Scheimpflug Imaging Parameters Associated with Tear Mediators and Bronchial Asthma in Keratoconus by Dorottya Pásztor, Bence Lajos Kolozsvári, Adrienne Csutak, András Berta, Ziad Hassan, Beáta Andrea Kettesy, Péter Gogolák, Mariann Fodor

“…Our research verifies that inflammation plays a crucial role in the pathogenesis of KC. Additionally this study confirms the effect of bronchial asthma on keratoconus.…”
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Contemplating the Bibliometric Data Onto Sepsis and Gut Microbiome: Mapping Trends, Collaborations, and Global Contributions by Zhang Li, Wang Yi, Li Ping, Li Xiang, Yu Xiangyou

“…The gut microbiome’s role in sepsis pathogenesis and progression necessitates a comprehensive bibliometric analysis to elucidate current research trends. …”
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The Microbiota–Gut–Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease by Che Mohd Nasril Che Mohd Nassir, Muhammad Danial Che Ramli, Mazira Mohamad Ghazali, Usman Jaffer, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Zaw Myo Hein

“…We discuss how microbial dysbiosis promotes neuroinflammation, vascular dysfunction, and impaired waste clearance in the brain, which are critical factors in the pathogenesis of CSVD. Further, we discuss lifestyle factors that shape the composition and functionality of the microbiota, focusing on sleep as a modifiable risk factor in neurological disorders. …”
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Investigating the Impact of HTNV Infection on the Gut Microbiota of Wild-Type and NLRX1 Knockout Mice by Wenjie Sun, Yaxin Ding, Ziyu Liu, Shiyuan Hou, Danni Sun, Ruixue Ma, Huarui Kang, Xiaohan Ma, Jiayu Wang, Hongrui Mu, Yunhua Lv, Tianle Gu, Qikang Ying, Fang Wang, Xingan Wu, Rongrong Liu

“…Investigating this further may help to improve our understanding of the pathogenesis of HTNV and provide potential therapeutic options.…”
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Experimental Evaluation of the Pathogenicity of Different Strains of Schistosoma mansoni by Antônio Aurélio Euzébio, Nádia Regina Borim Zuim, Arício Xavier Linhares, Luiz Augusto Magalhães, Eliana Maria Zanotti-Magalhães

“…The pathogenesis of three different Schistosoma mansoni strains from the Brazilian states of Minas Gerais (BH strain) and São Paulo (SJ and SD strains) was evaluated in experimentally infected mice. …”
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Possible Roles of Micro RNA‑142‑5p and Claudin-1 in Development of Hashimoto’s Thyroiditis in Iraqi Patients by Khaled Nather Taha, Farhan Abood Risan, Abdulameer Jasim Mohammed

“…Conclusions: Our data suggest that micro RNA 142-5p may play a role in HT development and pathogenesis through an as-yet-unidentified mechanism, even though serum Claudin1 is not significantly affected in the serum of HT. …”
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Downregulation of Thromboxane A2 Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery by Yaping Zhang, Man Mi, Yan-Hua Xie, Si-Wang Wang, Lars Edvinsson, Cang-Bao Xu

“…Thromboxane A2 (TXA2) acts on TXA2 receptors (TP) to regulate renal artery blood flow and subsequently contributes to the pathogenesis of renal ischemia. The present study was designed to examine if nuclear factor-kappaB (NF-κB) signaling pathway is involved in the downregulation of TP receptors in rat renal artery. …”
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Analysis and Characterization of the Immunogenicity of Rhoptry Protein 18 by Masoud Foroutan, Amir Karimipour-Saryazdi, Ali Dalir Ghaffari, Hamidreza Majidiani, Arezo Arzani Birgani, Elaheh Karimzadeh-Soureshjani, Shahrzad Soltani, Hany M Elsheikha

“…Rhoptry protein 18 (ROP18) is a key virulence factor secreted into host cells during the invasion of Toxoplasma gondii ( T. gondii ) and plays an important role in the pathogenesis of infection. Due to its potential as a vaccine candidate, this study aimed to characterize several properties of the T. gondii ROP18 (TgROP18) protein to support its inclusion in vaccine formulations. …”
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Osteopontin: Relation between Adipose Tissue and Bone Homeostasis by Carolina De Fusco, Antonietta Messina, Vincenzo Monda, Emanuela Viggiano, Fiorenzo Moscatelli, Anna Valenzano, Teresa Esposito, Chieffi Sergio, Giuseppe Cibelli, Marcellino Monda, Giovanni Messina

“…Besides its physiological functions, OPN is implicated in the pathogenesis of a variety of disease states, such as obesity and osteoporosis. …”
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Anal Sphincter Function After Hemorrhoidectomy by A. M. Kuzminov, O. Yu. Fomenko, I. A. Mukhin, S. A. Frolov, D. V. Vyshegorodtsev, V. Yu. Korolik, S. T. Minbaev, S. V. Belousova

“…However, these methods have shown little value at stage 4 hemorrhoids, largely because they fail to affect all parts of the disease pathogenesis. Thus, hemorrhoidectomy remains to be the “gold standard” for stage 4 hemorrhoids treatment, which is aimed at eliminating the three main vascular collectors. …”
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Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors by Neeti Swarup, Meghanand T. Nayak, Zoya Chowdhary, Monica Mehendiratta, Shikha Khatana, Su Jung Choi, Chandarani Sagolsem

“…The expression of BMP4 and FGF8 corelates well with the proliferative component of the pathologies, indicating a possible role in the pathogenesis and progression.…”
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Identification of Potential Abnormal Methylation-Modified Genes in Coronary Artery Ectasia by Xiuchun Yang, Yijun Zong, Zhentian Zhang, Yan Zhao, Xueying Gao, Jie Zhang, Qian Hou, Renyi Li, Bing Xiao

“…Coronary artery ectasia (CAE) is an easily recognized abnormality of coronary artery anatomy and morphology. However, its pathogenesis remains unclear. Objectives. This study aimed to identify abnormal methylation-modified genes in patients with CAE, which could provide a research basis for CAE. …”
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Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China by Xin He, RuLin Ma, Yu Li, Haixia Wang, YiZhong Yan, YiDan Mao, ShengYu Liao, XueYing Sun, ShuXia Guo, Heng Guo

“…And these three miRNAs may serve as biomarkers to provide clues to the potential pathogenesis of H-type hypertension.…”
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Recent updates of centromere proteins in hepatocellular carcinoma: a review by Zhongyuan Yang, Wenjiao Chen, Yunhui Liu, Yuxin Niu

“…The treatment of HCC is facing a bottleneck, and new treatment methods are urgently needed. Since the pathogenesis of HCC is not yet clear, identifying the molecular mechanisms and therapeutic targets related to it is crucial. …”
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Immunohistochemical Expression of CXCR4 on Breast Cancer and Its Clinical Significance by Marina Okuyama Kishima, Carlos Eduardo Coral de Oliveira, Bruna Karina Banin-Hirata, Roberta Losi-Guembarovski, Karen Brajão de Oliveira, Marla Karine Amarante, Maria Angelica Ehara Watanabe

“…The most studied role for CXCL12 chemokine and its receptor CXCR4 in breast cancer pathogenesis is the metastasis event, although several reports have demonstrated its involvement in other processes, such as angiogenesis and tumor growth. …”
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Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase by Lies De Groef, Manuel Salinas-Navarro, Griet Van Imschoot, Claude Libert, Roosmarijn E. Vandenbroucke, Lieve Moons

“…In this study, we sought to determine the spatiotemporal expression profile of MMP-2 in the excitotoxic retina and to unravel its role during glaucoma pathogenesis. We reveal that intravitreal NMDA injection induces MMP-2 expression to be upregulated in the Müller glia. …”
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A Picrorhiza kurroa Derivative, Picroliv, Attenuates the Development of Dextran-Sulfate-Sodium-Induced Colitis in Mice by De-Kui Zhang, Jian-Jie Yu, Yu-Min Li, Li-Na Wei, Yi Yu, Yan-Hu Feng, Xiang Wang

“…Free radicals and proinflammatory cytokines have been shown to play a critical role in the pathogenesis of ulcerative colitis (UC). Picroliv, a Picrorhiza kurroa derivative, has been demonstrated to have antioxidant and anti-inflammatory effect. …”
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MicroRNA Profiling in Cartilage Ageing by Panagiotis Balaskas, Katarzyna Goljanek-Whysall, Peter Clegg, Yongxiang Fang, Andy Cremers, Pieter Emans, Tim Welting, Mandy Peffers

“…We identified a number of recognised and novel miRNAs changing in cartilage ageing and OA including miR-126: a potential new candidate with a role in OA pathogenesis. These analyses represent important candidates that have the potential as cartilage ageing and OA biomarkers and therapeutic targets.…”
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GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway by Shao Xie, Shao Xie, Jiahai Ding, Zhaohao Wang, Hengliang Shi, Zheng-Quan Yu

“…Golgi phosphoprotein 3 (GOLPH3), predominantly localized at the trans-Golgi network, has been implicated in the pathogenesis of various cancers. However, its precise role in glioma progression remains under active investigation.MethodsTo elucidate the function of GOLPH3, U87 glioma cells were transfected with GOLPH3-specific small interfering RNA (siRNA) to suppress its expression. …”
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Kaempferol improves glucose uptake in skeletal muscle via an AMPK-dependent mechanism by William T. Moore, Jing Luo, Dongmin Liu

“…Insulin resistance is a hallmark of type-2 diabetes (T2D) pathogenesis. Because skeletal muscle (SkM) is the major tissue for insulin-mediated glucose disposal, insulin resistance in SkM is considered a major risk factor for developing T2D. …”
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