Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown by Susan Yung, Tak Mao Chan

“…This paper describes the mechanisms through which autoantibodies interact with resident renal cells and how this interaction plays a part in disease pathogenesis that ultimately leads to structural and functional alterations in lupus nephritis.…”
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Genital porokeratosis: A case report and review of pathogenesis and genitogluteal subtypes of porokeratosis by Camille Hamm, Jennifer Lipson

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Comprehensive Bioinformatics Method to Explore Immune-Related Genes in the Pathogenesis of Myocardial Infarction by Xin Zhang, Yiren Yao, Ying Ding, Wenting Yan, Yang Gu, Xiwen Zhang, Xiaojin Xu

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Aberrant Hepatic Methionine Metabolism and Gene Methylation in the Pathogenesis and Treatment of Alcoholic Steatohepatitis by Charles H. Halsted, Valentina Medici

“…The present paper describes the effects of ethanol on the hepatic methionine cycle, followed by evidence for the central role of reduced SAM in the pathogenesis of ASH according to clinical data and experiments in ethanol-fed animals and in cell models. …”
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Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesis by Joshua Kotlyar, Richard D. Granstein

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DNA methylation and its influence on the pathogenesis of osteoarthritis: a systematic literature review by Thomas Nau, Samira Cutts, Nerissa Naidoo

“…Purpose: Evolving evidence demonstrates the role of epigenetics in the pathogenesis of osteoarthritis (OA), whereas in terms of mechanism, DNA methylation has received the highest attention thus far. …”
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Possible Roles of IL-33 in the Innate-Adaptive Immune Crosstalk of Psoriasis Pathogenesis by Serafinella Patrizia Cannavò, Lucrezia Bertino, Eleonora Di Salvo, Valeria Papaianni, Elvira Ventura-Spagnolo, Sebastiano Gangemi

“…IL-33 belongs to the IL-1 family, playing a role in several biologic processes as well as in the pathogenesis of different diseases, including skin pathologies. …”
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The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk by Xueyi Zhu, Jie Cui, La Yi, Jingjing Qin, Wuniqiemu Tulake, Fangzhou Teng, Weifeng Tang, Ying Wei, Jingcheng Dong

“…Here, we discuss the role of T cells, macrophages, and their interactions in asthma pathogenesis.…”
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Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Sarala Raj Murthi, Andreas Petry, Bachuki Shashikadze, Jan B. Stöckl, Manuel Schmid, Gianluca Santamaria, Karin Klingel, Damir Kračun, Xinpei Chen, Sabine Bauer, Joachim P. Schmitt, Florian Flenkenthaler, Josh Gorham, Christopher N. Toepfer, David Potěšil, Pavel Hruška, Zbyněk Zdráhal, Zsuzsanna Mayer, Mathieu Klop, Luisa Lehmann, Yishi Qin, Laura Papanakli, Nadine Spielmann, Alessandra Moretti, Thomas Fröhlich, Peter Ewert, Stefan Holdenrieder, Jonathan G. Seidman, Christine E. Seidman, Agnes Görlach, Cordula M. Wolf

“…These results demonstrate that HIF signaling is involved in mouse and human HCM pathogenesis. Cardiomyocyte-specific knockout of Hif-1a attenuates disease phenotype in the mouse model. …”
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Functional Dyspepsia and Gastroesophageal Reflux Disease: From Pathogenesis to Current Treatment Strategies by A. S. Trukhmanov, D. E. Rumyantseva

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Glucose-Sensing Carbohydrate Response Element-Binding Protein in the Pathogenesis of Diabetic Retinopathy by Christopher R. Starr, Assylbek Zhylkibayev, Oleg Gorbatyuk, Alli M. Nuotio-Antar, James Mobley, Maria B. Grant, Marina Gorbatyuk

“…We aimed to investigate the potential role of ChREBP in the pathogenesis of diabetic retinopathy (DR). We used diabetic human and mouse retinal cryosections analyzed by immunohistochemistry. qRT-PCR was performed to quantify gene expression. …”
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Gestation complications in women with metabolic syndrome: pathogenesis, diagnosis and prevention (literature review) by L.P. Shelestova, L.F. Ushullu

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A Mechanistic, Stochastic Model Helps Understand Multiple Sclerosis Course and Pathogenesis by Isabella Bordi, Renato Umeton, Vito A. G. Ricigliano, Viviana Annibali, Rosella Mechelli, Giovanni Ristori, Francesca Grassi, Marco Salvetti, Alfonso Sutera

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Neutrophil extracellular traps as an important part of the pathogenesis of chronic rhinosinusitis without polyps by Valery М. Svistushkin, Galina N. Nikiforova, Boris V. Pinegin, Nina V. Vorobjeva, Artem S. Dekhanov, Yulia A. Dagil, Anna R. Mironova

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The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy by Felice Gragnano, Simona Sperlongano, Enrica Golia, Francesco Natale, Renatomaria Bianchi, Mario Crisci, Fabio Fimiani, Ivana Pariggiano, Vincenzo Diana, Andreina Carbone, Arturo Cesaro, Claudia Concilio, Giuseppe Limongelli, Mariagiovanna Russo, Paolo Calabrò

“…The VWF/ADAMTS13 axis is implicated in the pathogenesis of atherosclerosis, promoting plaque formation and inflammation through macrophage and neutrophil recruitment in inflamed lesions. …”
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HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases by Yi Liu, Guo-Bin Zhuang, Xue-Zhi Zhou

“…This proinflammatory activity is considered to be important in the pathogenesis of a wide range of ocular diseases resulting from hemodynamic changes, presence of neovascular endothelial cells, secretion of intraocular immune factors or inflammation, and apoptosis of retinal cell layers. …”
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Impact of Microbiota on Irritable Bowel Syndrome Pathogenesis and Management: A Narrative Review by Mhd Bashir Almonajjed, Mahdi Wardeh, Abdallah Atlagh, Abdulrahman Ismaiel, Stefan-Lucian Popa, Flaviu Rusu, Dan L. Dumitrascu

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Estradiol metabolism by gut microbiota in women’s depression pathogenesis: inspiration from nature by Wei Zhang, Jinghan Jia, Yuhang Yang, Dawei Ye, Yan Li, Di Li, Jinxi Wang

“…The recurrence and treatment resistance of depression remain significant issues, primarily due to an inadequate understanding of its pathogenesis. Recent scientific evidence indicates that gut microbiota influence estradiol metabolism and are associated with the development of depression in nonpremenopausal women. …”
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Trauma as Pathogenesis of a Plantar Forefoot Fibrolipoma: First Case and Review of the Literature by Juliana S. P. Vasconcelos, Faris Gharaibeh, Hans-Christoph Nittinger

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Pyogenic Brain Abscess: A Comprehensive Review of Epidemiology, Pathogenesis, Diagnosis, and Management by Peyman Eini, Pooya Eini, Latif Gachkar

“…The search terms included "pyogenic brain abscess," "epidemiology," "pathogenesis," "diagnosis," "treatment," "antibiotic therapy," and "prognosis." …”
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