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2581
Prevalence of Joint Hypermobility and Patterns of Articular Manifestations in Patients with Inflammatory Bowel Disease
Published 2009-01-01“…This implies an involvement of collagen varieties in the pathogenesis of IBD.…”
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2582
Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability
Published 2013-01-01“…Inflammatory damage plays an important role in cerebral ischemic pathogenesis and may represent a target for treatment. …”
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2583
Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection
Published 2013-01-01“…The infection activates immunological mechanisms that contribute to the pathogenesis and characteristics of the illness. In this study we measured cerebrospinal fluid (CSF) neopterin concentration from 23 acute-phase NE patients. …”
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2584
Intestinal microbiota as biomarkers for different colorectal lesions based on colorectal cancer screening participants in community
Published 2025-02-01“…IntroductionThe dysregulation of intestinal microbiota has been implicated in the pathogenesis of colorectal cancer (CRC). However, the utilization of intestinal microbiota for identify the lesions in different procedures in CRC screening populations remains limited.MethodsA total of 529 high-risk individuals who underwent CRC screening were included, comprising 13 advanced adenomas (Aade), 5 CRC, 59 non-advanced adenomas (Nade), 129 colon polyps (Pol), 99 cases of colorectal inflammatory disease (Inf), and 224 normal controls (Nor). 16S rRNA gene sequencing was used to profile the intestinal microbiota communities. …”
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2585
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2586
Impact of training dairy farm personnel on milking routine compliance, udder health, and milk quality
Published 2025-02-01“…The training session was delivered using an active learning approach prioritizing group discussions, and focused on the pathogenesis, identification, and risk factors for mastitis, as well as the rationale and importance of each step in the milking routine. …”
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2587
Effect of Kinases in Extracellular Vesicles from HIV-1-Infected Cells on Bystander Cells
Published 2025-01-01“…Given the relevance of such effects for the immune response, our results implicate exosome-associated kinases as new possible key contributors to HIV-1 pathogenesis that affect bystander cells. These findings may guide new therapeutic avenues to improve the current antiretroviral treatment regimens.…”
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2588
Elevated Plasma Level of 8-Hydroxy-2′-deoxyguanosine Is Associated with Primary Open-Angle Glaucoma
Published 2020-01-01“…The study shows that there is a significant association between elevated plasma 8-OHdG and POAG, supporting the role of systemic oxidative stress-induced DNA damage in POAG pathogenesis. However, with a high rate of false-positivity, plasma 8-OHdG may lack the ability to serve as a potential biomarker in POAG. …”
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2589
MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the IRF4-SHIP1 signaling pathway
Published 2025-01-01“…Abstract The involvement of B lymphocytes in the pathogenesis of rheumatoid arthritis (RA) is well-established, with their early and aberrant activation being a crucial factor. …”
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2590
Development of a prognostic model based on four genes related to exhausted CD8+ T cell in triple-negative breast cancer patients: a comprehensive analysis integrating scRNA-seq and...
Published 2025-02-01“…Although improving TEX and enhancing effector function are promising strategies for strengthening immunotherapy, their role in the pathogenesis of TNBC remains unclear. This study’s objective was to develop a prognostic model for TNBC based on exhausted CD8+ T-cell (CD8+ Tex)-related differentially expressed genes (DEGs) and to investigate its clinical and immune relevance. …”
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2591
Exploring the genetic correlation and causal relationships between breast cancer and meningioma using bidirectional Mendelian randomization
Published 2025-02-01“…ER-related signaling pathways and the regulation of DNA damage may play a critical role in the pathogenesis of both diseases.…”
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2592
CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population
Published 2012-01-01“…Other studies from Japan suggested the role of CD40L in the pathogenesis of CAL, and this might help explain the excessive number of males affected with KD but cannot be reproduced by Taiwanese population. …”
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2593
Alteration in the Cytokine Secretion of Bone Marrow Stromal Cells from Patients with Chronic Myelomonocytic Leukemia Contribute to Impaired Hematopoietic Supportive Activity
Published 2018-01-01“…These results suggested that BMSCs may contribute to the pathogenesis of CMML by altering their cytokine secretion, which will shed light on the further investigation to develop novel therapeutic strategies for CMML patients.…”
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2594
Regulatory role of S1P and its receptors in sepsis-induced liver injury
Published 2025-01-01“…By elucidating the role of S1P and its receptor in the pathogenesis of sepsis liver injury, this review established a molecular targeting framework, providing novel insights into clinical and drug development.…”
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2595
NF-κB Signaling in the Brain of Autistic Subjects
Published 2011-01-01“…Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this disorder. Nuclear factor-κB (NF-κB) is an important gene transcriptional factor involved in the mediation of inflammation and apoptosis. …”
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2596
Soluble Markers of Antibody Secreting Cell Function as Predictors of Infection Risk in Rheumatoid Arthritis
Published 2019-01-01“…Further delineating the link between ASC and infection susceptibility in RA may optimize disease management and provide novel insights into disease pathogenesis that are susceptible to intervention.…”
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2597
Integrated analysis of genetic, proteinic, and metabolomic alterations in Behcet’s disease
Published 2025-01-01“…Collectively, this study showed that the hyperactivity of Th1 and Th17 responses played an essential role in the pathogenesis of BD, and the progression of this disease was associated with enhanced neutrophil chemotaxis, vascular endothelial injury, activation of haemostatic system, and oxidative stress.…”
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2598
Pathological and Molecular Characterization of Grass Carp Co-Infected with Two <i>Aeromonas</i> Species
Published 2025-01-01“…This study investigated the pathogenesis and host immune response in grass carp following concurrent infection with <i>A. hydrophila</i> and <i>A. veronii</i>. …”
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2599
Primary Gallbladder Small Lymphocytic Lymphoma as a Rare Postcholecystectomy Finding
Published 2014-01-01“…The association of these lesions with chronic inflammation is the most convincing theory for their pathogenesis. For lesions confined to the gallbladder, cholecystectomy is considered to be sufficient, while supplementary chemotherapy significantly improves prognosis in more advanced disease.…”
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2600
IL-17 Genetic and Immunophenotypic Evaluation in Chronic Graft-versus-Host Disease
Published 2014-01-01“…Although interleukin-17 (IL-17) is a recently discovered cytokine associated with several autoimmune diseases, its role in the pathogenesis of chronic graft-versus-host disease (cGVHD) was not established yet. …”
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