The Expression Level of mRNA, Protein, and DNA Methylation Status of FOSL2 of Uyghur in XinJiang in Type 2 Diabetes by Jun Li, Siyuan Li, Ying Hu, Guolei Cao, Siyao Wang, Partab Rai, Xiaoli Wang, Kan Sun

“…FOSL2 protein and mRNA were downregulated and the DNA became hypermethylated, all of which may be involved in T2DM pathogenesis in this population.…”
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Levels of Inflammatory Cytokines in Type 2 Diabetes Patients with Different Urinary Albumin Excretion Rates and Their Correlation with Clinical Variables by Fen-qin Chen, Jiao Wang, Xiao-bo Liu, Xiao-yu Ma, Xiu-bin Zhang, Ting Huang, Dong-wei Ma, Qiu-yue Wang

“…This study revealed the importance of these inflammatory cytokines in DN pathogenesis. Further studies are needed to fully establish the potential of these cytokines as additional biomarkers for the development of DN.…”
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Alpha-1 Antitrypsin Deficiency and Pulmonary Morbidity in Patients with Primary Immunodeficiency Disease: A Single-Center Experience by Georg Evers, Arik Bernard Schulze, Michael Thrull, Jan-Philipp Hering, Christoph Schülke, Rainer Wiewrodt, Helmut Wittkowski, Lars Henning Schmidt, Michael Mohr

“…Alpha-1 antitrypsin deficiency (AATD) is of importance in the pathogenesis of pulmonary emphysema, chronic obstructive pulmonary diseases (COPD), and bronchiectasis. …”
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Chronic Unexpected Mild Stress Destroys Synaptic Plasticity of Neurons through a Glutamate Transporter, GLT-1, of Astrocytes in the Ischemic Stroke Rat by Dafan Yu, Zhenxing Cheng, Abdoulaye Idriss Ali, Jiamin Wang, Kai Le, Enkhmurun Chibaatar, Yijing Guo

“…This may indicate one potential pathogenesis of poststroke depression.…”
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Histopathologic Evaluation of Nonalcoholic Fatty Liver Disease in Hypothyroidism-Induced Rats by Şule Demir, Mustafa Ünübol, Serap Ünübol Aypak, Emrah İpek, Serdar Aktaş, Gamze Sevri Ekren, Murat Yılmaz, Recai Tunca, Engin Güney

“…It is speculated that thyroid hormones may be involved in nonalcoholic fatty liver disease (NAFLD) pathogenesis. A literature scan, however, demonstrated conflicting results from studies investigating the relationship between hypothyroidism and NAFLD. …”
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Impact of Bifidobacterium longum NSP001 on DSS-induced colitis in conventional and humanised mice by Menglin Chen, Hong Yao, Huizi Tan, Wenqi Huang, Quanyong Wu, Shaoping Nie

“…Most scientific investigations regarding inflammatory bowel disease (IBD) pathogenesis or therapeutic strategies use dextran sulfate sodium (DSS)-induced models performed on mice. …”
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Ferroptosis in thyroid cancer: mechanisms, current status, and treatment by Wenzhi Tian, Wenzhi Tian, Xi Su, Chenchen Hu, Dong Chen, Peng Li

“…Comprehensive investigations into the pathogenesis of TC have identified a significant association with ferroptosis, a newly characterized form of cell death mediated by iron ions. …”
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Identification of hub genes, non-coding RNAs and pathways in Renal cell carcinoma (RCC): A comprehensive in silico study by Ahmad Golestanifar, Hengameh Khedri, Parisa Noorabadi, Mohammadreza Saberiyan

“…We constructed a competitive endogenous RNA (ceRNA) network involving lncRNAs, circRNAs, and miRNAs, suggesting complex regulatory interactions that drive KIRC pathogenesis.Additionally, the study examined drug sensitivity associated with the expression of hub genes, revealing the potential for personalized treatments. …”
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Transcriptome Concordance Between Borderline Tumors and Endometrioid Carcinoma: An Integrative Genomic Analysis by Mio Takahashi, Kohei Nakamura, Tatsuyuki Chiyoda, Chihiro Okada, Sachio Nohara, Reika Takamatsu, Shintaro Yanazume, Hiroaki Kobayashi, Hiroshi Nishihara, Wataru Yamagami

“…These results underscore the potential need to reconsider the molecular classification of ovarian tumors and open new avenues for research into the pathogenesis and treatment strategies for BOTs.…”
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Different Anatomical Subsites of Colon Cancer and Mortality: A Population-Based Study by Xing-kang He, Wenrui Wu, Yu-e Ding, Yue Li, Lei-min Sun, Jianmin Si

“…In terms of incidence and pathogenesis, right-sided colon cancer (RCC) and left-sided colon cancer (LCC) exhibit several differences. …”
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Atractylenolide I prevents acute liver failure in mouse by regulating M1 macrophage polarization by Hui Zhang, Min Gao, Haiyan Wang, Junfeng Zhang, Lin Wang, Guanjun Dong, Qun Ma, Chunxia Li, Jun Dai, Zhihua Li, Fenglian Yan, Huabao Xiong

“…Given the key role of oxidative stress and inflammation in ALF pathogenesis, this study investigates the protective effects of ATR-I on LPS/D-GalN-induced ALF in mice. …”
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Prognostic significance of mast cell and microvascular densities in malignant peripheral nerve sheath tumor with and without neurofibromatosis type 1 by Roberto André Torres de Vasconcelos, Pedro Guimarães Coscarelli, Thyago Marsicano Vieira, Washington Silva Noguera, Davy Carlos Mendes Rapozo, Marcus André Acioly

“…Abstract Malignant peripheral nerve sheath tumors (MPNSTs) are rare and aggressive soft tissue sarcomas with a significant susceptibility to metastasize early in their course. Pathogenesis is yet to be fully elucidated. Recently, the essential role of mast cells in the tumor onset of neurofibromatosis type 1 (NF1)‐associated neurofibromas and MPNSTs was confirmed in both experimental and human studies. …”
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Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis by Alexandra Noble, Rodrigo Motta, Silvia Cabras, Belen Moron Flores, Jan Nowak, Aleksandra Glapa-Nowak, Alessandra Geremia, Jack Satsangi, Emma Culver

“…Conclusions We identify novel epigenetic alterations in IgG4-SC and PSC, with biological age acceleration in IgG4-SC, providing insights into disease pathogenesis, and highlight the role of genetic variation especially within the HLA region in shaping the methylome.…”
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Gender and melanoma subtype‐based prognostic implications of MUC16 and TTN co‐occurrent mutations in melanoma: A retrospective multi‐study analysis by Nilesh Kodali, Simona Alomary, Abhijit Bhattaru, Ahmed Eldaboush, Robert A. Schwartz, Shari R. Lipner

“…Abstract Background Most primary cutaneous melanomas have pathogenesis driven by ultraviolet exposure and genetic mutations, whereas acral lentiginous melanoma (ALM) and metastatic melanoma are much less, if at all, linked with the former. …”
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Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children by Yali Zhang, Yali Zhang, Yingying Xu, Yingying Xu, Ling Hu, Ling Hu, Xiaomei Wang

“…Recurrent respiratory tract infections (RRTIs) are a common condition in pediatrics and significantly impact children's quality of life; however, their pathogenesis and contributing factors are not yet fully elucidated. …”
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Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD by Charles I. V. Drummer, Fatma Saaoud, Yu Sun, Diana Atar, Keman Xu, Yifan Lu, Ying Shao, Candice Johnson, Lu Liu, Huimin Shen, Nirag C. Jhala, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…We performed a panoramic analysis on both human nonalcoholic steatohepatitis (NASH) microarray data and microarray/RNA-seq data from various mouse models of nonalcoholic fatty liver disease NASH/NAFLD with total 4249 genes examined and made the following findings: (i) human NASH and NAFLD mouse models upregulate both cytokines and chemokines; (ii) pathway analysis indicated that human NASH can be classified into metabolic and immune NASH; methionine- and choline-deficient (MCD)+high-fat diet (HFD), glycine N-methyltransferase deficient (GNMT-KO), methionine adenosyltransferase 1A deficient (MAT1A-KO), and HFCD (high-fat-cholesterol diet) can be classified into inflammatory, SAM accumulation, cholesterol/mevalonate, and LXR/RXR-fatty acid β-oxidation NAFLD, respectively; (iii) canonical and noncanonical inflammasomes play differential roles in the pathogenesis of NASH/NAFLD; (iv) trained immunity (TI) enzymes are significantly upregulated in NASH/NAFLD; HFCD upregulates TI enzymes more than cytokines, chemokines, and inflammasome regulators; (v) the MCD+HFD is a model with the upregulation of proinflammatory cytokines and canonical and noncanonical inflammasomes; however, the HFCD is a model with upregulation of TI enzymes and lipid peroxidation enzymes; and (vi) caspase-11 and caspase-1 act as upstream master regulators, which partially upregulate the expressions of cytokines, chemokines, canonical and noncanonical inflammasome pathway regulators, TI enzymes, and lipid peroxidation enzymes. …”
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No Correlation Exists between Disease Activity and the Expression of Killer-Cell Immunoglobulin-Like Receptors in Patients with Rheumatoid Arthritis by Toshiaki Kogure, Takeshi Tatsumi, Atsushi Niizawa, Hiroshi Fujinaga, Tomoyuki Ito, Yutaka Shimada, Katsutoshi Terasawa

“…There was no correlation between KIR expression and disease activity; therefore, the clinical use of KIR expression should be limited, while unnatural KIR expression may be involved in the pathogenesis of RA, but not a recruitment of chronic inflammation to induce joint damage.…”
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A Pregnant Woman with Excess Vasopressinase-Induced Diabetes Insipidus Complicated by Central Diabetes Insipidus like Lymphocytic Infundibulo-Neurohypophysitis by Shinnosuke Yanagisawa, Yoichi Oikawa, Mai Endo, Kazuyuki Inoue, Ritsuko Nakajima, Shigemitsu Yasuda, Masayasu Sato, Naoko Iwata, Haruki Fujisawa, Atsushi Suzuki, Yoshihisa Sugimura, Masashi Isshiki, Akira Shimada

“…In addition to the degradation of AVP by excess placental vasopressinase due to the enlarged placenta, an insufficient compensatory increase in AVP secretion from the posterior pituitary gland due to LINH-like pathogenesis might have led to DI symptoms.…”
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Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model by Yoshiaki Katsuda, Yusuke Kemmochi, Mimi Maki, Ryuhei Sano, Yasufumi Toriniwa, Yukihito Ishii, Katsuhiro Miyajima, Kochi Kakimoto, Takeshi Ohta

“…In conclusion, the SDT fatty rat is useful in investigations to elucidate the pathogenesis of human diabetic nephropathy and in new drug discovery.…”
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Complement activation in wasp venom-induced acute kidney injury by Rui Cheng, Liang Xu, Jianhua Gong, Fanglin Yu, Ying Lv, Hai Yuan, Fengqi Hu

“…Furthermore, complement depletion by CVF attenuates wasp venom-induced nephrotoxicity, suggesting that complement activation plays a primary role in the pathogenesis of wasp venom-induced AKI.…”
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