Gambaran Jumlah Eosinofil Darah Tepi Penderita Asma Bronkial di Bangsal Paru RSUP Dr. M. Djamil Padang by Demas Nico M Manurung, Ellyza Nasrul, Irvan Medison

“…One of cells which is known to play a major role in asthma pathogenesis is eosinophil. Eosinophil release a variety of mediators such as Major Basic Protein, Eosinophil Cationic Protein, Eosinophil Peroxidase, Leukotriene C4, and Platelet Activating Factor that will damage airway epithelium and cause inflammation. …”
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Exome Sequencing Identified a Recessive RDH12 Mutation in a Family with Severe Early-Onset Retinitis Pigmentosa by Bo Gong, Bo Wei, Lulin Huang, Jilong Hao, Xiulan Li, Yin Yang, Yu Zhou, Fang Hao, Zhihua Cui, Dingding Zhang, Le Wang, Houbin Zhang

“…Our results emphasize the importance of c.437T<A (p.V146D) substitution in RDH12 and provide further support for the causative role of this mutation in the pathogenesis and clinical diagnosis of RP.…”
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PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women by H. Gbelcová, P. Bakeš, P. Priščáková, V. Šišovský, I. Hojsíková, Ľ. Straka, M. Konečný, J. Markus, C. W. D’Acunto, T. Ruml, D. Böhmer, Ľ. Danihel, V. Repiská

“…Loss of PTEN function has been implicated in the pathogenesis of a number of different tumors, particularly endometrial carcinoma (ECa). …”
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Associations among circulating sphingolipids, β-cell function, and risk of developing type 2 diabetes: A population-based cohort study in China. by Huan Yun, Liang Sun, Qingqing Wu, Geng Zong, Qibin Qi, Huaixing Li, He Zheng, Rong Zeng, Liming Liang, Xu Lin

“…<h4>Background</h4>Animal studies suggest vital roles of sphingolipids, especially ceramides, in the pathogenesis of type 2 diabetes (T2D) via pathways involved in insulin resistance, β-cell dysfunction, and inflammation, but human studies are limited. …”
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Blood absolute lymphocyte count and trajectory are important in understanding severe COVID-19 by Catharine I. Paules, Jacqueline A. Nordwall, Kathryn Shaw-Saliba, Judith A. Aberg, Edward M. Gardner, Anna L. Goodman, N. Kumarasamy, Shikha Vasudeva, David M. Vock, Crystal M. North, Jens Lundgren, Neil R. Aggarwal, for the STRIVE Network and TICO Trial Study Group

“…A better understanding of the underlying risk factors for lymphopenia will help illuminate disease pathogenesis and guide management strategies.…”
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Evaluation of Inflammatory Cytokine Secretion by Human Alveolar Macrophages by J. E. Losa García, F. M. Rodríguez, M. R. Martín de Cabo, M. J. García Salgado, J. P. Losada, L. G. Villarón, A. J. López, J. L. P. Arellano

“…The alveolar macrophage (AM) secretes interleukin 1β (IL-1β), tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8), all of them inflammatory cytokines involved in the pathogenesis of many lung diseases. The aim of the present work was to evaluate the basal and stimulated secretion of these cytokines by human AMs. …”
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E3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseases by Li Zhu, Yong-Ping Liu, Yuan-Wang, Bo-Xuan Sun, Yu-Ting Huang, Ji-Kai Zhao, Jian-Feng Liu, Li-Ming Yu, Hui-Shan Wang

“…Consequently, SYVN1 plays a crucial role in both normal human physiology and the pathogenesis of various diseases, such as oncogenesis, cardiovascular disorders, immune regulation, skeletal anomalies, and neurological diseases. …”
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N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth by Joseph Gonzalez-Heydrich, Michelle Bosquet Enlow, Eugene D’Angelo, Larry J. Seidman, Sarah Gumlak, April Kim, Kristen A. Woodberry, Ashley Rober, Sahil Tembulkar, Kyle O’Donnell, Hesham M. Hamoda, Kara Kimball, Alexander Rotenberg, Lindsay M. Oberman, Alvaro Pascual-Leone, Matcheri S. Keshavan, Frank H. Duffy

“…Highly penetrant mutations leading to schizophrenia are enriched for genes coding for N-methyl-D-aspartate receptor signaling complex (NMDAR-SC), implicating plasticity defects in the disease’s pathogenesis. The importance of plasticity in neurodevelopment implies a role for therapies that target these mechanisms in early life to prevent schizophrenia. …”
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Diagnosis and Treatment of Peptic Ulcer in Adults (Clinical Guidelines of the Russian Gastroenterological Association, Russian Society of Colorectal Surgeons and the Russian Endosc... by V. T. Ivashkin, I. V. Maev, P. V. Tsar’kov, M. P. Korolev, D. N. Andreev, E. K. Baranskaya, S. G. Burkov, A. A. Derinov, S. K. Efetov, T. L. Lapina, P. V. Pavlov, S. S. Pirogov, A. V. Tkachev, A. S. Trukhmanov, E. D. Fedorov, A. A. Sheptulin

“…These clinical recommendations present modern ideas about the etiology and pathogenesis of peptic ulcer disease, its clinical manifestations, methods of laboratory and instrumental diagnostics and basic approaches to conservative and surgical treatment.…”
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Trends in incidence, mortality, and DALYs of cystic echinococcosis in Central Asia from 1992 to 2021: an age-period-cohort analysis by Wulan Talafuhan, Kaibinuer Tuoheti, Ye Lixia, Qi Shuang, Mieyier Yeerjiang, Guzalinuer Aizezi, Wei Jingjing, Peierdun Mijiti, Peierdun Mijiti

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Efferocytosis and inflammation: a bibliometric and systematic analysis by Xin Cao, Xin Cao, Fen Li, Fen Li, Xi Xie, Xi Xie, Guanghui Ling, Guanghui Ling, Xiaoyu Tang, Xiaoyu Tang, Wenfang He, Jing Tian, Jing Tian, Yan Ge, Yan Ge

“…Key areas of focus include the crucial role of efferocytosis on tissue homeostasis and the pathogenesis of nontumorous inflammatory diseases. Future research will likely continue to explore these frontiers, with an emphasis on understanding efferocytosis in the context of chronic diseases and cancer, as well as developing novel therapeutic strategies.…”
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Exosomes secreted by ATF3/Nrf2-mediated ferroptotic renal tubular epithelial cells promote M1/M2 ratio imbalance inducing renal interstitial fibrosis following ischemia and reperfu... by Qiao Tang, Jiatao Xie, Yifei Wang, Chong Dong, Chong Dong, Qian Sun

“…Although ferrptosis and macrophage polarization both play important roles in this model, their specific pathogenesis and interactions have not been elucidated. …”
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Primary Clear Cell Adenocarcinoma of the Cervix: A Clinical Analysis of 18 Cases without Exposure to Diethylstilbestrol by Dongying Wang, Chunhua Zhao, Li Fu, Yang Liu, Weiyang Zhang, Tianmin Xu

“…CCAC is a highly invasive malignant tumor, whose pathogenesis may not be associated with HPV infection. …”
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Gene networks and metabolomic screening analysis revealed specific pathways of amino acid and acylcarnitine profile alterations in blood plasma of patients with Parkinson’s disease... by A. A. Makarova, P. M. Melnikova, A. D. Rogachev, P. S. Demenkov, T. V. Ivanisenko, E. V. Predtechenskaya, S. Y. Karmanov, V. V. Koval, A. G. Pokrovsky, I. N. Lavrik, N. A. Kolchanov, V. A. Ivanisenko

“…Parkinson’s disease (PD) and vascular parkinsonism (VP) are characterized by similar neurological syndromes but differ in pathogenesis, morphology, and therapeutic approaches. …”
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Attenuated titin protein expression is associated with advanced stages of ovarian cancer by Harvey Sharma, Jaskaran Aujla, Asad Nawaz, Thabet Khasawneh, Ayesha Alvero, Robert T. Morris, Asma Basha, Laila Tutunji, Toshima Z. Parris, Khalil Helou, Ghassan M. Saed

“…Further elucidation of the mechanisms underlying attenuated titin expression holds promise for advancing our understanding of ovarian cancer pathogenesis.…”
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Burden of type 2 diabetes due to high body mass index in different SDI regions and projections of future trends: insights from the Global Burden of Disease 2021 study by Yun-fa Ding, An-xia Deng, Teng-fei Qi, Hao Yu, Liang-ping Wu, Hong-bing Zhang

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Proteomic analysis of spinal dorsal horn in prior exercise protection against neuropathic pain by Binglin Chen, Jiabao Guo, Chan Gong, Chenchen Zhu, Yang Wu, Shengbo Wang, Yili Zheng, Haixia Lu

“…Proteomic analyses revealed the potential target proteins and pathways for this process, offering valuable data resources and new insights into the pathogenesis and therapeutic targets of NP.…”
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The Role of Neuroglial Crosstalk and Synaptic Plasticity-Mediated Central Sensitization in Acupuncture Analgesia by Zhongxi Lyu, Yongming Guo, Yinan Gong, Wen Fan, Baomin Dou, Ningcen Li, Shenjun Wang, Yuan Xu, Yangyang Liu, Bo Chen, Yi Guo, Zhifang Xu, Xiaowei Lin

“…This study summarizes the pathogenesis of central sensitization from the perspective of neuroglial crosstalk and synaptic plasticity and underlines the related analgesic mechanisms of acupuncture. …”
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Globular-shaped Aβ oligomers have diverse mechanisms for promoting Aβ aggregations with the facilitation of fibril elongation by Hiroto Nakano, Sadao Hikishima, Makoto Mori, Jota Minamikawa, Daiki Muramatsu, Yasuhiro Sakashita, Tokuhei Ikeda, Moeko Noguchi-Shinohara, David B. Teplow, Kenjiro Ono

“…The results of our present research demonstrated that gAβO would have significant roles to accelerate Aβ aggregation in AD pathogenesis.225 < 250 words.…”
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Expression of Sclerostin in Osteoporotic Fracture Patients Is Associated with DNA Methylation in the CpG Island of the SOST Gene by Yanming Cao, Bin Wang, Ding Wang, Dongxiang Zhan, Caiyuan Mai, Peng Wang, Qiushi Wei, Yamei Liu, Haibin Wang, Wei He, Liangliang Xu

“…Our study demonstrated that DNA methylation influenced the transcriptional expression of SOST gene, which probably may play an important role in the pathogenesis of primary osteoporosis.…”
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