Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s Disease... by Long Li, Le Li, Jiayong Zhang, Sheng Huang, Weilin Liu, Zhifu Wang, Shengxiang Liang, Jing Tao, Lidian Chen

“…Microglia seemingly demonstrate two contradictory phenotypes in response to different microenvironmental cues, the M1 phenotype and the M2 phenotype, which are detrimental and beneficial to pathogenesis, respectively. Inhibiting the M1 phenotype with simultaneous promoting the M2 phenotype has been suggested as a potential therapeutic approach for cure AD. …”
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A collaborative network analysis for the interpretation of transcriptomics data in Huntington’s disease by Ozan Ozisik, Nazli Sila Kara, Tooba Abbassi-Daloii, Morgane Térézol, Elsa C. Kuijper, Núria Queralt-Rosinach, Annika Jacobsen, Osman Ugur Sezerman, Marco Roos, Chris T. Evelo, Anaïs Baudot, Friederike Ehrhart, Eleni Mina

“…Among the resulting enriched pathways, there are pathways that have been shown previously to be involved in Huntington’s disease and pathways whose direct contribution to disease pathogenesis remains unclear and requires further investigation. …”
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Genotyping of HCV RNA Reveals That 3a Is the Most Prevalent Genotype in Mardan, Pakistan by Sajid Ali, Ayaz Ahmad, Raham Sher Khan, Sanaullah Khan, Muhammad Hamayun, Sumera Afzal Khan, Amjad Iqbal, Abid Ali Khan, Abdul Wadood, Taj Ur Rahman, Ali Hydar Baig

“…Identification of the infecting virus genotype is indispensable for the exploration of many aspects of HCV infection, including epidemiology, pathogenesis, and response to antiviral therapy. 1419 individuals were screened for anti-HCV in this study, of which 166 (11.7%) were found reactive by ICT (Immunochromatographic test). …”
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Age-Related Macular Degeneration: Insights into Inflammatory Genes by Raffaella Cascella, Michele Ragazzo, Claudia Strafella, Filippo Missiroli, Paola Borgiani, Francesco Angelucci, Luigi Tonino Marsella, Andrea Cusumano, Giuseppe Novelli, Federico Ricci, Emiliano Giardina

“…Taking into consideration the genetic and molecular background, this review highlights the genetic role of inflammatory genes involved in AMD pathogenesis and progression.…”
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Probiotics alleviate painful diabetic neuropathy by modulating the microbiota–gut–nerve axis in rats by Ye Jiang, Jing Yang, Min Wei, Jiayin Shou, Shixiong Shen, Zhuoying Yu, Zixian Zhang, Jie Cai, Yanhan Lyu, Dongsheng Yang, Yongzheng Han, Jinpiao Zhu, Zhigang Liu, Daqing Ma, Guo-gang Xing, Min Li

“…Together, our findings suggest that gut microbiota dysbiosis participates in PDN pathogenesis, and probiotics offer therapeutic potential via modulating the microbiota-gut-nerve axis. …”
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Pituitary Stalk Interruption Syndrome: A Case and Literature Review by Anuja Choure, MD, Leena Shahla, MD

“…Discussion: PSIS is a rare condition with uncertain pathogenesis and variable presentation requiring a high index of suspicion and presenting with multiple anterior pituitary hormone deficiencies. …”
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Association Between Platelet-Albumin-Bilirubin Grade and the 30-Day Mortality in Patients with Acute Respiratory Distress Syndrome: Evidence from the MIMIC-IV Database by Dandan Ye, Wei Jiang, Deming Gu

“…Liver dysfunction is a key determinant of the pathogenesis and resolution of acute respiratory distress syndrome (ARDS), which affects the prognosis of patients. …”
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Exploratory analysis of a Novel RACK1 mutation and its potential role in epileptic seizures via Microglia activation by Sai Zhang, Zhaofei Dong, Jing Guo, Ze Li, Hong Wu, Linming Zhang, Fuli Min, Tao Zeng

“…Abstract Seizures is a prevalent neurological disorder with a largely elusive pathogenesis. In this study, we identified the key gene RACK1 and its novel mutation RACK1-p.L206P as being associated with seizures through single-cell transcriptome sequencing (scRNA-seq) and whole exome sequencing (WES) techniques. …”
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Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice by Jung-Yeon Kim, Jae-Hyung Park, Kiryeong Kim, Jungmin Jo, Jaechan Leem, Kwan-Kyu Park

“…Caspase-1 is a proinflammatory caspase responsible for the proteolytic conversion of the precursor forms of interleukin-1β to its active form and plays an important role in the pathogenesis of various inflammatory diseases. It was reported that genetic deficiency of caspase-1 prevented cisplatin-induced nephrotoxicity. …”
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Melanoma Development and Progression Are Associated with Rad6 Upregulation and β-Catenin Relocation to the Cell Membrane by Karli Rosner, Darius R. Mehregan, Evangelia Kirou, Judith Abrams, Seongho Kim, Michelle Campbell, Jillian Frieder, Kelsey Lawrence, Brittany Haynes, Malathy P. V. Shekhar

“…While β-catenin has been implicated in melanoma pathogenesis, Rad6 function has not been investigated. …”
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Extracellular Vesicles and Tunnelling Nanotubes as Mediators of Prostate Cancer Intercellular Communication by Jessica K. Heatlie, Joanna Lazniewska, Courtney R. Moore, Ian R. D. Johnson, Bukuru D. Nturubika, Ruth Williams, Mark P. Ward, John J. O’Leary, Lisa M. Butler, Doug A. Brooks

“…Prostate cancer (PCa) pathogenesis relies on intercellular communication, which can involve tunnelling nanotubes (TNTs) and extracellular vesicles (EVs). …”
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CLINICAL SIGNS AND TREATMENT OF NEW-ONSET BONE MARROW FAILURE ASSOCIATED SARS-COV-2 INFECTION IN CHILDREN : A SINGLE INSTITUTION PROSPECTIVE COHORT STUD by Mervat A M youssef, Ebtisam Shawky hmed, Dalia Tarik Kamal, khalid Elsayh, Mai A Abdelfatta, Hyam Hassan Mahran Mahran, Mostafa M Embaby

“…Conclusion: SARS-CoV-2 virus is added to several viral infections known to be implicated in the pathogenesis of aplastic anaemia. Studies are needed to establish a definitive association and determine whether the response of bone marrow failure to standard therapy differ from that of idiopathic cases. …”
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Muribaculum intestinale-derived 3-hydroxybutyric acid from Heterophyllin B attenuated pulmonary fibrosis through IDO1-mediated ferroptosis by Ce Chen, Jialin Wang, Mengqin Cheng, Haifeng Xie, Wei Li, Chaofeng Zhang

“…Pulmonary fibrosis (PF) is a fatal disease with increasing incidence, poor prognosis, and unclear pathogenesis. Our previous research demonstrated the beneficial effects of the natural cyclopeptide Heterophyllin B (HB) in PF. …”
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New Insights on Childhood Lupus Nephritis by Marchi-Silva R, De Aquino BM, Londe AC, Mazzola TN, Julio PR, Wampler Muskardin T, Appenzeller S

“…In this article, we review lupus nephritis in cSLE, including pathogenesis, diagnosis, biomarkers, and management through PUBMED search between July and December 2024. …”
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Transcript Changes of Placental Tissue in Gestational Diabetes Mellitus Based on Transcriptome Sequencing by Sun Y, Wang Y, Liu C, Yang J, Li Q, Zhao F

“…Yun Sun,1,* Yi Wang,1,* Chao Liu,2 Jie Yang,3 Qinwen Li,1 Fei Zhao1 1Department of Obstetrics, The Affiliated Taian City Central Hospital of Qingdao University, Taian, People’s Republic of China; 2Department of Obstetrics, Taian Maternal and Child Care Health Hospital, Taian, People’s Republic of China; 3Department of Gynaecology and Obstetrics, Liangshan County People’s Hospital, Jining, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qinwen Li; Fei Zhao, Department of Obstetrics, Taian Central Hospital (Taian Central Hospital affiliated to Qingdao University, Mount Taishan Medical Center), No. 29, Longtan Road, Mount Taishan District, Taian, Shandong, 271000, People’s Republic of China, Tel +86-13505482692, Email lqw81@126.com; 13505482692@163.comPurpose: This study aims to identify key genes that may be involved in the pathogenesis of gestational diabetes mellitus and to preliminarily elucidate the underlying mechanisms.Methods: High-throughput transcriptome sequencing was employed to identify Differentially expressed genes (DEGs) in placental tissue samples of GDM and normal pregnant women. …”
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Algorithm of selecting the tear replacement therapy in ambulatory practice by V.V. Brzheskiy

“…<br> <b>Results</b>: the choice of the «artificial tear» preparation depends on the pathogenesis of the dry eye syndrome, the severity of its clinical course and the concomitant pathology of the cornea and conjunctiva in a particular patient. …”
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Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study by Wenyan Jiang, Yiwu Lei, Jing Wei, Lu Yang, Shubao Wei, Qiong Yin, Shuguang Luo, Wenbin Guo

“…Local abnormalities and interhemispheric interaction deficits in the sensorimotor network (SMA, postcentral gyrus, and PCu), default mode network (MPFC and PCu), and basal ganglia may be the key characteristics in the pathogenesis mechanism of CD.…”
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Comprehensive Iranian guidelines for the diagnosis and management of maple syrup urine disease: an evidence- and consensus- based approach by Noushin Rostampour, Setila Dalili, Hossein Moravej, Zhila Afshar, Negar Yazdani, Seyedeh Tahereh Mousavi, Parastoo Rostami, Daniel Zamanfar, Maryam Yahay, Abdolhossein Nikravesh, Zahra Beyzaei, Mohamad Ahangar Davoodi, Atefeh Sedaghat, Tahora Hakemzadeh, Ali Talea

“…This article considers pathogenesis, epidemiology, clinical manifestations, diagnosis, treatment, and monitoring of MSUD patients with limited recourse.…”
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LINC01355 Contributes to Malignant Phenotype of Oral Squamous Cell Carcinoma and Cytotoxic T Cell Infiltration via Activating Notch Signaling Pathway by Chen Zou, Siyuan Wu, Haigang Wei, Hailing Luo, Zhe Tang, Xia Li, Xiaozhi Lv, Yilong Ai

“…However, the exact molecular function of LINC01355 in the pathogenesis of OSCC remains unstudied. Here, we reported the effect of LINC01355 in OSCC and investigated the mechanisms. …”
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Increased IL-21 Expression Induces Granzyme B in Peripheral CD5+ B Cells as a Potential Counter-Regulatory Effect in Primary Sjögren’s Syndrome by Gábor Papp, Edit Gyimesi, Krisztina Szabó, Éva Zöld, Margit Zeher

“…Our results suggest that enhanced IL-21R expression of CD19+CD5+ B cells and production of IL-21 by iNKT cells may play an important role in the pathogenesis of pSS by regulating CD19+CD5+ B cell functions and increasing GrB production, presumably leading to a counter-regulatory effect in the disease.…”
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