Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension by Ulla Kampmann, Ole N. Mathiassen, Kent L. Christensen, Niels H. Buus, Mette Bjerre, Henrik Vase, Niels Møller, Anne Kaltoft, Per L. Poulsen

“…Increased sympathetic activity is important in the pathogenesis of hypertension and insulin resistance. …”
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Drug-Induced Liver Injuries (Clinical Guidelines for Physicians) by Vladimir T. Ivashkin, Andrey Yu. Baranovsky, Karina L. Raikhelson, Lyudmila K. Palgova, Marina V. Maevskaya, Elina A. Kondrashina, Natalya V. Marchenko, Tatyana P. Nekrasova, Igor G. Nikitin

“…The criteria and types of DILI are described in detail, with the most reliable diagnostic and prognostic scales and indices being provided. The pathogenesis and risk factors for the development of DILI are considered. …”
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Changes in the transcriptome of the prefrontal cortex of OXYS rats as the signs of Alzheimer’s disease development by N. A. Stefanova, E. E. Korbolina, N. I. Ershov, E. I. Rogaev, N. G. Kolosova

“…There are no effective prophylactic inter­ventions because of insufficient understanding of the AD pathogenesis and the absence of adequate experimental models. …”
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Molecular Detection of FIPV among Imported Felines through Soekarno Hatta Airport, Indonesia by Fidyah Fitrawati, Suwarno, Ira Sari Yudaniayanti, Jola Rahmahani, Muchammad Yunus, Soeharsono, Desniwaty Karo-karo, Haeriah

“…Further research is needed to better understand the mechanism causing genetic diversification of FCoV or FIPV and its impact on the pathogenesis of FIP. Furthermore, the application of FIP vaccines from other countries should be tested for compatibility with the FIPV strains present in Indonesia.…”
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Leptin Receptor Deficiency Protects Mice against Chronic Cerebral Hypoperfusion-Induced Neuroinflammation and White Matter Lesions by Yu Du, Yufei Song, Xiaojie Zhang, Yan Luo, Wenying Zou, Jiawei Zhang, Jianliang Fu

“…But whether leptin participates in the pathogenesis of CCH-induced WMLs remains unknown. Therefore, we performed bilateral common carotid artery stenosis (BCAS) to induce CCH on the leptin receptor- (LepR-) deficient db/db mice, aiming to evaluate the possible involvement of leptin in CCH-induced cognitive impairment, WMLs, and neuroinflammation, and further explore the effect of leptin on chronic hypoxia-induced inflammation using the BV2 microglial cell line. …”
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Effect of miR-223-3p and miR-328a-3p Knockdown on Allergic Airway Inflammation in Rat Precision-Cut Lung Slices by Joanna Nowakowska, Maria Kachel, Wojciech Langwiński, Kamil Ziarniak, Aleksandra Szczepankiewicz

“…Asthma is a major non-communicable disease whose pathogenesis is still not fully elucidated. One of the asthma research models is precision-cut lung slices (PCLSs), and among the therapeutic options, miRNA molecules are of great interest. …”
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The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters by Monika Walankiewicz, Ewelina Grywalska, Grzegorz Polak, Izabela Korona-Glowniak, Elzbieta Witt, Agata Surdacka, Jan Kotarski, Jacek Rolinski

“…Alteration of the PD-1/PD-L1 axis may contribute to the pathogenesis of endometriosis, as patients with advanced disease are characterized by higher frequencies of PD-1-positive T and B cells. …”
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The associations between diet-induced inflammation and the improvement or worsening of hepatic steatosis and fibrosis: a longitudinal analysis of RaNCD cohort study by Mohammad Sedighi, Amir Saber, Amir Bagheri, Saba Hazratian, Yahya Pasdar, Farid Najafi, Mehdi Moradinazar, Davood Soleimani

“…Abstract Background Persistent inflammation plays a crucial role in the pathogenesis of metabolic dysfunction–associated steatotic liver disease (MASLD). …”
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HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics analysis by Enhao Wang, Shazhou Li, Yang Li, Tao Zhou

“…Conclusion HMOX1 may have a protective role in the pathogenesis of upper and lower airway diseases (CRSwNP, AR, and AS) by modulating oxidative stress. …”
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The Role of Inflammation in Crohn’s Disease Recurrence after Surgical Treatment by B. Sensi, L. Siragusa, C. Efrati, L. Petagna, M. Franceschilli, V. Bellato, A. Antonelli, C. Arcudi, M. Campanelli, S. Ingallinella, A. M. Guida, A. Divizia

“…To review the numerous factors involved in CD postoperative recurrence (POR) pathogenesis, focusing on single immune system components as well as the immune system as a whole and highlighting the clinical significance in terms of preventive strategies and future perspectives. …”
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Dangerous Liaison: Helicobacter pylori, Ganglionitis, and Myenteric Gastric Neurons: A Histopathological Study by Liana Sticlaru, Florica Stăniceanu, Mirela Cioplea, Luciana Nichita, Alexandra Bastian, Gianina Micu, Cristiana Popp

“…These findings could help gain understanding of some still unclear aspects of pathogenesis of H. pylori infection, with the possibility of having broader implications for gastric cancer progression.…”
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Malondialdehyde in Exhaled Breath Condensate as a Marker of Oxidative Stress in Different Pulmonary Diseases by M. L. Bartoli, F. Novelli, F. Costa, L. Malagrinò, L. Melosini, E. Bacci, S. Cianchetti, F. L. Dente, A. Di Franco, B. Vagaggini, P. L. Paggiaro

“…Oxidative stress plays a role in the pathogenesis of many chronic inflammatory lung diseases. …”
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Molecular Signature of miR-34a/NEAT-1/p53 Axis in Mycosis Fungoides by Reham Fares, Shimaa M. Elasmer, Abeer Khalefa A., Olfat G. Shaker, Samar M. El-Tahlawi, Ahmed Sabri, Sara M. Yaseen

“…To evaluate the serum levels of NEAT-1, miR-34a, and p53 in MF patients and its relation to healthy controls to indicate whether it has a potential role in the pathogenesis of the disease. Subjects and Methods. This prospective case-control study was carried out on 75 subjects subdivided into two groups, 35 MF patients (stages 1 and II) and 40 matched healthy controls. …”
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Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis by He Cao, Zhi Cao, Yue Han, Jing Shan

“…This study aims to design a novel multi-epitope vaccine targeting HSV-1 glycoproteins B, C, D, H, and L using an immuno-informatics approach, which are essential for viral entry and pathogenesis.MethodsThe study identified epitopes for CD8+ T cells, CD4+ T cells, and B cells within the target glycoproteins. …”
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The Use of Benzodiazepines in the Management of Hypertensive Crisis: A Literature Review by Łukasz Stojak, Mateusz Grego, Mateusz Baczewski, Dariusz Popiela, Karina Urbańska, Katarzyna Grego, Filip Kwiatkowski, Witold Czyż

“… Hypertensive crisis is a medical emergency that requires urgent pharmacological intervention to prevent organ damage. The pathogenesis of this condition is often linked to excessive sympathetic nervous system activation resulting from a strong stress response. …”
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Mutational Analysis of Extranodal NK/T-Cell Lymphoma Using Targeted Sequencing with a Comprehensive Cancer Panel by Seungkyu Choi, Jai Hyang Go, Eun Kyung Kim, Hojung Lee, Won Mi Lee, Chun-Sung Cho, Kyudong Han

“…Although extranodal NKTCL reportedly has a strong association with Epstein-Barr virus, the molecular pathogenesis of NKTCL has been unexplored. The recent technological advancements in next-generation sequencing (NGS) have made DNA sequencing cost- and time-effective, with more reliable results. …”
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Cytokine and Chemokine Profile in Patients with Multiple Myeloma Treated with Bortezomib by Paweł Robak, Edyta Węgłowska, Izabela Dróżdż, Damian Mikulski, Dariusz Jarych, Magdalena Ferlińska, Ewa Wawrzyniak, Małgorzata Misiewicz, Piotr Smolewski, Wojciech Fendler, Janusz Szemraj, Tadeusz Robak

“…In conclusion, distinct cytokines are involved in the pathogenesis of MM and may play a prominent role in the prediction of treatment response. …”
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Clinical Outcomes of Diffuse Axonal Injury According to Radiological Grade by Hak-Jae Lee, Hyun-Woo Sun, Jae-Seok Lee, Nak-Joon Choi, Yoon-Joong Jung, Suk-Kyung Hong

“…Recent researches have revealed the underlying mechanism and pathogenesis of diffuse axonal injury. This study aimed to investigate the correlation between the radiological grading of diffuse axonal injury and the clinical outcomes of patients. …”
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Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis by Yan Li, Mi Zhou, Xiuying Lv, Lina Song, Di Zhang, Yan He, Mian Wang, Xue Zhao, Xiaoqing Yuan, Guixiu Shi, Dashan Wang

“…Aberrant histone acetylation and deacetylation are increasingly thought to play important roles in the pathogenesis of rheumatoid arthritis (RA). However, limited data from studies about the activity of histone deacetylases (HDACs) and histone acetyltransferase (HAT) in RA are controversial. …”
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DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations by Jason Sheng Li, Karen Riggins, Li Yang, Chaorong Chen, Patricia Castro, Wedad Alfarkh, Neda Zarrin-Khameh, Michael E. Scheurer, Chad J. Creighton, Benjamin Musher, Wei Li, Lanlan Shen

“…Our exploratory findings in this cohort highlight epigenetic mechanisms underlying the pathogenesis of EOCRC and nominate novel biomarkers for EOCRC in underrepresented populations.…”
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