The role of inflammasomes in hepatocellular carcinoma: Mechanisms and therapeutic insights by Valentina Arrè, Roberto Negro, Gianluigi Giannelli

“…Inflammasomes, the multiprotein complexes that launch the innate immune response, emerge as important mediators in the pathogenesis of HCC. Among others, the inflammasome Nucleotide-binding oligomerization domain, Leucine rich Repeat (NLR) and Pyrin (NLRP) 3 (NLRP3), and absent in melanoma 2 (AIM2), exhibit a dual role in HCC background. …”
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Clinical Isolates of Mycobacterium tuberculosis Differ in Their Ability to Induce Respiratory Burst and Apoptosis in Neutrophils as a Possible Mechanism of Immune Escape by María M. Romero, Luciana Balboa, Juan I. Basile, Beatriz López, Viviana Ritacco, Silvia S. de la Barrera, María C. Sasiain, Lucía Barrera, Mercedes Alemán

“…Tuberculosis pathogenesis was earlier thought to be mainly related to the host but now it appears to be clear that bacterial factors are also involved. …”
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Natural bioactive compounds form herbal medicine in Alzheimer’s disease: from the perspective of GSK-3β by Mei Wang, Wendi Huang, Juan Huang, Juan Huang, Yong Luo, Yong Luo, Nanqu Huang, Nanqu Huang

“…Glycogen synthase kinase 3β (GSK-3β) plays a pivotal role in AD pathogenesis, particularly in tau protein hyperphosphorylation. …”
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Exploring Potential Complement Modulation Strategies for Ischemia–Reperfusion Injury in Kidney Transplantation by Dario Troise, Costanza Allegra, Luciana Antonia Cirolla, Silvia Mercuri, Barbara Infante, Giuseppe Castellano, Giovanni Stallone

“…Complement activation, particularly the alternative pathway, participates in the pathogenesis of IRI, involving all kidney compartments. …”
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Screening for transcriptomic associations with Swine Inflammation and Necrosis Syndrome by Katharina Gerhards, Sabrina Becker, Josef Kuehling, Mirjam Lechner, Hermann Willems, Robert Ringseis, Gerald Reiner

“…These genes could serve to clarify the pathogenesis of the syndrome and to develop diagnostic tools in future studies.…”
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Association of functional variants in miRNA genes with the risk of coronary heart disease by Taqweem Ul Haq, Muhammad Riaz Khan, Sajjad Ali, Tariq Aziz, Thamer H. Albekairi, Aftab Ali Shah

“…In this study, we investigated the associations of miRNA genes MIR222, MIR423, MIR4274, and MIR3117 with the pathogenesis of CHD. Methods Genetic inheritance models were applied to explore the association between these miRNA genes and CHD. …”
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Serum Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) in association with the Risk of Gestational Diabetes: A Prospective Case-Control Study by Maryam Mosavat, Siti Zawiah Omar, Sajad Jamalpour, Peng Chiong Tan

“…Defects in incretin have been shown to be related to the pathogenesis of type 2 diabetes. Whether such a deficiency happens in gestational diabetes mellitus (GDM) remains to be confirmed. …”
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Analysis of MicroRNA -155-5p Expression in Patients with Primary Myelofibrosis. by Sarah I. Khaleel, Jaffar N. AlAlsaidissa

“…Aberrant expression of MicroRNA-155-5p may contribute to the pathogenesis of Primary Myelofibrosis, warranting further research to understand the disease mechanisms better. …”
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Effects of Intravenous Administration of Human Umbilical Cord Blood Stem Cells in 3-Acetylpyridine-Lesioned Rats by Lucía Calatrava-Ferreras, Rafael Gonzalo-Gobernado, Antonio S. Herranz, Diana Reimers, Teresa Montero Vega, Adriano Jiménez-Escrig, Luis Alberto Richart López, Eulalia Bazán

“…Current therapies are based on the use of drugs that correct some of the molecular processes involved in their pathogenesis. Although these treatments yielded promising results, there is not yet an effective therapy for these diseases. …”
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Impact of headache in women with polycystic ovary syndrome by Lina Zabulienë, V. Hendrixson, M. Urbonas, I. Ilias, D. Jatužis

“…PCOS and migraine pathogenesis are closely associated with insulin resistance. …”
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Inflammatory lipid biomarkers and transplant-free mortality risk in hepatitis B-related cirrhosis and hepatic encephalopathy by Ke Shi, Xiaojing Wang, Zhang Yi, Yanqiu Li, Ying Feng, Xianbo Wang

“…ObjectiveInflammatory reactions and dyslipidemia are associated with the pathogenesis and prognosis of hepatitis B virus-related cirrhosis. …”
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Decoding HIV-associated neurocognitive disorders: a new perspective from multimodal connectomics by Zhongkai Zhou, Wei Wang, Hui Li, Ying Shi, Lingling Zhao, Yibo Lu, Xingchen Wei, Hongjun Li

“…Here, we start with the pathogenesis and risk factors of HAND, providing a comprehensive review of the basic concepts of unimodal and multimodal macro connectomics and related graph theory methods, and we review the latest progress in HAND connectomics research. …”
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A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients by Christoph Hölscher, Lisa Heitmann, Ellis Owusu-Dabo, Rolf D. Horstmann, Christian G. Meyer, Stefan Ehlers, Thorsten Thye

“…The contribution of interleukin- (IL-) 4 receptor-alpha- (Rα-) dependent events in the pathogenesis of tuberculosis (TB) is controversial. We have recently shown IL-13 overexpression in mice to cause recrudescent Mtb replication and centrally necrotizing granulomas strongly resembling pathology of human TB. …”
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Brown Bowel Syndrome Is a Rare and Commonly Missed Disease: A Case Report and Literature Review by Joaquin Ponce-Zepeda, Wenchang Guo, Giorgioni Carmen, Daniel Moon Kim, Gregory C. Albers, Vishal Suresh Chandan, Xiaodong Li

“…Mitochondrial damage with lipofuscin deposition is at the root of BBS pathogenesis. Any etiology associated with mitochondrial damage can cause this disease, and vitamin E deficiency is just one of them. …”
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A comprehensive pan-cancer analysis of RNF187 in human tumors by Xuezhong Zhang, Xuebin Zhang, Tonggang Liu, Kaihui Sha

“…GO enrichment and KEGG pathway analyses suggested that RNF187 may play a role in the pathogenesis of cancer through processes such as "bounding membrane of organelle," "macroautophagy," "proton-transporting V-type ATPase complex," "autophagy," "Ubiquitin mediated proteolysis," "Ferroptosis," "Phagosome," and etc. …”
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Rectus Abdominis Muscle Endometriosis: A Unique Case Report with a Literature Review by Marijana Turčić, Koviljka Matušan Ilijaš, Koraljka Rajković Molek, Petra Valković Zujić

“…Standardization will help raise awareness of this disease, and further our understanding of its pathogenesis, risk factors, recurrence patterns, and potential for malignant transformation—factors that are still not fully understood.…”
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Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke by Huaqiang Li, Huaqiang Li, Xiaohua Ke, Bianying Feng, Huan Tian, Huan Tian, Zhenzhen Cai, Anren Zhang, Qiuhong Man

“…There is an urgent need to better understand the pathophysiology and pathogenesis of PSCI, as well as to identify markers that can predict PSCI early in the clinical stage, facilitating early prevention, monitoring, and treatment. …”
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Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-te... by Alan B. Dogan, Spencer R. Marsh, Rachel J. Tschetter, Claire E. Beard, Md R. Amin, L. Jane Jourdan, Robert G. Gourdie

“…Abstract Extracellular vesicles (EVs) are widely investigated for their implications in cell-cell signaling, immune modulation, disease pathogenesis, cancer, regenerative medicine, and as a potential drug delivery vector. …”
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RNA-Binding Proteins and Alternative Splicing Genes Are Coregulated in Human Retinal Endothelial Cells Treated with High Glucose by Hongran Zhao, Hui Kong, Bozhao Wang, Sihui Wu, Tianran Chen, Yan Cui

“…The regulatory network between identified RBPs and RASGs suggests the presence of several signaling pathways possibly involved in the pathogenesis of DR. The verified RBPs should be further addressed by future studies investigating associations between RBPs and the downstream of AS, as they could serve as potential biomarkers and targets for DR.…”
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Extrapulmonary manifestations and complications of severe acute respiratory syndrome coronavirus-2 infection: a systematic review by Jiacai Cho, Joanne Lee, Ching-Hui Sia, Chieh Sian Koo, Benjamin YQ Tan, Weizhen Hong, Ellie Choi, Xueying Goh, Louis Chai, Nisha Suyien Chandran, Horng Ruey Chua, Bernard PL Chan, Mark Muthiah, Ting Ting Low, Eng Soo Yap, Manjari Lahiri

“…Introduction: We aimed to describe the extrapulmonary manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, including their frequency, onset with respect to respiratory symptoms, pathogenesis and association with disease severity. Methods: We searched the MEDLINE and Embase databases for SARS-CoV-2-related studies. …”
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