Natural Product Identification and Molecular Docking Studies of Leishmania Major Pteridine Reductase Inhibitors by Moses N. Arthur, George Hanson, Emmanuel Broni, Patrick O. Sakyi, Henrietta Mensah-Brown, Whelton A. Miller, Samuel K. Kwofie

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Network and systems biology approaches help investigate gene regulatory interactions between Salmonella disease and host in chickens: Model‐based in silico evidence combined with g... by Reza Tohidi, Hoda Javaheri Bargourooshi, Arash Javanmard

“…The host's genetic immune system determines the pathogenicity of a particular bacterium. To shed light on this topic, it was necessary to understand the key candidate genes essential for regulating susceptibility and resistance to the target disease. …”
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Kemampuan Daya Hambat Bahan Aktif Beberapa Merek Dagang Hand sanitizer terhadap Pertumbuhan Staphylococcus aureus by Putri Srikartika, Netti Suharti, Eliza Anas

“…</em><em> It prevents  </em><em>the disease </em><em>that </em><em>can be caused by normal flora that potentially pathogenic bacterium such as Staphylococcus aureus. …”
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Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain ba... by Yinrui Guo, Jianlang He, Shaojie Li, Shiqi Zou, Haiting Zhang, Xin Yang, Jian Wang

“…C. albicans co-cultured with RAW264.7 cells increased TNF-α secretion, and the supernatant promoted pathogenic bacterial proliferation and biofilm formation. …”
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Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii group in Taiwan by Tran Lam Tu Quyen, Yu-Chia Hsieh, Shiao-Wen Li, Lii-Tzu Wu, Ya-Zhu Liu, Yi-Jiun Pan

“…ABSTRACT Acinetobacter, particularly the Acinetobacter baumannii group, is a major cause of nosocomial infections, and carbapenem-resistant Acinetobacter spp. are important human pathogens. We collected 492 Acinetobacter spp. strains from two hospitals in Taiwan and classified them using MALDI-TOF MS and blaOXA-51-like PCR; 94.5% were A. baumannii, and 5.5% were non-A. baumannii (NAB). …”
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Novel complex medication containing medium chain triglycerides for the treatment of dry eye by T.N. Safonova, G.V. Zaytseva, K.Yu. Kravets, N.B. Polyakov

“…Alterations in their qualitative and quantitative composition can result in evaporative dry eye, which requires pathogenic treatment. Somatic comorbidities, particularly type 2 diabetes (T2D), may act as a potential etiological factor. …”
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Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients by Asaduzzaman Asad, Md. Abu Jaher Nayeem, Md. Golam Mostafa, Ruma Begum, Shah Nayeem Faruque, Suraia Nusrin, Israt Jahan, Shoma Hayat, Zhahirul Islam

“…Recent advances in genomics strengthen the surveillance of MDR-pathogens and antimicrobial resistance (AMR) mediators. …”
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Projet KIKI : Projet de conservation et de réintroduction des cercopithèques du Gabon by Carole Dilger, Guillaume Le Flohic, Noé Campagne, Peggy Motsch

“…Cet orphelin est parfois récupéré comme animal de compagnie, il sera élevé seul, souvent maltraité et recevra une nourriture inappropriée, il risquera aussi de transmettre des agents pathogènes aux enfants qui vivent en contact avec lui. …”
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Selection of lactic acid bacteria as a probiotic and evaluated its performance on gnotobiotic catfish Clarias sp. by Enita Romasni Turnip, Widanarni, Widanarni, Anja Meryandini

“…The in vitro assay was done to select several LAB isolates based on antagonistic activity against pathogenic bacteria. The selected isolate was tested in vivo to observe their ability to improve growth performances of catfish. …”
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A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…FindingsIn this series of observational, retrospective, case-control, pharmacovigilance analyses of the FDA Adverse Event Reporting System, the odds of reporting the adverse event pemphigus were significantly elevated among individuals exposed to 11/36 previously reported trigger drugs namely, gold sodium thiomalate, penicillamine, piroxicam, rifampin, hydroxychloroquine, imiquimod, hydrochlorothiazide, irbesartan, lisinopril, nivolumab, and nifedipine.MeaningEnvironmental exposures such as drugs are relevant players in the pathogenesis of autoimmune diseases and clinicians who treat patients with autoimmune blistering diseases such as pemphigus should consider performing a detailed medication history leveraging this information regarding deleterious drug-disease interactions at initial evaluation as well as longitudinal monitoring of patients to better inform clinical care decisions.ImportancePemphigus vulgaris (PV) is a rare, potentially fatal autoimmune disease with pathogenic contributions from both genetic as well as environmental factors, notably drug exposures. …”
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Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study by Heinz Wiendl, Frederik Barkhof, Frederik Barkhof, Xavier Montalban, Anat Achiron, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Letizia Leocani, Letizia Leocani, Klaus Schmierer, Klaus Schmierer, Finn Sellebjerg, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

“…The safety profile was consistent with previous reports.DiscussionDeep longitudinal immunophenotyping, analysis of transcriptional changes, reduction in cells expressing pro-inflammatory cytokines, along with the marker of neuroaxonal damage provide novel and innovative evidence of CladT rebalancing the immune system towards a more homeostatic and less pathogenic state.Clinical Trial Registrationhttps://clinicaltrials.gov/study/, identifier NCT03364036.…”
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Effectiveness of acupuncture on glycolipid metabolism in patients with coronary heart disease: A systematic review and meta-analysis by Yuxin Sun, Yu Liu, Jian Xiong, Xiao Li, Ying Wei, Qianhua Zheng, Xiang Li, Wenchuan Qi, Fanrong Liang

“…Objective: Disorders of glycolipid metabolism are important pathogenic factors leading to coronary artery disease, and there is no safe and effective comprehensive treatment, while acupuncture has a certain efficacy in heart disease and disorders of glycolipid metabolism. …”
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Study of anti-inflammatory, antioxidant, antimicrobial and mineralizing effects of an N-isopropenylimidazole zinc metal complex derivative in experimental endodontic-periodontal le... by Pavel A. Galenko-Yaroshevsky, Ivan I. Pavlyuchenko, Olga V. Shelemekh, Boris A. Trofimov, Lidiya N. Parshina, Viktor L. Popkov, Svetlana A. Demyanenko, Oleg V. Tsymbalov, Andrey V. Zadorozhniy, Anait V. Zelenskaya, Irina B. Nektarevskaya, Alina V. Sergeeva, Nikolay E. Korovaykin, Svetlana A. Lebedeva

“…Introduction: The combination treatment of patients with dentition problems including endodontic-periodontal lesions (EPL) is known to widely involve anti-inflammatory drugs, including non-steroidal anti-inflammatory agents, and antimicrobial drugs, in particular antibiotics and antiseptics, from which the former often lead to the development of gastro- and neuropathy, lesions of kidneys and liver, as well as the cardiovascular system, and the latter, in addition to serious side effects, lead to the development of steady resistance of pathogenic microorganisms and dysbacteriosis. This necessitates search for and development of new molecules with a wide range of therapeutic effects aimed to block the infectious and inflammatory process and to restore the functional ability of teeth in EPLs as much as possible (depending on a lesion severity). …”
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A novel nanomaterial baffle decrease aerosols and microbial aerosols during non-contact tonometry measurements by X. Shen, Y. Guo, X, X. Wang, Y. Ye, Q. Chi, W. Zhou, Y. Chen, C. Li

“…</p> <p> <b>Conclusion: </b>Aerosolized ocular surface microorganisms (AOSM) can spread by human eyes NCT measured, pathogens may among them. The effect of plastic baffle was beneficial but volatile. …”
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The Effect of Different Ratio of Methionine-Zinc and Zinc Oxide on Performance Indicators and Diarrhea in Suckling Holstein Calves by Morteza Rezapour, Yadollah Chashnidel, Asadollah Teimoury Yansary, Essa Dirandeh

“…Zinc is an effective anti-inflammatory and anti-diarrheal substance that improves the function of the immune system, reduces the number of pathogenic bacteria and increases the relative abundance of beneficial microbes in the digestive system. …”
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Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosisResearch in context by Stylianos Papadopoulos, David Hardy, Frédérique Vernel-Pauillac, Magali Tichit, Ivo G. Boneca, Catherine Werts

“…Methods: To investigate the causes of death in lethal leptospirosis, we compared intraperitoneal infection of male and female C57BL6/J mice with 108 Leptospira of two strains of pathogenic L. interrogans. One strain, L. interrogans Manilae L495, killed the mice 4 days after infection, whereas the other strain, L. interrogans Icterohaemorrhagiae Verdun, did not induce any major symptoms in the mice. …”
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Genetic testing of ocular manifestations of proliferative syndrome to provide pathophysiology-oriented treatment by M.E. Weener, N.A. Bakunina, J.M. Salmasi, G.V. Poryadin, D. Barh, Yu.D. Kuznetsova, L.M. Balashova

“…</i> </p> <p> <i><b>Conclusion</b>: specifying the prognosis of the course and severity of proliferative ocular disorders pathogenically-oriented targeted treatment requires specialized genetic testing using an improved data analysis approach.…”
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Genetic and Molecular Characterization of Avian Influenza A(H9N2) Viruses from Live Bird Markets (LBM) in Senegal by Mamadou Malado Jallow, Moussa Moise Diagne, Marie Henriette Dior Ndione, Mamadou Aliou Barry, Ndiendé Koba Ndiaye, Davy Evrard Kiori, Marie Pedapa Mendy, Déborah Goudiaby, Gamou Fall, Malick Fall, Ndongo Dia

“…The A/H9N2 strains carried the low pathogenicity RSSR/GLF motif at the HA cleavage site and possessed several key amino acid mutations, including HA-I155T and HA-Q226L, which are associated with human host adaptation, PB2-T105V, PB2-A661T, and PB2-A588V, which are linked to the human-to-human transmission and increased polymerase activity, NS2-T14M, NS2-M100I, NS1-I106M, NS1-V222M, NS1-E223A, NS1-I226V, NS1-E227G, and NS1-P228S, which are known to alter virulence (increased or reduced) in humans or mice, and M2-S31N, which promotes drug resistance. …”
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IOP-lowering and neuroprotective treatment for glaucoma: reality and prospects by A.E. Egorov, N.G. Glazko, A.B. Movsisyan

“…Therefore, the aim of pathogenically-based treatment using modern therapeutic agents is to save maximum vision and the quality of life in most patients.…”
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Wild grasses as the reservoirs of infection of rust species for winter soft wheat in the Northern CaucasusWild grasses as the reservoirs of infection of rust species for winter sof... by E. I. Gultyaeva, L. A. Bespalova, I. B. Ablova, E. L. Shaydayuk, Zh. N. Khudokormova, D. R. Yakovleva, Yu. A. Titova

“…The virulence analysis of the leaf, stem and stripe rust populations did not reveal significant differences in the virulence of the pathogens between wild-growing cereals and soft wheat. …”
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