Ascaris lumbricoides a rare cause gastric perforation: a case report and brief literature review by Tian-Hao Xie, Tian-Hao Xie, Yan Fu, Xiang-Xiang Ren, Xin-Li Sun, Qiang Wang, Qian Sun

“…Meanwhile, this article combines cases of gastrointestinal perforation caused by AL documented in the literature since 1903, elaborates on the epidemiological characteristics, pathogenesis, diagnosis, treatment, and prevention of ascariasis, and analyzes the reasons for the occurrence of such complications.…”
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Lens disorders in degenerative myopia. Treatment options by M.H. Rabadanova, Zh.G. Oganezova, E.V. Kremkova, M.M. Yakh'yaeva

“…This article discusses the pathogenesis of cataracts with a focus on oxidative stress, which is also important for myopia progression. …”
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The Th17/Treg ratio, IL-1RA and sCD14 levels in primary HIV infection predict the T-cell activation set point in the absence of systemic microbial translocation. by Mathieu F Chevalier, Gaël Petitjean, Catherine Dunyach-Rémy, Céline Didier, Pierre-Marie Girard, Maria Elena Manea, Pauline Campa, Laurence Meyer, Christine Rouzioux, Jean-Philippe Lavigne, Françoise Barré-Sinoussi, Daniel Scott-Algara, Laurence Weiss

“…Impairment of the intestinal barrier and subsequent microbial translocation (MT) may be involved in chronic immune activation, which plays a central role in HIV pathogenesis. Th17 cells are critical to prevent MT. …”
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Evaluation of Regulatory Immune Response in Skin Lesions of Patients Affected by Nonulcerated or Atypical Cutaneous Leishmaniasis in Honduras, Central America by Gabriela Venicia Araujo Flores, Carmen Maria Sandoval Pacheco, Thaise Yumie Tomokane, Wilfredo Sosa Ochoa, Concepción Zúniga Valeriano, Claudia Maria Castro Gomes, Carlos Eduardo Pereira Corbett, Marcia Dalastra Laurenti

“…Considering that little is known about the pathogenesis of NUCL, the aim of this study was to evaluate the regulatory response in situ in skin lesions of patients affected by NUCL. …”
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B Lymphocyte—A Prognostic Indicator in Post‐Acute Pancreatitis Diabetes Mellitus by Xiaoyan Lin, Xiaoling Li, Junsheng Wang, Huiheng Liu

“…This would help clarify the pathogenesis of PPDM‐A at the cellular level and potentially provide new strategies for immunotherapy and even disease prevention. …”
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Isolation, genetic, and biological characterization of human adenovirus type 55 positive isolates from Wuhan, China by Jing Xie, Yan Wang, Huan Li, Bingxiu Tan, Zhengying Yu, Lizhong Li, Wei Zhang, Hongbin Song, Leili Jia

“…Conclusion We isolated and characterized the HAdV-55 strains circulating in Wuhan from 2018 to 2019, which may be meaningful for further studies on HAdV-55 infection and pathogenesis.…”
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A distinct metabolomic pattern revealed intestinal microenvironment factor-mediated food allergy in a BALB/c mouse model by Qiang Xie, Chenglong Liu, Wenhui Fu, Chen Chen, Dan Luo, Shimin Gu, Wentong Xue

“…Intestinal immune homeostasis plays a critical role in the pathogenesis of food allergy. However, the association between intestinal microenvironment factors and food allergy severity is not well studied. …”
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The 40S ribosomal subunit recycling complex modulates mitochondrial dynamics and endoplasmic reticulum - mitochondria tethering at mitochondrial fission/fusion hotspots by Foozhan Tahmasebinia, Yinglu Tang, Rushi Tang, Yi Zhang, Will Bonderer, Maisa de Oliveira, Bretton Laboret, Songjie Chen, Ruiqi Jian, Lihua Jiang, Michael Snyder, Chun-Hong Chen, Yawei Shen, Qing Liu, Boxiang Liu, Zhihao Wu

“…It advances our molecular understanding of RQC regulation and helps explain the pathogenesis of human proteostasis and mitochondrial dysfunction diseases.…”
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Protein palmitoylation is involved in regulating mouse sperm motility via the signals of calcium, protein tyrosine phosphorylation and reactive oxygen species by Yuping Xiong, Chenchen Yi, Haixia Zheng, Ya Ni, Yamei Xue, Kun Li

“…It is also implicated in the pathogenesis of diseases, such as cancer, neurological disorders, inflammation, metabolic disorders, infections, and neurodegenerative diseases. …”
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The Effect of Autologous Dendritic Cell Immunotherapy on Kidney Function and Endothelial Dysfunction of Patients with Diabetic Kidney Disease (DKD): An Open Label Clinical Trial by Martina Lily Yana, Enda Cindylosa Sitepu, Jonny, Linda Chiuman, I Nyoman Ehrich Lister, Terawan Agus Putranto

“…Endothelial dysfunction induced by inflammation is one of the key factors in the pathogenesis of DKD. In this one-group pretest–posttest quasi-experimental study, 69 subjects with DKD were administered a single dose of autologous DC immunotherapy ex vivo. …”
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Hypergammaglobulinemia in Hidradenitis Suppurativa Patients: A New Emerging Association by Martora F, Battista T, Giordano A, Potestio L, Megna M

“…The findings suggest further investigation is needed to determine whether hypergammaglobulinemia is merely a marker or contributes to HS pathogenesis. If validated, hypergammaglobulinemia could be used to monitor disease progression and customize treatments. …”
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High mobility group box 1 (HMGB1) mediates nicotine-induced podocyte injury by Sayantap Datta, Mohammad Atiqur Rahman, Saisudha Koka, Krishna M. Boini

“…High mobility group box 1(HMGB1) is a highly conserved non-histone chromatin associated protein that largely contributes to the pathogenesis of chronic inflammatory and autoimmune diseases such as sepsis, atherosclerosis, and chronic kidney diseases. …”
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Negative Expression of DSG1 and DSG2, as Prognostic Biomarkers, Impacts on the Overall Survival in Patients with Extrahepatic Cholangiocarcinoma by Shu Xu, Shengfu Huang, Daiqiang Li, Qiong Zou, Yuan Yuan, Zhulin Yang

“…Negative protein expression of DSG1 and DSG2 is closely related to the pathogenesis, severe clinicopathological characteristics, aggressive biological behaviours, and dismal prognosis in EHCC.…”
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Poly ADP-Ribosylation in a Plant Pathogenic Oomycete <i>Phytophthora infestans</i>: A Key Controller of Growth and Host Plant Colonisation by Viktoriya O. Samarskaya, Sofya Koblova, Tatiana Suprunova, Eugene A. Rogozhin, Nadezhda Spechenkova, Sofiya Yakunina, Andrew J. Love, Natalia O. Kalinina, Michael Taliansky

“…Virulence test on detached leaves also suggests an important role of ADP-ribosylation in <i>Phytophthora</i> host plant colonisation and pathogenesis. On a practical level, our data suggest that targeting the PARylation system may constitute a novel powerful approach for the management of <i>Phytophthora</i> diseases.…”
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Quantitative proteomic studies of the intestinal mucosa provide new insights into the molecular mechanism of ulcerative colitis by Yandong Guo, Dahal Pabitra, Lei Pan, Lanbo Gong, Aimin Li, Side Liu, Jing Xiong

“…Conclusions The pathways, networks, and proteins identified in this study may provide new insights into the molecular pathogenesis of UC. Further studies are required to determine if the proteins identified may help in the diagnosis and treatment of UC.…”
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The Gut Microbiota in Women Suffering from Gestational Diabetes Mellitus with the Failure of Glycemic Control by Lifestyle Modification by Guangyong Ye, Long Zhang, Min Wang, Yunbo Chen, Silan Gu, Keyi Wang, Jianhang Leng, Yujia Gu, Xinyou Xie

“…Increasing evidences suggest that gut microbiota plays a role in the pathogenesis of GDM. Lifestyle modification is the cornerstones of GDM treatment. …”
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Nε-Carboxymethyl-Lysine Negatively Regulates Foam Cell Migration via the Vav1/Rac1 Pathway by Zhengyang Bao, Lili Zhang, Lihua Li, Jinchuan Yan, Qiwen Pang, Zhen Sun, Yue Geng, Lele Jing, Chen Shao, Zhongqun Wang

“…Previous studies have shown that the Vav1/Rac1 pathway affects the macrophage cytoskeleton and cell migration, but its role in the pathogenesis of diabetic atherosclerosis is unknown. …”
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PEDF Overexpression Ameliorates Cardiac Lipotoxicity in Diabetic Cardiomyopathy via Regulation of Energy Metabolism by Mao T, Wang Y

“…Tuohua Mao, Ye Wang Department of Endocrinology, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of ChinaCorrespondence: Ye Wang, Department of Endocrinology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang, Wuhan, Hubei, 430060, People’s Republic of China, Email wye2018@whu.edu.cnBackground: Early alterations in cardiac energy metabolism and lipotoxicity are crucial factors in the pathogenesis and progression of diabetic cardiomyopathy (DCM). …”
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Xanthone and Flavone Derivatives as Dual Agents with Acetylcholinesterase Inhibition and Antioxidant Activity as Potential Anti-Alzheimer Agents by Inês Cruz, Ploenthip Puthongking, Sara Cravo, Andreia Palmeira, Honorina Cidade, Madalena Pinto, Emília Sousa

“…Considering that the malfunctions of different, but interconnected, biochemical complex pathways play an important role in the pathogenesis of this disease, a promising therapy may consist in administration of drugs that act on more than a target on biochemical scenery of AD. …”
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Rare variants in previously identified linkage regions associated with carotid plaque in Dominican Republic families. by Nicole D Dueker, Ashley Beecham, Liyong Wang, Chuanhui Dong, Ralph L Sacco, Susan H Blanton, Tatjana Rundek

“…In conclusion, using targeted sequencing of previously-identified linkage regions, we have identified suggestive evidence for the role of RVs in carotid plaque pathogenesis.…”
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