Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-Induced PGE2, IL-6, and IL-8 Production by Katriina Vuolteenaho, Anna Koskinen, Meiju Kukkonen, Riina Nieminen, Unto Päivärinta, Teemu Moilanen, Eeva Moilanen

“…Obesity is an important risk factor for osteoarthritis (OA) in weight-bearing joints, but also in hand joints, pointing to an obesity-related metabolic factor that influences on the pathogenesis of OA. Leptin is an adipokine regulating energy balance, and it has recently been related also to arthritis and inflammation as a proinflammatory factor. …”
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Machine learning potential predictor of idiopathic pulmonary fibrosis by Chenchun Ding, Quan Liao, Renjie Zuo, Shichao Zhang, Zhenzhen Guo, Junjie He, Ziwei Ye, Weibin Chen, Sunkui Ke

“…Finally, the roles of PODNL1 and PIGA as biomarkers were validated through in vivo and in vitro experiments using qRT-PCR, Western blotting, and immunohistochemistry.ResultsThese findings suggest that PODNL1 and PIGA may serve as critical biomarkers for IPF onset and contribute to its pathogenesis.DiscussionThis study highlights their potential for early biomarker discovery and risk prediction in IPF, offering insights into disease mechanisms and diagnostic strategies.…”
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Association between neutrophil-albumin ratio and ultrasound-defined metabolic dysfunction-associated fatty liver disease in U.S. adults: evidence from NHANES 2017–2018 by Ming-yu He, Xin-jie Du, Yi-ming Liu

“…Abstract Background Metabolic dysfunction-associated fatty liver disease (MAFLD) is increasingly prevalent, and systemic inflammation markers may play a role in its pathogenesis. This study aimed to investigate the relationship between neutrophil-albumin ratio (NAR) and MAFLD. …”
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The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis by Katarzyna Kasperkiewicz, Anna S. Świerzko, Marta Przybyła, Janusz Szemraj, Jarosław Barski, Mikael Skurnik, Andrzej Kałużyński, Maciej Cedzyński

“…Having an adjuvant activity, LPS may enhance production of anticollagen antibodies, involved in the pathogenesis of rheumatoid arthritis. Furthermore, its ability to activate complement contributes to the inflammation. …”
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Molecular characterization and potential therapeutic roles of miR125a in HER-2 positive gastric cancer by Afraa Mamoori, Zena Hasan Sahib, Haider Alkafaji

“…Conclusion: miR-125a-3p plays a significant role in the pathogenesis of gastric carcinoma. Therapeutic transfection of miR-125a-3p in HER2 positive gastric cancer cells resulted in reduced cell proliferation and potentiate the effect of 5-FU.…”
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T-Cell Cytokine Gene Polymorphisms and Vitamin D Pathway Gene Polymorphisms in End-Stage Renal Disease due to Type 2 Diabetes Mellitus Nephropathy: Comparisons with Health Status a... by Alicja E. Grzegorzewska, Grzegorz Ostromecki, Paulina Zielińska, Adrianna Mostowska, Paweł P. Jagodziński

“…IL18 rs360719 is probably associated with the pathogenesis of chronic infective tubulointerstitial nephritis.…”
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Postoperative Pulmonary Hemodynamics and Systemic Inflammatory Response in Pediatric Patients Undergoing Surgery for Congenital Heart Defects by Maria Francilene S. Souza, Juliano G. Penha, Nair Y. Maeda, Filomena R. B. G. Galas, Kelly C. O. Abud, Eloisa S. Carvalho, Ana Maria Thomaz, Claudia R. P. Castro, Juliana Pereira, Antonio Augusto Lopes

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Adult Wilms Tumor With Inferior Vena Cava Thrombus on an Incomplete Duplex Collecting System Ureter Fissus Proximalis Managed at a Tertiary Hospital in Tanzania: A Case Report and... by Amini Mitamo Alexandre, Joseph Martin Lori, Gabriel F. Mtaturu, Victor Patrick Sensa, Sylvia Bedas Nsato, Mariam Athumani Mbezi, Obadia V. Nyongole, Charles A. Mkony

“…The increasing incidence of non‐syndromic WT cases associated with duplex collecting systems suggests a potential shared pathogenesis, necessitating further research.…”
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Chronic kidney disease and inflammatory cytokines in rheumatoid arthritis: a potential pathogenic link by Hironari Hanaoka, Takumi Aoki, Taiji Kosaka, Shoichi Yoshinaga, Akiko Shibata, Ryota Sakai, Takahiko Kurasawa, Koichi Amano

“…Inflammatory cytokines, notably interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and IL-1, play significant roles in the pathogenesis of both RA and CKD, promoting systemic inflammation and renal impairment. …”
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Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference by Olga Golounina, Ildar Minniakhmetov, Ramil Salakhov, Rita Khusainova, Ekaterina Zakharova, Igor Bychkov, Natalia Mokrysheva

“…Antisense therapy can be utilized not only for the treatment of monogenic diseases but also holds significant promise for addressing polygenic and complex diseases by targeting key genes and molecular pathways involved in disease pathogenesis. In the context of endocrine disorders, molecular therapy is particularly effective in modulating pathogenic mechanisms such as defective insulin signaling, beta-cell dysfunction and hormonal imbalances. …”
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NF-κB-94ins/del ATTG Genotype Contributes to the Susceptibility and Imbalanced Th17 Cells in Patients with Immune Thrombocytopenia by Jie Yu, Mingqiang Hua, Xueyun Zhao, Rui Wang, Chaoqing Zhong, Chen Zhang, Ruiqing Wang, Guosheng Li, Na He, Ming Hou, Daoxin Ma

“…The NLRP3 inflammasome plays important roles in the pathogenesis of autoimmune diseases. However, the role of the NLRP3 inflammasome in the pathophysiology of immune thrombocytopenia (ITP) remains unclear. …”
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Lysophosphatidylethanolamine improves diastolic dysfunction by alleviating mitochondrial injury in the aging heart by Guiwen Xu, Wei Xiao, Pengqi Sun, Yuanjun Sun, Xinyu Yang, Xiaomeng Yin, Yang Liu

“…Here, we investigated whether a reduction in PE levels in myocardial mitochondria contributes to mitochondrial injury as well as HFpEF pathogenesis and whether modulation of PE levels could ameliorate aging-induced HFpEF. …”
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Dysregulation of Innate Lymphoid Cells in Patients with Active Rheumatoid Arthritis and Mice with Collagen-Induced Arthritis by Fengfan Yang, Xing Luo, Wenxiao Zhu, Jia Li, Zhaohui Zheng, Ping Zhu

“…Our results indicate that dysregulation of ILCs occurs during the pathogenesis of RA and CIA.…”
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Mesenchymal Stem Cells Attenuate Cisplatin-Induced Nephrotoxicity in iNOS-Dependent Manner by Bojana Simovic Markovic, Marina Gazdic, Aleksandar Arsenijevic, Nemanja Jovicic, Jovana Jeremic, Valentin Djonov, Nebojsa Arsenijevic, Miodrag L. Lukic, Vladislav Volarevic

“…We used murine model of cisplatin nephrotoxicity to explore the effects of MSCs on immune cells involved in the pathogenesis of this disease. Intraperitoneal application of MSCs significantly attenuated cisplatin nephrotoxicity, decreased inflammatory cytokines TNF-α and IL-17, and increased anti-inflammatory IL-10, IL-6, nitric oxide (NO), and kynurenine in sera of cisplatin-treated mice. …”
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Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice by Wei Song, Zi-ming Zhou, Le-le Zhang, Hai-feng Shu, Jin-ru Xia, Xia Qin, Rong Hua, Yong-mei Zhang

“…Abstract Neuroinflammation is a key factor in the pathogenesis of Parkinson’s disease (PD). Activated microglia in the central nervous system (CNS) and infiltration of peripheral immune cells contribute to dopaminergic neuron loss. …”
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Gene Expression Profiling of IL-17A-Treated Synovial Fibroblasts from the Human Temporomandibular Joint by Toshio Hattori, Naomi Ogura, Miwa Akutsu, Mutsumi Kawashima, Suguru Watanabe, Ko Ito, Toshirou Kondoh

“…IL-17 is an inflammatory cytokine produced primarily by Th17 cells which plays critical role in the pathogenesis of numerous autoimmune and inflammatory diseases. …”
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Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection by Clara Mônica Lima, Silvane Santos, Adriana Dourado, Natália B. Carvalho, Valéria Bittencourt, Marcus Miranda Lessa, Isadora Siqueira, Edgar M. Carvalho

“…However the increased production of TNF-α and IFN-γ in this group of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1.…”
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Improved brain functional network in major depressive disorder with suicidal ideation after individual target-transcranial magnetic stimulation treatment: a graph-theory analysis by Yao Zhang, Nan Mu, Shun Qi, Chuanzhu Sun, Yang Rao, Xinyi Yang, Jianying Guo, Yunfeng Mu

“…There is an urgent need for clarifying the pathogenesis and developing novel treatment methods.MethodsSubjects were recruited for the collection of Magnetic Resonance Imaging data and clinical scales. …”
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Gut microbiota dysfunction in Crohn’s disease by Sylvie Buffet-Bataillon, Sylvie Buffet-Bataillon, Gabriela Durão, Isabelle Le Huërou-Luron, Olivier Rué, Olivier Rué, Yann Le Cunff, Vincent Cattoir, Guillaume Bouguen

“…Virulence factors involved in host invasion, host evasion and inflammation were also increased in CS.ConclusionsThis functional metagenomic information provides new insights into community-wide microbial processes and pathways associated with CD pathogenesis. This study paves the way for new advanced strategies to rebalance gut microbiota and/or eliminate oxidative stress, and biofilm to downregulate gut inflammation.…”
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Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice by Yinshan Tang, Shujun Shao, Yu Guo, You Zhou, Jin Cao, Anping Xu, Jihong Wu, Zhigang Li, Dulian Xiang

“…Therefore, revealing the underlying mechanism of BACE1 in the pathogenesis of AD might have a significant impact on the future development of therapeutic agents targeting dementia. …”
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