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2321
GITR-GITRL System, A Novel Player in Shock and Inflammation
Published 2007-01-01“…Recent evidence suggests that the GITR/GITRL system participates in the development of inflammatory responses, including shock, either due to early response of neutrophils and macrophages, or together with autoimmune/allergic pathogenesis. The pro-inflammatory role of the GITR/GITRL system is due to: 1) modulation of the extravasation process, 2) activation of innate immunity cells, 3) activation of effector T cells also favored by partial inhibition of suppressor T cells and modulation of dendritic function. …”
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2322
Multi-omic and machine learning analysis of mitochondrial RNA modification genes in lung adenocarcinoma for prognostic and therapeutic implications
Published 2025-03-01“…Lung cancer remains the leading cause of cancer-related deaths, driven by complex pathogenesis and poor prognosis. Recognizing the pivotal role of mitochondrial RNA modifications (MRM) in cancer progression, this study aims to provide a comprehensive analysis of MRM-related genes and their clinical relevance in lung adenocarcinoma (LUAD). …”
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2323
High Intestinal and Systemic Levels of Interleukin-23/T-Helper 17 Pathway in Chinese Patients with Inflammatory Bowel Disease
Published 2013-01-01“…Interleukin-23/T-helper 17 (IL-23/Th17) pathway plays a key role in the pathogenesis of inflammatory bowel disease (IBD), but little is known about its expression in Chinese population. …”
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2324
Pretreatment of Ascorbic Acid Inhibits MPTP-Induced Astrocytic Oxidative Stress through Suppressing NF-κB Signaling
Published 2020-01-01“…Taken together, our results demonstrate that preadministration of AA improves the antioxidative function of astrocytes through suppressing NF-κB signaling, following alleviated the pathogenesis of PD which induced by MPTP. Hence, our findings elucidate a novel protective mechanism of AA in astrocytes.…”
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2325
Closer look at circulating nitric oxide levels and their association with polycystic ovary syndrome: A meta-analytical exploration
Published 2025-02-01“…Conclusion: This meta-analysis provides evidence for an association between PCOS and dysregulated NO levels and suggests a potential role of NO as a biomarker in the diagnosis and pathogenesis of PCOS. …”
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2326
Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production
Published 2025-02-01“…Missense mutations in the amyloid precursor protein (APP) and presenilin-1 (PSEN1) cause early-onset familial Alzheimer’s disease (FAD) and alter proteolytic production of secreted 38-to-43-residue amyloid β-peptides (Aβ) by the PSEN1-containing γ-secretase complex, ostensibly supporting the amyloid hypothesis of pathogenesis. However, proteolysis of APP substrate by γ-secretase is processive, involving initial endoproteolysis to produce long Aβ peptides of 48 or 49 residues followed by carboxypeptidase trimming in mostly tripeptide increments. …”
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2327
Phytomedicine nanoformulations for Parkinson's disease
Published 2025-02-01“…This approach may be effective in addressing the underlying pathogenesis of PD, thereby slowing the disease progression.…”
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2328
Selective epithelial expression of KRASG12D in the Oncopig pancreas drives ductal proliferation and desmoplasia that is accompanied by an immune response
Published 2025-02-01“…Innovations in modeling pancreatic epithelial transformation provide valuable insights into the pathogenesis and potential therapeutic strategies for PDAC. …”
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2329
Susceptibility of different mice species to chemical induction of colorectal cancer by 1,2-dimethylhydrazine
Published 2025-01-01“…Conclusion In conclusion, C57BL/6 has a higher susceptibility toward chemical induction to CRC; therefore, it can be used to study CRC pathogenesis, prevention, and treatment.…”
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2330
Towards a Vaccine Against Rheumatic Fever
Published 2006-01-01“…Our studies allowed us a better understanding of the cellular and molecular pathogenesis of RHD, paving the way for the development of a safe vaccine for a post-infection autoimmune disease. …”
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2331
Update on Pulmonary Toxicity Induced by New Breast Cancer Treatments
Published 2025-01-01“…We conducted an update including the available published data regarding the incidence, mechanisms of pathogenesis, clinical presentations, and treatment of lung toxicity induced by new anticancer drugs. …”
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2332
Quantification of Free Circulating DNA and Differential Methylation Profiling of Selected Genes as Novel Non-Invasive Biomarkers for Endometriosis Diagnosis
Published 2025-01-01“…We also identified nine target genes potentially involved in the pathogenesis of endometriosis, with a different methylation profile between the two groups. …”
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2333
Smad4 deficiency in hepatocytes attenuates NAFLD progression via inhibition of lipogenesis and macrophage polarization
Published 2025-01-01“…Although the Smad4 signaling pathway has been implicated in the progression of NAFLD, the specific role of Smad4 in hepatocytes in NAFLD pathogenesis remains unclear. Hepatocyte-specific knockout Smad4 mice (AlbSmad4−/−) were first constructed using the Cre-Loxp recombinant system to establish a high-fat diet induced NAFLD model. …”
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2334
Research progress of protein haze in white wines
Published 2023-09-01“…Unstable wine proteins were usually pathogenesis-related (PR) proteins of grapes, mainly chitinases and thaumatin-like proteins (TLPs), which had lower isoelectric point (pI) and smaller molecular weight, and were highly resistant to the low pH values of wines and the protease hydrolysis during fermentation. …”
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2335
Chemokines and Growth Factors Produced by Lymphocytes in the Incompetent Great Saphenous Vein
Published 2019-01-01“…The role of cytokines in the pathogenesis of chronic venous disease (CVD) remains obscure. …”
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2336
Phytomedicine Potential of <i>Oroxylum indicum</i> Root and Its Constituents: Targeting Alzheimer’s Disease
Published 2025-01-01“…These findings suggest that <i>O. indicum</i> root extract, particularly baicalein, possesses multifaceted neuroprotective properties, targeting various aspects of AD pathogenesis, including oxidative stress, cholinergic dysfunction, β-amyloid formation, aggregation, and apoptosis. …”
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2337
STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines
Published 2025-01-01“…Conclusion These findings exhibit the critical role of STAT6 in the pathogenesis of CIH induced PH by regulating Th2 immune response.STAT6 could be a significant therapeutic target for OSA-related PH.…”
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2338
Periductal Mastitis: An Inflammatory Disease Related to Bacterial Infection and Consequent Immune Responses?
Published 2017-01-01“…Bacterial infection and the increased expression of some proinflammatory cytokines are associated with the pathogenesis of this disease.…”
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2339
Correlation between Serum IL-35 Levels and Bone Loss in Postmenopausal Women with Rheumatoid Arthritis
Published 2019-01-01“…IL-35, an important anti-inflammatory cytokine, may participate in the pathogenesis of bone loss in postmenopausal women with RA.…”
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2340
Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model
Published 2019-01-01“…Our results provide potential evidence for previously undescribed mechanisms that may play a role in the pathogenesis of autistic-like phenotypes in BTBR mice.…”
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