Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study by Esra Cataltepe, Eda Ceker, Ayse Fadiloglu, Fatih Gungor, Nermin Karakurt, Zekeriya Ulger, Hacer Dogan Varan

“…Abstract Background Chronic inflammation is increasingly recognized as a crucial contributor to sarcopenia pathogenesis, but accurate diagnosis remains a challenge. …”
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Yersinia Infection with Clostridium Difficile Colitis by M.J. Fishman, M.A. Noble, H.J. Freeman

“…Antibimic associated diarrhea appears to be largely due to Closcridium difficile and may have, at least in part. a toxin mediated pathogenesis. Because a poor correlation exists between measurable toxin titres and symptoms, additional copathogenic factors may be important. …”
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Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats by Madhavan Nampoothiri, Jessy John, Nitesh Kumar, Jayesh Mudgal, Gopalan Kutty Nampurath, Mallikarjuna Rao Chamallamudi

“…Aluminium, a neurotoxic agent in humans, has been implicated in the pathogenesis of neurodegenerative disorders. In this study, we examined the behavioral and biochemical effects of aluminium in rats with special emphasis on memory centres, namely, hippocampus and frontal cortex. …”
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Replication-transcription complex of coronaviruses: functions of individual viral non-structural subunits, properties and architecture of their complexes by E. L. Mishchenko, V. A. Ivanisenko

“…This indicates that there may be common mechanisms of coronavirus pathogenesis and, therefore, potential therapeutic targets for each virus may be the same. …”
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Novel cycloviruses identified by mining human blood metagenomic data show close relationship to those from animals by Yuanqing Wang, Yuanqing Wang, Xiaojie Jiang, Yuan Xi, Siqi Wei, Songyi Ning, Wen Zhang, Wen Zhang

“…Further research is needed to explore the functional roles of these cycloviruses in viral pathogenesis, particularly how they may influence host immunity and contribute to chronic infections. …”
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Association of Fibrinogen Aα Thr312Ala (rs6050) Polymorphism with Venous Thrombosis and Chronic Thromboembolic Pulmonary Hypertension: A Meta-Analysis by Han Cheng MM, Haozhe Yang BM, Yantong Zhang BM, Zhanxu Wei MM, Lei Xia BM, Jing Yang PhD

“…Chronic thromboembolic pulmonary hypertension (CTEPH) typically arises from acute pulmonary embolism. The pathogenesis of them involves multiple risk factors such as genetic predisposition. …”
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Elevated Transforming Growth Factor-β2 in the Aqueous Humor: A Possible Explanation for High Rate of Capsular Contraction Syndrome in High Myopia by Keke Zhang, Xiangjia Zhu, Minjie Chen, Xinghuai Sun, Jin Yang, Peng Zhou, Yi Lu

“…Elevated TGF-β2 levels in high myopic cataract patients may play an important role in the pathogenesis of capsular contraction syndrome.…”
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Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits by Qi Yu, Zhengcao Liu, Ahmed Bilal Waqar, Bo Ning, Xianghong Yang, Masashi Shiomi, Mark J. Graham, Rosanne M. Crooke, Enqi Liu, Sijun Dong, Jianglin Fan

“…Increased plasma levels of C-reactive protein (CRP) are closely associated with cardiovascular diseases, but whether CRP is directly involved in the pathogenesis of atherosclerosis is still under debate. …”
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IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome by Min Guo, Rui Yan, Hongmei Yao, Liqin Duan, Meng Sun, Zheng Xue, Yongping Jia

“…We propose that IRF-1 may be implicated in macrophage pyroptosis in the pathogenesis of AS and ACS. Methods. Patients with stable angina, unstable angina, acute myocardial infarction, and clinical presentation of chest pain were enrolled. …”
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The Association Between the Presence of Human Facial Mites Demodex (Acari, Demodicidae) and Dermatological Symptoms in Rosacea Patients in Central Anatolia, Türkiye by Merve Kahraman, Zübeyda Akın Polat, Mustafa Esen, Feride Çoban Gül

“…Conclusion: This study provides evidence suggesting a potential role for Demodex mites in the pathogenesis of rosacea, specifically in relation to skin symptoms such as burning, pain, and stinging. …”
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Hydrogen-Rich Saline Inhibits NLRP3 Inflammasome Activation and Attenuates Experimental Acute Pancreatitis in Mice by Jian-Dong Ren, Jie Ma, Jun Hou, Wen-Jin Xiao, Wei-Hua Jin, Juan Wu, Kai-Hua Fan

“…Increasing evidence has demonstrated that reactive oxygen species (ROS) induces oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP). Hydrogen-rich saline (HRS), a well-known ROS scavenger, has been shown to possess therapeutic benefit on AP in many animal experiments. …”
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Chromosome-level genome assembly of the sweet potato rot nematode Ditylenchus destructor by Yiwei Yang, Ruirui Feng, Bo Hong, Yuchuan Fang, Chen Liu, Kui Wang, Deliang Peng, Yingmei Li, Huan Peng, Qing Chang

“…This high-quality reference genome will serve as a valuable genomic resource for future research aimed at understanding the pathogenesis of D. destructor and developing effective control strategies.…”
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Beneficial microbiome and diet interplay in early-onset colorectal cancer by Zhengyuan Zhou, Linda Kleis, Ana Depetris-Chauvin, Stefanie Jaskulski, Victoria Damerell, Karin B Michels, Biljana Gigic, Ute Nöthlings, Gianni Panagiotou

“…We aim here to shed light on the complex interplay between diet and gut microbiome in the pathogenesis and prevention of early-onset CRC (EO-CRC). …”
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Necrostatin-1 Alleviates Diffuse Pulmonary Haemorrhage by Preventing the Release of NETs via Inhibiting NE/GSDMD Activation in Murine Lupus by Xinai Han, Xiaoming Zhang, Rui Song, Shiqi Li, Shujing Zou, Quanguang Tan, Tianyang Liu, Shugeng Luo, Zhe Wu, Hongyu Jie, Jinhong Wang

“…Thus, NETs released by neutrophils contributed to the pathogenesis of DAH in SLE, and Nec-1 showed protective effects by the inhibition of NET production via the reduction of NE activation and N-GSDMD expression.…”
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Lipotoxicity and metabolic disorders at obesity by V. T. Ivashkin, M. V. Mayevskaya

“…It is possible to explain lipotoxicity phenomenon as follows: in conditions of insulin resistance glucose stops to be an energy source and is substituted by lipolysis, therefore a plenty of free fatty acids is formed, having potential of toxicity and realizing metabolic disorders in target organs: the liver, the pancreas, muscles. New data on pathogenesis of metabolic disorders at obesity assume changes in comprehension of therapeutic actions. …”
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An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity by Chun-Bing Chen, Riichiro Abe, Ren-You Pan, Chuang-Wei Wang, Shuen-Iu Hung, Yi-Giien Tsai, Wen-Hung Chung

“…This review highlights recent advances in our understanding of the predisposing factors, immune mechanisms, pathogenesis, diagnostic tools, and therapeutic approaches for drug hypersensitivity.…”
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Two Cases of Diffuse Duodenitis Associated with Ulcerative Colitis by Katsuya Endo, Masatake Kuroha, Hisashi Shiga, Yoichi Kakuta, Seiichi Takahashi, Yoshitaka Kinouchi, Tooru Shimosegawa

“…The occurrence of gastrointestinal involvement in UC has been attracting attention because such lesions could potentially open a new window for studying the etiology and pathogenesis of UC. Further studies involving a large number of patients are needed to clarify whether the upper gastrointestinal tract is a target organ in UC.…”
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Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation by Roberta Ramonda, Leonardo Punzi, Anna Scanu, Francesca Oliviero, Roberto Luisetto, Paola Galozzi, Marta Favero

“…A variety of molecular, mechanobiological and cellular events involved in the pathogenesis and the progression of PTA have been identified. …”
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The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases by Huihui Xu, Meijie Liu, Jinfeng Cao, Xiaoya Li, Danping Fan, Ya Xia, Xiangchen Lu, Jingtao Li, Dahong Ju, Hongyan Zhao

“…Gut microbiota dysbiosis plays a crucial role in autoimmune disease pathogenesis as well as in bowel-related diseases. However, the role of the gut microbiota, which causes or influences systemic immunity in autoimmune diseases, remains elusive. …”
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Resistance Response of the Jasmonic Acid and Salicylic Acid Signaling Pathways in Mango Fruits Infected with Lasodiplodia theobromae by QU Xiangxiang, HU Meijiao, SUN Jinhua, GONG Deqiang, GAO Zhaoyin, CHEN Gengxin, LI Min

“…The gene expression of isochorismate synthase (MiICS), a SA signaling pathway-related gene, was down-regulated, while the gene expression of non-expressor of pathogenesis-related genes 1 (MiNPR1) was up-regulated at the early stage and down-regulated at the late stage. …”
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