kai Shen, Chenlu Yang, Jie Huang, Xiao Shuai, Ting Niu, Hongbing Ma

“…Thus, the management of AKI in APL patients is still a clinical challenge, and a deeper understanding of its pathogenesis, along with multidisciplinary efforts, is needed.…”
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The Expression of T Cell FOXP3 and T-Bet Is Upregulated in Severe but Not Euthyroid Hashimoto’s Thyroiditis by Stana Tokić, Mario Štefanić, Ljubica Glavaš-Obrovac, Sonja Jaman, Eva Novosadová, Jana Petrkova, Zdenka Navratilova, Mirjana Suver Stević, Martin Petrek

“…Th1 and Treg subset of CD4+ cells have been implicated in the pathogenesis; however, less is known about their respective roles across the spectrum of HT clinical presentations. …”
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Expression of AIM2 in Rheumatoid Arthritis and Its Role on Fibroblast-Like Synoviocytes by Yong Chen, Qiu Fujuan, Ensheng Chen, Beijia Yu, Fangfang Zuo, Yi Yuan, Xiaofeng Zhao, Changhong Xiao

“…AIM2 inflammasome pathway involves in the pathogenesis of RA. si-AIM2 inhibits the proliferation of RA-FLS, which may be a promising therapeutic strategy for the treatment of RA.…”
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Pulmonary Bacterial Communities in Surgically Resected Noncystic Fibrosis Bronchiectasis Lungs Are Similar to Those in Cystic Fibrosis by Heather Maughan, Kristopher S. Cunningham, Pauline W. Wang, Yu Zhang, Marcelo Cypel, Cecilia Chaparro, D. Elizabeth Tullis, Thomas K. Waddell, Shaf Keshavjee, Mingyao Liu, David S. Guttman, David M. Hwang

“…Recurrent bacterial infections play a key role in the pathogenesis of bronchiectasis, but conventional microbiologic methods may fail to identify pathogens in many cases. …”
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Proteomic profiling of Labeo rohita intestine infected with Edwardsiella tarda: Unveiling the mucosal defense mechanisms, cell adhesion, and cytoskeletal pathways by Nevil Pinto, Mehar Un Nissa, Gowhar Iqbal, Yashwanth BS, Darshan P, Sanjeeva S, Mukunda Goswami

“…The reduction in the metabolic and immune pathways of affected rohu intestine mechanisms evoked by E. tarda is critical to the pathogenesis of infection. Conclusion: Our study directly points to the possible disease biomarkers involved in cell adhesion, cytoskeleton rearrangement, and mucosal defense in the rohu intestine after Edwardsiellosis. …”
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Microwave Thermal Ablation in an Unusual Case of Malignant and Locally Advanced Rare Tumor of Pancreas in ASA IV Old Male Patient and Literature Review by Francesco D’Amico, Michele Finotti, Chiara Di Renzo, Alessio Pasquale, Alessandra Bertacco, Giorgio Caturegli, Gabriel E. Gondolesi, Umberto Cillo

“…Pancreatic intraductal papillary-mucinous neoplasm is a rare primary neoplasm of unknown pathogenesis. This kind of tumor represents 0.2–2.7% of all pancreatic cancers and they may proceed to malignant lesions. …”
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TLR4/AP-1-Targeted Anti-Inflammatory Intervention Attenuates Insulin Sensitivity and Liver Steatosis by Xiang Hu, Jing Zhou, Sha-sha Song, Wen Kong, Yan-Chuan Shi, Lu-Lu Chen, Tian-Shu Zeng

“…Insulin resistance has been shown to be the common pathogenesis of many metabolic diseases. Metainflammation is one of the important characteristics of insulin resistance. …”
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Cerebrospinal fluid‐specific oligoclonal bands in dogs with idiopathic epilepsy by Junwei Föhr, Julia K. Prümmer, Arianna Maiolini, Eliane Marti, Ilijas Jelcic, Beatriz Vidondo, Mario Ziegler, Andrea Bathen‐Nöthen, Andrea Tipold, Holger A. Volk, Veronika M. Stein

“…This finding could indicate that intrathecal IgG synthesis as a sign of neuroinflammation may play a role in disease pathogenesis.…”
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Phenylbutyric Acid Modulates Apoptosis and ER Stress‐Related Gene Expression in Glycogen Storage Disease Type Ib In Vitro Model by Marina Parezanovic, Nina Stevanovic, Marina Andjelkovic, Milena Ugrin, Sonja Pavlovic, Maja Stojiljkovic, Anita Skakic

“…ABSTRACT Introduction Chronic endoplasmic reticulum (ER) stress and increased apoptosis are involved in the pathogenesis of glycogen storage disease Ib (GSD Ib), whereas small molecule phenylbutyrate (4‐PBA) showed the capability of reducing ER stress‐induced apoptosis. …”
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Urinary I-FABP, L-FABP, TFF-3, and SAA Can Diagnose and Predict the Disease Course in Necrotizing Enterocolitis at the Early Stage of Disease by Stepan Coufal, Alena Kokesova, Helena Tlaskalova-Hogenova, Barbora Frybova, Jiri Snajdauf, Michal Rygl, Miloslav Kverka

“…Therefore, we analyzed diagnostic and prognostic potential of the markers of early NEC pathogenesis, such as excessive inflammatory response (serum amyloid A (SAA)) and gut epithelium damage (intestinal and liver fatty acid-binding protein (I-FABP and L-FABP, respectively) and trefoil factor-3 (TFF-3)). …”
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Mechanisms of Hearing Loss in a Guinea Pig Model of Superior Semicircular Canal Dehiscence by Bu-Sheng Tong, Zi-Yu He, Chen-Ru Ding, Juan-Mei Yang, Jing Wang, Zhao Han, Yi-Bo Huang, Na Gao, Xian-Hao Jia, Fang-Lu Chi, Dong-Dong Ren

“…Among them, semicircular canal dehiscence (SCD) with a defective semicircular bone is typical. Currently, the pathogenesis of SCD is usually explained by the third window hypothesis; however, this hypothesis fails to explain the variability in the symptoms and signs experienced by superior SCD (SSCD) patients. …”
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Effects of laparoscopic sleeve gastrectomy on nonalcoholic fatty liver disease and TGF-β signaling pathway by Hideki Kumagai, Akira Sasaki, Akira Umemura, Keisuke Kakisaka, Takeshi Iwaya, Satoshi S Nishizuka

“…TGF-β-related proteins dramatically fluctuated before and after LSG and were correlated with NAFLD pathogenesis. Asporin may be a useful prognostic marker of liver fibrosis in NAFLD after LSG.…”
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L-Citrulline in Neonates: From Bench to Bed Side by Dwayne Mascarenhas, Atefeh Mohammadi, Randa Higazy, Julijana Ivanovska, Estelle Gauda, Bonny Jasani

“…Endothelial dysfunction, characterized by deficient nitric oxide synthesis, is implicated in the pathogenesis of various neonatal conditions such as necrotizing enterocolitis (NEC) and bronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH). …”
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