Axial length to corneal curvature radius ratio is negatively correlated with choroidal blood flow in myopic children by Yurong Ye, Zizhong Hu, Na Su, Yeyu Shen, Songtao Yuan

“…BackgroundThe pathophysiologic mechanisms underlying early-onset myopia remain unclear; in this study, we investigate the pathogenesis by examining the interrelationships between axial length to corneal curvature radius ratio (AL/CR) and choroidal blood flow.MethodsThis cross-sectional study included 202 eyes from myopic children, categorized into 141 eyes with mild myopia, 47 eyes with moderate myopia, and 14 eyes with high myopia. …”
Get full text

Disulfidptosis-related lncRNA signature to assess the immune microenvironment and drug sensitivity in acute myeloid leukemia by Yuying Zhao, Hai-en Cheng, Jingfei Wang, Yunke Zang, Zhijun Liu, Yanhua Sun, Yanli Sun

“…In addition, further studies on the molecular mechanisms of key biomarkers, such as LINC00944 and LINC00926, will greatly contribute to our understanding of AML pathogenesis and drug resistance mechanisms in the future.…”
Get full text

COVID-19 encephalopathy with severe neurological symptoms: a clinical case presentation with literature review by G. Baranauskienė, N. Tutlienė, G. Kaubrys

“…In exceptional cases, encephalopathy may be an early or even a major symptom of COVID-19 in young patients. The pathogenesis of COVID-19 encephalopathy is not fully understood. …”
Get full text

Therapeutic Potential of Agmatine in Essential Tremor Through Regulation of Lingo‐1 and Inflammatory Pathways by Zeynab Pirmoradi, Zahra Esmaili, Mohsen Nakhaie, Kristi A. Kohlmeier, Mohammad Shabani, Moazamehosadat Razavinasab, Mehran Ilaghi

“…Conclusions Collectively, this study provides the first evidence that agmatine dampens tremor severity, improves behavioral outcomes, and modulates key pathways implicated in ET pathogenesis in a rodent model. The ability of agmatine to normalize Lingo‐1 and IL‐6 expression suggests regulation of these pathways could underlie its neuroprotective action. …”
Get full text

Expression of IGF-1R in oral submucous fibrosis and oral squamous cell carcinoma – An RT-PCR study by Vivek Nayyar, Vinay Hazarey, Sindhu M. Ganvir, Hemant J. Purohit, Reshma Talkal, Kiran Jot

“…Conclusion: The study reflected a potential role of IGF-1R in the pathogenesis of OSMF and OSCC, thus implying its possible exploitation as a diagnostic and prognostic marker and also as a therapeutic target in future.…”
Get full text

Chronic stress resulting from stressful life events and its role in the onset of primary Sjögren’s syndrome: a comparative analysis using the modified Holmes-Rahe stress scale by Marta Jaskólska, Iga Kościńska-Shukla, Dawid Jaskólski, Alessandro Viti, Marcin Ziętkiewicz, Michał Chmielewski

“…The results support the view that pSS belongs to the group of diseases which pathogenesis is closely related to stressful life events. …”
Get full text

Neonatal Sepsis and Inflammatory Mediators by Juliana Reis Machado, Danilo Figueiredo Soave, Marcos Vinícius da Silva, Liliana Borges de Menezes, Renata Margarida Etchebehere, Maria Luiza Gonçalves dos Reis Monteiro, Marlene Antônia dos Reis, Rosana Rosa Miranda Corrêa, Mara Rúbia Nunes Celes

“…By taking into account the magnitude of neonatal sepsis, the aim of this review is to address the role of cytokines in the pathogenesis of neonatal sepsis and its value as a diagnostic criterion.…”
Get full text

Altered Macular Vasculature in Migraine Patients without Aura: Is It Associated with Ocular Vasculature and White Matter Hyperintensities? by Nurdan Gamze Taşlı, Alevtina Ersoy

“…We suggest that for not only migraine with aura but also migraine without aura, neurovascular structures play an important role in pathogenesis, and novel studies are warranted to elucidate the alterations in these and determine the significance of WMHs in these patient groups.…”
Get full text

Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: Clinical Characteristics, Psychological Factors, and Peripheral Cytokines by Hua Chu, Mark Fox, Xia Zheng, Yanyong Deng, Yanqin Long, Zhihui Huang, Lijun Du, Fei Xu, Ning Dai

“…Small intestinal bacterial overgrowth (SIBO) has been implicated in the pathogenesis of irritable bowel syndrome (IBS). Psychosocial factors and low-grade colonic mucosal immune activation have been suggested to play important roles in the pathophysiology of IBS. …”
Get full text

Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI by Victoria Kegel, Elisa Pfeiffer, Britta Burkhardt, Jia L. Liu, Katrin Zeilinger, Andreas K. Nüssler, Daniel Seehofer, Georg Damm

“…Aim of the present study was to establish a human in vitro liver model for the investigation of immune-mediated signaling in the pathogenesis of DILI. Hepatocytes and KC were isolated from human liver specimens. …”
Get full text

Reactive Metabolites and AGE-RAGE-Mediated Inflammation in Patients following Liver Transplantation by Thorsten Brenner, Thomas H. Fleming, David Spranz, Peter Schemmer, Thomas Bruckner, Florian Uhle, Eike O. Martin, Markus A. Weigand, Stefan Hofer

“…Recent investigations have indicated that reactive metabolites and AGE-RAGE-mediated inflammation might play an important role in the pathogenesis of ischemia-reperfusion injury in liver transplantation. …”
Get full text

ACTIVITY OF NITRO-OXIDATIVE PROCESSES IN PREGNANT WOMEN WITH IDIOPATHIC ARTERIAL HYPOTENSION by Leonid Markin, Olena Popovych, Alla Popovych

“…Primary violation of vascular tone and reactivity is considered the main hemodynamic link in the pathogenesis of idiopathic arterial hypotension (IAH). …”
Get full text

Differential Expression of -Associated Genes in Autosomal Dominant Polycystic Kidney Disease by Yeon Joo Yook, Yu Mi Woo, Moon Hee Yang, Je Yeong Ko, Bo Hye Kim, Eun Ji Lee, Eun Sun Chang, Min Joo Lee, Sunyoung Lee, Jong Hoon Park

“…These data may be helpful in PKD2-related mechanisms of ADPKD pathogenesis.…”
Get full text

Systemic Lupus Erythematosus Presenting as Anorexia Nervosa in a Middle‐Aged Woman: A Rare Case Report and Literature Review by Maen Nizam Baroudi, Anwar I. Joudeh, Mohammed Kays Alattiya, Abdo Qaid Ahmed Lutf, Hassan Abuzaid, Salah Mahdi

“…Conclusions The concurrence of anorexia nervosa with SLE and the complete resolution of anorexia nervosa symptoms with immunosuppressive therapy suggest common autoinflammatory pathogenesis for both conditions. Further research is needed to elucidate any potential association between SLE and anorexia nervosa.…”
Get full text

The Central Roles of Noncoding RNA in Estrogen-Dependent Female Reproductive System Tumors by Jiajie Tu, Huan Yang, Lei Jiang, Yu Chen, Yu Chen, Zhe Li, Lei Li, Yuanyuan Zhang, Xiaochun Chen, He Chen, Zhiying Yu

“…The pathogenesis of ovarian and endometrial cancers is closely associated with estrogen-related pathways. …”
Get full text

Non-alcoholic fatty liver disease: comparative assessment of diagnostic and treatment approaches in the Russian Federation and People’s Republic of China by M. Ch. Semenistaya, Fan Jian-Gao, O. B. Velichenko, Ye. A. Kuznetsova, Ch. S. Pavlov

“…NAFLD is the leading disease entity among the other chronic liver diseases in the countries of various regions of the world, at the present time it is considered to be one of the main causes for cryptogenic liver cirrhosis development. The pathogenesis of NAFLD closely correlates to both hepatic and cardiovascular involvement that significantly influences both treatment choice and life prognosis. …”
Get full text

The Iron-Klotho-VDR Axis Is a Major Determinant of Proximal Convoluted Tubule Injury in Haptoglobin 2-2 Genotype Diabetic Nephropathy Patients and Mice by Inbal Dahan, Nadia Thawho, Evgeny Farber, Nakhoul Nakhoul, Rabea Asleh, Andrew P. Levy, Yan Chun Li, Ofer Ben-Izhak, Farid Nakhoul

“…Targeting this axis may open the way for new ideas regarding the pathogenesis and treatment of DN.…”
Get full text

Adherent junctions: Physiology, role in hydrocephalus and potential therapeutic targets by Zhiye Chen, Jian He, Yating Guo, Yue Hao, Wentao Lv, Zexin Chen, Junqiang Wang, Yijian Yang, Kaiyue Wang, Zhikun Liu, Qian Ouyang, Zhangjie Su, Pingsheng Hu, Gelei Xiao

“…At present, the researches on the pathogenesis of hydrocephalus are mainly focused on the development of ependymal cells and cilia, while less attention has been paid to molecules such as AJs, which play an important role in maintaining the polarity of ependymal cells. …”
Get full text

Metabolic profile of blood serum in experimental arterial hypertension by A. A. Seryapina, A. A. Malyavko, Yu. K. Polityko, L. V. Yanshole, Yu. P. Tsentalovich, A. L. Markel

“…The etiology of essential hypertension is intricate, since it employs simultaneously various body systems related to the regulation of blood pressure in one way or another: the sympathetic nervous system, renin-angiotensin-aldosterone and hypothalamic-pituitary-adrenal systems, renal and endothelial mechanisms. The pathogenesis of hypertension is influenced by a variety of both genetic and environmental factors, which determines the heterogeneity of the disease in human population. …”
Get full text

Use of disease modifying anti-rheumatic drugs and risk of multiple myeloma in US Veterans with rheumatoid arthritis by Kate Tokareva, Alexander C. Peterson, Aaron Baraff, Sarah P. Chung, Jennifer Barton, Joshua F. Baker, Bryant R. England, Ted R. Mikuls, Nicholas L. Smith, David G. Coffey, Noel S. Weiss, Namrata Singh

“…Abstract Background Biologic (b) and targeted synthetic (ts) disease-modifying anti-rheumatic drugs (DMARDs) used in the management of rheumatoid arthritis (RA) target inflammatory pathways implicated in the pathogenesis of multiple myeloma (MM). It is unknown whether use of b/tsDMARDs affects the incidence of MM. …”
Get full text