Modern view on the treatment of diabetic macular edema by A.V. Shelankova, M.V. Budzinskaya, I.V. Andreeva

“…Dexamethasone has the highest clinical efficacy among all corticosteroids used in ophthalmic practice, the drug demonstrates its multifaceted effects due to its influence on various links in the pathogenesis of DME. Dexamethasone implant reduces the concentration of both inflammatory cytokines in the eye and VEGF.…”
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A compound heterozygous ADAMTS13 mutation causes congenital thrombotic thrombocytopenic purpura: a case report by Yezi Huang, Lixia Zhou, Yuan Song, Wanting Zou, Aiping Tang, Si Tao, Duozhuang Tang

“…This report highlights a cTTP caused by a compound heterozygous ADAMTS13 mutation, although its pathogenesis requires further investigation. Given the atypical clinical manifestations of cTTP, it is necessary to conduct ADAMTS13 activity and even genetic testing in patients with recurrent thrombocytopenia and end-organ damage.…”
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Peripheral tryptophan-kynurenine pathway dysfunction in first-episode schizophrenia by Mian Li, Yue Wu, Yan Xu, Xin Huang, Kerun Gao, Nannan Hu, Shuangyue Zhu, Chengpeng Wang, Sugai Liang

“…Abstract The tryptophan (TRP)-kynurenine (KYN) pathway is involved in the pathogenesis of schizophrenia. This study aimed to investigate the levels of TRP-KYN metabolites in serum and urine of patients with first-episode schizophrenia (FES) and their association with clinical manifestations. …”
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Analytical validation of a novel bioassay for thyroid-stimulating immunoglobulin by Paul D. Olivo, Hannah Kim, Lynn Miao, Jeffery A. Houtz, George J. Kahaly

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Pharmacological Inhibition of Glutaminase 1 Normalized the Metabolic State and CD4+ T Cell Response in Sjogren’s Syndrome by Jiayao Fu, Yiping Pu, Baoli Wang, Hui Li, Xiujuan Yang, Lisong Xie, Huan Shi, Zhijun Wang, Junhao Yin, Tianle Zhan, Yanxiong Shao, Changyu Chen, Qi Luo, Jiabao Xu, Zirui Zong, Xindi Wei, Wanwen Xiao, Chuangqi Yu, Lingyan Zheng

“…Here, we report that glutaminase 1 (Gls1), a pivotal factor in glutaminolysis, might be involved in the pathogenesis of SS. The expression of Gls1 was upregulated in infiltrated labial CD4+ T cells and circulating CD4+ T cells of SS patients. …”
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Clinical Characteristics, Intraoperative Findings, and Surgical Outcomes of Canalicular Laceration Repair with Monocanalicular Stent in Asia by Chun-Hsien Lin, Chun-Yuan Wang, Ying-Cheng Shen, Li-Chen Wei

“…To report the epidemiological and clinical data as well as surgical outcomes of canalicular lacerations with Mini-Monoka insertion at a tertiary center in Taiwan and to discuss differences in traumatic pattern, pathogenesis, and surgical outcomes between Taiwan and other countries. …”
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Hydroxytyrosol Protects against Myocardial Ischemia/Reperfusion Injury through a PI3K/Akt-Dependent Mechanism by Ying-hao Pei, Jiao Chen, Liang Xie, Xiao-min Cai, Run-Hua Yang, Xing Wang, Jian-bin Gong

“…To investigate the effects and mechanisms of hydroxytyrosol (HT) during the pathogenesis of myocardial ischemia reperfusion (I/R) in rat hearts. …”
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Molting of laying hens can activate AMPK- lipophagy - lipid metabolism pathway and improve intestinal digestion and absorption by Meiwei Lv, Chenxin Liu, Xiaowen Jiang, Ming Ge, Haibin Wang, Wenhui Yu

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Salvia-Nelumbinis Naturalis Formula Improved Inflammation in LPS Stressed Macrophages via Upregulating MicroRNA-152 by Zansong Ma, Xiangbing Shu, Jie Huang, Haiyan Zhang, Zhen Xiao, Li Zhang

“…Activation of Kupffer cells by gut-derived lipopolysaccharide (LPS) plays a central role in the pathogenesis of NASH. In the present study, we aimed to explore the epigenetic regulation of microRNAs under the beneficial effects of SNN-containing serum in LPS stressed macrophages. …”
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Direct and Indirect Methods for Studying Human Gut Microbiota by V. T. Ivashkin, O. S. Medvedev, E. A. Poluektova, A. V. Kudryavtseva, I. R. Bakhtogarimov, A. E. Karchevskaya

“…This approach may increase our understanding of the pathogenesis of various diseases as well open up new opportunities for prevention and treatment.…”
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Interventricular septal dissection secondary to acute inferior myocardial infarction: case series and literature review by Ping Chen, Xiuqin Wang, Yun Mou

“…By exploring the etiology, pathogenesis, and key diagnostic points of IVSD, this study aims to provide valuable insights for clinical practice.…”
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The role of interleukin-17 in inflammation-related cancers by Xingru Zhang, Xingru Zhang, Bangjie Li, Tian Lan, Tian Lan, Conner Chiari, Xiaoyang Ye, Kepeng Wang, Ju Chen

“…IL-17 is a highly versatile pro-inflammatory cytokine that plays a pivotal role in host defense, tissue repair, the pathogenesis of inflammatory diseases, and cancer progression. …”
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A Role of Fluoride on Free Radical Generation and Oxidative Stress in BV-2 Microglia Cells by Xi Shuhua, Liu Ziyou, Yan Ling, Wang Fei, Guifan Sun

“…The generation of ROS and lipid peroxidation has been considered to play an important role in the pathogenesis of chronic fluoride toxicity. In the present study, we observed that fluoride activated BV-2 microglia cell line by observing OX-42 expression in immunocytochemistry. …”
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<i>In silico</i> mapping of coronary artery disease genes by I. V. Zorkoltseva, N. M. Belonogova, G. R. Svishcheva, A. V. Kirichenko, T. I. Axenovich

“…For some of the several hundreds of genes located in these loci, roles in the pathogenesis of the disease have been shown. However, the genetic mechanisms and specific genes controlling this disease are still not fully understood. …”
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Targeting B and T Lymphocyte Attenuator Regulates Lupus Disease Development in NZB/W Mice by Gherardi L, Aubergeon L, Sayah M, Fauny JD, Dumortier H, Monneaux F

“…Regarding its mode of action, we demonstrated that the 6F7 antibody is not a depleting antibody and does not block HVEM binding to BTLA, but instead induces BTLA down modulation and exhibits in vivo agonist activity.Conclusion: Overall, our data confirm the involvement of BTLA in lupus pathogenesis and provide the first evidence that BTLA is a potential therapeutic target for the treatment of lupus.Keywords: systemic lupus erythematosus, BTLA, lupus mice, inhibitory receptors…”
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Salivary Levels of Interleukin-17 in Iranian Patients With Systemic Sclerosis by Ali Tadayon, Javad Moayedi, Mohamad Ali Nazarinia, Mahyar Malekzadeh, Sara Kazemi, Maryam Mardani

“…Considering the role of this inflammatory cytokine in tissue inflammation and its association with ACA concentration, IL-17 might be involved in the pathogenesis of SSc; however, further comprehensive studies are needed to confirm our findings. …”
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Promiscuous Chemokine Antagonist (BKT130) Suppresses Laser-Induced Choroidal Neovascularization by Inhibition of Monocyte Recruitment by Shira Hagbi-Levi, Michal Abraham, Liran Tiosano, Batya Rinsky, Michelle Grunin, Orly Eizenberg, Amnon Peled, Itay Chowers

“…Mononuclear phagocytes, including monocytes and their tissue descendants, macrophages, have long been implicated in the pathogenesis of neovascular AMD (nvAMD). Current therapies for nvAMD are based on targeting vascular endothelial growth factor (VEGF). …”
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Liver diseases: epidemiology, causes, trends and predictions by Can Gan, Yuan Yuan, Haiyuan Shen, Jinhang Gao, Xiangxin Kong, Zhaodi Che, Yangkun Guo, Hua Wang, Erdan Dong, Jia Xiao

“…Recent advances in understanding the pathogenesis of liver diseases hold critical implications and translational value for the development of novel therapeutic strategies.…”
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Exploring the role of ubiquitination modifications in migraine headaches by Qian Zhu, Qian Zhu, Jin Yang, Jin Yang, Lei Shi, Lei Shi, Jieying Zhang, Jieying Zhang, Peng Zhang, Peng Zhang, Junlong Li, Junlong Li, Xiaoli Song, Xiaoli Song

“…Migraine is a complex neurovascular disorder whose pathogenesis involves activation of the trigeminal vascular system, central and peripheral sensitization, and neuroinflammation. …”
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Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like Synoviocytes by D. Lattuada, R. Gualtierotti, K. Crotta, P. Seneci, F. Ingegnoli, C. Corradini, R. Viganò, O. Marelli, C. Casnici

“…Fibroblast-like synoviocytes (FLSs) are apoptosis-resistant and contribute to the pathogenesis of RA by producing cytokines and proteolytic enzymes, which degrade the extracellular matrix. …”
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