γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation by Weixi Zhang, Xueya Zhang, Anqun Sheng, Cuiye Weng, Tingting Zhu, Wei Zhao, Changchong Li

“…T helper 17 (Th17) cells play an important role in the pathogenesis of allergic asthma. Th17 cell differentiation requires Notch signaling. γ-Secretase inhibitor (GSI) blocks Notch signaling; thus, it may be considered as a potential treatment for allergic asthma. …”
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Research progress of femoral head necrosis in HIV-infected patients by Youhan Yang, Futao Ke, Zhengqi Pan, Liaobin Chen

“…A more profound comprehension of the disease’s pathogenesis may facilitate the implementation of early prevention and treatment strategies, as well as the development of alternative conservative therapeutic options. …”
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Effect of Lipoxin A4 on Lipopolysaccharide-Induced Endothelial Hyperpermeability by Huayan Pang, Pan Yi, Ping Wu, Zhuoya Liu, Zhongjie Liu, Jianming Gong, Hua Hao, Lei Cai, Duyun Ye, Yinping Huang

“…Excessive oxidative stress, decreased antioxidant capacity, and enhanced cellular calcium levels are initial factors that cause endothelial cell (EC) hyperpermeability, which represents a crucial event in the pathogenesis of pre-eclampsia. Lipoxin A4 (LXA4) strongly attenuated lipopolysaccharide (LPS)-induced hyperpermeability through maintaining the normal expression of VE-cadherin and β-catenin. …”
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Aqp 9 and Brain Tumour Stem Cells by Guri Fossdal, Einar O. Vik-Mo, Cecilie Sandberg, Mercy Varghese, Mari Kaarbø, Emily Telmo, Iver A. Langmoen, Wayne Murrell

“…Several studies have implicated the aquaporins (aqp) 1, 4, and 9 in the pathogenesis of malignant brain tumours, suggesting that they contribute to motility, invasiveness, and oedema formation and facilitate metabolism in tumour cells under hypoxic conditions. …”
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Brain-Specific SNAP-25 Deletion Leads to Elevated Extracellular Glutamate Level and Schizophrenia-Like Behavior in Mice by Hua Yang, Mengjie Zhang, Jiahao Shi, Yunhe Zhou, Zhipeng Wan, Yicheng Wang, Yinghan Wan, Jun Li, Zhugang Wang, Jian Fei

“…It is suggested that a SNAP-25 cKO mouse, a valuable model for schizophrenia, could address questions regarding presynaptic alterations that contribute to the etiopathophysiology of SZ and help to consummate the pre- and postsynaptic glutamatergic pathogenesis of the illness.…”
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Decreased Apoptotic Rate of Alveolar Macrophages of Patients with Idiopathic Pulmonary Fibrosis by Fotios Drakopanagiotakis, Areti Xifteri, Evaggelos Tsiambas, Andreas Karameris, Konstantina Tsakanika, Napoleon Karagiannidis, Demetrios Mermigkis, Vlasis Polychronopoulos, Demosthenes Bouros

“…Increased apoptosis of epithelial cells and decreased apoptosis of myofibroblasts are involved in the pathogenesis of IPF. The apoptotic profile of alveolar macrophages (AMs) in IPF is unclear. …”
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Betaine Treatment Attenuates Chronic Ethanol-Induced Hepatic Steatosis and Alterations to the Mitochondrial Respiratory Chain Proteome by Kusum K. Kharbanda, Sandra L. Todero, Adrienne L. King, Natalia A. Osna, Benita L. McVicker, Dean J. Tuma, James L. Wisecarver, Shannon M. Bailey

“…Mitochondrial damage and disruption in oxidative phosphorylation contributes to the pathogenesis of alcoholic liver injury. Herein, we tested the hypothesis that the hepatoprotective actions of betaine against alcoholic liver injury occur at the level of the mitochondrial proteome. …”
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Resistance mechanisms involved in complex immunity of wheat against rust diseases by E. S. Skolotneva, E. A. Salina

“…The presence of these genes in the genotype ensures the interruption of early pathogenesis through the following mechanisms: disorientation and branching of the germ tube; formation of aberrant fungal penetration structures (appressorium, substomatal vesicle); accumulation of callose in mesophyll cell walls. …”
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Esophageal Intramural Pseudodiverticulosis: A Rare Endoscopic Finding by Luciana Lopes de Oliveira, Fred Olavo Aragão Andrade Carneiro, Elisa Ryoka Baba, Thiago Guimarães Vilaça, Dalton Marques Chaves, Everson Luiz de Almeida Artifon, Eduardo Guimarães Hourneaux de Moura, Paulo Sakai

“…Dysphagia is the predominant symptom and can be accompanied by esophageal stricture in 80% to 90% of patients. The pathogenesis is unknown, and as the pseudodiverticulosis is an intramural finding, endoscopy biopsies are inconclusive. …”
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Metformin Exhibits Anti‐Inflammatory Effects by Regulating microRNA‐451/CXCL16 and B Cell Leukemia/Lymphoma 2 in Patients With Osteoarthritis by Nahid Alimoradi, Amin Ramezani, Mohammad Tahami, Negar Firouzabadi

“…Inflammation and aging are involved in the pathogenesis of pain in OA. In this study, we evaluated the ability of metformin to regulate microRNAs, such as miR‐451 and miR‐15b, and their target proteins, CXCL16 and B cell leukemia/lymphoma 2 (BCL‐2), involved in inflammation and apoptosis. …”
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Endothelial SHANK3 regulates tight junctions in the neonatal mouse blood-brain barrier through β-Catenin signaling by Yong-Eun Kim, Minseong Kim, Sunwhi Kim, Raham Lee, Yusuke Ujihara, Esther Magdalena Marquez-Wilkins, Yong-Hui Jiang, Esther Yang, Hyun Kim, Changhoon Lee, Changwon Park, Il Hwan Kim

“…Despite the blood-brain barrier (BBB) serving as a crucial gatekeeper, conveying environmental influences into the brain parenchyma, the contributions of BBB in ASD pathogenesis remain largely uncharted. Here we report that SHANK3, an ASD-risk gene, expresses in the BBB-forming brain endothelial cells (BECs) and regulates tight junctional (TJ) integrity essential for BBB’s barrier function. …”
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Multiparametric grading of glaucoma severity by histopathology can enable post-mortem substratification of disease state by Chuanxi Xiang, VijayKrishna Raghunathan, Yubin Qiu, Manisha Mehta, John T. Demirs, Cynthia L. Grosskreutz, Christopher W. Wilson, Ganesh Prasanna

“…These are difficult confounders that cannot be easily controlled. As pathogenesis and molecular mechanisms can vary depending on the stage and severity of glaucoma, there is a need for the field to maximize use of donated tissue to better understand the molecular mechanisms of glaucoma and develop new therapeutic hypotheses. …”
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Transgenic plants as genetic models for studying functions of plant genes by A. V. Kochetov, V. K. Shumny

“…In addition, some pathogenesis-related proteins (PR-4 family) possess RNase activity and can inhibit growth of pathogenic fungi. …”
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Effects of interleukin-12/23 inhibitors and interleukin-17 inhibitors on myocardial functions in patients with severe psoriasis by Leyla Baykal Selçuk, Mursel Şahin, Burcu Aydemir, Deniz Aksu Arıca, Savaş Yaylı

“…Background and Design: Systemic inflammation, which is involved in the pathogenesis of psoriasis, has been associated with the development of systemic diseases such as metabolic syndrome and cardiovascular disease. …”
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KAT2B inhibits proliferation and invasion via inactivating TGF-β/Smad3 pathway-medicated autophagy and EMT in epithelial ovarian cancer by Yuqin Yao, Yuna Niu, Honggui Zhou, Min Yong

“…Abstract Lysine acetyltransferase 2B (KAT2B) plays a crucial role in epigenetic regulation and tumor pathogenesis. Our study investigates KAT2B’s function in epithelial ovarian cancer (EOC) using in vivo and in vitro methods. …”
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RETRACTED ARTICLE: Clinical and immuno-proteomic approach on Lantana camara pollen allergy—a major health hazard by Kavita Ghosal, Bodhisattwa Saha, Swati Gupta Bhattacharya

“…Mass spectrometric analysis identified nine spots that grouped into four diverse proteins. Pathogenesis-related Thaumatin-like protein was found to be one of the major allergens in Lantana camara. …”
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Characterization of HIV-1 Infection and Innate Sensing in Different Types of Primary Human Monocyte-Derived Macrophages by Elisabeth A. Diget, Kaja Zuwala, Randi K. Berg, Rune R. Laursen, Stine Søby, Lars Østergaard, Jesper Melchjorsen, Trine H. Mogensen

“…Macrophages play an important role in human immunodeficiency virus (HIV) pathogenesis and contribute to establishment of a viral reservoir responsible for continuous virus production and virus transmission to T cells. …”
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Assessment of Serum Dynamic Thiol/Disulfide Homeostasis and Oxidative/Nitrosative Stress in Patients with Crohn’s Disease by Ancel Aysun Bağdaş, Sezgin Barutçu, Ahmet Saracaloğlu, Abdullah Tuncay Demiryürek

“…In this study, we assessed the possible contributions of serum oxidative/nitrosative stress and dynamic thiol/disulfide homeostasis to CD pathogenesis. Materials and Methods: Patients with active CD (A-CD) at onset (n = 38), CD patients in the remission (R-CD) (n = 38), and healthy controls (n = 38) were prospectively included in this study. …”
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Notch Signaling Pathway Promotes Th17 Cell Differentiation and Participates in Thyroid Autoimmune Injury in Experimental Autoimmune Thyroiditis Mice by Hao Liu, Yiwen Li, Yujiao Zhu, Lei Ma, Haibo Xue

“…These findings suggested that the Notch signaling pathway may be involved in the pathogenesis of thyroid autoimmune injury in EAT mice by promoting the differentiation of Th17 cells.…”
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Characterization of gene expression profiles in Alzheimer's disease and osteoarthritis: A bioinformatics study. by Nian Liu, Qian Deng, Zining Peng, Danning Mao, Yuanbo Huang, Fanyu Meng, Xiaoyu Zhang, Jiayan Shen, Zhaofu Li, Weitian Yan, Jiangyun Peng

“…<h4>Background</h4>Alzheimer's disease (AD) and Osteoarthritis (OA) have been shown to have a close association in previous studies, but the pathogenesis of both diseases are unclear. This study explores the potential common molecular mechanisms between AD and OA through bioinformatics analysis, providing new insights for clinical treatment strategies.…”
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