Phytomedicine Potential of <i>Oroxylum indicum</i> Root and Its Constituents: Targeting Alzheimer’s Disease by Rattana Summat, Pornthip Waiwut, Supawadee Daodee, Natsajee Nualkaew, Khemjira Phemphunananchai, Puguh Novi Arsito, Yaowared Chulikhit, Orawan Montakantirat, Charinya Khamphukdee, Chantana Boonyarat

“…These findings suggest that <i>O. indicum</i> root extract, particularly baicalein, possesses multifaceted neuroprotective properties, targeting various aspects of AD pathogenesis, including oxidative stress, cholinergic dysfunction, β-amyloid formation, aggregation, and apoptosis. …”
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STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines by Pan Jiang, Huai Huang, Zilong Liu, Guiling Xiang, Xiaodan Wu, Shengyu Hao, Shanqun Li

“…Conclusion These findings exhibit the critical role of STAT6 in the pathogenesis of CIH induced PH by regulating Th2 immune response.STAT6 could be a significant therapeutic target for OSA-related PH.…”
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Periductal Mastitis: An Inflammatory Disease Related to Bacterial Infection and Consequent Immune Responses? by Lu Liu, Fei Zhou, Pin Wang, Lixiang Yu, Zhongbing Ma, Yuyang Li, Dezong Gao, Qiang Zhang, Liang Li, Zhigang Yu

“…Bacterial infection and the increased expression of some proinflammatory cytokines are associated with the pathogenesis of this disease.…”
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Correlation between Serum IL-35 Levels and Bone Loss in Postmenopausal Women with Rheumatoid Arthritis by Yuxuan Li, Lutian Yao, Siyan Liu, JishengWu, Liping Xia, Hui Shen, Jing Lu

“…IL-35, an important anti-inflammatory cytokine, may participate in the pathogenesis of bone loss in postmenopausal women with RA.…”
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Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model by Musaad A. Alshammari, Mohammad R. Khan, Fawaz Alasmari, Abdulaziz O. Alshehri, Rizwan Ali, Mohamed Boudjelal, Khalid A. Alhosaini, Abdurahman A. Niazy, Tahani K. Alshammari

“…Our results provide potential evidence for previously undescribed mechanisms that may play a role in the pathogenesis of autistic-like phenotypes in BTBR mice.…”
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Diagnostic potential of urinary CX3CL1 for amnestic mild cognitive impairment and Alzheimer’s disease by Yali Xu, Yali Xu, Jie Zhang, Jie Zhang, Ying-Ying Shen, Wei-Wei Li, Bin Li, Hai-Ping Cheng, Gui-Hua Zeng

“…IntroductionThe role of the chemokine CX3CL1 in the processes of aging and Alzheimer’s disease (AD) pathogenesis is well-established. This study aims to evaluate the diagnostic potential of urinary CX3CL1 levels in distinguishing between AD patients, those experiencing amnestic mild cognitive impairment (aMCI), and cognitively normal (CN) individuals.MethodsA cohort comprising 516 CN individuals across various age groups, 102 AD patients, and 65 subjects with aMCI was assembled, alongside 93 age- and sex-matched CN controls. …”
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UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway by Lijie Yang, Penghui Si, Tuoheti Kuerban, Linfa Guo, Shanzhi Zhan, Yisha Zuhaer, Yingtong Zuo, Peixiang Lu, Xiaojie Bai, Tongzu Liu

“…UHRF1, as a critical epigenetic regulator, may play an essential role in the pathogenesis and progression of renal fibrosis and EMT. …”
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Neutrophils Are Dysregulated in Patients with Hereditary Angioedema Types I and II in a Symptom-Free Period by Tereza Grymova, Marcela Vlkova, Premysl Soucek, Roman Hakl, Jana Nechvatalova, Peter Slanina, Julie Stichova, Jiri Litzman, Tomas Freiberger

“…Neutrophils impact on processes preceding the formation of bradykinin, a major swelling mediator in hereditary angioedema (HAE), yet their potential role in HAE pathogenesis has not been sufficiently studied. We assessed the relative mRNA expression of 10 genes related to neutrophil activation using RNA extracted from the peripheral blood neutrophils of 23 HAE patients in a symptom-free period and 39 healthy donors. …”
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The association between dietary sodium density and Hashimoto’s thyroiditis in US adults by Peilin An, Silin Wang, Lingyun Liu, Xuelin Li, Xin Lv, Xin Lv

“…Higher sodium density was also associated with increased TPOAb positivity (OR 1.28, 95% CI 1.05–1.56), but not TgAb positivity.ConclusionElevated dietary sodium density is associated with an increased risk of HT and TPOAb positivity, suggesting that sodium intake may play a role in the pathogenesis of HT.…”
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Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms by Haiyang Li, Wenjian Jiang, Weihong Ren, Dong Guo, Jialong Guo, Xiaolong Wang, Yuyong Liu, Feng Lan, Jie Du, Hongjia Zhang

“…In summary, through assessment of clinical samples, we revealed the association between downregulation of YAP in VSMCs and the development of ascending aortic aneurysms, providing new insight into the pathogenesis of this disease.…”
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Prognostic Factors of Liposarcoma in Head and Neck by Shuo DING, Zhigang HUANG, Jugao FANG, Yang ZHANG, Lizhen HOU, Wei GUO, Gaofei YIN, Qi ZHONG

“…ObjectiveTo explore the pathogenesis and prognostic factors of liposarcoma in the head and neck region, and simultaneously analyze the efficacy of different treatment regimens. …”
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Methyl Canthin-6-one-2-carboxylate Inhibits the Activation of the NLRP3 Inflammasome in Synovial Macrophages by Upregulating Nrf2 Expression by Yuanyuan Chen, Zongying Zhang, Yuan Yao, Xiaorong Zhou, Yong Ling, Liming Mao, Zhifeng Gu

“…Previous studies have indicated that the aberrant activation of the NLRP3 inflammasome in synovial macrophages plays a significant role in the pathogenesis of RA and has been regarded as a therapeutic target for the disease. …”
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HSPB1 Regulates Autophagy and Apoptosis in Vascular Smooth Muscle Cells in Arteriosclerosis Obliterans by Keqin Chen, Changmiao Hou, Lei Xu, Hanwu Peng, Chaogui He, Jing Liu, Guoqing Wang, Shaoshuai Huang, Xiehong Liu

“…However, the roles of HSPB1 in autophagy and apoptosis in the context of ASO pathogenesis remain unclear. Methods. In vivo and in vitro studies were used to determine whether HSPB1 is associated with ASO progression. …”
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Autoantibodies to NR2A Peptide of the Glutamate/NMDA Receptor in Patients with Seizure Disorders in Neuropsychiatric Systemic Lupus Erythematosus by Yan Yang, Chao Yuan, Shu-qun Shen, Xue-er Wang, Qing-hua Mei, Wen-qing Jiang, Qin Huang

“…We suggest that anti-NR2A antibodies play a role in the pathogenesis of NPSLE with seizure disorders.…”
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Immune-mediated mechanisms in acute osteofascial compartment syndrome: insights from multi-omics analysis by Qinzhen Lu, He Ling, Yonghui Lao, Junjie Liu, Wei Su, Zhao Huang

“…Furthermore, these findings reveal the interactions between immune molecules and pathways in AOCS, which are significant for a deeper understanding of the pathogenesis of the disease and the development of targeted therapeutic strategies.…”
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Detection of Insulin in Insulin-Deficient Islets of Patients with Type 1 Diabetes by Yuliya Krivova, Alexandra Proshchina, Dmitry Otlyga, Anastasia Kharlamova, Sergey Saveliev

“…Future studies are needed to evaluate the role of α-cells in insulin secretion and diabetes pathogenesis.…”
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Challenges in Diagnosing Intrahepatic Cholangiolithiasis in a 39-Year-Old Patient by A. K. Guseva, O. N. Sergeyeva, T. P. Nekrasova, O. T. Imaraliev, A. V. Okhlobystin, Y. N. Shirokova, A. S. Ostrovskaya, M. S. Zharkova, A. S. Cherenda, V. T. Ivashkin

“…The presented clinical case demonstrates the difficulties in assessing pathogenesis, choosing diagnostic and therapeutic approaches in patients with severe intrahepatic lithiasis that may mimic hepatic neoplasm. …”
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Correlation of serum Vitamin D levels and disease severity in patients with atopic dermatitis: A hospital-based, cross-sectional study from North India by Shreya Malhan, Loveleen Kaur, Maninder Kaur, Dimple Chopra, Sharang Gupta, Snehdeep Kaur

“…INTRODUCTION: Atopic dermatitis (AD) is a chronic, inflammatory relapsing, and remitting skin condition with a profound impact on the quality of life of the patient as well as the caregivers. Although its pathogenesis is multifactorial, Vitamin D is now postulated to play a complex and multifaceted role in the development and progression of AD. …”
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Morphological and molecular changes in renal tissue following experimental unilateral ureteral obstruction in rat kidneys by Tuncer KUTLU, Huseyin OZKAN, Ziya YURTAL, Ufuk KAYA, Mehmet GUVENC

“…In conclusion; these results provide valuable insights for future studies on UUO pathogenesis and research into potential treatment modalities.…”
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Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications by Alina Mihaela Leustean, Manuela Ciocoiu, Anca Sava, Claudia Florida Costea, Mariana Floria, Claudia Cristina Tarniceriu, Daniela Maria Tanase

“…The purpose of this article is to highlight issues related to the involvement of microbiota and trimethylamine N-oxide in the pathogenesis of diabetes mellitus and cardiovascular disease. …”
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