PPARD May Play a Protective Role for Major Depressive Disorder by Tao Yang, Juhua Li, Liyuan Li, Xuehua Huang, Jiajun Xu, Xia Huang, Lijuan Huang, Kamil Can Kural

“…However, PPARD could also activate nitric oxide formation and ceramide synthesis, which was implicated as promoters in the pathogenesis of MDD, indicating the complexity of the relationship between PPARD and MDD. …”
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Alternative Expression Pattern of MALT1-A20-NF-κB in Patients with Rheumatoid Arthritis by Xu Wang, Lihua Zhu, Ziwei Liao, Fan Zhang, Ling Xu, Yan Xu, Shaohua Chen, Lijian Yang, Yi Zhou, Yangqiu Li

“…Recently, A20 was identified as a key negative regulator for T cell activation and inflammatory signaling and may be involved in RA pathogenesis. In this study, we analyzed the expression level of A20, NF-κB, and A20 regulatory factor mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) in patients with RA. …”
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Vitamin D Receptor Polymorphisms Predispose to Primary Biliary Cirrhosis and Severity of the Disease in Polish Population by Agnieszka Kempińska-Podhorecka, Ewa Wunsch, Tomasz Jarowicz, Joanna Raszeja-Wyszomirska, Beata Loniewska, Mariusz Kaczmarczyk, Małgorzata Milkiewicz, Piotr Milkiewicz

“…Polymorphisms of vitamin D receptor (VDR) are considered to contribute to its pathogenesis however their incidence varies in different populations and their potential association with the course of the disease has not been studied. …”
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The Impact of Anti-Diabetics on Platelets Function and Cardiovascular Outcomes in Type 2 Diabetes Mellitus: A Narrative Review by Muthanna Zaki, Mohammed Abed, Fawaz Alassaf

“…Changes in platelet metabolism and alterations in intra platelet signaling pathways are the main contributors to the pathogenesis of atherothrombotic complications of diabetes. …”
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Characterizing temporal and global host innate immune responses against SARS-CoV-1 and -2 infection in pathologically relevant human lung epithelial cells. by Vivian Y Tat, Aleksandra K Drelich, Pinghan Huang, Kamil Khanipov, Jason C Hsu, Steven G Widen, Chien-Te Kent Tseng, George Golovko

“…Therefore, a better understanding of host responses to β-CoVs would provide insights into the pathogenesis of these viruses to identify potential targets for medical countermeasures. …”
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Ketamine-associated upper urinary tract dysfunction: What we know from current literature by Zhihuan Zheng, Zhongyi Li, Jiazhe Yuan, Feng Han, Li Huang, Zhao Wang

“…Objective: To review the current literature on ketamine-associated upper urinary tract (UUT) dysfunction and provide an overview of its pathogenesis and treatment principles. Methods: A literature search was conducted using PubMed and Cochrane databases for relevant articles published in English between 2008 and 2023. …”
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Sparse Gene Coexpression Network Analysis Reveals EIF3J-AS1 as a Prognostic Marker for Breast Cancer by Xin Chen, Zuyuan Yang, Chao Yang, Kan Xie, Weijun Sun, Shengli Xie

“…However, few prognostic lncRNAs are reported for breast cancer, and little is known about their functions that contribute to cancer pathogenesis. In this paper, we used weighted correlation network analysis (WGCNA) to construct networks containing noncoding and protein-coding genes based on their expression in 1097 breast cancer patients. …”
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Development and Evaluation of an In-House ELISA to Detect Anti-FcεR1α IgG Autoantibodies in Chronic Spontaneous Urticaria Patients by Chattip Sripatumtong, Tunsuda Tansit, Papapit Tuchinda, Duangjit Kanistanon, Kanokvalai Kulthanan, Yuttana Srinoulprasert

“…It was found that immunoglobulin G (IgG) autoantibodies (autoAbs) against high-affinity IgE receptor (FcεR1) were suggested as a potential trigger in the pathogenesis of CSU. Although many ELISA protocols have been developed to detect these autoAbs, they lacked validation or a reliable cut-off point. …”
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The road ahead: emerging therapies for primary IgA nephropathy by Edward J. Filippone, Rakesh Gulati, John L. Farber

“…A slowly progressive disease presenting in the young to middle-aged, most patients with reduced eGFR or proteinuria will progress to end-stage kidney disease (ESKD) in their lifetimes. The pathogenesis involves increased production of galactose-deficient IgA1 (Gd-IgA1) that forms immune complexes that deposit in the glomerulus, eliciting mesangial cell proliferation, inflammation, and complement activation. …”
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Mitofusin2 Promotes β Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation by Li Lu, Li Zhitao, Cui Nannan, Huang Mingzhu, Hu Xiaoping, Hong Dongsheng, Pan Zongfu, Lu Xiaoyang

“…Our data contribute to understanding diabetes pathogenesis and offer potential new targets for β cell regeneration therapies.…”
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Perspectives on Adipose Tissue, Chagas Disease and Implications for the Metabolic Syndrome by Fnu Nagajyothi, Mahalia S. Desruisseaux, Linda A. Jelicks, Fabiana S. Machado, Streamson Chua, Philipp E. Scherer, Herbert B. Tanowitz

“…The contribution of adipose tissue an autocrine and endocrine organ in the pathogenesis of infectious disease and metabolic syndrome is gaining attention. …”
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Characterization and miRNA Profiling of Extracellular Vesicles from Human Osteoarthritic Subchondral Bone Multipotential Stromal Cells (MSCs) by Clara Sanjurjo-Rodríguez, Rachel E. Crossland, Monica Reis, Hemant Pandit, Xiao-nong Wang, Elena Jones

“…Subchondral bone (SB) resident cells and its microenvironment are increasingly recognised to have a major role in OA pathogenesis. The aim of this study was to investigate the EV production from OA SB mesenchymal stromal cells (MSCs) and their possible influence on OA chondrocytes. …”
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Role of Microbiota and Innate Immunity in Recurrent Clostridium difficile Infection by Stefano Bibbò, Loris Riccardo Lopetuso, Gianluca Ianiro, Teresa Di Rienzo, Antonio Gasbarrini, Giovanni Cammarota

“…Recurrent Clostridium difficile infection represents a burdensome clinical issue whose epidemiology is increasing worldwide. The pathogenesis is not yet completely known. Recent observations suggest that the alteration of the intestinal microbiota and impaired innate immunity may play a leading role in the development of recurrent infection. …”
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Stevens-Johnson Syndrome and Erythema Multiforme Induced by Imiquimod 5% Cream by Ilaria Salvi, Ilaria Trave, Riccardo Castelli, Aurora Parodi, Emanuele Cozzani

“…Conclusions: We hypothesize a possible role of interferon-γ, a cytokine involved in the pathogenesis of both herpes-associated erythema multiforme and Stevens-Johnson syndrome, which is released in response to the administration of imiquimod. …”
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Flow cytometry sorting of cells infected with African swine fever virus by A. S. Pershin, I. V. Shevchenko, T. N. Komova, A. Mazloum, N. N. Vlasova, E. O. Morozova, A. S. Igolkin, K. N. Gruzdev

“…The disease control is hindered  by the lack of commercially available and effective vaccines, which, in its turn, is attributable  to the insufficient knowledge of ASF pathogenesis  and immune defense against the disease. …”
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Effects of Lipoic Acid Supplementation on Activities of Cyclooxygenases and Levels of Prostaglandins E2 and F2α Metabolites, in the Offspring of Rats with Streptozotocin-Induced Di... by Hisham Y. Al-Matubsi, Ghaleb A. Oriquat, Mahmoud Abu-Samak, Othman A. Al Hanbali, Maher D. Salim

“…Thus, other factors may be involved in the pathogenesis of the diabetes-induced congenital malformations.…”
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Expression of osteogenic proteins in kidneys of cats with nephrocalcinosis by Nuttha Hengtrakul, Eva Furrow, Michael Borofsky, Ferenc Toth, Jody P. Lulich

“…Understanding its pathogenesis may identify future therapeutic targets. …”
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Multiple Sclerosis and COVID-19: An Overview on Risk, Severity, and Association With Disease Modifying Therapies by Mary Hollist, Abraham Hollist, Katherine Au, Colton Betts, Maha Kirmani, Maaida Kirmani, Benjamin Armour, Mercy C Udeh, Batool F Kirmani

“…This review explores the evolving understanding of MS and its association with SARS-CoV-2, encompassing neuroinvasiveness, pathogenesis, disease severity, and outcomes. Research findings reveal substantial neurological implications for some MS patients with COVID-19, with a potential risk of disease relapse and severity. …”
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Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECs by Ming-Xia Duan, Heng Zhou, Qing-Qing Wu, Chen Liu, Yang Xiao, Wei Deng, Qi-Zhu Tang

“…Inflammation, apoptosis, and impaired angiogenesis are implicated in the pathogenesis of high glucose (HG)-induced injury of vascular endotheliocytes. …”
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Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis by Tarek Mahmoud Elghandour, Sahar El Sayed Youssef, Dalia Gamal Aly, Mohamed Said Abd Elhameed, Mehrevan Mostafa Abdel Moneim

“…There is raised interest in the involvement of interleukin-(IL-)23/T-helper 17 cells (Th17) axis in the pathogenesis of psoriasis. Objectives. To compare the effect of narrow band ultraviolet B (NB-UVB) and methotrexate (MTX) therapy on serum levels of IL-17 and IL-23 in psoriatic patients. …”
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