Differential Expression of -Associated Genes in Autosomal Dominant Polycystic Kidney Disease by Yeon Joo Yook, Yu Mi Woo, Moon Hee Yang, Je Yeong Ko, Bo Hye Kim, Eun Ji Lee, Eun Sun Chang, Min Joo Lee, Sunyoung Lee, Jong Hoon Park

“…These data may be helpful in PKD2-related mechanisms of ADPKD pathogenesis.…”
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Systemic Lupus Erythematosus Presenting as Anorexia Nervosa in a Middle‐Aged Woman: A Rare Case Report and Literature Review by Maen Nizam Baroudi, Anwar I. Joudeh, Mohammed Kays Alattiya, Abdo Qaid Ahmed Lutf, Hassan Abuzaid, Salah Mahdi

“…Conclusions The concurrence of anorexia nervosa with SLE and the complete resolution of anorexia nervosa symptoms with immunosuppressive therapy suggest common autoinflammatory pathogenesis for both conditions. Further research is needed to elucidate any potential association between SLE and anorexia nervosa.…”
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The Central Roles of Noncoding RNA in Estrogen-Dependent Female Reproductive System Tumors by Jiajie Tu, Huan Yang, Lei Jiang, Yu Chen, Yu Chen, Zhe Li, Lei Li, Yuanyuan Zhang, Xiaochun Chen, He Chen, Zhiying Yu

“…The pathogenesis of ovarian and endometrial cancers is closely associated with estrogen-related pathways. …”
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Non-alcoholic fatty liver disease: comparative assessment of diagnostic and treatment approaches in the Russian Federation and People’s Republic of China by M. Ch. Semenistaya, Fan Jian-Gao, O. B. Velichenko, Ye. A. Kuznetsova, Ch. S. Pavlov

“…NAFLD is the leading disease entity among the other chronic liver diseases in the countries of various regions of the world, at the present time it is considered to be one of the main causes for cryptogenic liver cirrhosis development. The pathogenesis of NAFLD closely correlates to both hepatic and cardiovascular involvement that significantly influences both treatment choice and life prognosis. …”
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The Iron-Klotho-VDR Axis Is a Major Determinant of Proximal Convoluted Tubule Injury in Haptoglobin 2-2 Genotype Diabetic Nephropathy Patients and Mice by Inbal Dahan, Nadia Thawho, Evgeny Farber, Nakhoul Nakhoul, Rabea Asleh, Andrew P. Levy, Yan Chun Li, Ofer Ben-Izhak, Farid Nakhoul

“…Targeting this axis may open the way for new ideas regarding the pathogenesis and treatment of DN.…”
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Adherent junctions: Physiology, role in hydrocephalus and potential therapeutic targets by Zhiye Chen, Jian He, Yating Guo, Yue Hao, Wentao Lv, Zexin Chen, Junqiang Wang, Yijian Yang, Kaiyue Wang, Zhikun Liu, Qian Ouyang, Zhangjie Su, Pingsheng Hu, Gelei Xiao

“…At present, the researches on the pathogenesis of hydrocephalus are mainly focused on the development of ependymal cells and cilia, while less attention has been paid to molecules such as AJs, which play an important role in maintaining the polarity of ependymal cells. …”
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Metabolic profile of blood serum in experimental arterial hypertension by A. A. Seryapina, A. A. Malyavko, Yu. K. Polityko, L. V. Yanshole, Yu. P. Tsentalovich, A. L. Markel

“…The etiology of essential hypertension is intricate, since it employs simultaneously various body systems related to the regulation of blood pressure in one way or another: the sympathetic nervous system, renin-angiotensin-aldosterone and hypothalamic-pituitary-adrenal systems, renal and endothelial mechanisms. The pathogenesis of hypertension is influenced by a variety of both genetic and environmental factors, which determines the heterogeneity of the disease in human population. …”
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Use of disease modifying anti-rheumatic drugs and risk of multiple myeloma in US Veterans with rheumatoid arthritis by Kate Tokareva, Alexander C. Peterson, Aaron Baraff, Sarah P. Chung, Jennifer Barton, Joshua F. Baker, Bryant R. England, Ted R. Mikuls, Nicholas L. Smith, David G. Coffey, Noel S. Weiss, Namrata Singh

“…Abstract Background Biologic (b) and targeted synthetic (ts) disease-modifying anti-rheumatic drugs (DMARDs) used in the management of rheumatoid arthritis (RA) target inflammatory pathways implicated in the pathogenesis of multiple myeloma (MM). It is unknown whether use of b/tsDMARDs affects the incidence of MM. …”
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Serum Sclerostin as a Possible Biomarker in Ankylosing Spondylitis: A Case-Control Study by Fabio Massimo Perrotta, Fulvia Ceccarelli, Cristiana Barbati, Tania Colasanti, Antonia De Socio, Silvia Scriffignano, Cristiano Alessandri, Ennio Lubrano

“…Several molecules are involved in the pathogenesis of a new bone formation in ankylosing spondylitis (AS). …”
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The Role of Duodenogastroesophageal Reflux in the Progression of Gastroesophageal Reflux Disease: From Esophagitis to Adenocarcinoma by O. A. Storonova, A. V. Paraskevova, A. A. Makushina

“…The basic therapy for GERD is proton pump inhibitors (PPIs), but up to 40 % of patients do not fully respond to PPI monotherapy, which indicates the need to consider, among the factors in the pathogenesis of GERD, the persistence of weakly acidic and weakly alkaline refluxes, the presence of which can be diagnosed by performing 24-hour impedance-pH monitoring. …”
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The Wnt/β-Catenin Pathway Regulated Cytokines for Pathological Neuropathic Pain in Chronic Compression of Dorsal Root Ganglion Model by Ye Zhang, Dan Zhao, Xutong Li, Beiyao Gao, Chengcheng Sun, Shaoting Zhou, Yanhong Ma, Xuemei Chen, Dongsheng Xu

“…Collectively, our findings suggest that the Wnt/β-catenin pathway plays a critical role in the pathogenesis of NP and may be an effective target for the treatment of NP.…”
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Polymorphism of lipid exchange genes in some populations of South and East Siberia by L. E. Tabikhanova, L. P. Osipova, E. N. Voronina, A. O. Bragin, M. L. Filipenko

“…Lipid metabolism disorders underlie the pathogenesis of a number of diseases. Indigenous peoples of Siberia have a specific genetically determined type of metabolism supporting such lipid blood parameters that favor increased consumption (in comparison with Caucasians) of animal products. …”
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Novel genes involved in vascular dysfunction of the middle temporal gyrus in Alzheimer’s disease: transcriptomics combined with machine learning analysis by Meiling Wang, Aojie He, Yubing Kang, Zhaojun Wang, Yahui He, Kahleong Lim, Chengwu Zhang, Li Lu

“…Studies have shown that vascular dysfunction is closely related to the pathogenesis of Alzheimer’s disease. The middle temporal gyrus region of the brain is susceptible to pronounced impairment in Alzheimer’s disease. …”
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SARS-CoV-2 Evolution: Implications for Diagnosis, Treatment, Vaccine Effectiveness and Development by Fabrizio Angius, Silvia Puxeddu, Silvio Zaimi, Serena Canton, Sepehr Nematollahzadeh, Andrea Pibiri, Ilenia Delogu, Gualtiero Alvisi, Meng Ling Moi, Aldo Manzin

“…In the past four years, immense research efforts have contributed much to our understanding of the viral pathogenesis mechanism, the COVID-19 syndrome, and the host–microbe interactions, leading to the development of effective vaccines, diagnostic tools, and treatments. …”
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Inhibition of mmu_circ_0009303 improves metabolic dysfunction-associated steatotic liver disease by regulating lipid metabolism and oxidative stress by Ju Zhou, Wu Li, Xiaowei Chi, Dingchun Li, Chunxia Yang, Zhiwen Duan

“…Circular RNAs (circRNAs) play an important role in regulating inflammation and oxidative stress during the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD); however, the underlying mechanism is unclear. …”
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Causal analysis of dietary preferences and the risk of endometriosis using large-scale population data by Xin Cheng, Dan Ma, Xiuhong Wang, Meiling Li, Jinpeng Jiang

“…Abstract Dietary factors have recently been recognized as potentially influential in the pathogenesis of endometriosis (EM), yet studies on the causal relationship between dietary preferences and EM are limited. …”
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Protective effects of peptide KSPLY derived from Hericium erinaceus on H2O2-induced oxidative damage in HepG2 cells by Zhengli Xu, Qiuhui Hu, Minhao Xie, Jianhui Liu, Anxiang Su, Hui Xu, Wenjian Yang

“…Reactive oxygen species (ROS)-induced oxidative damage is strongly associated with the pathogenesis of chronic diseases, and natural antioxidant peptides have good abilities of scavenging ROS. …”
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High-Mobility Group Box-1 Induces Decreased Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in the Diabetic Retina by Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Mohammad Mairaj Siddiquei, Abdullah S. Al-Kharashi, Dustan Kangave, Ghulam Mohammad

“…Our results suggest that HMGB1-induced downregulation of BDNF might be involved in pathogenesis of diabetic retinal neurodegeneration.…”
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Differential between Protein and mRNA Expression of CCR7 and SSTR5 Receptors in Crohn's Disease Patients by Nathalie Taquet, Serge Dumont, Jean-Luc Vonesch, Didier Hentsch, Jean-Marie Reimund, Christian D. Muller

“…Once confirmed by further large-scale studies, our preliminary results suggest a role for SSTR5 and CCR7 in CD pathogenesis.…”
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Aβ-Induced Repressor Element 1-Silencing Transcription Factor (REST) Gene Delivery Suppresses Activation of Microglia-Like BV-2 Cells by Tongya Yu, Hui Quan, Yuzhen Xu, Yunxiao Dou, Feihong Wang, Yingying Lin, Xue Qi, Yanxin Zhao, Xueyuan Liu

“…Compelling evidence from basic molecular biology has demonstrated the crucial role of microglia in the pathogenesis of Alzheimer’s disease (AD). Microglia were believed to play a dual role in both promoting and inhibiting Alzheimer’s disease progression. …”
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