Identification of critical endoplasmic reticulum stress-related genes in advanced atherosclerotic plaque by Ning Zhao, Dan Liu, Haixu Song, Xiaolin Zhang, Chenghui Yan, Yaling Han

“…This study aims to identify the molecular mechanisms of ERS in AS pathogenesis to inform innovative diagnostic approaches and therapeutic targets for managing AS. …”
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Functional constipation by Yu. O. Shulpekova, A. A. Kurbatova, A. V. Sedova

“…To discuss the recent updates in classification of constipation of functional origin (both as separate entity, and within the pattern of constipationpredominant irritable bowel syndrome), the concepts on pathogenesis and recommended treatment approaches. Key points. …”
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A Systematic Literature Review and Bucher Indirect Comparison: Tildrakizumab versus Guselkumab by Kristian Garn Du Jardin, Pepi Hurtado Lopez, Mette Lange, Rachael McCool, Silvia Maeso Naval, Sandra Quickert

“…Interleukin-23 (IL-23) has emerged as a key player in the pathogenesis of psoriasis and tildrakizumab and guselkumab are both immunomodulatory agents that inhibit the p19 subunit of IL-23. …”
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Role of T cell metabolism in brain tumor development: a genetic and metabolic approach by Bo Yang, Zhenyu Li, Peiliang Li, Bo Liang, Yuhan Liu, Enshan Feng

“…Conclusion The study identifies key T cell phenotypes and plasma metabolites involved in the pathogenesis of malignant brain tumors, offering potential biomarkers and therapeutic targets for future interventions.…”
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Association of Serum Adiponectin, Leptin, and Resistin Concentrations with the Severity of Liver Dysfunction and the Disease Complications in Alcoholic Liver Disease by Beata Kasztelan-Szczerbinska, Agata Surdacka, Maria Slomka, Jacek Rolinski, Krzysztof Celinski, Agata Smolen, Mariusz Szczerbinski

“…There is growing evidence that white adipose tissue is an important contributor in the pathogenesis of alcoholic liver disease (ALD). We investigated serum concentrations of total adiponectin (Acrp30), leptin, and resistin in patients with chronic alcohol abuse and different grades of liver dysfunction, as well as ALD complications. …”
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The effects of the ventral truncal vagotomy on the functions of the forestomach and abcmasum in sheep by Kürşat TURGUT, Abdullah BAŞOĞLU, Yilmaz KOÇ, Kemal ÇİFTÇİ, Saadettin TIPIRDAMAZ, Veysi ASLAN, Mehmet GÜRBİLEK, Mahmut OK, Cevat ÖZKAN

“…Theresult of the study showed that functional disorders of the nervus vagus did not play a role of the pathogenesis of vagus indigestion.…”
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Inhibition of skin fibrosis via regulation of Th17/Treg imbalance in systemic sclerosis by Akiko Sekiguchi, Chikako Shimokawa, Tamotsu Kato, Akihiko Uchiyama, Yoko Yokoyama, Sachiko Ogino, Ryoko Torii, Hajime Hisaeda, Hiroshi Ohno, Sei-ichiro Motegi

“…Abstract Systemic sclerosis (SSc) is an idiopathic systemic connective tissue disorder characterized by fibrosis of the skin and internal organs, with growing interest in the imbalance between Th17 cells and regulatory T cells (Tregs) in the disease’s pathogenesis. Heligmosomoides polygyrus (Hp), a natural intestinal parasite of mice, is known to induce Tregs in the host. …”
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Heterogeneity of Clostridioides difficile asymptomatic colonization prevalence: a systematic review and meta-analysis by Daniel De-la-Rosa-Martínez, Rodrigo Villaseñor-Echavarri, Diana Vilar-Compte, Virna Mosqueda-Larrauri, Paola Zinser-Peniche, Seth Blumberg

“…This heterogeneity could be partially explained by population characteristics and settings, supporting their role in the pathogenesis and burden of this disease. This highlights the need to identify high-risk groups to improve infection control strategies, decrease transmission dynamics, and better understand the natural history of this disease.…”
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Associations of infection burden with Kawasaki disease in a population-based setting during 30 years by Johannes Mofors, Håkan Eliasson, Gunnar Bergman, Sven-Erik Sonesson, Marie Wahren-Herlenius, Göran Elinder, André Rudolph, Bodil Schiller

“…Objectives The objective of this study was to investigate the role of infections in the pathogenesis of Kawasaki disease.Methods The investigation was a nationwide epidemiological case-control study, comprising all cases of Kawasaki disease diagnosed in Sweden 1987–2018. …”
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Morphological and Molecular Characterization of Toxigenic Aspergillus flavus from Groundnut Kernels in Kenya by Robert O. Okayo, Darius O. Andika, Mathews M. Dida, George O. K’Otuto, Bernard M. Gichimu

“…Pathogenesis of Aspergillus flavus on important agricultural products is a key concern on human health due to the synthesis and secretion of the hazardous secondary metabolite, aflatoxin. …”
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Association between Sarcopenia and Insulin-Like Growth Factor-1, Myostatin, and Insulin Resistance in Elderly Patients Undergoing Hemodialysis by Novira Widajanti, SoebagijoAdi Soelistijo, Usman Hadi, Mochammad Thaha, null Aditiawardana, null Widodo, Hadiq Firdausi, YafanitaIzzati Nurina, MiraDelima Asikin, Hersih Srinowati, NoerHalimatus Syakdiyah

“…This study aims to investigate the correlation of insulin-like growth factor-1 (IGF-1) levels as an anabolic factor, myostatin levels, and insulin resistance as catabolic factors with sarcopenia in the pathogenesis of sarcopenia in elderly patients undergoing hemodialysis. …”
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Clinical, immune and genetic risk factors of malaria-associated acute kidney injury in Zambian children: A study protocol. by Chisambo Mwaba, Sody Munsaka, David Mwakazanga, David Rutagwerae, Owen Ngalamika, Suzanna Mwanza, Mignon McCulloch, Evans Mpabalwani

“…<h4>Background</h4>Acute kidney injury (AKI) affects nearly half of children with severe malaria and increases the risk of adverse outcomes such as death and poor cognitive function. The pathogenesis and predictors of malaria-associated acute kidney injury (MAKI) are not fully described. …”
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Characterization of novel human endogenous retrovirus structures on chromosomes 6 and 7 by Nicholas Pasternack, Nicholas Pasternack, Ole Paulsen, Avindra Nath

“…Of these, HERV-K subtype HML-2 is a transposable element that plays a critical role in embryonic development and in the pathogenesis of several diseases. Quantification and characterization of these multiple HML-2 insertions in the human chromosome has been challenging due to their size, sequence homology with each other, and their repetitive nature. …”
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Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature Review by Siddharth Shah, Hadeel M. Mansour, Brandon Lucke-Wold

“…Current treatment only aims at relieving the symptoms rather than treating the pathogenesis of the disease. Although preclinical trials in HD models have shown promise in improving cognitive and motor functions, stem cell therapy still faces many challenges and disadvantages including immunosuppression and immunorejection as well as ethical, technical, and safety concerns. …”
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A Survey of SNP Data Analysis by Xiaojun Ding, Xuan Guo

“…Experiments on individual SNPs may reveal their non-detectable effects on complex diseases. Pathogenesis is a complicated topic, and it is difficult to correctly predict multiple SNPs. …”
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Investigating the functional and structural effect of non-synonymous single nucleotide polymorphisms in the cytotoxic T-lymphocyte antigen-4 gene: An in-silico study. by Md Mostafa Kamal, Kazi Fahmida Haque Shantanu, Shamiha Tabassum Teeya, Md Motiar Rahman, A K M Munzurul Hasan, Douglas P Chivers, Tanveer A Wani, Atekah Hazzaa Alshammari, Mahesh Rachamalla, Francisco Carlos da Silva Junior, Md Munnaf Hossen

“…The current comprehensive study shows how various nsSNPs in the CTLA4 gene can modify the structural and functional characteristics of the protein, potentially influencing the pathogenesis of diseases in humans. Further, experimental studies are needed to analyze the effect of these nsSNPs on the susceptibility of pathological phenotype populations.…”
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4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions by Sujin Park, Yoon A Kim, Jaewang Lee, Hyunsoo Seo, Sang-Jip Nam, Dong-Gyu Jo, Dong-Hoon Hyun

“…Some therapeutic applications focus on enhancing neuronal cell survival during the pathogenesis of neurodegenerative diseases, including mitochondrial dysfunction. …”
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Dental problems and oral microbiome alterations in ulcerative colitis by Robert Kucharski, Robert Kucharski, Bartosz Kamil Sobocki, Ewa Stachowska, Nikola Bulman, Leszek Kalinowski, Leszek Kalinowski, Karolina Kaźmierczak-Siedlecka

“…The role of microbial dysregulation in its pathogenesis has been recently highlighted. Overall, microbiome alterations concern the reduction of bacterial abundance and diversity, resulting in gut microbiome imbalance negatively affecting immunological aspects. …”
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Review of Herbal Traditional Chinese Medicine for the Treatment of Diabetic Nephropathy by Guang-dong Sun, Chao-yuan Li, Wen-peng Cui, Qiao-yan Guo, Chang-qing Dong, Hong-bin Zou, Shu-jun Liu, Wen-peng Dong, Li-ning Miao

“…Diabetic nephropathy (DN) is the most serious chronic complications of diabetes; 20–40% of diabetic patients develop into end stage renal disease (ESRD). However, exact pathogenesis of DN is not fully clear and we have great difficulties in curing DN; poor treatment of DN led to high chances of mortality worldwide. …”
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Breakthrough Psoriasis in Patients Receiving Biologicals by Damsin T, Absil G, Libon F, Tassoudji N, Nikkels AF

“…No biological class or agent could be systematically incriminated.Conclusion: Breakthrough psoriasis is an exceptional event among patients with stabilized psoriasis using biologicals, either triggered by the Köbner phenomenon or by severe psychological stress. The pathogenesis of the breakthrough events could be linked to stress- or Köbner-related immunomodulation, permitting breakthrough psoriasis lesions to appear.Keywords: psoriasis, biologicals, TNF-alpha, IL17, IL23, Köbner phenomenon, stress…”
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