Dihydrotanshinone I Alleviates Crystalline Silica-Induced Pulmonary Inflammation by Regulation of the Th Immune Response and Inhibition of STAT1/STAT3 by Yiting Zhang, Chao Li, Siyi Li, Yiping Lu, Sitong Du, Xinning Zeng, Xi Chen, Jie Chen

“…CD4+ T cells play a pivotal role in the pathogenesis of CS-induced pulmonary disease, which has no proven curative therapy. …”
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Computational identification and experimental validation of novel Saccharum officinarum microRNAs along with their targets through RT-PCR approach by Abdul Baqi, Samiullah, Jadoon Khan, Asma Sadiq, Yousaf Khan, Shahid Ali, Syed Nadeem ul Hassan Mohani, Naqeebullah Khan, Tawaf Ali Shah, Khalid S. Almaary, Youssouf Ali Younous, Mohammed Bourhia

“…Similarly, the sof-miR7768b and sof-miR6249b monitor the pathogenesis-related protein and zinc finger, C2H2 type protein, which assist as transcription factors. …”
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Population features of prevalence and clinical-diagnostic role of NOD2 gene polymorphisms associated with Crohn’s disease by D. A. Kuznetsova, M. V. Merzlyakov, G. V. Vavin, A. S. Razumov, V. L. Emanue

“…According to literature data analysis it is possible to conclude that there are clear populationrelated features of the prevalence, clinical and diagnostic role of NOD2 genetic polymorphism associated to Crohn's disease that requires development of the international data bank of all genetic nucleotide polymorphisms associated to various stages of CD pathogenesis in different countries and populations. …”
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Expression of Proinflammatory and Regulatory Cytokines via NF-κB and MAPK-Dependent and IFN Regulatory Factor-3-Independent Mechanisms in Human Primary Monocytes Infected by Mycob... by Elena Giacomini, Maria Elena Remoli, Marta Scandurra, Valérie Gafa, Manuela Pardini, Lanfranco Fattorini, Eliana M. Coccia

“…Knowledge of the molecular events regulating the innate response to Mycobacterium tuberculosis (Mtb) is critical for understanding immunological pathogenesis and protection from tuberculosis. To this aim, the regulation and the expression of regulatory and proinflammatory cytokines were investigated in human primary monocytes upon Mtb infection. …”
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MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations by Athanasia Tsaousi, Ellen Witte, Katrin Witte, Hans-Joachim Röwert-Huber, Hans-Dieter Volk, Wolfram Sterry, Kerstin Wolk, Sylke Schneider-Burrus, Robert Sabat

“…Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. …”
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Salivary Fractalkine Differentiating Periodontitis from Periodontally Healthy Subjects by Omer Mohammed Harbood, Raghad Fadhil Abbas

“…Fractalkine and its receptor are linked to periodontitis and may distinguish between periodontitis and healthy periodontal tissues, suggesting its role as a possible part of periodontal disease pathogenesis.…”
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Serum interleukin-6, interleukin-8, and interleukin-1 receptor antagonist levels in South Indian fibromyalgia patients and its correlation with disease severity by Sandeep Surendran, C B Mithun, Vishnu S Chandran, Suma Balan, Arun Tiwari

“…Cytokines have been proposed to play an important role in the pathogenesis of fibromyalgia. Different studies, mainly done in the Western population, have shown dysregulated cytokines in fibromyalgia patients. …”
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A New Case of DRESS Syndrome Induced by Sulfasalazine and Triggered by Amoxicillin by Francesco Girelli, Simone Bernardi, Lucia Gardelli, Bruna Bassi, Gianluca Parente, Alessandra Dubini, Luigi Serra, Maurizio Nizzoli

“…Fatal cases are reported. The exact pathogenesis of DRESS syndrome is not completely understood, while it is reported that amoxicillin could trigger it in patients who are taking allopurinol, sulfasalazine, NSAIDs, carbamazepine, strontium ranelate, lisinopril, lansoprazole, and minocycline. …”
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Th1 and Th2 cytokine profile in patients with early onset periodontitis and their healthy siblings by Jiřina Bártová, Zuzana Krátká-Opatrná, Jarmila Procházková, Otakar Krejsa, Jana Dušková, Lubor Mrklas, Helena Tlaskalová, Božena Cukrowská

“…In the familial studies we tested the hypothesis about the role of Th1 and Th2 cytokines in the pathogenesis of EOP disease. The study involved 6 individuals with EOP disease and their 6 siblings with healthy periodontium. …”
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PPARγ activation attenuates neonatal CRD-induced visceral pain sensitization and anxiety in male rats by alleviating oxidative stress by Minjie Li, Xiyu Zhuo, Yongxiao Liu, Jinchao You, Jianqing Lin

“…Oxidative stress plays a crucial role in the pathogenesis of IBS. Previous studies have demonstrated that activation of peroxisome proliferator-activated receptor gamma (PPARγ) has analgesic effects. …”
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Immune cell profiles and predictive modeling in osteoporotic vertebral fractures using XGBoost machine learning algorithms by Yi-Chou Chen, Hui-Chen Su, Shih-Ming Huang, Ching-Hsiao Yu, Jen-Huei Chang, Yi-Lin Chiu

“…These findings underscore the critical role of immune cells in the pathogenesis of osteoporotic fractures and highlight the potential of XGBoost in identifying key biomarkers and therapeutic targets for mitigating fracture risk in osteoporotic patients.…”
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Variants in the 3′ End of SLC6A3 in Northwest Han Population with Parkinson’s by Peiye Chang, Yongwang Fu, Ping Zhao, Chunmei Wang, Mingfang Jiang, Rui Li, Yulin He

“…It is possible that multifactorial and genetic factors are related to its pathogenesis. Recently, there have been reports of SLC6A3 genetic variants leading to PD. …”
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Identification of critical endoplasmic reticulum stress-related genes in advanced atherosclerotic plaque by Ning Zhao, Dan Liu, Haixu Song, Xiaolin Zhang, Chenghui Yan, Yaling Han

“…This study aims to identify the molecular mechanisms of ERS in AS pathogenesis to inform innovative diagnostic approaches and therapeutic targets for managing AS. …”
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Functional constipation by Yu. O. Shulpekova, A. A. Kurbatova, A. V. Sedova

“…To discuss the recent updates in classification of constipation of functional origin (both as separate entity, and within the pattern of constipationpredominant irritable bowel syndrome), the concepts on pathogenesis and recommended treatment approaches. Key points. …”
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A Systematic Literature Review and Bucher Indirect Comparison: Tildrakizumab versus Guselkumab by Kristian Garn Du Jardin, Pepi Hurtado Lopez, Mette Lange, Rachael McCool, Silvia Maeso Naval, Sandra Quickert

“…Interleukin-23 (IL-23) has emerged as a key player in the pathogenesis of psoriasis and tildrakizumab and guselkumab are both immunomodulatory agents that inhibit the p19 subunit of IL-23. …”
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Association of Serum Adiponectin, Leptin, and Resistin Concentrations with the Severity of Liver Dysfunction and the Disease Complications in Alcoholic Liver Disease by Beata Kasztelan-Szczerbinska, Agata Surdacka, Maria Slomka, Jacek Rolinski, Krzysztof Celinski, Agata Smolen, Mariusz Szczerbinski

“…There is growing evidence that white adipose tissue is an important contributor in the pathogenesis of alcoholic liver disease (ALD). We investigated serum concentrations of total adiponectin (Acrp30), leptin, and resistin in patients with chronic alcohol abuse and different grades of liver dysfunction, as well as ALD complications. …”
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Heterogeneity of Clostridioides difficile asymptomatic colonization prevalence: a systematic review and meta-analysis by Daniel De-la-Rosa-Martínez, Rodrigo Villaseñor-Echavarri, Diana Vilar-Compte, Virna Mosqueda-Larrauri, Paola Zinser-Peniche, Seth Blumberg

“…This heterogeneity could be partially explained by population characteristics and settings, supporting their role in the pathogenesis and burden of this disease. This highlights the need to identify high-risk groups to improve infection control strategies, decrease transmission dynamics, and better understand the natural history of this disease.…”
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Associations of infection burden with Kawasaki disease in a population-based setting during 30 years by Johannes Mofors, Håkan Eliasson, Gunnar Bergman, Sven-Erik Sonesson, Marie Wahren-Herlenius, Göran Elinder, André Rudolph, Bodil Schiller

“…Objectives The objective of this study was to investigate the role of infections in the pathogenesis of Kawasaki disease.Methods The investigation was a nationwide epidemiological case-control study, comprising all cases of Kawasaki disease diagnosed in Sweden 1987–2018. …”
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Morphological and Molecular Characterization of Toxigenic Aspergillus flavus from Groundnut Kernels in Kenya by Robert O. Okayo, Darius O. Andika, Mathews M. Dida, George O. K’Otuto, Bernard M. Gichimu

“…Pathogenesis of Aspergillus flavus on important agricultural products is a key concern on human health due to the synthesis and secretion of the hazardous secondary metabolite, aflatoxin. …”
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Association between Sarcopenia and Insulin-Like Growth Factor-1, Myostatin, and Insulin Resistance in Elderly Patients Undergoing Hemodialysis by Novira Widajanti, SoebagijoAdi Soelistijo, Usman Hadi, Mochammad Thaha, null Aditiawardana, null Widodo, Hadiq Firdausi, YafanitaIzzati Nurina, MiraDelima Asikin, Hersih Srinowati, NoerHalimatus Syakdiyah

“…This study aims to investigate the correlation of insulin-like growth factor-1 (IGF-1) levels as an anabolic factor, myostatin levels, and insulin resistance as catabolic factors with sarcopenia in the pathogenesis of sarcopenia in elderly patients undergoing hemodialysis. …”
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