Cerebrovascular accidents association between serum trace elements and toxic metals level, a case-control study. by Khosro Jamebozorgi, Alireza Kooshki, Mahbobeh Saljoughi, Mohamadjavad Sanjari, Zahra Ahmadi, Seyed Mohammad Mosavi Mirzaei

“…However, further studies with a larger population and investigation of the exact pathogenesis of these metals are needed.…”
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Algorithm of management of patient with alcohol-induced liver disease by M. V. Mayevskaya, M. A. Morozova

“…Article presents the clinical case of successful treatment of severe alcohol-induced hepatitis.Conclusion. Pathogenesis of ALD is based on direct toxic operation action of ethanol on one hand and on endotoxemia and increased production of proinflammatory cytokines, on another hand. …”
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The SpxA1-TenA toxin-antitoxin system regulates epigenetic variations of Streptococcus pneumoniae by targeting protein synthesis. by Shaomeng Wang, Xiu-Yuan Li, Mengran Zhu, Haiteng Deng, Juanjuan Wang, Jing-Ren Zhang

“…As manifested by phase switch between opaque and transparent colonies, different genome methylation patterns or epigenomes confer pathogenesis-associated traits, but it is unknown how the pathogen controls the hsdS inversion orientations. …”
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SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma by Lianxiang Luo, Jiating Su, Yushi Zheng, Fangfang Huang, Riming Huang, Hui Luo

“…This study is aimed at elucidating the function of SLC2A5 in the prognosis and pathogenesis of LUAD by analyzing public databases. The differential expression of SLC2A5 in various tissues from Oncomine, GEPIA, and other databases was obtained, and SLC2A5 expression at the protein level in normal and tumor tissues was detected with the use of the HPA database. …”
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Integrated analysis of proteomics and metabolomics in infantile epileptic spasms syndrome by Jun Chen, Xiaoqian Wang, Xueyi Rao, Huan Luo, Yajun Shen, Jing Gan

“…The treatment of IESS poses a significant challenge, primarily due to the incomplete understanding of its etiology and pathogenesis. Objective: This study aims to investigate the pathogenic mechanisms of IESS, utilizing metabolomics and proteomics analyses to uncover potential biomarkers for the disease, thereby providing new insights for diagnostic and therapeutic strategies. …”
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Decoding TDP-43: the molecular chameleon of neurodegenerative diseases by Jixiang Zeng, Chunmei Luo, Yang Jiang, Tao Hu, Bixia Lin, Yuanfang Xie, Jiao Lan, Jifei Miao

“…The review also examines the complex pathogenesis of TDP-43-related disorders, discussing the protein’s propensity for aggregation, its effects on mitochondrial function, and its non-cell autonomous impacts on glial cells. …”
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Monocyte Chemotactic Protein 1-Induced Protein 1 Is Highly Expressed in Inflammatory Bowel Disease and Negatively Regulates Neutrophil Activities by Jian Lin, Gengfeng Li, Chunjin Xu, Huiying Lu, Cui Zhang, Zhi Pang, Zhanju Liu

“…However, its role in regulating neutrophil functions in the pathogenesis of inflammatory bowel disease (IBD) is still unclear. …”
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Impact of Tat Genetic Variation on HIV-1 Disease by Luna Li, Satinder Dahiya, Sandhya Kortagere, Benjamas Aiamkitsumrit, David Cunningham, Vanessa Pirrone, Michael R. Nonnemacher, Brian Wigdahl

“…Consequently, the genetic variability within tat may impact the molecular architecture of functional domains of the Tat protein that may impact HIV pathogenesis and disease. Tat as a therapeutic target for anti-HIV drugs has also been discussed.…”
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Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis by Marta Sacchetti, Alessandro Lambiase, Costanzo Moretti, Flavio Mantelli, Stefano Bonini

“…These findings suggest a role played by sex hormones in the pathogenesis and/or activity of VKC.…”
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Integrative transcriptome profiling for identifying ALS potential treatment using the drug repurposing approach by Navid Kashani, Amir Sabbaghian, Fatemeh EmamiPari, Mohammad Khalili Gorjimahalleh, Mahdi Aalikhani

“…Thus, we here attempted to identify crucial genetic biomarkers through transcriptome profiling and systems biology methodologies to advance our knowledge of the diagnosis and pathogenesis of ALS. Following this, a drug repurposing approach was employed to introduce possible treatments for ALS. …”
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Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery by Massimo Nunes, Mare Vlok, Amy Proal, Douglas B. Kell, Etheresia Pretorius

“…This study highlights potential systems and proteins that require further research with regards to their contribution to the pathogenesis of ME/CFS, symptom manifestation, and biomarker potential, and also gives insight into the hematological and cardiovascular risk for ME/CFS individuals affected by diabetes mellitus. …”
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Hypermethylation of the PRKCZ Gene in Type 2 Diabetes Mellitus by Li Zou, Shirong Yan, Xueping Guan, Yunjun Pan, Xin Qu

“…This study suggests that the PRKCZ gene is the hypermethylated gene of T2DM and the hypermethylation PRKCZ gene may be involved in the pathogenesis of T2DM.…”
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Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis by Azael Torales-Cardeña, Isaí Martínez-Torres, Sandra Rodríguez-Martínez, Fernando Gómez-Chávez, Juan C. Cancino-Díaz, Ernesto A. Vázquez-Sánchez, Mario E. Cancino-Díaz

“…In this review, the role of HIF-1α in the cross talk between the cytokines and cells of the immunological system involved in the pathogenesis of psoriasis is discussed.…”
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Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases by Ajit A. Kulkarni, Collynn F. Woeller, Thomas H. Thatcher, Sesquile Ramon, Richard P. Phipps, Patricia J. Sime

“…These PPARγ-independent mechanisms are of significant interest because they suggest new therapeutic uses for currently approved drugs and because they can be used as probes to identify novel proteins and pathways involved in the pathogenesis or treatment of disease, which can then be targeted for further investigation and drug development.…”
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Understanding the Activation of Platelets in Diabetes and Its Modulation by Allyl Methyl Sulfide, an Active Metabolite of Garlic by Navya Malladi, Ebin Johny, Shravan K. Uppulapu, Vikas Tiwari, Md Jahangir Alam, Ramu Adela, Sanjay K. Banerjee

“…Platelets play a promising role in the pathogenesis of cardiovascular complications in diabetes. …”
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Oxidative stress and reactive oxygen species in otorhinolaryngological diseases: insights from pathophysiology to targeted antioxidant therapies by Linghui Meng, Shengyang Liu, Jinfeng Luo, Yanyi Tu, Tao Li, Ping Li, Jinzhuang Yu, Li Shi

“…Oxidative stress, characterized by an imbalance between excessive reactive oxygen species (ROS) production and impaired antioxidant defenses, is closely linked to the pathogenesis of various otorhinolaryngological disorders. …”
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Unveiling the Significance of Surrogate Markers of Insulin Resistance in Metabolic Health Assessment by Najmunnissa, Kishorkumar M Guruswamy, Jadeppa Gowda, Swetha N Kempegowda, Akila Prashant, Suma M Nataraj

“…Insulin resistance (IR) plays a pivotal role in the pathogenesis of various metabolic disorders. Assessing the IR in the initial stages would therefore help in early detection of patients who are susceptible to metabolic disorders. …”
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Relationship between plasma uric acid levels, antioxidant capacity, and oxidative damage markers in overweight and obese adults: A cross-sectional study. by Natalia Albuja-Quintana, Aida M Chisaguano-Tonato, Maria E Herrera-Fontana, Sandra Figueroa-Samaniego, José M Alvarez-Suarez

“…Consequently, the presented evidence supports the potential antioxidant role of uric acid in the pathogenesis of obesity, contributing to our understanding of oxidative stress and inflammation that characterizes this illness.…”
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Differences Between Amblyopic and Fellow Eyes in Optical Coherence Tomography: A Cohort from Jordanian Population by Noor M. Alqudah, Hasan Mohidat, Abdelwahab Aleshawi, Wedad Al-Dolat, Ali Alshami

“…More studies using larger cohorts and longitudinal designs are necessary to improve our knowledge of the pathogenesis of amblyopia and to provide the best possible clinical management approaches.…”
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Treatment of Multiple Sclerosis with Cladribine Tablets: Literature Review and the Guidance of the Lithuanian Association of Neurologists by R. Kizlaitienė, D. Mickevičienė, L. Malcienė, N. Giedraitienė, R. Balnytė, D. Jatužis

“…Cladribine is a purine nucleoside analogue which selectively targets lymphocyte subpopulations involved in the pathogenesis of multiple sclerosis, and therefore it is classified as an immune reconstitution therapy drug. …”
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